Inaliti yeSarilumab

-Delile

• Ngaphambi kokuthatha umjovo we-sarilumab,
• Umjovo weSarilumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Umjovo weSarilumab unganciphisa ikhono lakho lokulwa nokutheleleka futhi wandise ubungozi bokuthi uthole ukutheleleka okungathi sína, kufaka phakathi ukutheleleka okunzima kwe-fungal, bacterial, noma virus okusakazeka emzimbeni wonke. Lezi zifo zingadinga ukwelashwa esibhedlela futhi zingadala nokufa. Tshela udokotela wakho uma uvame ukuthola noma yiluphi uhlobo lokutheleleka noma uma ucabanga ukuthi ungaba nanoma yiluphi uhlobo lokutheleleka manje. Lokhu kufaka ukutheleleka okuncane (njengokusikeka okuvulekile noma izilonda), izifo ezifika zidlule (njengezilonda ezibandayo), kanye nezifo ezingamahlalakhona ezingapheli. Phinda utshele udokotela wakho uma ngabe uke waba nesifo sikashukela noma unesifo sikashukela, i-human immunodeficiency virus (HIV), uthola i-immunodeficiency syndrome (i-AIDS), noma esinye isimo esithinta amasosha akho omzimba. Kufanele futhi utshele udokotela wakho ukuthi ngabe uhlala, wake waphila yini, ukuthi ngabe uke waya ezindaweni ezinjengezigodi zemifula i-Ohio noma iMississippi lapho ukutheleleka okunzima kwefungal kuvame kakhulu. Buza udokotela wakho uma ungaqiniseki ukuthi lezi zifo zivamile yini endaweni yangakini. Tshela udokotela wakho uma uphuza imishanguzo eyehlisa ukusebenza kohlelo lokuzivikela komzimba njengokulandelayo: i-abatacept (i-Orencia); i-adalimumab (Humira); anakinra (Kineret); isitifiketi se-certolizumab (Cimzia); i-etanercept (Enbrel); i-golimumab (iSimponi); infliximab (i-Remicade); i-methotrexate (i-Otrexup, i-Rasuvo, i-Trexall); i-rituximab (i-Rituxan); ama-steroids afaka i-dexamethasone, i-methylprednisolone (i-A-Methapred, iMedrol, iSolu-Medrol), i-prednisolone (i-Orapred, i-Pediapred), ne-prednisone (i-Rayos); i-tocilizumab (i-Actemra) ne-tofacitinib (i-Xeljanz).

Udokotela wakho uzokuqapha ngezibonakaliso zokutheleleka ngesikhathi nangemva kokwelashwa kwakho. Uma unezinye zalezi zimpawu ezilandelayo ngaphambi kokuba uqale ukwelashwa kwakho noma uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi noma ngokushesha ngemuva kokwelashwa kwakho, shayela udokotela wakho ngokushesha: umkhuhlane; ukujuluka; Ukugodola; ubuhlungu bemisipha; ukukhwehlela; ukukhwehlela amafinyila anegazi; ukuphelelwa umoya; ukuncipha komzimba; isikhumba esifudumele, esibomvu, noma esibuhlungu; izilonda esikhumbeni; imizwa ejwayelekile, ebuhlungu, noma evuthayo ngesikhathi sokuchama; isifo sohudo; ubuhlungu besisu; noma ukukhathala ngokweqile.

