I-Elagolix, i-Estradiol, ne-Norethindrone

-Delile

• Ngaphambi kokuthatha inhlanganisela ye-elagolix, i-estradiol, ne-norethindrone,
• I-Elagolix, i-estradiol, ne-norethindrone kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka:

Imithi equkethe i-estradiol ne-norethindrone ingakhuphula ubungozi bokuhlaselwa yisifo senhliziyo, isifo sohlangothi, namahlule egazini emaphashini nasemilenzeni. Tshela udokotela wakho uma ubhema nokuthi uke wahlaselwa yinhliziyo noma wake wahlaselwa yini; isifo sohlangothi; amahlule egazi emilenzeni, emaphashini noma emehlweni; isifo se-valve yenhliziyo; ukushaya kwenhliziyo okusheshayo noma okungajwayelekile; i-thrombophilia (isimo lapho igazi lishaya kalula); ikhanda le-migraine; umfutho wegazi ophakeme; amazinga aphezulu egazi e-cholesterol noma amafutha; noma isifo sikashukela esithinte ukusakazeka kwakho. Udokotela wakho angakutshela ukuthi akufanele uphuze lo muthi uma ngabe uke waba noma unayo yalezi zimo. Uma uhlinzwa noma uzobe ulala embhedeni, udokotela wakho angafuna ukuthi uyeke ukuthatha le mithi okungenani amasonto amane kuya kwayisithupha ngaphambi kokuhlinzwa noma indawo yokulala.

Uma uhlangabezana nanoma yimiphi imiphumela emibi elandelayo, shayela udokotela wakho ngokushesha: ikhanda elingalindelekile, elibi kakhulu; ukulahleka kombono okuncane ngokungazelelwe noma okuphelele; ukubona kabili; izinkinga zokukhuluma; isiyezi noma ukuquleka; ubuthakathaka noma ukuba ndikindiki kwengalo noma komlenze; ukuchoboza ubuhlungu besifuba noma isisindo sesifuba; ukukhwehlela igazi; ukuphefumula ngokuzumayo; noma ubuhlungu, ubumnene, noma ubomvu emlenzeni owodwa.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-elagolix, estradiol, ne-norethindrone futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngobungozi (s) bokuthatha i-elagolix, i-estradiol, ne-norethindrone.

Inhlanganisela ye-elagolix, i-estradiol, ne-norethindrone isetshenziselwa ukwelapha ukopha okunzima kokuya esikhathini okubangelwa yi-uterine fibroids (ukukhula esibelethweni akuwona umdlavuza). U-Elagolix usesigabeni semithi ebizwa nge-gonadotropin-releasing hormone (GnRH) receptor antagonists. I-Estradiol isekilasini lemithi ebizwa ngama-estrogen hormone. INorethindrone isekilasini lemithi ebizwa ngama-progestins. I-Elagolix isebenza ngokunciphisa inani lamahomoni athile emzimbeni. I-Estradiol isebenza ngokufaka esikhundleni se-estrogen evame ukukhiqizwa ngumzimba. INorethindrone isebenza ngokuvimba ulwelwesi lwesibeletho ukuthi lungakhuli futhi ibangele ukuthi isibeletho sikhiqize amahomoni athile.

Inhlanganisela ye-elagolix, i-estradiol, ne-norethindrone iza njengamaphilisi okuthatha ngomlomo. Imvamisa kuthathwa ngokudla noma ngaphandle kokudla kabili ngosuku kuze kube izinyanga ezingama-24. Lo muthi uza ngephakeji eliqukethe izinsuku ezingama-28 zemithi. Iphakethe ngalinye ledosi lamasonto onke linezinhlobo ezimbili ezahlukahlukene zamaphilisi, ayi-7 aqukethe inhlanganisela ye-elagolix, i-estradiol, ne-norethindrone (amaphilisi aphuzi namhlophe) no-7 aqukethe i-elagolix (amaphilisi aluhlaza okwesibhakabhaka nokumhlophe). Thatha i-elagolix, i-estradiol, ne-norethindrone (1 capsule) njalo ekuseni bese uthatha i-elagolix (1 capsule) njalo kusihlwa. Thatha i-elagolix, i-estradiol, ne-norethindrone ngasikhathi sinye nsuku zonke.Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-elagolix, i-estradiol, ne-norethindrone njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Udokotela wakho angakunikeza noma ancoma ukwengezwa kwe-calcium nevithamini D okufanele ukwenze ngesikhathi sokwelashwa kwakho. Kufanele uthathe lezi zithasiselo njengoba uqondiswe ngudokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha inhlanganisela ye-elagolix, i-estradiol, ne-norethindrone,

