UNelfinavir

-Delile

• Ngaphambi kokuthatha i-nelfinavir,
• INelfinavir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

INelfinavir isetshenziswa kanye neminye imithi yokwelapha ukutheleleka ngegciwane lesandulela ngculaza (i-HIV). INelfinavir isekilasini lemithi ebizwa nge-protease inhibitors. Isebenza ngokunciphisa inani le-HIV egazini. Yize i-nelfinavir ingayelaphi i-HIV, ingahle inciphise amathuba akho okuba ne-immunodeficiency syndrome (i-AIDS) kanye nezifo ezihlobene ne-HIV ezinjengezifo ezinqala noma umdlavuza. Ukuthatha le mithi kanye nokwenza ucansi oluphephile nokwenza ezinye izinguquko kwimpilo yakho kunganciphisa ingozi yokudlulisela igciwane lesandulela ngculaza kwabanye abantu.

INelfinavir iza njengethebhulethi kanye nempuphu okuzothathwa ngomlomo. Imvamisa kuthathwa kabili noma kathathu ngosuku nokudla. Thatha i-nelfinavir ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-nelfinavir njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Uma ungakwazi ukugwinya ithebhulethi, ungayifaka engilazini bese uyihlakaza emanzini amancane. Hlanganisa uketshezi kahle, bese uliphuza ngokushesha. Hlanza ingilazi ngamanzi amaningi bese ugwinya yonke ingxube ukuqinisekisa ukuthi uwudle wonke umuthi.

I-Nelfinavir powder powder ingangezwa emanzini, ubisi, ifomula, ubisi lwe-soy, noma izithako zokudla. Hlanganisa kahle, uphuze lonke uketshezi khona manjalo ukuze uthathe umthamo ophelele. Ilebuli yakho kadokotela ikutshela ukuthi mangaki ama-scoops we-nelfinavir powder ongawangeza kuketshezi. Uma ingxube ingathathwa ngokushesha kufanele igcinwe esiqandisini bese ithathwa kungakapheli amahora ayisithupha. Ungaxubi i-nelfinavir powder yomlomo nokudla okune-asidi noma ujusi (ijusi le-orange, ijusi le-apula, noma isoso se-apula) Ungaxubi i-nelfinavir namanzi esitsheni sokuqala.

