Ertugliflozin

-Delile

• Ngaphambi kokuthatha i-ertugliflozin,
• Lo muthi ungadala ushintsho kushukela wakho wegazi. Kufanele wazi izimpawu zikashukela wegazi ophansi futhi ophakeme nokuthi yini okufanele uyenze uma unalezi zimpawu.
• I-Ertugliflozin ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:
• Uma uhlangabezana nalezi zimpawu ezilandelayo, yeka ukuthatha i-ertugliflozin bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo ze-ketoacidosis, yeka ukuthatha i-ertugliflozin bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo. Uma kunokwenzeka, hlola ama-ketone emchameni wakho uma unalezi zimpawu, noma ngabe ushukela wegazi lakho ungaphansi kuka-250 mg / dL:

I-Ertugliflozin isetshenziswa kanye nokudla nokuzivocavoca umzimba, futhi kwesinye isikhathi neminye imithi, ukwehlisa amazinga kashukela egazini kubantu abanesifo sikashukela sohlobo 2 (isimo lapho ushukela wegazi uphakeme kakhulu ngoba umzimba awukhiqizi noma ungasebenzisi i-insulin ngokwejwayelekile). U-Ertugliflozin usekilasini lemithi ebizwa nge-sodium-glucose co-transporter 2 (SGLT2) inhibitors. Yehlisa ushukela egazini ngokwenza izinso zisuse i-glucose eningi emchameni. I-Ertugliflozin ayisetshenziswanga ukwelapha uhlobo lwesifo sikashukela sohlobo 1 (isimo lapho umzimba ungakhiqizi khona i-insulin, ngakho-ke, awukwazi ukulawula inani likashukela egazini) noma i-ketoacidosis yesifo sikashukela (isimo esibi esingakhula uma ushukela ophakeme wegazi ungelashwa ).

Ngokuhamba kwesikhathi, abantu abanesifo sikashukela kanye noshukela ophakeme wegazi bangakhula babe nezinkinga ezinkulu noma ezisongela impilo, kufaka phakathi isifo senhliziyo, isifo sohlangothi, izinkinga zezinso, ukulimala kwemizwa nezinkinga zamehlo. Ukuthatha imishanguzo, ukwenza ushintsho endleleni ophila ngayo (isb., Ukudla, ukuzivocavoca umzimba, ukuyeka ukubhema), nokuhlola njalo ushukela wegazi lakho kungasiza ukuphatha isifo sikashukela nokuthuthukisa impilo yakho. Lokhu kwelashwa kunganciphisa namathuba akho okuhlaselwa yisifo senhliziyo, isifo sohlangothi, noma ezinye izinkinga ezihlobene nesifo sikashukela njengokuhluleka kwezinso, ukulimala kwemizwa (okundikindiki, imilenze ebandayo noma izinyawo; ukwehla kwekhono lezocansi kwabesilisa nabesifazane), izinkinga zamehlo, kufaka phakathi izinguquko noma ukulahleka kombono, noma isifo sezinsini. Udokotela wakho nabanye abahlinzeki bezokunakekelwa kwezempilo bazokhuluma nawe ngendlela engcono yokuphatha isifo sikashukela.

U-Ertugliflozin uza njengethebhulethi azoyithatha ngomlomo. Imvamisa kuthathwa kanye ngosuku ekuseni noma ngaphandle kokudla. Thatha i-ertugliflozin ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-ertugliflozin njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Udokotela wakho angakuqala ngomthamo ophansi we-ertugliflozin futhi kancane kancane andise umthamo wakho.

I-Ertugliflozin ilawula uhlobo lwesifo sikashukela esingu-2 kodwa ayiselaphi. Qhubeka uthathe i-ertugliflozin noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-ertugliflozin ngaphandle kokukhuluma nodokotela wakho.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-ertugliflozin futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ukuthola uMhlahlandlela Wezokwelapha.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-ertugliflozin,

