Ozanimod

-Delile

• Ngaphambi kokuthatha i-ozanimod,
• I-Ozanimod ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukuthatha i-ozanimod bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Ozanimod isetshenziselwa ukwelapha abantu abadala abanezinhlobo zokubuyela emuva ze-multiple sclerosis (MS; isifo lapho izinzwa zingasebenzi kahle futhi abantu bangathola ubuthakathaka, ukuba ndikindiki, ukulahleka kokuhlangana kwemisipha, nezinkinga ngombono, ukukhuluma, nokulawula isinye) kufaka phakathi i-Clinic isolated syndrome (i-CIS; iziqephu zezimpawu zemizwa ezihlala okungenani amahora angama-24), amafomu okubuyisela emuva (izifo lapho izimpawu zivela khona ngezikhathi ezithile), noma amafomu wesibili aqhubekayo (inkambo yesifo lapho ukubuyela emuva kwenzeka kaningi). I-Ozanimod isekilasini lemithi ebizwa nge-sphingosine l-phosphate receptor modulators. Isebenza ngokunciphisa isenzo samaseli omzimba angadala ukulimala kwezinzwa.

I-Ozanimod iza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa noma ngaphandle kokudla kanye ngosuku. Thatha i-ozanimod ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-ozanimod njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya amaphilisi aphelele; ungazivuli, uzihlafune noma uzichoboze.

Udokotela wakho mhlawumbe uzokuqala ngomthamo ophansi we-ozanimod futhi akhuphule kancane umthamo wakho ngesonto lokuqala.

I-Ozanimod ingasiza ekulawuleni izimpawu eziningi ze-sclerosis, kepha ayizelaphi. Udokotela wakho uzokubuka ngokucophelela ukuze abone ukuthi i-ozanimod isebenza kanjani kuwe. Kubalulekile ukutshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-ozanimod futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-ozanimod,

• Tshela udokotela kanye nosokhemisi wakho uma une-aleji ku-ozanimod, noma imiphi eminye imithi, noma iziphi izithako kuma-ozanimod capsules. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma uthatha i-MAO inhibitor efana ne-isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), noma i-tranylcypromine (iParnate) noma uyekile ukuthatha enye le mithi emasontweni amabili edlule. Udokotela wakho uzokutshela ukuthi akufanele uthathe i-ozanimod ngalesi sikhathi. Uma uyeka ukuthatha i-ozanimod, kufanele ulinde okungenani izinsuku eziyi-14 ngaphambi kokuqala ukuthatha i-MAO inhibitor.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-clopidogrel (i-Plavix); i-cyclosporine (Gengraf, Neoral, Sandimmune); i-eltrombopag (i-Promacta); i-erythromycin (E.E.S., Erythromycin, abanye); gemfibrozil (Lopid); imishanguzo yokushaya kwenhliziyo okungajwayelekile njenge-amiodarone (Nexterone, Pacerone), procainamide, ne-quinidine (eNuedexta); i-opioid (narcotic) imithi yezinhlungu efana ne-meperidine (Demerol), i-methadone (i-Dolophine, i-Methadose) ne-tramadol; i-rifampin (Rifadin, Rimactane, eRifamate, abanye); i-serotonin-reuptake inhibitors ekhethiwe njenge-citalopram (Celexa), i-escitalopram (Lexapro), i-fluoxetine (i-Prozac, i-Sarafem, e-Symbyax), i-fluvoxamine (i-Luvox), i-paroxetine (i-Brisdelle, i-Prozac, i-Pexeva) ne-sertraline (i-Zoloft); kanye ne-serotonin ne-norepinephrine reuptake inhibitors efana ne-desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), milnacipran (Savella), ne-venlafaxine (Effexor); ne-sotalol (iBetapace, iSorine, iSotylize). Tshela nodokotela wakho uma ngabe uthatha noma iyiphi yale mithi elandelayo, noma uma uyiphuzile muva nje: i-alemtuzumab (Campath, Lemtrada); ama-corticosteroids afana ne-dexamethasone, i-methylprednisolone (iMedrol), ne-prednisone (i-Rayos); imithi yomdlavuza; nemithi yokwenza buthakathaka noma ulawule amasosha omzimba njenge-glatiramer (Copaxone, Glatopa) ne-interferon beta (Betaseron, Extavia, Plegridy). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingaxhumana ne-ozanimod, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• Tshela udokotela wakho uma uke wahlaselwa yinhliziyo, ubuhlungu besifuba, isifo sohlangothi noma ukushaywa unhlangothi, noma ukwehluleka kwenhliziyo ezinyangeni eziyisithupha ezidlule. Futhi, tshela udokotela wakho uma unenhliziyo engajwayelekile engalungiswa yi-pacemaker, noma uma une-apnea yokulala (ukuyeka ukuphefumula isikhathi esifushane ngesikhathi sokulala). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-ozanimod.
• Tshela udokotela wakho uma ngabe unomkhuhlane, umphimbo, ukukhwehlela, ukubanda, izindlala ezivuvukele, noma ezinye izimpawu zokutheleleka, uma unesifo esifika futhi sidlule noma esingapheli, noma uma ungakwazi ukulwa nezifo ngenxa yesinye isifo. Futhi, tshela udokotela wakho uma uke waba nomfutho wegazi ophakeme noma waba nesisindo esisheshayo senhliziyo, isifo sikashukela, uveitis (ukuvuvukala kweso) noma ezinye izinkinga zamehlo, noma isifo senhliziyo noma sesibindi.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho ne-ozanimod nezinyanga ezintathu ngemuva komthamo wakho wokugcina. Uma ukhulelwa ngenkathi uthatha i-ozanimod, shayela udokotela wakho ngokushesha.
• Tshela udokotela wakho uma ngabe ube nokugoma ezinsukwini ezingama-30 ezedlule ngaphambi kokuba uqale ukwelashwa kwakho nge-ozanimod. Ungabi nayo imigomo ngesikhathi sokwelashwa kwakho noma ezinyangeni ezi-3 ngemuva komthamo wakho wokugcina ngaphandle kokukhuluma nodokotela wakho.
• Tshela udokotela wakho uma ungakaze ube nenkukhu futhi awutholanga umuthi wokugomela inkukhu (varicella). Udokotela wakho angalawula ukuhlolwa kwegazi ukuze abone ukuthi utholakale ku-chickenpox. Ungadinga ukuthola umuthi wokugomela inkukhu bese ulinda inyanga engu-1 ngaphambi kokuqala ukwelashwa kwakho nge-ozanimod.
• kufanele wazi ukuthi i-ozanimod ingadala isiyezi, ikhanda elikhanyayo, nokuquleka lapho uvuka ngokushesha okukhulu kusuka endaweni elele. Lokhu kuvame kakhulu lapho uqala ukuthatha i-ozanimod. Ukugwema le nkinga, phuma embhedeni kancane, uphumule izinyawo zakho phansi imizuzu embalwa ngaphambi kokuma.