Kungenzeka ukuthi usungenwe yisifo sofuba (i-TB; ukutheleleka okungathi sína kwamaphaphu) kodwa ungenazo izimpawu zesifo. Kulokhu, ukusebenzisa umjovo we-sarilumab kungenza ukutheleleka kwakho kube kubi kakhulu futhi kukwenze ube nezimpawu. Udokotela wakho uzohlola isikhumba ukuze abone ukuthi une-TB engasebenzi yini ngaphambi kokuba uqale ukwelashwa ngomjovo we-sarilumab. Uma kunesidingo, udokotela wakho uzokunika imithi yokwelapha lesi sifo ngaphambi kokuqala ukusebenzisa umjovo we-sarilumab. Tshela udokotela wakho uma uke waba ne-TB noma wake waba nayo, uma wake wahlala noma wavakashela izwe lapho i-TB ijwayelekile khona, noma uma wake waba seduze komuntu one-TB. Uma unalezi zimpawu ezilandelayo ze-TB, noma uma uba nalezi zimpawu phakathi nokwelashwa kwakho, shayela udokotela wakho ngokushesha: ukukhwehlela, ukukhwehlela amafinyila anegazi, ukwehla kwesisindo, ukulahleka kwethoni lezicubu, noma umkhuhlane.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa ngomjovo we-sarilumab futhi isikhathi ngasinye lapho ugcwalisa khona incwadi kadokotela. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Umjovo weSarilumab usetshenziswa wedwa noma uneminye imithi yokwelapha i-rheumatoid arthritis (RA: isimo lapho umzimba uhlasela khona amalunga ayo obangela ubuhlungu, ukuvuvukala, nokulahleka komsebenzi). I-Sarilumab ivame ukusetshenziswa ngabantu abangasizwanga ngezinye izidakamizwa ze-RA noma abangakwazanga ukuthatha le mithi. Umjovo weSarilumab usesigabeni semithi ebizwa nge-interleukin-6 (IL-6) receptor inhibitors. Isebenza ngokuvimba umsebenzi we-interleukin-6, into esemzimbeni ebangela ukuvuvukala.

Umjovo weSarilumab uza njengesirinji ekhethiwe yokujova ngomgogodla (ngaphansi kwesikhumba). Imvamisa isetshenziswa kanye njalo emavikini ama-2.Udokotela wakho anganquma ukuthi wena noma umnakekeli wakho ningenza imijovo ekhaya. Udokotela wakho uzokukhombisa noma umuntu ozojova umuthi ukuthi ungawujova kanjani. Wena noma umuntu ozojova umuthi kufanele futhi ufunde imiyalo ebhaliwe yokusetshenziswa eza nomuthi. Qiniseka ukuthi ubuza udokotela noma usokhemisi wakho uma unemibuzo mayelana nokuthi ungawujova kanjani umuthi.

Susa umuthi esiqandisini imizuzu engama-30 ngaphambi kokuba usukulungele ukujova umuthi. Yibeke endaweni ebanzi bese uyivumela ukuthi ifinyelele kuthempelesha yegumbi. Lapho ukhipha umjovo owufakile ebhokisini, qaphela ukuwubamba kuphela maphakathi nomzimba wesirinji futhi unganyakazisi isirinji noma ususe ikepisi elimboze inaliti. Ungazami ukufudumeza umuthi ngokuwufudumeza ngemicrowave, uwufake emanzini afudumele noma elangeni ngqo, noma nganoma iyiphi enye indlela.

Ngaphambi kokujova, hlola isirinji efakiwe ukuze uqiniseke ukuthi usuku lokuphelelwa yisikhathi oluprintwe kwiphakethe alukadluli. Bheka eduze uketshezi olukusipontsho. Okuketshezi kufanele kucace noma kuphuzi ngokukhanyayo futhi akufanele kube namafu noma kungabi nebala noma kuqukethe izigaxa noma izinhlayiya. Bheka ukuthi isirinji ibukeka ilimele yini noma ngabe ikepisi lenaliti lilahlekile noma cha. Shayela usokhemisi wakho uma kunezinkinga futhi ungawujovi umuthi.

Ungajova umjovo we-sarilumab ngaphambili kwamathanga noma noma yikuphi esiswini sakho ngaphandle kwenkaba yakho (inkinobho yesisu) nendawo engama-intshi amabili ukuyizungeza. Uma omunye umuntu ejova umuthi wakho, indawo engaphandle yezingalo ezingaphezulu nayo ingasetshenziswa. Ungawufaki umuthi esikhumbeni esithambile, esilimele, esonakele noma esinesibazi. Khetha indawo ehlukile njalo lapho ufaka umuthi.

Ungayisebenzisi imijovo esetshenzisiwe yakwa-sarilumab futhi ungaphindi amajojo ngemuva kokuyisebenzisa. Phonsa imijovo esetshenzisiwe esitsheni esingamelana nokubhoboza bese ubuza usokhemisi wakho ukuthi usilahla kanjani isitsha.

