Zanubrutinib

-Delile

• Ngaphambi kokuthatha i-zanubrutinib,
• I-Zanubrutinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Zanubrutinib isetshenziselwa ukwelapha i-mantle cell lymphoma (i-MCL; umdlavuza okhula ngokushesha oqala kumaseli amasosha omzimba) kubantu abadala asebelashwe okungenani ngomunye umuthi wokwelashwa ngamakhemikhali. UZanubrutinib usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba ukusebenza kweprotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunqanda ukusabalala kwamangqamuzana omdlavuza.

UZanubrutinib uza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa kanye noma kabili ngosuku noma ngaphandle kokudla. Thatha i-zanubrutinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-zanubrutinib njengoba kushiwo. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi ngengilazi yamanzi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Udokotela wakho anganciphisa umthamo wakho, noma aphazamise noma ayeke ukwelashwa kwakho. Lokhu kuncike ekutheni umuthi usebenza kanjani kuwe kanye nemiphumela emibi oyitholayo. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Qhubeka uthathe i-zanubrutinib noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-zanubrutinib ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-zanubrutinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-zanubrutinib, noma imiphi eminye imithi, noma yiziphi izithako kuma-capsules e-zanubrutinib. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: imishanguzo yokulwa nesifo segazi (‘i-blood thinner’) efana ne-warfarin (i-Coumadin, i-Jantoven); ama-antifungals afana ne-fluconazole (Diflucan), i-itraconazole (i-Onmel, i-Sporanox), noma i-ketoconazole; i-aprepitant (iCinvanti, i-Emend); i-clarithromycin (i-Biaxin, ku-Prevpac); i-digoxin (i-Lanoxin); i-diltiazem (Cardizem, Cartia, Tiazac, abanye); i-erythromycin (E.E.S., Erythrocin, abanye); imishanguzo ethile yokwelapha igciwane lesandulela ngculazi (i-HIV) noma i-immunodeficiency syndrome (i-AIDS) efana ne-efavirenz (Sustiva, e-Atripla), i-nelfinavir (i-Viracept), i-ritonavir (i-Norvir, e-Kaletra), ne-saquinavir (i-Invirase); nefazodone; omeprazole (Prilosec); i-phenobarbital; i-phenytoin (iDilantin, Phenytek); i-pioglitazone (Actos); i-rifampin (i-Rifadin, i-Rifamate, i-Rimactane, abanye); i-midazolam; kanye ne-steroids yomlomo efana ne-dexamethasone, i-methylprednisolone (i-Medrol), ne-prednisone (i-Rayos). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi yimiphi imikhiqizo yamakhambi oyithathayo, ikakhulukazi iSt John's Wort.
• utshele udokotela wakho uma unesifo noma usanda kuhlinzwa. Phinda utshele udokotela wakho uma uke waba nokushaya kwenhliziyo okungajwayelekile, umfutho wegazi ophakeme, izinkinga zokopha, noma isifo senhliziyo noma sesibindi.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uma uhlela ukuba ngubaba wengane. Akufanele ukhulelwe ngenkathi uthatha i-zanubrutinib. Uma ungowesifazane, kuzodingeka uthathe ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa futhi kufanele usebenzise ukuvimbela ukukhulelwa ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nangesonto elilodwa ngemuva komthamo wakho wokugcina. Uma ungowesilisa, wena nomlingani wakho wesifazane kufanele nisebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa nge-zanubrutinib futhi niqhubeke isonto elilodwa ngemuva kwesilinganiso sakho sokugcina. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-zanubrutinib, shayela udokotela wakho ngokushesha. I-Zanubrutinib ingadala ukulimala kwengane.
• tshela udokotela wakho uma uncelisa. Ungancelisi ibele ngenkathi uthatha i-zanubrutinib kanye namasonto ama-2 ngemuva komthamo wakho wokugcina.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-zanubrutinib. Udokotela wakho angakutshela ukuthi uyeke ukuthatha i-zanubrutinib isikhathi esithile ngaphambi nangemva kokuhlinzwa noma inqubo.
• hlela ukugwema ukuvezwa yilanga ngokungadingekile noma isikhathi eside futhi ugqoke izingubo zokuzivikela, izibuko zelanga, nesikhumba selanga. I-Zanubrutinib ingenza isikhumba sakho sizwele emiphumeleni eyingozi yokukhanya kwelanga, futhi singakhuphula ubungozi bokuba nomdlavuza wesikhumba.

Khuluma nodokotela wakho ngokudla isithelo samagilebhisi nokuphuza ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula ngalolo suku bese uqhubeka nesimiso sakho somthamo ojwayelekile ngosuku olulandelayo. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Zanubrutinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• ukuqunjelwa
• ukukhwehlela
• ubuhlungu bemisipha, obuhlangene noma obuya emuva

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• umkhuhlane, umphimbo obuhlungu, amakhaza, noma ezinye izimpawu zokutheleleka
• ukuchama okubuhlungu, okuvamile, noma okuphuthumayo
• ukukhwehlela, ukuphelelwa umoya, ubuhlungu besifuba lapho uphefumula noma ukhwehlela, noma umkhuhlane
• ukulimaza noma ukopha okungavamile
• igazi kwizitulo zakho noma emnyama, izitulo zokulinda; umchamo obomvana noma onsundu; ukuhlanza igazi noma ikhofi emhlabathini; ekhwehlela igazi
• ukuzizwa unesiyezi, ubuthakathaka, noma udidekile; izinguquko enkulumweni; ikhanda elithatha isikhathi eside
• ukuqubuka
• ukushaya kwenhliziyo okusheshayo noma okungajwayelekile, ukushaya kwenhliziyo, ukuzwa ikhanda elincane noma isiyezi, ukuquleka, ukuphefumula, ubuhlungu besifuba

I-Zanubrutinib ingakhuphula ubungozi bokuthuthukisa izinhlobo ezithile zomdlavuza kubandakanya umdlavuza wesikhumba. Khuluma nodokotela wakho ngezingozi zokuthatha i-zanubrutinib.

I-Zanubrutinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho angalawula izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-zanubrutinib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Brukinsa^®