IGlasdegib

-Delile

• Ngaphambi kokuthatha i-glasdegib,
• IGlasdegib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka:

IGlasdegib akumele ithathwe yiziguli ezikhulelwe noma ezingakhulelwa. Kukhona ingozi enkulu yokuthi i-glasdegib izodala ukukhubazeka okukhulu kokuzalwa (izinkinga zomzimba ezikhona lapho kuzalwa) noma ukufa kwengane engakazalwa.

Uma ungowesifazane ongakhulelwa, kufanele ube nokuhlolwa kokukhulelwa okungalungile zingakapheli izinsuku eziyi-7 ngaphambi kokuqala ukwelashwa nge-glasdegib. Uzodinga ukusebenzisa ukulawulwa kokubeletha okusebenzayo ngenkathi welashwa nge-glasdegib futhi okungenani izinsuku ezingama-30 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezinketho zokulawula ukubeletha ezizokusebenzela.

Uma ungowesilisa onomlingani wesifazane ongakhulelwa noma okhulelwe, kufanele wazi ukuthi i-glasdegib ingaba khona kusidoda futhi ingadala ingozi enganeni engakazalwa. Sebenzisa ikhondomu ngenkathi welashwa nge-glasdegib futhi okungenani izinsuku ezingama-30 ngemuva komthamo wokugcina noma ngabe une-vasectomy (ukuhlinzwa ukuvikela isidoda ekuphumeni emzimbeni wakho futhi kubangele ukukhulelwa). Unganikeli ngesidoda ngesikhathi sokwelashwa kwakho futhi okungenani izinsuku ezingama-30 ngemuva komthamo wakho wokugcina.

Uma uye ocansini olungaphephile, cabanga ukuthi ukuvimbela inzalo yakho kwehlulekile, noma ucabanga ukuthi wena noma umlingani wakho wesifazane kungenzeka ukuthi ukhulelwe shayela udokotela wakho khona manjalo.

Musa ukunikela ngegazi noma imikhiqizo yegazi ngesikhathi sokwelashwa kwakho nge-glasdegib futhi okungenani izinsuku ezingama-30 ngemuva komthamo wakho wokugcina.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-glasdegib futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

IGlasdegib isetshenziswa kanye ne-cytarabine njengokwelashwa kokuqala kwe-acute myeloid leukemia (AML; uhlobo lomdlavuza oqala kumaseli amhlophe egazi) kubantu abaneminyaka engaphezu kwengama-75 ubudala, noma kubantu abadala abanezinye izimo zezokwelapha futhi abangakwazi ukwelashwa neminye imithi yokwelashwa ngamakhemikhali. IGlasdegib isekilasini lemithi ebizwa nge-hedgehog pathway inhibitors. Isebenza ngokuvimba ukusebenza kweprotheni ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukumisa noma ukubambezela ukusabalala kwamangqamuzana omdlavuza.

IGlasdegib iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kunikezwa ngokudla noma ngaphandle kokudla kanye ngosuku okungenani izinyanga eziyisithupha, noma inqobo nje uma udokotela wakho encoma ukwelashwa. Thatha i-glasdegib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-glasdegib njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Uma uhlanza ngemuva kokuthatha i-glasdegib, ungathathi omunye umthamo. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Udokotela wakho angadinga ukuphazamisa ukwelashwa kwakho, anciphise umthamo wakho, noma ayeke ukwelashwa kwakho ngokuya ngempendulo yakho emithini kanye nanoma imiphi imiphumela emibi ohlangabezana nayo. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho nge-glasdegib.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-glasdegib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-glasdegib, noma imuphi omunye umuthi, noma iziphi izithako ezibhebheni ze-glasdegib. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela noma engabhaliswanga, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: amiodarone (Nexterone, Pacerone), carbamazepine (Carbatrol, Equetro, Tegretol, abanye), chlorpromazine, cilostazol, citalopram (Celexa), clarithromycin, disopyramide (Norpace), dofetilide, donepezil (Aphilipili) dronedarone (Multaq), efavirenz (Sustiva, e-Atripla, Symfi), escitalopram (Lexapro), flecainide (Tambocor), fluconazole (Diflucan), haloperidol (Haldol), ibutilide (Corvert), indinavir (Crixivan), Itraconazx ), ketaconazole, methadone (Dolophine, Methadose), nefazodone, nelfinavir (Viracept), nevirapine (Viramune), ondansetron (Zofran, Zuplenz), phenobarbital, phenytoin (Dilantin, Phenytek), pimozide (Orap), Actogosit, pioglit , Duetact, Actoplus Met), procainamide, quinidine (eNuedexta), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, eRifater, Rifamate), ritonavir (Norvir, eViekira Pak, Kaletra, Technivie), sotaloline Betapace , Sotylize), ne-thioridazine. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-glasdegib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma uke waba nesikhathi se-QT isikhathi eside (inkinga engavamile yenhliziyo engadala ukushaya kwenhliziyo okungajwayelekile, ukuquleka, noma ukufa okungazelelwe), ukwehluleka kwenhliziyo (isimo lapho inhliziyo ingakwazi ukupompa igazi elanele kwezinye izingxenye zomzimba) , noma amazinga aphansi we-magnesium noma i-potassium egazini lakho.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngesikhathi sokwelashwa kwakho nge-glasdegib futhi okungenani izinsuku ezingama-30 ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala emadodeni. Khuluma nodokotela wakho ngezingozi zokuthatha i-glasdegib.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma kungaphansi kwamahora angu-12 kuze kufike umthamo wakho olandelayo, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

IGlasdegib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuphazamiseka kwemisipha
• imisipha, ithambo noma ubuhlungu bamalunga
• ukukhathala ngokweqile
• isicanucanu
• ukuhlanza
• ubuhlungu besisu
• ukuqunjelwa
• ubuhlungu noma izilonda emlonyeni noma emphinjeni
• ukuncipha kokudla
• shintsha ngendlela izinto ezinambitha ngayo
• ukuncipha komzimba
• ikhanda
• ukuqubuka
• ukuvuvukala kwezandla noma imilenze
• ukulahleka kwezinwele
• ubuhlungu bamazinyo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• ukuzizwa uphela amandla, unekhanda elincane, noma unesiyezi; ukushaya kwenhliziyo okusheshayo noma okungajwayelekile
• ukulimaza noma ukopha okungavamile
• umkhuhlane wedwa noma kanye nokubanda, ubuthakathaka. noma ezinye izimpawu zokutheleleka
• ukuncipha kokuchama
• ubuhlungu besifuba

IGlasdegib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka:

• isicanucanu
• ukuhlanza
• ukukhathala ngokweqile
• isiyezi

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ezifana ne-electrocardiograms (EKG, ukuhlolwa okurekhoda umsebenzi kagesi wenhliziyo) nokuhlolwa kwegazi ngaphambi nangesikhathi sokwelapha ukuqinisekisa ukuthi kuphephile kuwe ukuthatha i-glasdegib nokuhlola ukuphendula komzimba wakho emithini .

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Daurismo^®