I-Cabozantinib (umdlavuza we-thyroid)

-Delile

• Ngaphambi kokuthatha i-cabozantinib (Cometriq),
• ICabozantinib (Cometriq) ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Cabozantinib (Cometriq) isetshenziselwa ukwelapha uhlobo oluthile lomdlavuza wegilo oluya ngokuya ludlulela kwezinye izingxenye zomzimba. ICabozantinib (Cometriq) isekilasini lemithi ebizwa nge-tyrosine kinase inhibitors. Isebenza ngokuvimba isenzo sephrotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunciphisa noma ukumisa ukusabalala kwamangqamuzana omdlavuza.

I-Cabozantinib iyatholakala njengethebhulethi (i-Cabometyx) yokwelapha i-renal cell carcinoma (RCC; uhlobo lomdlavuza oluqala kumaseli ezinso) kanye ne-hepatocellular carcinoma (HCC; uhlobo lomdlavuza wesibindi) ezigulini ezithile ezake zaba khona ngaphambilini welashwe ngomunye umuthi. Le monograph inika kuphela imininingwane ngamaphilisi e-cabozantinib (Cometriq) womdlavuza wegilo. Uma usebenzisa lo muthi we-RCC noma i-HCC ethuthukile, funda i-monograph enesihloko esithi cabozantinib (umdlavuza wesibindi nowezinso).

ICabozantinib (Cometriq) iza njengephilisi elizothathwa ngomlomo. Kuthathwa imvamisa kanye ngosuku esiswini esingenalutho, okungenani ihora eli-1 ngaphambi kanye namahora ama-2 ngemuva kokudla. Thatha i-cabozantinib (Cometriq) ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-cabozantinib (Cometriq) njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi ngengilazi egcwele (ama-ounces ayi-8, ama-240 mL) wamanzi. Ungavuli.

Udokotela wakho anganciphisa umthamo wakho we-cabozantinib (Cometriq) noma umise unomphela noma okwesikhashana ukwelashwa kwakho uma uba nemiphumela emibi kakhulu. Qiniseka ukuthi ukhuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngenkathi welashwa nge-cabozantinib (Cometriq).

Ubude bokwelashwa kwakho buncike ekutheni usabela kanjani emithini kanye nemiphumela emibi oyitholayo. Qhubeka uthathe i-cabozantinib (Cometriq) noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-cabozantinib (Cometriq) ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-cabozantinib (Cometriq),

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-cabozantinib (Cabometyx, Cometriq), noma imuphi omunye umuthi, noma iziphi izithako ezikuma-cabozantinib capsules. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela noma engabhaliswanga, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: adefovir (Hepsera); ama-antifungals afana ne-itraconazole (Sporanox), ketoconazole, ne-voriconazole (Vfend); i-clarithromycin (i-Biaxin, ku-Prevpac); i-dexamethasone; i-furosemide (i-Lasix); imishanguzo ethile ye-HIV noma i-AIDS efana ne-abacavir (Ziagen), atazanavir (Reyataz), cidofovir, indinavir (Crixivan), lamivudine (Epivir, eCombivir); i-nelfinavir (i-Viracept), i-nevirapine (i-Viramune), i-ritonavir (i-Norvir, e-Kaletra), i-saquinavir (i-Invirase), ne-tenofovir (i-Viread); imithi ethile yokuquleka efana ne-carbamazepine (i-Equetro, iTegretol, iTeril), i-phenobarbital, ne-phenytoin (iDilantin, Phenytek); nefazodone; i-probenecid (i-Probalan), i-rifabutin (i-Mycobutin); i-rifampin (Rifactin, Rifadin, eRifamate, eRifater); i-rifapentine (Priftin); i-telithromycin (Ketek); kanye ne-warfarin (Coumadin, Jantoven). Eminye imishanguzo eminingi ingaxhumana ne-cabozantinib (Cometriq), ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• utshele udokotela wakho uma usanda kuba nokopha okungajwayelekile noma okunzima njengokukhwehlela igazi, ukugabha igazi, noma izitulo ezilindayo ezinegazi noma ezimnyama. Phinda utshele udokotela wakho uma unesilonda esivulekile noma esipholisayo, noma uma uke waba nomfutho wegazi ophakeme noma isifo sesibindi.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uzodinga ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa nge-cabozantinib. Akufanele ukhulelwe ngesikhathi sokwelashwa kwakho nge-cabozantinib nezinyanga ezi-4 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma ukhulelwa ngenkathi uthatha i-cabozantinib (Cometriq), shayela udokotela wakho ngokushesha. ICabozantinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Udokotela wakho angakutshela ukuthi ungancelisi ngesikhathi sokwelashwa kwakho nezinyanga ezine ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala kwabesilisa nabesifazane. Khuluma nodokotela wakho ngezingozi zokuthatha i-cabozantinib (Cometriq).
• uma uhlinzwa, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-cabozantinib (Cometriq). Udokotela wakho mhlawumbe uzokutshela ukuthi uyeke ukuthatha i-cabozantinib (Cometriq) okungenani izinsuku ezingama-21 ngaphambi kokuhlinzwa kwakho futhi uzokutshela ukuthi kufanele uqale nini ukuphuza umuthi ngemuva kokuhlinzwa kwakho.
• kufanele wazi ukuthi i-cabozantinib (Cometriq) ingadala izinkinga ezinkulu ngomhlathi wakho. Udokotela wamazinyo kufanele ahlole amazinyo akho ngaphambi kokuba uqale ukuthatha i-cabozantinib futhi njalo ngesikhathi sokwelashwa kwakho. Qiniseka ukuthi uxubha amazinyo futhi uhlanze umlomo wakho kahle ngenkathi uthatha i-cabozantinib (Cometriq). Khuluma nodokotela wakho ngaphambi kokuthola noma yikuphi ukwelashwa kwamazinyo ngenkathi uthatha lo muthi. Udokotela wakho uzokutshela ukuthi uyeke ukuthatha i-cabozantinib okungenani izinsuku ezingama-21 ngaphambi kokuhlinzwa kwamazinyo.
• kufanele wazi ukuthi umfutho wegazi wakho ungakhuphuka ngenkathi welashwa nge-cabozantinib (Cometriq). Udokotela wakho mhlawumbe uzoqapha ukucindezelwa kwakho kwegazi ngesikhathi sokwelashwa kwakho.

