I-Dolutegravir neLamivudine

-Delile

• Ngaphambi kokuthatha i-dolutegravir ne-lamivudine,
• I-Dolutegravir ne-lamivudine kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, shayela udokotela wakho ngokushesha:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukuthatha i-dolutegravir ne-lamivudine bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Tshela udokotela wakho uma une noma ucabanga ukuthi ungaba nokutheleleka ngegciwane le-hepatitis B (HBV; ukutheleleka kwesibindi okuqhubekayo). Udokotela wakho angakuhlola ukuthi unayo yini i-HBV ngaphambi kokuba uqale ukwelashwa nge-dolutegravir ne-lamivudine. Uma une-HBV futhi uthatha i-dolutegravir ne-lamivudine, isimo sakho singase sibe sibi ngokuzumayo lapho uyeka ukuthatha i-dolutegravir ne-lamivudine. Udokotela wakho uzokuhlola futhi a-oda izivivinyo zebhu njalo ezinyangeni ezimbalwa ngemuva kokuyeka ukuthatha i-dolutegravir ne-lamivudine ukubona ukuthi i-HBV yakho isiba kubi kakhulu.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ukuze ahlole impendulo yomzimba wakho ku-dolutegravir ne-lamivudine.

Khuluma nodokotela wakho ngezingozi zokuthatha i-dolutegravir ne-lamivudine.

Inhlanganisela ye-dolutegravir ne-lamivudine isetshenziswa yodwa ukwelapha ukutheleleka ngegciwane lesandulela ngculaza (i-HIV) kubantu abathile abangakaze belashwe ngemithi ye-HIV phambilini. ILamivudine isekilasini lemithi ebizwa nge-nucleoside analogue reverse transcriptase inhibitors (NRTIs) kanti i-dolutegravir isekilasini lemithi ebizwa nge-integrase strand transfer inhibitors (INSTIs). Zisebenza ngokunciphisa inani le-HIV egazini lakho nokwandisa inani lamaseli omzimba asiza ukulwa nezifo emzimbeni wakho. Yize i-dolutegravir ne-lamivudine zingeke ziyelaphe i-HIV, le mithi inganciphisa amathuba okuba ne-immunodeficiency syndrome (i-AIDS) kanye nezifo ezihlobene ne-HIV ezinjengezifo ezibucayi noma umdlavuza. Ukuthatha le mithi kanye nokwenza ucansi oluphephile nokwenza ezinye izinguquko kwimpilo yakho kunganciphisa ubungozi bokuthola noma ukudlulisela igciwane le-HIV kwabanye abantu.

Inhlanganisela ye-dolutegravir ne-lamivudine iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa nokudla noma ngaphandle kokudla kanye ngosuku. Thatha i-dolutegravir ne-lamivudine ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-dolutegravir ne-lamivudine njengoba nje kuqondisiwe. Ungayithathi kancane, noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

I-Dolutegravir ne-lamivudine zisiza ukulawula ukutheleleka nge-HIV kepha ayikulapheki. Qhubeka uphuze i-dolutegravir ne-lamivudine noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-dolutegravir, ne-lamivudine ngaphandle kokukhuluma nodokotela wakho. Uma uyeka ukuthatha i-dolutegravir ne-lamivudine noma uphuthelwe imithamo, isimo sakho singase sibe nzima ukwelashwa. Lapho ukunikezwa kwakho kwe-dolutegravir ne-lamivudine kuqala ukwehla, thola okuningi kudokotela wakho noma ekhemisi.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-dolutegravir ne-lamivudine,

