I-Pemigatinib

-Delile

• Ngaphambi kokuthatha i-pemigatinib,
• I-Pemigatinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Pemigatinib isetshenziswa kubantu abadala asebethole ukwelashwa kwangaphambilini ukwelapha uhlobo oluthile lwe-cholangiocarcinoma (umdlavuza we-bile duct) osabalele ezicutshini eziseduze noma kwezinye izingxenye zomzimba futhi olungasuswa ngokuhlinzwa. I-Pemigatinib isekilasini lemithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba ukusebenza kweprotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukumisa noma ukubambezela ukusabalala kwamangqamuzana omdlavuza.

IPemigatinib iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa noma ngaphandle kokudla kanye nsuku zonke ezinsukwini zokuqala eziyi-14 zomjikelezo wezinsuku ezingama-21. Umjikelezo ungaphindwa njengoba kunconywe udokotela wakho. Thatha i-pemigatinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-pemigatinib njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Uma uhlanza ngemuva kokuthatha i-pemigatinib, ungathathi omunye umthamo. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Udokotela wakho anganciphisa umthamo wakho noma ayeke ukwelashwa kwakho okwesikhashana noma unomphela uma uhlangabezana nemiphumela ethile emibi. Lokhu kuncike ekutheni umuthi usebenza kanjani kuwe kanye nemiphumela emibi oyitholayo. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngenkathi welashwa nge-pemigatinib.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-pemigatinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-pemigatinib, noma imuphi omunye umuthi, noma iziphi izithako kumaphilisi e-pemigatinib. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ama-antifungal anjenge-fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), ne-voriconazole (Vfend); carbamazepine (Epitol, Tegretol, Teril, nabanye); i-clarithromycin (i-Biaxin); i-erythromycin (E.E.S., Erythrocin, abanye); imishanguzo ethile yokwelapha igciwane lengculazi (i-HIV) njenge-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, kwezinye), noma i-saquinavir (Invirase); nefazodone; i-phenobarbital; i-phenytoin (iDilantin, Phenytek); i-pioglitazone (Actos); i-rifabutin (i-Mycobutin); i-rifampin (iRifadin, iRimactane, eRifamate); kanye ne-verapamil (Calan, Verelan, abanye). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-pemigatinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• utshele udokotela wakho uma unenkinga yokugwinya amaphilisi noma uma uke waba nesifo sezinso noma sesibindi.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uma uhlela ukuba ngubaba wengane. Uma ungowesifazane, kuzodingeka uthathe ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa futhi usebenzise izilawuli zokubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho futhi okungenani isonto elilodwa ngemuva komthamo wakho wokugcina. Uma ungowesilisa, wena nomlingani wakho kufanele nisebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa kwakho nangesonto eli-1 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-pemigatinib, shayela udokotela wakho ngokushesha. I-Pemigatinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngenkathi uthatha i-pemigatinib kanye neviki elilodwa ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi ungadala amehlo omile. Udokotela wakho angakutshela ukuthi usebenzise izinyembezi zokufakelwa noma amathonsi wamehlo okugcoba ngenkathi welashwa nge-pemigatinib.

Ungadli inani elikhulu lamagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Uma uphuthelwa umthamo we-pemigatinib ngaphansi kwamahora ama-4, thatha isilinganiso esilahlekile ngokushesha nje lapho usikhumbula bese uthatha umthamo olandelayo ngesikhathi esihleliwe. Kodwa-ke, uma uphuthelwa umthamo ngamahora ama-4 noma ngaphezulu, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Pemigatinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• isicanucanu
• izinguquko ekunambithekeni
• ukuhlanza
• ukulahlekelwa isifiso sokudla
• ukuncipha komzimba
• ukuqunjelwa
• ubuhlungu besisu
• izilonda ezindebeni, emlonyeni, noma emphinjeni
• umlomo owomile kanye / noma isikhumba; ukuncipha kokuchama; noma ukushaya kwenhliziyo okusheshayo
• izipikili
• ukulahleka kwezinwele
• ikhanda
• ukukhathala
• ubuhlungu obuhlangene noma obuya emuva
• ukuchama okushisayo noma okubuhlungu
• ubuhlungu noma ukuvuvukala kwezandla, izinyawo, imilenze noma amaqakala

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukungaboni kahle, okuntantayo esweni, ukubona ukukhanya kokukhanya, noma olunye ushintsho kumbono
• amajaqamba, ukuba ndikindiki, noma ukuncinza emlonyeni

I-Pemigatinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help.Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina konke ukubonana nodokotela wakho, udokotela wamehlo, kanye nelabhorethri. Udokotela wakho uzoku-oda ukuhlolwa kwelebhu ngaphambi kokuba uqale ukwelashwa kwakho ukuze ubone ukuthi umdlavuza wakho ungelashwa nge-pemigatinib. Udokotela wakho uzophinde a-oda ezinye izivivinyo zelebhu nezamehlo ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-pemigatinib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Pemazyre^®