• Tshela udokotela wakho kanye nosokhemisi uma ungenwe yisifo somzimba (ukuqubuka, isifuba, ukuvuvukala kobuso bakho, izindebe, ulimi, noma umphimbo, noma ukuphefumula kanzima) ku-ertugliflozin, noma imuphi omunye umuthi, noma iziphi izithako ezikumaphilisi e-ertugliflozin. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: i-angiotensin-converting enzyme (ACE) inhibitors efana ne-benazepril (Lotensin, ku-Lotrel), i-captopril, i-enalapril (i-Vasotec, e-Vaseretic), i-fosinopril, i-lisinopril (i-Qbrelis, i-Zestril), i-moexipril, i-perindopril e-Prestalia), i-quinapril (i-Accupril, nge-Accuretic, ngesi-Quinaretic), i-ramipril (i-Altace), ne-trandolapril (i-Mavik, eTarka); ama-angiotensin receptor blockers afana ne-azilsartan (Edarbi, e-Edarbyclor), candesartan (Atacand, e-Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, e-Avalide), losartan (Cozaar, e-Hyzaar), olmesartan (Benicar, e-Azor, e-Benicar HCT, e-Tribenzor), e-telmisartan (Micardis, e-Micardis HCT, e-Twynsta), nase-valsartan (Diovan, e-Diovan HCT, e-Exforge); i-aspirin neminye imishanguzo yokulwa nokuvuvukala (ama-NSAID) njenge-ibuprofen (Advil, Motrin) ne-naproxen (Aleve, Naprosyn); isisu (‘amaphilisi amanzi’); kanye ne-insulin noma imithi yomlomo yesifo sikashukela njenge-chlorpropamide (i-Diabinese), i-glimepiride (i-Amaryl, e-Duetact), i-glipizide (i-Glucotrol), i-glyburide (i-DiaBeta, i-Glynase), i-tolazamide ne-tolbutamide. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho uma uku-dialysis nokuthi unesifo sezinso noma wake waba nesifo sezinso. Udokotela wakho angakutshela ukuthi ungathathi i-ertugliflozin.
• utshele udokotela wakho uma uphuza njalo utshwala noma kwesinye isikhathi uphuza utshwala obuningi ngesikhathi esifushane (ukuzitika ngotshwala), uke wanqunywa, noma udla ukudla okune-sodium ephansi. Futhi, tshela udokotela wakho uma uke waba nomfutho wegazi ophansi noma waba ne-cholesterol ephansi, izifo zomgudu womchamo noma izinkinga zomchamo, isifo se-pancreatic kufaka phakathi i-pancreatitis (ukuvuvukala kwamanyikwe) noma uke wahlinzwa kumanyikwe, ukutheleleka ngemvubelo endaweni yangasese , ukwehluleka kwenhliziyo, isifo semithambo yegazi (ukuncipha kwemithambo yegazi ezinyaweni, emilenzeni, noma ezingalweni okubangela ukuba ndikindiki, ubuhlungu, noma ukubanda kuleyo ngxenye yomzimba), i-neuropathy (ukulimala kwemizwa okubangela ukundindizela, ukuba ndikindiki, nobuhlungu, ngokuvamile izandla nezinyawo), izilonda ezinyaweni noma izilonda, noma inhliziyo, izinso, noma isifo sesibindi. Uma ungowesilisa, tshela udokotela wakho uma ungakaze usokwe. Tshela udokotela wakho uma udla kancane ngenxa yokugula, ukuhlinzwa, noma ushintsho ekudleni kwakho noma uma ungakwazi ukudla noma ukuphuza ngokwejwayelekile ngenxa yesicanucanu, ukuhlanza, isifo sohudo, noma uma uphelelwe amanzi emzimbeni ngenxa yokuba selangeni isikhathi eside .
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Musa ukuncelisa ngesikhathi uthatha i-ertugliflozin. Uma ukhulelwa ngenkathi uthatha i-ertugliflozin, shayela udokotela wakho.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-ertugliflozin.
• utshwala bungadala ushintsho kushukela wegazi. Buza udokotela wakho mayelana nokusetshenziswa okuphephile kweziphuzo ezidakayo ngenkathi uthatha i-ertugliflozin.
• kufanele wazi ukuthi i-ertugliflozin ingadala isiyezi, ikhanda elikhanyayo, nokuquleka lapho uvuka ngokushesha okukhulu endaweni yokulala. Uma unale nkinga, shayela udokotela wakho. Ukugwema le nkinga, phuma embhedeni kancane, uphumule izinyawo zakho phansi imizuzu embalwa ngaphambi kokuma.
• buza udokotela wakho ukuthi yini okufanele uyenze uma ugula, uba nesifo noma umkhuhlane, uba nengcindezi engajwayelekile, noma ulimele. Lezi zimo zingathinta ushukela wegazi lakho kanye nenani le-ertugliflozin ongayidinga.

