I-Rituximab ne-Hyaluronidase Injection Yomuntu

-Delile

• Ngaphambi kokuthola umjovo womuntu we-rituximab ne-hyaluronidase,
• Umjovo womuntu we-Rituximab ne-hyaluronidase ungadala imiphumela emibi.Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Umjovo womuntu we-Rituximab ne-hyaluronidase ubangele ukusabela okukhulu kwesikhumba nomlomo. Uma uhlangabezana nalezi zimpawu ezilandelayo, tshela udokotela wakho ngokushesha: izilonda ezibuhlungu noma izilonda esikhunjeni, ezindebeni, noma emlonyeni; amabhamuza; ukuqubuka; noma ukuxebuka isikhumba.

Kungenzeka ukuthi usungenwe yi-hepatitis B (igciwane elithelela isibindi futhi lingadala ukulimala kwesibindi) kepha ungabi nazimpawu zesifo. Kulokhu, ukuthola umjovo womuntu we-rituximab ne-hyaluronidase kungandisa ingozi yokuthi ukutheleleka kwakho kube kubi kakhulu noma kusongele impilo futhi uzoba nezimpawu. Tshela udokotela wakho uma ngabe uke waba nokutheleleka okunzima, kufaka phakathi ukutheleleka kwegciwane le-hepatitis B. Udokotela wakho uzoku-oda ukuhlolwa kwegazi ukuze abone ukuthi unesifo esingasebenzi se-hepatitis B esingasebenzi. Uma kunesidingo, udokotela wakho angakunika imithi yokwelapha lesi sifo ngaphambi nangesikhathi sokwelashwa kwakho ngomjovo womuntu we-rituximab ne-hyaluronidase. Udokotela wakho uzokuhlola futhi nangezimpawu zokutheleleka kwesifo sokusha kwesibindi kohlobo B ngesikhathi nangezinyanga ezimbalwa ngemuva kokwelashwa kwakho. Uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi noma ngemuva kokwelashwa kwakho, shayela udokotela wakho ngokushesha: ukukhathala ngokweqile, ukuphuzi kwesikhumba noma kwamehlo, ukulahlekelwa isifiso sokudla, isicanucanu noma ukuhlanza, ubuhlungu bemisipha, ubuhlungu besisu, noma umchamo omnyama.

Abanye abantu abathole umjovo womuntu we-rituximab ne-hyaluronidase bahlakulele i-leukoencephalopathy (PML) eqhubekayo eqhubekayo, ukutheleleka okungavamile kobuchopho okungenakulashwa, ukuvinjelwa, noma ukwelashwa okuvame ukudala ukufa noma ukukhubazeka okukhulu) ngesikhathi noma ngemuva kokwelashwa kwabo. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: izinguquko ezintsha noma ezingazelelwe ekucabangeni noma ekudidekeni; ubunzima bokukhuluma noma ukuhamba; ukulahlekelwa ibhalansi; ukuphelelwa amandla; izinguquko ezintsha noma ezingazelelwe embonweni; noma ezinye izimpawu ezingavamile eziqubuka kungazelelwe.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho kumjovo womuntu we-rituximab ne-hyaluronidase.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa ngomjovo we-rituximab futhi isikhathi ngasinye lapho uthola umuthi. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokusebenzisa umjovo womuntu we-rituximab ne-hyaluronidase.

Umjovo womuntu we-Rituximab ne-hyaluronidase usetshenziswa wedwa noma neminye imithi yokwelapha izinhlobo ezahlukahlukene ze-non-Hodgkin's lymphoma (NHL; uhlobo lomdlavuza oluqala ngohlobo lwamaseli amhlophe egazi ngokuvamile alwa nokutheleleka). Umjovo womuntu we-Rituximab ne-hyaluronidase uyasetshenziswa neminye imithi yokwelapha i-lymphocytic leukemia (CLL; uhlobo lomdlavuza wamaseli amhlophe egazi). Umjovo womuntu we-Rituximab ne-hyaluronidase usesigabeni semithi ebizwa ngama-antibody monoclonal. Iphatha izinhlobo ezahlukahlukene ze-NHL ne-CLL ngokubulala amangqamuzana omdlavuza.

Umjovo womuntu we-Rituximab ne-hyaluronidase uza njengesisombululo (uketshezi) sokujovwa ngomgogodla (ngaphansi kwesikhumba, endaweni yesisu) cishe imizuzu engaba ngu-5 kuye kwengu-7. Isikhathi sakho sokulinganisa sizoncika esimweni onaso, eminye imithi oyisebenzisayo, nokuthi umzimba wakho uphendula kahle kanjani ekwelashweni.