Udokotela wakho uzokubuka ngokucophelela ukuze abone ukuthi umjovo we-sarilumab usebenza kanjani kuwe. Udokotela wakho angalungisa umthamo wakho noma abambezele noma ayeke ukwelashwa kwakho ngokuya ngempendulo yakho kulo muthi. Kubalulekile ukutshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho.

Umjovo weSarilumab ungasiza ukulawula izimpawu zakho, kepha ngeke uselaphe isimo sakho. Qhubeka nokusebenzisa umjovo we-sarilumab noma ngabe uzizwa uphilile. Ungayeki ukusebenzisa umjovo we-sarilumab ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha umjovo we-sarilumab,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-sarilumab, noma imiphi eminye imithi, noma yiziphi izithako zomjovo we-sarilumab. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imishanguzo ebhalwe esigabeni ESIBALULEKILE SESEXWAYISO nanoma yikuphi okulandelayo: i-aspirin nezinye izidakamizwa ezingezona ukuvuvukala (ama-NSAID) njenge-ibuprofen (Advil, Motrin), ne-naproxen (Aleve, Anaprox, abanye); i-atorvastatin (Lipitor, eCaduet); i-clarithromycin (i-Biaxin, ku-Prevpac); i-cyclosporine (Gengraf, Neoral, Sandimmune); i-erythromycin (E.E.S., Eryc, PCE); i-lovastatin (Altoprev); izinto zokuvimbela inzalo ngomlomo (amaphilisi okuvimbela inzalo); i-quinidine (ku-Nuedexta); simvastatin (iZocor, eVytorin); i-sirolimus (i-Rapamune, iTorisel); tacrolimus (Astagraf, Envarsus XR, Prograf); i-telithromycin (Ketek); i-theophylline (Theo-24, Theochron); kanye ne-warfarin (Coumadin, Jantoven). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana nomjovo we-sarilumab, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• Tshela udokotela wakho uma uke waba ne-diverticulitis (izikhwama ezincane emgqeni wamathumbu amakhulu angavuvuka), izilonda esiswini noma emathunjini, umdlavuza, noma i-hepatitis B noma esinye isifo sesibindi. Phinda utshele udokotela wakho uma uhlela ukuhlinzwa noma inqubo yokwelashwa kungekudala.
• utshele udokotela wakho uma usanda kuthola noma uhlelelwe ukuthola noma yimiphi imithi yokugoma. Akufanele uthole noma yimiphi imigomo ngenkathi usebenzisa umjovo we-sarilumab ngaphandle kokukhuluma nodokotela wakho.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha umjovo we-sarilumab, shayela udokotela wakho. Uma uthola imijovo ye-sarilumab ngenkathi ukhulelwe, tshela udokotela ngaphambi kokuba ingane ithole noma yimiphi imigomo.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha umjovo we-sarilumab.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Buza udokotela wakho ukuthi wenzeni uma ukhohlwa ukujova umthamo. Ungasebenzisi umthamo ophindwe kabili ukwenza okulahlekile.

Umjovo weSarilumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhala eligcwele noma eligijimayo
• ububomvu noma ukulunywa eduze kwalapho umuthi wajova khona

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukopha noma ukulimaza kalula
• ukuqubuka
• isifuba
• ubunzima bokugwinya noma ukuphefumula
• ukuvuvukala kwezindebe zakho, ulimi, noma ubuso
• ubuhlungu besifuba
• uzizwe unesiyezi noma uqulekile
• ubuhlungu besisu
• ukuhlanza
• isikhumba esibuhlungu, esivuthayo, esikindizayo, noma esishayayo noma esikhunjeni

Imithi efana nomjovo we-sarilumab ingadala ingozi yokwanda komdlavuza. Khuluma nodokotela wakho ngezingozi zokusebenzisa lo muthi.

Umjovo weSarilumab ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi usebenzisa lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi ebhokisini efike kuyo ukuyivikela ekukhanyeni, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleli khona. Yigcine esiqandisini kodwa ungafrizi. Uma umuthi ubugcinwe ngaphandle kwesiqandisi, kufanele usetshenziswe kungakapheli izinsuku eziyi-14.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho kumjovo we-sarilumab.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Kevzara^®