Larotrectinib

-Delile

• Ngaphambi kokuthatha i-larotrectinib,
• I-Larotrectinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo esigabeni esikhethekile SOKUQAPHA, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Larotrectinib isetshenziselwa ukwelapha uhlobo oluthile lwezimila eziqinile kubantu abadala nasezinyangeni ezineminyaka engu-1 ubudala nangaphezulu eziye zasakazeka kwezinye izingxenye zomzimba noma azikwazi ukwelashwa ngempumelelo ngokuhlinzwa. Lo muthi usetshenziswa kuphela uma kungekho okunye ukwelashwa okutholakalayo futhi izicubu ziye zaba zimbi kakhulu ngemuva kokuthola ezinye izindlela zokwelashwa. I-Larotrectinib isekilasini lemithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo samaprotheni angajwayelekile atshela amangqamuzana omdlavuza ukuthi ande. Lokhu kungasiza ukunciphisa ukukhula kwezimila.

I-Larotrectinib iza njenge-capsule nanjengesixazululo (uketshezi) ukuthatha ngomlomo. Imvamisa kuthathwa ngokudla noma ngaphandle kokudla kabili ngosuku. Thatha i-larotrectinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-larotrectinib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi ngamanzi; ungawahlafune noma uwachoboze.

Sebenzisa isirinji yomlomo (ithuluzi lokulinganisa) ukukala ngokunembile futhi uthathe umthamo wakho wesixazululo se-larotrectinib. Buza usokhemisi wakho ngesirinji yomlomo uma eyodwa ingafakwanga nemithi yakho. Ungasebenzisi isipuni sasekhaya ukukala isisombululo. Shintsha isirinji ngayinye yomlomo ngemuva kokuyisebenzisa izinsuku eziyi-7 noma uma ilimala. Landela imiyalelo yomkhiqizi mayelana nokuthi ungayisebenzisa kanjani futhi uyihlanze kanjani isirinji yomlomo. Buza udokotela wakho noma usokhemisi uma unemibuzo.

Uma unikeza isisombululo enganeni, faka ichopho lesipontsho lomlomo emlonyeni wengane ngaphakathi kwesihlathi. Gcina ingane isesimweni esiqondile imizuzu embalwa ngemuva nje kokunikeza umthamo we-larotrectinib. Uma ingane ikhafula umthamo noma ungaqiniseki ukuthi wonke umthamo unikezwe, unganikezi omunye umthamo.

Uma uhlanza ngokushesha ngemuva kokuthatha i-larotrectinib, ungaphindi umthamo. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Udokotela wakho angadinga ukumisa ukwelashwa kwakho okwesikhashana noma unomphela noma anciphise umthamo wakho we-larotrectinib ngesikhathi sokwelashwa kwakho. Lokhu kuncike ekutheni umuthi usebenza kanjani kuwe kanye nemiphumela emibi oyitholayo. Qinisekisa ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngenkathi ukwelashwa nge-larotrectinib.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-larotrectinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-larotrectinib, noma imuphi omunye umuthi, noma iziphi izithako kuma-capsule we-larotrectinib noma isisombululo. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ama-antifungal athile afana ne-itraconazole (Onmel, Sporanox) ne-ketoconazole; i-avanafil (iStendra); buspirone; i-clarithromycin (i-Biaxin, ku-PrevPac); imishanguzo ethile yegciwane lesandulela-ngculazi (i-HIV) noma i-immunodeficiency syndrome (i-AIDS) efana ne-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, e Kaletra), kanye i-saquinavir (i-Invirase); imithi ethile ecindezela amasosha omzimba njenge-everolimus (Afinitor, Zortress), sirolimus (Rapamune), ne-tacrolimus (Astagraf, Envarsus XR, Prograf); lovastatin; i-midazolam; nefazodone; i-pioglitazone (Actos); i-rifabutin (i-Mycobutin); i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); imithi ethile yokuquleka efana ne-carbamazepine (Carbatrol, Epitol, Tegretol, abanye), phenobarbital, ne-phenytoin (Dilantin, Phenytek); i-sildenafil (i-Revatio, i-Viagra), i-simvastatin (i-Flolipid, i-Zocor); futhi vardenafil (Levitra, Staxyn). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-larotrectinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort. Ungathathi i-wort yaseSt. John ngenkathi uthatha i-larotrectinib.
• utshele udokotela wakho uma ngabe uke waba nezimo ezithinta uhlelo lwezinzwa noma isifo sesibindi.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uma uhlela ukuba ngubaba wengane. Uma ungowesifazane, kuzodingeka uthathe ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa futhi usebenzise izilawuli zokubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nangesonto eli-1 ngemuva komthamo wakho wokugcina. Uma ungowesilisa, wena nomlingani wakho wesifazane kufanele nisebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa kwenu nangesonto eli-1 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa. I-Larotrectinib inganciphisa ukuzala kwabesifazane. Kodwa-ke, akufanele ucabange ukuthi awukwazi ukukhulelwa. Uma wena noma umlingani wakho ukhulelwa, shayela udokotela wakho ngokushesha. I-Larotrectinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngesikhathi sokwelashwa kwakho nangesonto eli-1 ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi i-larotrectinib ingadala ukozela, isiyezi, noma ukudideka. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma kungaphansi kwamahora angu-6 ngaphambi komthamo wakho olandelayo, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Larotrectinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukukhwehlela
• ukuqunjelwa
• isifo sohudo
• isicanucanu
• ukuhlanza
• ubuhlungu besisu
• ikhanda
• ukuminyana kwamakhala
• ukuzuza kwesisindo
• ubuhlungu bemisipha, obuhlangene noma obuya emuva
• ubuthakathaka bemisipha
• ukoma okwandisiwe; shintsha inani noma umbala womchamo; isikhumba esomile; noma ukuquleka

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo esigabeni esikhethekile SOKUQAPHA, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• inkulumo ehamba kancane noma enzima; ukuwa ngengozi; noma ukuncinza, ukuba ndikindiki, noma ukushisa okuvuthayo ezandleni nasezinyaweni zakho
• imfiva
• ukuvuvukala ezandleni, ezinyaweni, emaqakaleni, noma emilenzeni engezansi
• ukuphelelwa umoya
• ukukhathala okungajwayelekile noma ubuthakathaka; noma isikhumba esiphaphathekile
• ukulahlekelwa ukudla; isicanucanu; ukuhlanza; ukuphuzi kwesikhumba noma kwamehlo; noma ubuhlungu engxenyeni engaphezulu kwesokudla yesisu

I-Larotrectinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina amaphilisi ekamelweni lokushisa kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Gcina isisombululo somlomo esiqandisini bese uvale uvalwe; ungafrizi. Lahla noma isiphi isisombululo somlomo esingasetshenziswanga ezinsukwini ezingama-90 ngemuva kokuvula ibhodlela okokuqala.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi nangesikhathi sokwelashwa ukuze ahlole impendulo yomzimba wakho ku-larotrectinib. Kwezinye izimo, udokotela wakho uzo-oda ukuhlolwa kwelebhu ngaphambi kokuthi uqale ukwelashwa kwakho ukuze ubone ukuthi umdlavuza wakho ungelashwa nge-larotrectinib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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