Umjovo womuntu we-Rituximab ne-hyaluronidase ungadala ukusabela okukhulu ngenkathi uthola umuthi noma kungakapheli amahora angama-24 ngemuva kokuthola umthamo. Uzothola isilinganiso ngasinye somjovo womuntu we-rituximab ne-hyaluronidase esikhungweni sezokwelapha, futhi udokotela noma umhlengikazi uzokuqapha ngokucophelela ngenkathi uthola umuthi futhi okungenani imizuzu eyi-15 ngemuva kokuthola umuthi. Uzothola imithi ethile yokusiza ukuvimbela ukusabela okweqile ngaphambi kokuthola umthamo ngamunye we-rituximab ne-hyaluronidase injection yabantu.

Kufanele uthole umthamo wakho wokuqala njengomkhiqizo womjovo we-rituximab ojojwe kancane ngemithambo (emthanjeni). Ngemuva kwesilinganiso sokuqala, ungathola umjovo womuntu we-rituximab ne-hyaluronidase ngaphansi kwesikhumba, kuya ngokuthi uphendula kanjani ekwelashweni ngemithambo ngomkhiqizo womjovo we-rituximab.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo womuntu we-rituximab ne-hyaluronidase,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-rituximab, hyaluronidase, noma imuphi omunye umuthi, noma yiziphi izithako ku-rituximab naku-hyaluronidase injection yomuntu. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha.
• Tshela udokotela wakho uma unezinye zezimo ezishiwo esigabeni ESIBALULEKILE SESEXWAYISO futhi uma uke waba nesifo sokusha kwesibindi kohlobo C noma amanye amagciwane anjenge-pox, i-herpes (igciwane elingadala izilonda ezibandayo noma ukuqubuka kwamabhamuza esithweni sangasese indawo), ama-shingles, igciwane le-West Nile (igciwane elisakazwa ngokulunywa omiyane futhi lingadala izimpawu ezimbi), i-parvovirus B19 (isifo sesihlanu; igciwane elivamile ezinganeni ezivame ukudala izinkinga ezinkulu kwabanye abantu abadala), noma i-cytomegalovirus (a igciwane elivamile okuvame ukudala kuphela izimpawu ezinzima kubantu abanamasosha omzimba abuthakathaka noma abanesifo lapho bezalwa), ukushaya kwenhliziyo okungajwayelekile, ubuhlungu besifuba, ezinye izinkinga zenhliziyo, noma izinkinga zamaphaphu noma zezinso. Phinda utshele udokotela wakho uma unanoma yiluphi uhlobo lokutheleleka manje noma uma uke waba nokutheleleka okungeke kwaphela noma ukutheleleka okuzayo nokudlulayo.
• utshele udokotela wakho uma ukhulelwe noma uma uhlela ukukhulelwa. Kufanele usebenzise ukulawulwa kokuzalwa ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho ngomjovo womuntu we-rituximab ne-hyaluronidase nezinyanga eziyi-12 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezinhlobo zokulawulwa kokuzalwa okuzokusebenzela. Uma ukhulelwa ngenkathi usebenzisa umjovo womuntu we-rituximab ne-hyaluronidase, shayela udokotela wakho. I-Rituximab ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngesikhathi sokwelashwa kwakho ngomjovo womuntu we-rituximab ne-hyaluronidase nezinyanga eziyisithupha ngemuva komthamo wakho wokugcina.
• buza udokotela wakho ukuthi kufanele yini ugonywe ngaphambi kokuba uqale ukwelashwa nge-rituximab ne-hyaluronidase injection yabantu. Ungabi nayo imigomo ngesikhathi sokwelashwa kwakho ngaphandle kokukhuluma nodokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa isikhathi sokuthola umjovo womuntu we-rituximab ne-hyaluronidase, shayela udokotela wakho ngokushesha.

Umjovo womuntu we-Rituximab ne-hyaluronidase ungadala imiphumela emibi.Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuqunjelwa
• ukuqhuma
• ukulahleka kwezinwele
• ubuhlungu, ukucasuka, ukuvuvukala, ububomvu noma ukulunywa endaweni lapho ujove khona
• ubuhlungu bemisipha, obuhlangene noma obuya emuva

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• isifuba, ukuqubuka, ukulunywa, ukuvuvukala kwezindebe, ulimi, noma umphimbo, ukuphefumula kanzima, ukuphefumula kanzima noma ukugwinya
• isifuba
• isiyezi noma ukuquleka
• ubuthakathaka
• isifo sohudo
• ukungabi namandla
• ubuhlungu besifuba
• ukushaya kwenhliziyo okushaya ngamandla noma okungajwayelekile
• umphimbo obuhlungu, umkhuhlane, amakhaza, ukukhwehlela, ubuhlungu bendlebe, ikhanda elibuhlungu, noma ezinye izimpawu zokutheleleka
• amabala amhlophe emphinjeni noma emlonyeni
• ukuchama okunzima, okubuhlungu, noma okuvamile
• ububomvu, isisa, ukuvuvukala noma ukufudumala kwendawo yesikhumba

Umjovo womuntu we-Rituximab ne-hyaluronidase ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi usebenzisa lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• URituxan Hycela^®