Injection ye-Enfortumab vedotin-ejfv

-Delile

• Ngaphambi kokuthola umjovo we-enfortumab vedotin-ejfv,
• Umjovo we-Enfortumab vedotin-ejfv ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo esigabeni esikhethekile SOKUQAPHA, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Umjovo we-Enfortumab vedotin-ejfv usetshenziselwa ukwelapha umdlavuza we-urothelial (umdlavuza wolwelwesi lwesinye nezinye izingxenye zomgudu womchamo) osabalalele ezicutshini eziseduze noma kwezinye izingxenye zomzimba futhi uye waba muncu ngemuva kokwelashwa ngeminye imithi ye-chemotherapy. Umjovo we-Enfortumab vedotin-ejfv usesigabeni semithi ebizwa ngama-antibody monoclonal. Isebenza ngokusiza amasosha akho omzimba ukwehlisa noma ukumisa ukukhula kwamangqamuzana omdlavuza.

Umjovo we-Enfortumab vedotin-ejfv uza njengempuphu ezoxutshwa noketshezi futhi ifakwe ngomjovo (emthanjeni) ngaphezu kwemizuzu engama-30 ngudokotela noma umhlengikazi esibhedlela noma esikhungweni sezokwelapha. Kuvamise ukujova ngezinsuku 1, 8, no-15 zomjikelezo wezinsuku ezingama-28 inqobo nje uma udokotela wakho encoma ukuthi uthole ukwelashwa.

Udokotela wakho angakubambezela noma ayeke ukwelashwa kwakho ngomjovo we-enfortumab vedotin-ejfv, noma akuphathe ngemithi eyengeziwe, ngokuya ngempendulo yakho emithini kanye neminye imiphumela emibi ohlangabezana nayo. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-enfortumab vedotin-ejfv,

• Tshela udokotela kanye nosokhemisi wakho uma une-aleji ye-enfortumab vedotin-ejfv injection, noma imuphi omunye umuthi, noma iziphi izithako zomjovo we-enfortumab vedotin-ejfv. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-clarithromycin (i-Biaxin); idelalisib (iZydelig); indinavir (Crixivan); ketoconazole (Nizoral); nefazodone; i-nelfinavir (i-Viracept); i-ritonavir (iNorvir, eKaletra); noma i-saquinavir (i-Invirase). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma ngabe uke waba ne-peripheral neuropathy (uhlobo lokulimala kwemizwa olubangela ukurhawuzelela, ukuba ndikindiki, nobuhlungu ezandleni nasezinyaweni), isifo sikashukela noma ushukela ophakeme wegazi, noma isifo sesibindi.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uma uhlela ukuba nobaba wengane. Wena noma umlingani wakho akufanele ukhulelwe ngenkathi uthola umjovo we-enfortumab vedotin-ejfv. Udokotela wakho angenza isivivinyo sokukhulelwa ukuze aqiniseke ukuthi awukhulelwe ngaphambi kokuthola umjovo we-enfortumab vedotin-ejfv. Uma ungowesifazane, kufanele usebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa kwakho nezinyanga ezi-2 ngemuva komthamo wakho wokugcina. Uma ungowesilisa, wena nomlingani wakho wesifazane kufanele nisebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa kwenu nezinyanga ezine ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthola umjovo we-enfortumab vedotin-ejfv, shayela udokotela wakho. Umjovo we-Enfortumab vedotin-ejfv ungalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngenkathi uthola umjovo we-enfortumab vedotin-ejfv futhi okungenani amasonto ama-3 ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala emadodeni. Khuluma nodokotela wakho ngezingozi zokuthola umjovo we-enfortumab vedotin-ejfv.
• kufanele wazi ukuthi ungathola i-hyperglycemia (inyuka kushukela egazini lakho) ngenkathi uthola lo muthi, noma ngabe awunaso vele isifo sikashukela. Tshela udokotela wakho ngokushesha uma unalezi zimpawu ezilandelayo ngenkathi uthola umjovo we-enfortumab vedotin-ejfv: ukoma ngokweqile, ukuchama njalo, ukulamba ngokweqile, ukungaboni kahle, noma ubuthakathaka. Kubaluleke kakhulu ukubiza udokotela wakho ngokushesha uma unezinye zalezi zimpawu, ngoba ushukela wegazi ongelashwa ungadala isimo esibi esibizwa nge-ketoacidosis. I-Ketoacidosis ingasongela impilo uma ingelashwa kusenesikhathi. Izimpawu ze-ketoacidosis zifaka phakathi: umlomo owomile, isicanucanu nokuhlanza, ukuphefumula okuncane, ukuphefumula okunuka izithelo, nokuncipha kokwazi.
• kufanele wazi ukuthi lo muthi ungadala amehlo omile nezinye izinkinga zamehlo, ezingaba zimbi kakhulu. Udokotela wakho angakutshela ukuthi usebenzise izinyembezi zokufakelwa noma amathonsi wamehlo okugcoba ngenkathi welashwa nge-enfortumab vedotin-ejfv.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Umjovo we-Enfortumab vedotin-ejfv ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• ukuhlanza
• isicanucanu
• ukulahlekelwa isifiso sokudla
• izinguquko zokunambitheka
• ukulahleka kwezinwele
• isikhumba esomile

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo esigabeni esikhethekile SOKUQAPHA, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuphelelwa umoya
• isikhumba esiphaphathekile
• ukuqubuka noma ukulunywa
• ukubomvu kwesikhumba, ukuvuvukala, imfiva, noma ubuhlungu endaweni yomjovo
• ukungaboni kahle, ukungaboni, ubuhlungu bamehlo noma ubomvu, noma ezinye izinguquko ezibonakalayo
• ukuba ndikindiki, ukushiswa, noma ukuncinza ezandleni noma ezinyaweni
• ubuthakathaka bemisipha
• ukukhathala ngokweqile noma ukungabi namandla

Umjovo we-Enfortumab vedotin-ejfv ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-enfortumab vedotin-ejfv.

Buza usokhemisi wakho noma imiphi imibuzo onayo ngomjovo we-enfortumab vedotin-ejfv.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UPadcev^®