Enasidenib

-Delile

• Ngaphambi kokuthatha i-enasidenib,
• I-Enasidenib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

I-Enasidenib ingadala iqembu lezimpawu ezibucayi noma ezisongela ukuphila elibizwa nge-differentiation syndrome. Udokotela wakho uzokuqapha ngokucophelela ukuze abone ukuthi uyayihlakulela yini le syndrome. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: umkhuhlane, ukukhuluphala okungazelelwe, ukwehla kokuchama, ukuvuvukala kwezingalo zakho, imilenze, intamo, ukubhoboza, noma indawo engaphansi, ukuphefumula kanzima, ukuphefumula kanzima, ubuhlungu besifuba, ukukhwehlela, noma ubuhlungu bamathambo. Esibonakalisweni sokuqala sokuthi uthuthukisa isifo sokuhlukaniswa, udokotela wakho uzokunika imithi yokwelapha lesi sifo, futhi angakutshela ukuthi uyeke ukuthatha i-enasidenib isikhashana.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-enasidenib futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

I-Enasidenib isetshenziselwa ukwelapha uhlobo oluthile lwe-acute myeloid leukemia (AML; uhlobo lomdlavuza oluqala kumaseli amhlophe egazi) oluye lwashuba noma lwabuya ngemuva kokwelashwa ngeminye imithi ye-chemotherapy. U-Enasidenib usesigabeni semithi ebizwa nge-isocitrate dehydrongenase-2 (IDH2) inhibitor. Isebenza ngokunciphisa noma ngokumisa ukukhula kwamangqamuzana omdlavuza.

U-Enasidenib uza njengethebhulethi azoyithatha ngomlomo. Imvamisa kuthathwa kanye ngosuku noma ngaphandle kokudla. Thatha i-enasidenib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-enasidenib njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi ngenkomishi (ama-ounces angu-240) wamanzi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Uma uhlanza ngemuva kokuthatha umthamo we-enasidenib, thatha omunye umthamo ngokushesha ngangokunokwenzeka ngosuku olufanayo.

Udokotela wakho angamisa ukwelashwa kwakho okwesikhashana noma unomphela, anciphise umthamo wakho we-enasidenib, noma akuphathe ngeminye imithi kuye ngemiphumela oyitholayo. Qiniseka ukuthi ukhuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Ungayeki ukuthatha i-enasidenib ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-enasidenib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-enasidenib, noma imuphi omunye umuthi, noma iziphi izithako ezibhebheni ze-enasidenib. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uhlele ukuba nobaba wengane. Akufanele ukhulelwe ngenkathi uthatha i-enasidenib. Kuzodingeka ube nokuhlolwa kokukhulelwa okungekuhle ngaphambi kokuthi uqale ukuthatha le mithi. Sebenzisa ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho nge-enasidenib nangenyanga eyodwa ngemuva komthamo wakho wokugcina. Uma ungowesilisa futhi umlingani wakho angakhulelwa, kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho nenyanga eyodwa ngemuva komthamo wakho wokugcina. I-Enasidenib inganciphisa ukusebenza kwezindlela ezithile zokuvimbela inzalo ngomlomo ngakho-ke khuluma nodokotela wakho ngezindlela zokulawula inzalo ezizokusebenzela. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-enasidenib, shayela udokotela wakho.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngenkathi use-enasidenib nenyanga eyodwa ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala kwabesilisa nabesifazane. Khuluma nodokotela wakho ngezingozi zokuthatha i-enasidenib.

Phuza amanzi amaningi noma olunye uketshezi nsuku zonke ngenkathi welashwa nge-enasidenib,

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje uma uwukhumbula ngosuku olufanayo. Kodwa-ke, uma sekuvele usuku olulandelayo, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa okujwayelekile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Enasidenib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• isifo sohudo
• ukuncipha kokudla
• shintsha ngendlela izinto ezinambitha ngayo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• ukuphuzi kwamehlo akho noma isikhumba
• ukuqhuma kwemisipha noma ukudikiza; ukuvutha, ukubhoboza, noma ukuzwa imizwa esikhunjeni; ukushaya kwenhliziyo okungajwayelekile; noma ukuquleka

I-Enasidenib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Ungayikhiphi i-desiccant (iphakethe elincane elifakwe nemithi yokubamba umswakama) esitsheni.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-enasidenib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Idhifa^®