• Tshela udokotela kanye nosokhemisi wakho uma unegciwane ku-dolutegravir, lamivudine, noma imuphi omunye umuthi, noma iziphi izithako ezikumaphilisi e-dolutegravir kanye ne-lamivudine. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• tshela udokotela wakho uma uthatha i-dofetilide (Tikosyn). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-dolutegravir ne-lamivudine uma uphuza lo muthi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokunganikezwa imishanguzo, amavithamini, izithako zokudla okunempilo ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: carbamazepine (Carbatrol, Equetro, Tegretol, others), dalfampridine (Ampyra), metformin (Glumetza, Glucophage, Riomet, e-Invokamet, eJanumet, abanye), oxcarbazepine (Oxtellar XR, Trileptal), phenobarbital, phenytoin (Dilantin, Phenytek), rifampin (Rifadin, Rimactane, eRifamate, eRifater), kanye ne-sorbitol noma imishanguzo equkethe i-sorbitol. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• uma uthatha ama-antacids noma ama-laxatives aqukethe i-aluminium noma i-magnesium; i-sucralfate (iCarafate); noma imishanguzo ephukile efana ne-aspirin ebhajethiwe, thatha okungenani amahora amabili ngemuva noma amahora ayisithupha ngaphambi kokuba uthathe i-dolutegravir ne-lamivudine.
• uma uthatha izithasiselo zensimbi noma ze-calcium, noma ama-multivitamin aqukethe i-iron noma i-calcium, thatha ngasikhathi sinye lapho uphuza khona i-dolutegravir ne-lamivudine kanye nokudla, noma ubathathe okungenani amahora amabili ngemuva noma amahora angu-6 ngaphambi kokuthatha i-dolutegravir ne-lamivudine .
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma ngabe uke waba nokutheleleka ngegciwane lesifo sokusha kwesibindi kohlobo C (i-HCV; ukutheleleka kwesibindi okuqhubekayo) noma esinye isifo sesibindi, noma isifo sezinso.
• utshele udokotela wakho uma ukhulelwe, noma uhlele ukukhulelwa. Uzodinga ukwenza ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa. Akufanele ukhulelwe ngenkathi uthatha i-dolutegravir ne-lamivudine. Khuluma nodokotela wakho ngezindlela ezisebenzayo zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma ukhulelwa ngenkathi uthatha i-dolutegravir ne-lamivudine, shayela udokotela wakho ngokushesha.
• tshela udokotela wakho uma uncelisa.Akufanele uncelise ibele uma utheleleke nge-HIV noma uma uphuza i-dolutegravir ne-lamivudine.
• kufanele wazi ukuthi ngenkathi uthatha imishanguzo yokwelapha ukutheleleka nge-HIV, amasosha omzimba wakho angaqina futhi aqale ukulwa nezinye izifo ezazivele zisemzimbeni wakho noma zidale ukuthi ezinye izimo zivele. Lokhu kungadala ukuthi uthuthukise izimpawu zalezo zifo noma izimo. Uma unezimpawu ezintsha noma eziya ziba zimbi phakathi nokwelashwa kwakho nge-dolutegravir ne-lamivudine, qiniseka ukuthi utshela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Dolutegravir ne-lamivudine kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• isicanucanu
• isifo sohudo
• igesi
• ubunzima bokulala noma ukulala
• ukukhathala
• ubuthakathaka bemisipha

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, shayela udokotela wakho ngokushesha:

• ukuphuzi kwamehlo noma kwesikhumba, ubuhlungu besisu, indle enombala okhanyayo, umchamo onombala omnyama, isicanucanu, ukuhlanza, ukungathandi ukudla
• ukukhathala ngokweqile noma ukuba buthakathaka, ubuhlungu bemisipha, ukuphefumula kanzima, ubuhlungu besisu, isicanucanu, ukuhlanza, ukuzwa ukubanda ikakhulukazi ezingalweni nasemilenzeni, isiyezi, ukushaya kwenhliziyo okusheshayo noma okungafanele
• ukuqubuka (ngaphandle kwezinye izimpawu)

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukuthatha i-dolutegravir ne-lamivudine bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• isifuba, ukuvuvukala kobuso, umphimbo, ulimi, noma izindebe, amehlo abomvu noma avuvukele, ubunzima bokugwinya noma ukuphefumula
• ukuqubuka kanye nezinye zalezi zimpawu ezilandelayo; imfiva; izimpawu ezinjengomkhuhlane; ukukhathala ngokweqile; ubuhlungu bemisipha noma obuhlangene; isikhumba esihlabayo noma esishayayo; izilonda noma amabhamuza emlonyeni; noma amehlo abomvu, alumayo, anamanzi,

I-Dolutegravir ne-lamivudine kungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ngaphambi kokwenza noma yiluphi uvivinyo lwelabhoratri, tshela udokotela wakho kanye nabasebenzi be-laboratory ukuthi uthatha i-dolutegravir ne-lamivudine.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Gcina i-dolutegravir ne-lamivudine esandleni. Ungalindi uze uphelelwe yimithi yokugcwalisa imishanguzo yakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UDovato^® (njengomkhiqizo ohlanganisiwe oqukethe iDolutegravir, iLamivudine)

• i-dolutegravir ne-3TC