Ungase uthole ukusabela okungathi sína uma udla ukudla okune-tyramine enkulu ngesikhathi sokwelashwa kwakho nge-ozanimod. I-Tyramine itholakala ekudleni naseziphuzweni eziningi, kufaka phakathi inyama, izinkukhu, inhlanzi, noma ushizi oshunqisiwe, osugugile, ogcinwe ngendlela engafanele noma okonakele; izithelo ezithile, imifino, nobhontshisi; iziphuzo ezidakayo; nemikhiqizo yemvubelo ebilile. Udokotela wakho noma isazi sokudla uzokutshela ukuthi yikuphi ukudla okufanele ukugweme ngokuphelele, nokuthi yikuphi ukudla ongakudla ngamanani amancane. Uma udla ukudla okune-tyramine enkulu ngenkathi uthatha i-ozanimod, xhumana nodokotela wakho.

Uma uphuthelwa umthamo owodwa noma ngaphezulu ezinsukwini zokuqala eziyi-14 zokwelashwa, khuluma nodokotela wakho ngaphambi kokuthi uqale ukukuthatha futhi. Uzodinga ukuqala kabusha umuthi ngomthamo ophansi futhi ukhuphule kancane umthamo.

Uma uphuthelwa umthamo ngemuva kwezinsuku zokuqala eziyi-14 zokwelashwa, qhubeka nesimiso sakho sokulinganisa okujwayelekile ngosuku olulandelayo. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Ozanimod ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuhlungu obusemhlane

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukuthatha i-ozanimod bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• umkhuhlane, ukukhwehlela, umphimbo obuhlungu, ikhala eligijimayo, noma ukuchama okubuhlungu nokuvame ukwelashwa ngesikhathi sokwelashwa futhi kuze kube izinyanga ezingama-3 ngemuva komthamo wakho wokugcina
• ikhanda, ukuqina kwentamo, umkhuhlane, ukuzwela ekukhanyeni, isicanucanu, noma ukudideka ngesikhathi sokwelapha kanye nezinyanga ezi-3 ngemuva komthamo wakho wokugcina
• isicanucanu, ukuhlanza, ukungathandi ukudla, ubuhlungu besisu, ukuphuzi kwesikhumba noma kwamehlo, noma umchamo omnyama
• ukufiphala, izithunzi, noma indawo engaboni maphakathi nombono wakho; ukuzwela ekukhanyeni; umbala ongavamile kumbono wakho noma ezinye izinkinga zombono
• ikhanda elibuhlungu ngokuzumayo, ukudideka, izinguquko kumbono, noma ukuquleka
• ubuthakathaka ohlangothini olulodwa lomzimba noma ubuthakathaka bezingalo noma imilenze obuba bucayi ngokuhamba kwesikhathi; izinguquko emcabangweni wakho, ememori, noma ekulinganiseni; ukudideka noma izinguquko zobuntu; noma ukuphelelwa amandla
• ukuqubuka; isifuba; noma ukuvuvukala kwezindebe, ubuso, noma ulimi
• ukuphefumula okusha noma okuya kuba kubi kakhulu
• isiyezi, ukukhathala, ubuhlungu besifuba, noma ukushaya kwenhliziyo okuhamba kancane noma okungajwayelekile

I-Ozanimod ingakhuphula ubungozi bokuba nomdlavuza wesikhumba. Khuluma nodokotela wakho ngezingozi zokuthatha lo muthi.

Ukwanda okungazelelwe kweziqephu zezimpawu ze-MS nokwanda kokukhubazeka kungenzeka ngemuva kokuyeka ukuthatha i-ozanimod. Tshela udokotela wakho uma izimpawu zakho ze-MS ziba zimbi kakhulu ngemuva kokuyeka ukuthatha i-ozanimod.

I-Ozanimod ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Uzothola i-electrocardiogram (ECG; ukuhlolwa okurekhoda umsebenzi kagesi wenhliziyo) ngaphambi kokuthatha umthamo wakho wokuqala. Udokotela wakho uzophinde a-ode izivivinyo ezithile zelebhu, izivivinyo zamehlo, futhi uzoqapha umfutho wegazi lakho ngaphambi nangesikhathi sokwelashwa kwakho ukuze aqiniseke ukuthi kuphephile kuwe ukuqala ukuthatha noma ukuqhubeka nokuthatha i-ozanimod.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Zeposia^®