Qiniseka ukuthi ulandela zonke izincomo zokuzivocavoca nezokudla ezenziwa ngudokotela wakho noma udokotela odlayo. Kubalulekile ukudla ukudla okunempilo.

Landela imiyalo kadokotela wakho mayelana nokuphuza uketshezi olwanele usuku lonke ngenkathi ukule mithi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

Lo muthi ungadala ushintsho kushukela wakho wegazi. Kufanele wazi izimpawu zikashukela wegazi ophansi futhi ophakeme nokuthi yini okufanele uyenze uma unalezi zimpawu.

I-Ertugliflozin ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuchama kakhulu, kufaka phakathi nasebusuku
• ukoma okwandisiwe
• umlomo owomile

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• ukuchama njalo, okuphuthumayo, okushisayo, noma okubuhlungu
• ukuncipha kwenani lomchamo
• umchamo onamafu, obomvu, opinki, noma onsundu
• umchamo onukayo onamandla
• ubuhlungu be-pelvic noma be-rectal
• (kwabesifazane) iphunga lesitho sangasese sowesifazane, ukuphuma okumhlophe noma okuphuzi kwesitho sangasese sowesifazane (kungaba nesigaxa noma kubukeke njenge-cottage shizi), noma ukulunywa kwesitho sangasese sowesifazane
• (emadodeni) ububomvu, ukulunywa, noma ukuvuvukala kwenduku; ukuqhuma emthondweni; ukukhishwa okunuka kabi okuvela epeni; noma ubuhlungu esikhunjeni esizungeze ipipi
• ukuzizwa ukhathele, ubuthakathaka, noma ungakhululekile; kanye nomkhuhlane nobuhlungu, isisa, ubomvu, nokuvuvukala kwezitho zangasese noma indawo ephakathi kwezitho zangasese kanye nengxenyeni
• ukuncipha komzimba
• umkhuhlane, ukubanda, noma ezinye izimpawu zokutheleleka
• ubuhlungu, isisa, izilonda, izilonda, noma ukuvuvukala, indawo efudumele, ebomvu endaweni yomlenze noma yonyawo

Uma uhlangabezana nalezi zimpawu ezilandelayo, yeka ukuthatha i-ertugliflozin bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuqubuka
• isifuba
• ukulunywa
• ubunzima bokugwinya
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe, umlomo, noma amehlo
• ukushaqeka

Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo ze-ketoacidosis, yeka ukuthatha i-ertugliflozin bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo. Uma kunokwenzeka, hlola ama-ketone emchameni wakho uma unalezi zimpawu, noma ngabe ushukela wegazi lakho ungaphansi kuka-250 mg / dL:

• isicanucanu
• ukuhlanza
• ubuhlungu bendawo esiswini
• ukukhathala
• ukuphefumula kanzima

I-Ertugliflozin ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda ukuhlolwa kwelebhu ngaphambi nangesikhathi sokwelashwa kwakho nge-ertugliflozin ukubheka ukuthi izinso zakho zisebenza kahle kangakanani. Amazinga kashukela egazini lakho kufanele ahlolwe njalo ukuthola impendulo yakho ku-ertugliflozin. Udokotela wakho uzo-oda ezinye izivivinyo zelebhu, kufaka phakathi i-hemoglobin ye-glycosylated (HbA1c), ukuze uhlole impendulo yakho ku-ertugliflozin. Udokotela wakho uzokutshela nokuthi ungayihlola kanjani impendulo yakho kulo muthi ngokulinganisa amazinga kashukela egazini lakho ekhaya. Landela le miyalo ngokucophelela.

Ngaphambi kokwenza noma yiluphi uvivinyo lwelabhoratri, tshela udokotela wakho kanye nabasebenzi be-laboratory ukuthi uthatha i-ertugliflozin. Ngenxa yendlela osebenza ngayo lo muthi, umchamo wakho ungahlola ukuthi une-glucose.

Kufanele njalo ufake isongo lokuhlonza isifo sikashukela ukuze uqiniseke ukuthi uthola ukwelashwa okufanele esimeni esiphuthumayo.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Steglatro^®

• I-Segluromet^® (equkethe i-Ertugliflozin, iMetformin)
• Ngobese^® (equkethe i-Ertugliflozin, iSitagliptin)