ISofosbuvir, iVelpatasvir, neVoxilaprevir

-Delile

• Ngaphambi kokuthatha i-sofosbuvir, i-velpatasvir, ne-voxilaprevir,
• I-Sofosbuvir, i-velpatasvir, ne-voxilaprevir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

Kungenzeka ukuthi usungenwe yi-hepatitis B (igciwane elithelela isibindi futhi lingadala ukulimala kwesibindi), kepha ungabi nazimpawu zesifo. Kulokhu, ukuthatha inhlanganisela ye-sofosbuvir, i-velpatasvir, ne-voxilaprevir kungandisa ubungozi bokuthi ukutheleleka kwakho kuzoba kubi kakhulu noma kusongele impilo futhi uzoba nezimpawu. Tshela udokotela wakho uma ngabe uke waba nokutheleleka ngegciwane le-hepatitis B. Udokotela wakho uzokuyalela ukuhlolwa kwegazi ukuze abone ukuthi uke waba nokutheleleka kwesifo sikashukela B. Udokotela wakho uzokuhlola futhi nangezimpawu zokutheleleka kwesifo sokusha kwesibindi kohlobo B ngesikhathi nangezinyanga ezimbalwa ngemuva kokwelashwa kwakho. Uma kunesidingo, udokotela wakho angakunika imithi yokwelapha lesi sifo ngaphambi nangesikhathi sokwelashwa kwakho ngokuhlanganiswa kwe-sofosbuvir, i-velpatasvir, ne-voxilaprevir. Uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi noma ngemuva kokwelashwa kwakho, shayela udokotela wakho ngokushesha: ukukhathala ngokweqile, ukuphuzi kwesikhumba noma kwamehlo, ukulahlekelwa isifiso sokudla, isicanucanu noma ukuhlanza, indle ephaphathekile, ubuhlungu ohlangothini olungaphezulu kwesokudla sendawo yesisu, noma umchamo omnyama.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ngaphambi, ngesikhathi, nangemva kokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ekuhlanganisweni kwe-sofosbuvir, i-velpatasvir, ne-voxilaprevir.

Khuluma nodokotela wakho ngobungozi (s) bokuthatha i-sofosbuvir, i-velpatasvir, ne-voxilaprevir.

Inhlanganisela ye-sofosbuvir, i-velpatasvir, ne-voxilaprevir isetshenziselwa ukwelapha ukutheleleka okungapheli (kwesikhathi eside) kwesifo sokusha kwesibindi kohlobo C (ukuvuvukala kwesibindi okubangelwa igciwane) kubantu abadala asebethole ezinye izindlela zokwelashwa ze-HCV. ISofosbuvir iyi-non-nucleoside NS5B polymerase inhibitor. Isebenza ngokunciphisa inani legciwane le-hepatitis C emzimbeni. IVelpatasvir igciwane le-hepatitis C (HCV) NS5A inhibitor. Isebenza ngokuvimba igciwane elibangela ukusha kwesibindi kohlobo C ekusakazekeni ngaphakathi komzimba.IVoxilaprevir isekilasini lemithi ebizwa nge-HCV NS3 / 4A protease inhibitors. Isebenza ngokunciphisa inani le-HCV emzimbeni.

Inhlanganisela yesofosbuvir, i-velpatasvir, ne-voxilaprevir iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa ngokudla kanye ngosuku amasonto ayi-12. Thatha i-sofosbuvir, i-velpatasvir, ne-voxilaprevir ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-sofosbuvir, i-velpatasvir, ne-voxilaprevir njengoba kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Qhubeka nokuthatha i-sofosbuvir, i-velpatasvir, ne-voxilaprevir noma ngabe uzizwa uphilile. Ubude bokwelashwa kwakho buxhomeke esimeni sakho, ukuthi uphendula kahle kanjani emithini, nokuthi ngabe unemiphumela emibi kakhulu yini. Ungayeki ukuthatha i-sofosbuvir, i-velpatasvir, ne-voxilaprevir ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-sofosbuvir, i-velpatasvir, ne-voxilaprevir,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-sofosbuvir, i-velpatasvir, ne-voxilaprevir, noma imuphi omunye umuthi, noma iziphi izithako ekuhlanganisweni kwamaphilisi e-sofosbuvir, i-velpatasvir, ne-voxilaprevir. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma uthatha i-rifampin (Rifadin, Rimactane, eRifamate, eRifater). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-sofosbuvir, i-velpatasvir, ne-voxilaprevir uma uthatha i-rifampin.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: amiodarone (Nexterone, Pacerone); imithi yokwehlisa i-cholesterol (ama-statins) njenge-atorvastatin (Lipitor, eCaduet), i-fluvastatin (Lescol), i-lovastatin (i-Altoprev), i-pitavastatin (i-Livalo), i-pravastatin (i-Pravachol), i-rosuvastatin (i-Crestor), i-simvastatin (i-Flolipid, i-Zocor, e-Vytorin ); i-cyclosporine (Gengraf, Neoral, Sandimmune); dabigatran (Pradaxa); i-digoxin (i-Lanoxin); H₂ ama-blocker afana ne-cimetidine (Tagamet), i-famotidine (i-Pepcid), i-nizatidine (i-Axid), ne-ranitidine (i-Zantac); imishanguzo ethile yegciwane lesandulela ngculazi (i-HIV) noma i-immunodeficiency syndrome (i-AIDS) efaka i-atazanavir (Reyataz), efavirenz (Sustiva, e-Atripla), lopinavir (eKaletra), tenofovir (Viread, e-Atripla, Complera, Stribild, Truvada, abanye ), kanye ne-tipranavir (Aptivus) lapho ithathwa nge-ritonavir (Norvir); imatinib (Gleevec); i-irinotecan (iCamptosar); i-lapatinib (iTykerb); i-methotrexate (i-Otrexup, i-Rasuvo, i-Xatmep); mitoxantrone; i-rifabutin (i-Mycobutin); i-rifapentine (Priftin); imithi ethile yokuquleka efana ne-carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), oxcarbazepine (Trileptal), phenobarbital, noma phenytoin (Dilantin, Phenytek); i-sulfasalazine (i-Azulfidine); i-topotecan (iHycamtin); kanye ne-warfarin (Coumadin, Jantoven). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingaxhumana ne-sofosbuvir ne-velpatasvir, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• uma uthatha i-aluminium noma i-magnesium equkethe ama-antacids (Maalox, Mylanta), thatha amahora amane ngaphambi noma amahora amane ngemuva kwe-sofosbuvir, velpatasvir, ne-voxilaprevir.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• utshele udokotela wakho uma ngabe uke waba nanoma yiluphi uhlobo lwesifo sesibindi noma wake waba naso.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-sofosbuvir, i-velpatasvir, ne-voxilaprevir, shayela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ophuthelwe ngokudla ngokushesha nje lapho usakukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Sofosbuvir, i-velpatasvir, ne-voxilaprevir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• ukukhathala
• isifo sohudo
• ubuthakathaka
• ubunzima bokulala noma ukulala
• ukudana

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• ukuqubuka
• ubuthongo
• ukudideka
• ukuvuvukala kwendawo yesisu
• ukuhlanza igazi noma okokusebenza okubukeka njengezizathu zekhofi
• indle emnyama, emnyama, noma enegazi

I-Sofosbuvir, i-velpatasvir, ne-voxilaprevir ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Zonkevi^®