I-Tagraxofusp-erzs Injection

-Delile

• Ngaphambi kokuthola i-tagraxofusp-erzs,
• I-Tagraxofusp-erzs ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Umjovo weTagraxofusp-erzs ungadala ukusabela okubucayi nokusongela impilo okubizwa nge-capillary leak syndrome (CLS; isimo esibi lapho izingxenye zegazi zivuza emithanjeni yegazi futhi kungaholela ekufeni). Tshela udokotela wakho ngokushesha uma uthola ukukhuluphala okungazelelwe; ukuvuvukala kobuso, izingalo, imilenze, izinyawo, noma enye indawo emzimbeni; ukuphelelwa umoya; noma isiyezi. Udokotela wakho angaphazamisa noma ayeke ukwelashwa kwakho nge-tagraxofusp-erzs, futhi angakuphatha ngeminye imithi. Qiniseka ukuthi uzilinganisela usuku ngalunye ukuze ubone ukuthi uzuza isisindo yini.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ngaphambi nangesikhathi sokwelashwa kwakho ukuze aqiniseke ukuthi kuphephile kuwe ukuthola i-tagraxofusp-erzs nokuhlola impendulo yomzimba wakho emithini.

Umjovo weTagraxofusp-erzs usetshenziselwa ukwelapha i-blasm plasmacytoid dendritic cell neoplasm (BPDCN; umdlavuza wegazi obangela izilonda zesikhumba, futhi ongasakazeka emnkantsheni wethambo nohlelo lwe-lymphatic) kubantu abadala nezingane ezineminyaka engu-2 nangaphezulu. I-Tagraxofusp-erzs isekilasini lemithi ebizwa nge-CD123 cytotoxin. Isebenza ngokubulala amangqamuzana omdlavuza.

Umjovo weTagraxofusp-erzs uza njengesisombululo (uketshezi) esizohlanjululwa futhi sijojowe ngomjovo (emthanjeni) ngaphezu kwemizuzu engu-15. Imvamisa inikezwa kanye ngosuku ngezinsuku 1, 2, 3, 4 no-5 zomjikelezo wokwelashwa wezinsuku ezingama-21. Kumjikelezo wokuqala wokwelashwa uzodinga ukuhlala esibhedlela kuze kube amahora angama-24 ngemuva komthamo wakho wokugcina (wesi-5) ukuze odokotela nabahlengikazi bakwazi ukukubuka ngokucophelela nganoma yimiphi imiphumela emibi. Kule mijikelezo yokwelashwa elandelayo uzodinga kuphela ukuhlala esibhedlela amahora angu-4 ngemuva komthamo ngamunye.

Udokotela wakho mhlawumbe uzokuphatha ngeminye imithi cishe ihora elilodwa ngaphambi komthamo ngamunye ukusiza ukuvimbela imiphumela ethile emibi. Qiniseka ukuthi utshela udokotela ukuthi uzizwa kanjani ngenkathi welashwa nge-tagraxofusp-erzs. Udokotela wakho kungadingeka ukuthi akubambezele noma ayeke ukwelashwa kwakho uma uhlangabezana nemiphumela ethile emibi.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola i-tagraxofusp-erzs,

• Tshela udokotela kanye nosokhemisi wakho uma une-aleji ku-tagraxofusp-erzs, noma imuphi omunye umuthi, noma iziphi izithako zomjovo we-tagraxofusp-erzs. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho uma ukhulelwe, noma uhlele ukukhulelwa. Kufanele uhlolwe ukukhulelwa zingakapheli izinsuku eziyi-7 ngaphambi kokuqala ukwelashwa. Akufanele ukhulelwe ngesikhathi sokwelashwa kwakho nge-tagraxofusp-erzs. Sebenzisa ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa nangezinsuku eziyi-7 ngemuva komthamo wakho wokugcina. Uma ukhulelwa ngenkathi uthola i-tagraxofusp-erzs, shayela udokotela wakho.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngesikhathi sokwelashwa kwakho nge-tagraxofusp-erzs nangezinsuku eziyi-7 ngemuva komthamo wakho wokugcina.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

I-Tagraxofusp-erzs ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• ukuqunjelwa
• isifo sohudo
• ukukhathala ngokweqile
• ikhanda
• ukuncipha kokudla
• Umphimbo obuhlungu
• ubuhlungu emhlane, ezingalweni, noma emilenzeni
• ukukhwehlela
• ubunzima bokulala noma ukulala
• uzizwe unovalo noma udidekile
• kwaphuma amakhala
• amabala amancane abomvu, ansundu, noma ansomi esikhunjeni

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuqubuka, ukulunywa, ukuphefumula kanzima, izilonda zomlomo noma ukuvuvukala
• ukukhathala ngokweqile, ukuphuzi kwesikhumba noma kwamehlo, ukulahlekelwa isifiso sokudla, ubuhlungu engxenyeni engaphezulu kwesokudla yesisu
• umkhuhlane, ukubanda
• ukushaya kwenhliziyo okusheshayo
• igazi emchameni

I-Tagraxofusp-erzs ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• U-Elzonris^®