I-Midostaurin

-Delile

• Ngaphambi kokuthatha i-midostaurin,
• I-Midostaurin ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Midostaurin isetshenziswa nezinye izidakamizwa zamakhemikhali ukwelapha izinhlobo ezithile ze-acute myeloid leukemia (AML; uhlobo lomdlavuza wamaseli amhlophe egazi). I-Midostaurin ibuye isetshenziselwe izinhlobo ezithile ze-mastocytosis (isifo segazi lapho kunamaseli amangqamuzana amaningi kakhulu [uhlobo oluthile lweseli emhlophe yegazi]). IMidostaurin isekilasini lemithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba ukusebenza kweprotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunqanda ukusabalala kwamangqamuzana omdlavuza nomdlavuza.

IMidostaurin iza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa ngokudla kabili ngosuku. Thatha i-midostaurin ngezikhathi ezilinganayo nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-midostaurin njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungazivuli noma uzichoboze.

Uma uhlanza ngemuva kokuthatha i-midostaurin, ungathathi omunye umthamo. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Udokotela wakho anganciphisa umthamo wakho we-midostaurin noma akutshele ukuthi uyeke ukuthatha i-midostaurin isikhathi esithile noma unomphela ngesikhathi sokwelashwa kwakho. Lokhu kuya ngemiphumela emibi oyitholayo. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Qhubeka uthathe i-midostaurin noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-midostaurin ngaphandle kokukhuluma nodokotela wakho.

Udokotela wakho angakutshela ukuthi uthathe imithi yokuvikela isicanucanu nokuhlanza ngaphambi komthamo ngamunye we-midostaurin.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-midostaurin,

• Tshela udokotela wakho kanye nosokhemisi uma une-aleji ye-midostaurin, noma imiphi eminye imithi, noma iziphi izithako ezikuma-capsules e-midostaurin. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: i-boceprevir (ayisatholakali e-U.S .; iVictrelis); carbamazepine (Carbatrol, Equetro, Tegretol, abanye); i-clarithromycin (i-Biaxin, ku-Prevpac); i-diltiazem (Cardizem, Cartia, Tiazac, abanye); enzalutamide (Xtandi); idelalisib (iZydelig); itraconazole (Onmel, Sporanox); ketoconazole (Nizoral); imishanguzo esetshenziselwa ukwelapha igciwane lesandulela ngculazi (i-HIV) njenge-cobicistat (iTybost, e-Evotaz, eGenvoya, e-Prezcobix, eStribild), elvitegravir (Vitekta), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra , eTechnivie, eViekira), e-saquinavir (i-Invirase) nase-tipranavir (i-Aptivus); i-mitotane (iLysodren); nefazodone; i-phenytoin (iDilantin, Phenytek); i-posaconazole (Noxafil); i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); i-troleandomycin (ayitholakali e-U.S.); kanye ne-voriconazole (Vfend). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingase futhi ihlanganyele ne-midostaurin, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma uke waba nokushaya kwenhliziyo okungajwayelekile, ukwelulwa kwe-QT (inkinga yenhliziyo engadala ukushaya kwenhliziyo okungajwayelekile, ukuquleka, noma ukufa ngokuzumayo), amaphaphu, isibindi noma isifo sezinso.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uma ungowesifazane, akufanele ukhulelwe ngenkathi uthatha i-midostaurin kanye nezinyanga ezi-4 ngemuva komthamo wakho wokugcina. Uzodinga ukuhlolwa kokukhulelwa okungalungile zingakapheli izinsuku eziyi-7 ngaphambi kokuba uqale ukuthatha i-midostaurin. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ungowesilisa, wena nomlingani wakho wesifazane kufanele nisebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa futhi niqhubeke nokusebenzisa ukubeletha izinyanga ezine ngemuva komthamo wakho wokugcina. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-midostaurin, shayela udokotela wakho ngokushesha. I-Midostaurin ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngenkathi uthatha i-midostaurin nezinyanga ze-4 ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala kwabesilisa nabesifazane.

Khuluma nodokotela wakho ngokudla isithelo samagilebhisi nokuphuza ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Yeqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa esivamile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Midostaurin ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• isifo sohudo
• ikhanda
• ukuphuma kwamakhala
• ukukhathala
• ubuthakathaka
• isiyezi
• ukuqunjelwa
• ama-hemorrhoids
• ukujuluka okwandayo
• ubuhlungu besisu
• amabala amhlophe noma izilonda ezindebeni noma emlonyeni nasemphinjeni
• ukuvuvukala kwezandla, izinyawo, amaqakala, noma imilenze engezansi
• iqolo, ithambo, ilunga, isitho noma ubuhlungu bemisipha
• ubunzima bokulala noma ukulala

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• umkhuhlane, ukukhwehlela, umphimbo obuhlungu, ukugodola nezinye izimpawu zokutheleleka
• ukushaya kwenhliziyo okusheshayo, okungajwayelekile, noma okushaya ngamandla
• ukuphelelwa umoya
• ubuhlungu besifuba
• ukuqhuma
• ukuvuvukala kwezindebe, ulimi, noma umphimbo
• ukuphefumula kanzima noma ukugwinya
• isifuba
• ukuqubuka
• ukulunywa
• ukukhwehlela okusha noma okuba kubi kakhulu
• isifuba
• ukuhlanza igazi noma okokuhlanza okubukeka njengezizathu zekhofi
• ukopha okungajwayelekile noma ukulinyazwa
• ukusha noma ubuhlungu lapho uchama

I-Midostaurin ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho angalawula izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-midostaurin.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Rydapt^®