I-Calaspargase pegol-mknl Injection

-Delile

• Ngaphambi kokuthola umjovo we-calaspargase pegol-mknl,
• Umjovo weCalaspargase pegol-mknl ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu shayela udokotela wakho ngokushesha:

I-Calaspargase pegol-mknl isetshenziswa neminye imishanguzo yokwelapha ngamakhemikhali ukwelapha i-acute lymphocytic leukemia (BONKE; uhlobo lomdlavuza wamaseli amhlophe egazi) ezinganeni, ezinganeni, nakubantu abadala abasebasha abaneminyaka engu-1 kuya kwengu-21 ubudala. ICalaspargase pegol-mknl iyi-enzyme ephazamisa izinto zemvelo ezidingekayo ekukhuleni kweseli lomdlavuza. Isebenza ngokubulala noma ngokumisa ukukhula kwamangqamuzana omdlavuza.

ICalaspargase pegol-mknl iza njengesisombululo (uketshezi) esizofakwa ngaphakathi (emthanjeni) ngaphezu kwehora eli-1 ngudokotela noma umhlengikazi ehhovisi lezokwelapha noma esibhedlela. Imvamisa inikezwa kanye njalo emavikini ama-3 inqobo nje uma udokotela wakho encoma ukwelashwa.

Udokotela wakho kungadingeka ukuthi anciphise ukumnika kwakho, akubambezele, noma ayeke ukwelashwa kwakho ngomjovo we-calaspargase pegol-mknl, noma akuphathe ngeminye imithi uma uhlangabezana nemiphumela ethile emibi. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngenkathi welashwa nge-calaspargase pegol-mknl.

I-Calaspargase pegol-mknl ingadala ukusabela okweqile noma okusongela impilo okungenzeka kwenzeke ngesikhathi sokumnika noma kungakapheli ihora elilodwa ngemuva kokufakwa. Udokotela noma umhlengikazi uzokuqapha ngesikhathi sokumnika kanye nehora elilodwa ngemuva kokuminyelwa kwakho ukuqeda ukubona ukuthi unempendulo engathi sína yini emithini. Tshela udokotela wakho noma umhlengikazi ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo: ukuvuvukala kobuso, umphimbo, ulimi, izindebe, noma amehlo; ukuqhuma; isifuba; ukulunywa; ukuqubuka; noma ubunzima bokugwinya noma ukuphefumula.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-calaspargase pegol-mknl,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-calaspargase pegol-mknl, pegaspargase (Oncaspar), noma imuphi omunye umuthi, noma iziphi izithako zomjovo we-calaspargase pegol-mknl. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma uke waba ne-pancreatitis (ukuvuvukala kwamanyikwe), amahlule egazi, noma ukuphuma kwegazi okunzima, ikakhulukazi uma lokhu kwenzeka ngesikhathi sokwelashwa kwangaphambili nge-asparaginase (Elspar), asparaginase erwinia chrysanthemi (Erwinaze) noma i-pegaspargase (i-Oncaspar). Phinda utshele udokotela wakho uma unesifo sesibindi. Udokotela wakho angahle angafuni ukuthi uthole i-calaspargase pegol-mknl.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Kufanele uhlolwe ukukhulelwa ngaphambi kokuqala ukwelashwa. Akufanele ukhulelwe ngesikhathi sokwelashwa kwakho ngomjovo we-calaspargase pegol-mknl. Kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ukuvikela ukukhulelwa ngenkathi welashwa ngomjovo we-calaspargase pegol-mknl kanye nezinyanga ezi-3 ngemuva komthamo wakho wokugcina. I-Calaspargase pegol-mknl inganciphisa ukusebenza kwezinye izindlela zokuvimbela inzalo zomlomo (amaphilisi okulawula ukubeletha). Uzodinga ukusebenzisa enye indlela yokulawula ukubeletha ngenkathi uthola le mithi. Khuluma nodokotela wakho ngezinye izindlela zokulawula ukubeletha ezizokusebenzela.Uma ukhulelwa ngenkathi uthola umjovo we-calaspargase pegol-mknl, shayela udokotela wakho ngokushesha. ICalaspargase pegol-mknl ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngesikhathi sokwelashwa kwakho ngomjovo we-calaspargase pegol-mknl nezinyanga ezi-3 ngemuva komthamo wakho wokugcina.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Umjovo weCalaspargase pegol-mknl ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu shayela udokotela wakho ngokushesha:

• ukopha okungavamile noma okunzima noma ukulinyazwa
• ubuhlungu obuqhubekayo obuqala endaweni yesisu, kepha bungasabalala baye emuva
• ukoma okwandisiwe, ukuchama kaningi noma okwengeziwe
• ukuphuzi kwesikhumba noma kwamehlo; ubuhlungu besisu; isicanucanu; ukuhlanza; ukukhathala ngokweqile; indle enombala okhanyayo; umchamo omnyama
• ubuhlungu obukhulu bekhanda; okubomvu, ukuvuvukala, ingalo noma umlenze obuhlungu; ubuhlungu besifuba; ukuphelelwa umoya
• ukushaya kwenhliziyo okungajwayelekile noma okusheshayo
• umkhuhlane, ukubanda, ukukhwehlela, noma ezinye izimpawu zokutheleleka
• ukuphefumula kanzima ikakhulukazi lapho uzivocavoca; ukukhathala ngokweqile; ukuvuvukala kwemilenze, amaqakala nezinyawo; ukushaya kwenhliziyo okungajwayelekile noma okusheshayo

I-Calaspargase pegol-mknl ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho kumjovo we-calaspargase pegol-mknl.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Asparlas^®