INelfinavir ilawula ukutheleleka nge-HIV kepha ayiyelaphi. Qhubeka nokuthatha i-nelfinavir noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-nelfinavir ngaphandle kokukhuluma nodokotela wakho. Uma uyeka ukuthatha i-nelfinavir noma ukweqa imithamo, ukutheleleka kwakho kungahle kube kubi kakhulu noma kungazweli emithini.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi kwesinye isikhathi ubekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-nelfinavir,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-nelfinavir, noma imuphi omunye umuthi, noma iziphi izithako ezibhebheni ze-nelfinavir noma i-powder. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• tshela udokotela wakho uma uthatha i-alfuzosin (Uroxatral); amiodarone (Cordarone, Nexterone, Pacerone); i-cisapride (Propulsid; ayitholakali e-U.S.); imishanguzo yohlobo lwe-ergot efana ne-bromocriptine (i-Cycloset, i-Parlodel), i-dihydroergotamine (i-DHE 45, i-Migranal), i-ergoloid mesylates (i-Hydergine), i-ergotamine (i-Ergomar, i-Cafergot, i-Migergot), ne-methylergonovine (Methergine); i-lovastatin (Altoprev); i-lurasidone (Latuda); i-midazolam (ihunyushiwe) ngomlomo; ipimozide (i-Orap); i-quinidine (ku-Nuedexta); i-rifampin (Rimactane, Rifadin, eRifater, eRifamate); i-sildenafil (uphawu lwe-Revatio kuphela olusetshenziselwa isifo samaphaphu); simvastatin (iZocor, eVytorin); ISt John's wort; kanye ne-triazolam (Halcion). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-nelfinavir uma uphuza eyodwa noma ngaphezulu yale mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela noma engabhaliswanga, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: ama-anticoagulants (’ama-thinner egazi’) njenge-warfarin (i-Coumadin, i-Jantoven); i-azithromycin (i-Azasite, iZithromax, iZmax); i-bosentan (iTracleer); imishanguzo ethile yokuvimba isiteshi se-calcium efana ne-amlodipine (Norvasc, ePrestalia, eTwynsta, abanye), felodipine, isradipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab, Procardia), nimodipine (Nymalize), ne-nisoldipine (Sular); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, abanye); imishanguzo ethile yokwehlisa i-cholesterol (ama-statins) anjenge-atorvastatin (Lipitor, eCaduet) ne-rosuvastatin (Crestor); i-colchicine (Colcrys, Mitigare); i-delavirdine (i-Rescriptor); i-fluticasone (i-Flonase, i-Flovent; e-Advair); indinavir (Crixivan); imithi ecindezela amasosha omzimba njenge-cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune, Torisel), ne-tacrolimus (Astagraf XL, Prograf); i-methadone (i-Dolophine, i-Methadose); i-nevirapine (i-Viramune); ama-phosphodiesterase inhibitors (PDE-5 inhibitors) athile asetshenziselwa ukungasebenzi kahle kwe-erectile njenge-sildenafil (Viagra), tadalafil (Adcirca, Cialis), ne-vardenafil (Levitra); i-phenobarbital; i-phenytoin (iDilantin, Phenytek); ama-proton-pump inhibitors afana ne-esomeprazole (Nexium), i-lansoprazole (i-Prevacid), i-omeprazole (i-Prilosec), i-pantoprazole (i-Protonix), ne-rabeprazole (i-AcipHex); i-quetiapine (iSeroquel); i-rifabutin (i-Mycobutin); i-ritonavir (iNorvir, eKaletra, eViekira Pak); i-salmeterol (iSerevent, e-Advair); i-saquinavir (i-Invirase); ne-trazodone. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingaxhumana ne-nelfinavir, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• uma uthatha i-didanosine (Videx), yithathe ihora eli-1 ngaphambi noma ngaphezulu kwamahora ama-2 ngemuva kwe-nelfinavir.
• utshele udokotela wakho uma uphuza amaphilisi okulawula ukubeletha. INelfinavir inganciphisa ukusebenza kahle kwezindlela zokuvimbela inzalo ngomlomo. Kufanele usebenzise enye indlela yokulawula ukubeletha ngenkathi usebenzisa le mithi. Khuluma nodokotela wakho mayelana nokulawulwa kokuzalwa ngenkathi uthatha i-nelfinavir.
• Tshela udokotela wakho uma uke waba nesifo sikashukela noma i-hemophilia (iqembu lokuphazamiseka kwegazi okuzuzwe njengefa lapho ikhono legazi lokunqanda lingajwayelekile), noma isifo sesibindi.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-nelfinavir, shayela udokotela wakho. Akufanele uncelise ibele uma une-HIV futhi uthatha i-nelfinavir.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-nelfinavir.
• kufanele wazi ukuthi amafutha omzimba wakho angakhuphuka noma ahambele ezindaweni ezahlukahlukene zomzimba wakho, njengasemhlane wakho ongaphezulu, entanyeni (’buffalo hump’), emabeleni, naseduze kwesisu sakho. Ungaqaphela ukulahleka kwamafutha omzimba ebusweni bakho, emilenzeni nasezingalweni.
• kufanele wazi ukuthi ungathola i-hyperglycemia (iyanda kushukela wakho wegazi) ngenkathi uthatha lo muthi, noma ngabe awunaso vele isifo sikashukela. Tshela udokotela wakho ngokushesha uma unanoma iyiphi yalezi zimpawu ezilandelayo ngenkathi uthatha i-nelfinavir: ukoma ngokweqile, ukuchama kaningi, ukulamba ngokweqile, ukungaboni kahle, noma ubuthakathaka. Kubaluleke kakhulu ukubiza udokotela wakho ngokushesha uma unezinye zalezi zimpawu, ngoba ushukela wegazi ongelashwa ungadala isimo esibi esibizwa nge-ketoacidosis. I-Ketoacidosis ingasongela impilo uma ingelashwa kusenesikhathi. Izimpawu ze-ketoacidosis zifaka phakathi umlomo owomile, isicanucanu nokuhlanza, ukuphefumula okuncane, ukuphefumula okunuka izithelo, nokuncipha kokwazi.
• uma une-phenylketonuria (i-PKU, isimo esizuzwe njengefa lapho kufanele kulandelwe ukudla okhethekile ukuvimbela ukubola kwengqondo), kufanele wazi ukuthi i-nelfinavir powder powder iswidi ne-aspartame eyakha i-phenylalanine.
• kufanele wazi ukuthi ngenkathi uthatha imishanguzo yokwelapha ukutheleleka nge-HIV, amasosha omzimba wakho angaqina futhi aqale ukulwa nezinye izifo ezazivele zisemzimbeni wakho. Lokhu kungadala ukuthi ube nezimpawu zalezo zifo. Uma unezimpawu ezintsha noma eziya ziba zimbi noma kunini ngesikhathi sokwelashwa kwakho ne-nelfinavir, qiniseka ukuthi utshela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

INelfinavir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• isicanucanu
• igesi
• ubuhlungu besisu
• ukulahlekelwa isifiso sokudla
• ukuqubuka

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• isifuba
• ukulunywa
• ukuphefumula kanzima noma ukugwinya

INelfinavir iqukethe ikhemikhali elitholwe lidala umdlavuza ezilwaneni zaselebhu. I-Food and Drug Administration (i-FDA) icele umenzi wayo ukuthi enze ushintsho endleleni okwenziwa ngayo i-nelfinavir ukunciphisa inani laleli khemikhali emikhiqizweni ye-nelfinavir. Ingozi kubantu ayaziwa kepha ingahle ibe phezulu ezinganeni nakwabesifazane abakhulelwe. Khuluma nodokotela wakho ngezingozi zokuthatha i-nelfinavir.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Ngemuva kokuthi i-nelfinavir powder yengezwe kuketshezi, ingxube ingagcinwa ekamelweni lokushisa amahora angafinyelela kwayisithupha.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukubheka impendulo yakho ku-nelfinavir.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Gcina ukutholakala kwe-nelfinavir kusesandleni. Ungalindi uze uphelelwe yimithi yokugcwalisa imishanguzo yakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Viracept^®