Ungaphuzi ijusi yamagilebhisi noma udle isithelo samagilebhisi noma yikuphi ukudla noma izithasiselo eziqukethe ubhamubhamu noma ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma kungaphansi kwamahora angu-12 kuze kufike umthamo wakho olandelayo ohleliwe, weqa umthamo ongabanjwanga bese uqhubeka nesimiso sakho sokulinganisa okujwayelekile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

ICabozantinib (Cometriq) ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuqunjelwa
• ama-hemorrhoids
• isicanucanu
• ukuhlanza
• isilungulela
• shintsha emandleni okunambitha ukudla
• ubunzima bokugwinya
• ububomvu, ukuvuvukala, izilonda, noma ubuhlungu emlonyeni noma emphinjeni
• ukulahlekelwa isifiso sokudla
• ukuncipha komzimba
• ukukhathala noma ubuthakathaka
• ubuhlungu emalungeni
• ubuhlungu bemisipha noma ukuphazamiseka
• ukukhathazeka
• ukuba ndikindiki, ukushiswa, noma ukuncinza ezandleni, ezingalweni, ezinyaweni noma emilenzeni
• isikhumba esomile
• ukuqina okuluhlaza kwesikhumba
• ukulahleka kwezinwele
• umbala wezinwele uphenduka ulula noma ube mpunga
• ukushintsha kwezwi noma ukusikisela

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukukhwehlela igazi noma amahlule egazi
• izinto zokuhlanza ezinegazi noma ezibukeka njengezizathu zekhofi
• ukopha kokuya esikhathini okunzima kakhulu kunokujwayelekile
• okubomvu noma okumnyama, isitulo sokulinda
• noma yikuphi ukopha okungasetshenziswanga noma okusindayo noma ukulinyazwa
• isifo sohudo
• indawo yesisu ethambile noma ebuhlungu
• ukuvuvukala noma ubuhlungu ezingalweni noma emilenzeni
• ukuphelelwa umoya
• ikhanda elikhanyayo noma ukuquleka
• ukujuluka
• ukuba ndikindiki noma ukubuthakathaka kobuso, ingalo, noma umlenze ohlangothini olulodwa lomzimba wakho
• isiyezi
• ubunzima obungazelelwe ngokulinganisela noma ukuxhumanisa
• Izinsini ezivuvukile noma ezibuhlungu
• ngokuzumayo, ikhanda elibi kakhulu
• ubuhlungu bomhlathi
• ubuhlungu bamazinyo
• isithuthwane
• ukuhamba ngokuzumayo
• izinkinga zokubona okungazelelwe
• ukudideka
• ubunzima ngokungazelelwe bokucabanga noma ukukhuluma ngokucacile
• ukuqubuka
• ububomvu, ubuhlungu, ukuvuvukala, noma ukushisa ezintendeni zezandla noma ematheni
• ubunzima bokudla noma ukuphuza ngenxa yezilonda zomlomo noma isicanucanu nokuhlanza

ICabozantinib (Cometriq) ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo.http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ukulahleka kwememori
• ukudideka
• ukuncipha komzimba

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-cabozantinib (Cometriq).

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Cometriq^®