Ivosidenib

-Delile

• Ngaphambi kokuthatha i-ivosidenib,
• I-Ivosidenib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Ivosidenib ingadala iqembu lezimpawu ezibucayi noma ezisongela ukuphila elibizwa nge-differentiation syndrome. Udokotela wakho uzokuqapha ngokucophelela ukuze abone ukuthi uyayihlakulela yini le syndrome. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: umkhuhlane, ukukhwehlela, ukuqubuka, ukukhuluphala okungazelelwe, ukwehla kokuchama, ukuvuvukala kwezingalo noma imilenze, isiyezi noma ikhanda elikhanyayo, ukuphefumula okuncane, noma ukuphefumula kanzima. Lezi zimpawu zingavela ezinyangeni ezintathu ngemuva kokuqala ukwelashwa nge-ivosidenib. Esibonakalisweni sokuqala sokuthi uthuthukisa isifo sokuhlukanisa, udokotela wakho uzokunika imithi yokwelapha lesi sifo, futhi angakutshela ukuthi uyeke ukuthatha i-ivosidenib isikhathi esithile.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-ivosidenib.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-ivosidenib futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ukuthola uMhlahlandlela Wezokwelapha.

I-Ivosidenib isetshenziselwa ukwelapha uhlobo oluthile lwe-acute myeloid leukemia (AML; uhlobo lomdlavuza oluqala kumaseli amhlophe egazi) olubuyile noma olungakathuthuki ngemuva kokwelashwa kwangaphambilini. I-Ivosidenib isetshenziselwa ukwelapha uhlobo oluthile lwe-AML kwabanye abantu abadala abaneminyaka engaphezu kwengama-75 njengokwelapha kokuqala. I-Ivosidenib isekilasini lemithi ye-cad IDH1 inhibitors. Isebenza ngokunciphisa noma ngokumisa ukukhula kwamangqamuzana omdlavuza.

I-Ivosidenib iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa noma ngaphandle kokudla kanye ngosuku. Ingabe hhayi yithathe ngesidlo esinamafutha amaningi (njengokudla okuthosiwe noma ukudla okusheshayo). Thatha i-ivosidenib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-ivosidenib njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Uma uhlanza ngemuva kokuthatha i-ivosidenib, ungathathi omunye umthamo. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Udokotela wakho anganciphisa umthamo wakho noma ayeke ukwelashwa kwakho okwesikhashana noma unomphela nge-ivosidenib ngokuya ngempendulo yakho ekwelashweni noma yimiphi imiphumela emibi oyitholayo. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-ivosidenib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-ivosidenib, noma imuphi omunye umuthi, noma yiziphi izithako ezibhebheni ze-ivosidenib. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: amiodarone (Nexterone, Pacerone), carbamazepine (Equetro, Tegretol, Teril, others), clarithromycin, diltiazem (Cardizem, Cartia, Diltzac, Tiazac, others), efavirenz (Sustiva, in Atripla, in Symfi), i-erythromycin (i-Eryc), i-fluconazole (i-Diflucan), i-indinavir (i-Crixivan), i-itraconazole (i-Onmel, i-Sporanox, i-Tolsura), i-ketoconazole, izinto zokuvimbela inzalo zomlomo ezinjengalezi ezithile ('amaphilisi okulawula ukubeletha'), iziqeshana, nezindandatho zesitho sangasese sowesifazane, i-nefazodone , nelfinavir (Viracept), i-nevirapine (Viramune), phenobarbital, phenytoin (Dilantin, Phenytek), pioglitazone (Actos), procainamide, quinidine (e Nuedexta), rifabutin (Mycobutin), rifampin (Rifadin, e Rifamate, e Rifater), ritonavir (UNorvir, eKaletra, eViekira), saquinavir (Fortovase, Invirase), telithromycin (Ketek), kanye ne-verapamil (Calan, Verelan, eTarka). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-ivosidenib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imishanguzo oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• utshele udokotela wakho ukuthi yimiphi imikhiqizo yamakhambi oyithathayo, ikakhulukazi iSt John's Wort.
• utshele udokotela wakho uma wena noma omunye emndenini wakho enesikhathi eside se-QT (isimo esandisa ingozi yokuhlaselwa ukushaya kwenhliziyo okungafanele okungadala ukuquleka noma ukufa ngokuzumayo); uma uke waba nokushaya kwenhliziyo okuhamba kancane noma okungajwayelekile noma ezinye izinkinga zenhliziyo; amazinga aphansi egazi e-sodium, i-potassium, noma i-magnesium; izinkinga zesistimu yezinzwa; isifo sesibindi, kufaka phakathi i-cirrhosis; noma uma uthola ukwelashwa nge-dialysis noma uma uke waba nesifo sezinso noma wake waba naso.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa, noma uncelisa. Kufanele wazi ukuthi i-ivosidenib inganciphisa ukusebenza kahle kokuvimbela inzalo ngamahomoni (amaphilisi okulawula ukubeletha, amabala, izindandatho, noma imijovo) ngenkathi uthatha lo muthi. Khuluma nodokotela wakho ngokusebenzisa enye indlela yokulawula ukubeletha. Uma ukhulelwa ngenkathi uthatha i-ivosidenib, shayela udokotela wakho ngokushesha. I-Ivosidenib ingadala ukulimala kwengane.
• Tshela udokotela wakho uma uncelisa. Ungancelisi ngesikhathi sokwelashwa kwakho nge-ivosidenib nangenyanga e-1 ngemuva komthamo wakho wokugcina.

Khuluma nodokotela wakho ngokudla isithelo samagilebhisi nokuphuza ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Qiniseka ukuthi uphuza amanzi amaningi noma olunye uketshezi nsuku zonke ngenkathi uthatha i-ivosidenib.

Uma umthamo wakho olandelayo ufanele amahora angu-12 noma ngaphezulu, thatha isilinganiso esilahlekile ngokushesha nje lapho usikhumbula. Kodwa-ke, uma umthamo olandelayo uzothathwa ngaphansi kwamahora we-12, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Ivosidenib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• ukukhathala
• ubuhlungu obuhlangene noma besisipha
• isifo sohudo
• ukuqunjelwa
• ukuhlanza
• isicanucanu
• ukulahlekelwa isifiso sokudla
• ubuhlungu bomlomo nezilonda
• ubuhlungu besisu

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• isiyezi, ikhanda elikhanyayo, noma ukuquleka
• ubuthakathaka noma ukuzwa imizwa emilenzeni, ezingalweni, noma emzimbeni ongaphezulu; ukuba ndikindiki nobuhlungu ohlangothini olulodwa noma ezinhlangothini zombili zomzimba; izinguquko kwikhono lakho lokubona, ukuthinta, ukuzwa, noma ukunambitha; ukuvutha noma ukuzwa ukuzwa; noma ukuphefumula kanzima
• ubuhlungu besifuba

I-Ivosidenib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Udokotela wakho uzoku-oda ukuhlolwa kwelebhu ngaphambi kokuba uqale ukwelashwa kwakho ukuze ubone ukuthi umdlavuza wakho ungelashwa nge-ivosidenib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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