• Tshela udokotela wakho kanye nosokhemisi uma une-alegolix, i-estradiol, i-norethindrone, i-aspirin, i-tartrazine (idayi ephuzi etholakala kweminye imithi), noma imiphi eminye imithi, noma iziphi izithako kuma-capsule e-elagolix, estradiol, norethindrone. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma uthatha i-cyclosporine (Gengraf, Neoral, Sandimmune) noma i-gemfibrozil (Lopid). Udokotela wakho mhlawumbe angakutshela ukuthi ungathathi inhlanganisela ye-elagolix, estradiol, ne-norethindrone uma uthatha eyodwa noma ngaphezulu yale mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: digoxin (Lanoxin); ketoconazole; levothyroxine (Levoxyl, Synthroid, Tirosint, nabanye); i-midazolam (i-Nayzilam); i-phenytoin (iDilantin, Phenytek); proton pump inhibitors njenge-dexlansoprazole (Dexilant), esomeprazole (Nexium, eVimovo), lansoprazole (Prevacid), omeprazole (Prilosec, eTalicia, eYosprala, eZegred), pantoprazole (Protonix), kanye rabeprazole (Aciphex) i-rifampin (iRifadin, eRifamate, eRifater); i-rosuvastatin (iCrestor); kanye ne-steroids efana ne-dexamethasone (Hemady), i-methylprednisolone (Medrol), i-prednisone, ne-prednisolone (i-Orapred ODT, i-Pediapred, i-Prelone). Futhi, tshela udokotela noma usokhemisi wakho uma uthatha izithako zokudla okunamavithamini noma amaminerali aqukethe insimbi. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-elagolix, estradiol, ne-norethindrone, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• tshela udokotela wakho uma uke waba nomdlavuza webele noma wake waba nawo; umdlavuza wesibeletho, isitho sangasese sowesifazane, noma ulwelwesi lwesibeletho; i-osteoporosis (isimo lapho amathambo ezacile futhi kungenzeka ukuthi aphuke); ukopha okungavamile okungaziwa kwesitho sangasese sowesifazane; isifo semithambo yegazi (ukusakazeka okungafanele emithanjeni yegazi); isifo senhliziyo noma sesibindi noma olunye uhlobo lwezinkinga zesibindi. Udokotela wakho mhlawumbe angakutshela ukuthi ungathathi inhlanganisela ye-elagolix, estradiol, ne-norethindrone.
• utshele udokotela wakho uma uke waphula amathambo; ukudana, ukukhathazeka, izinguquko ezingavamile ekuziphatheni noma emoyeni, noma imicabango mayelana noma ukuzama ukuzibulala; isifo senyongo; i-jaundice (ukuphuzi kwesikhumba noma kwamehlo); izinkinga ze-thyroid; noma ukungasebenzi kahle kwe-adrenal (isimo lapho izindlala ze-adrenal zingakhiqizi ngokwanele amahomoni athile adingekayo emisebenzini ebalulekile yomzimba).
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Ungathathi i-elagolix, i-estradiol, ne-norethindrone uma ukhulelwe noma ucabanga ukuthi ukhulelwe. Udokotela wakho uzokwenza isivivinyo sokukhulelwa ngaphambi kokuqala ukwelashwa noma akutshele ukuthi uqale ukwelashwa kwakho ezinsukwini ezingu-7 ngemuva kokuqala ukuya esikhathini ukuze uqiniseke ukuthi awukhulelwe lapho uthatha i-elagolix, i-estradiol, ne-norethindrone. I-Elagolix, i-estradiol, ne-norethindrone zingaphazamisa ukusebenza kwezindlela ezithile zokuvimbela inzalo zamahomoni, ngakho-ke akufanele uzisebenzise njengendlela yakho kuphela yokulawula ukubeletha ngenkathi welashwa. Uzodinga ukusebenzisa indlela ethembekile engeyona eye-hormonal control control ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nangesonto eli-1 ngemuva komthamo wakho wokugcina. Buza udokotela wakho ukuthi akusize ukhethe indlela yokulawula ukubeletha ezokusebenzela. Uma ukhulelwa ngenkathi uthatha i-elagolix, i-estradiol, ne-norethindrone, shayela udokotela wakho ngokushesha. I-Elagolix, i-estradiol, ne-norethindrone zingalimaza umbungu.
• kufanele wazi ukuthi impilo yakho yengqondo ingashintsha ngezindlela ezingalindelekile futhi ungazibulala (ucabanga ngokuzilimaza noma ukuzibulala noma ukuhlela noma ukuzama ukwenza lokho) ngenkathi uthatha i-elagolix, estradiol, ne-norethindrone. Wena, umndeni wakho, noma umnakekeli wakho kufanele ushayele udokotela wakho ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo: ukucasuka okusha noma okuba kubi kakhulu, ukukhathazeka, noma ukucindezeleka; ukukhuluma noma ukucabanga ngokufuna ukuzilimaza noma ukuqeda impilo yakho; ukuhoxa kubangani nomndeni; ukukhathazeka ngokufa nokufa; noma olunye uguquko olungajwayelekile ekuziphatheni noma emoyeni. Qiniseka ukuthi umndeni wakho noma umnakekeli wakho uyazi ukuthi yiziphi izimpawu ezingaba zimbi kakhulu ukuze bakwazi ukubiza udokotela uma ungakwazi ukuzifunela ukwelashwa wedwa.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma kungaphezu kwamahora ama-4 kusukela kumthamo wakho wokugcina, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa okujwayelekile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Elagolix, i-estradiol, ne-norethindrone kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukulahleka kwezinwele noma ukuncipha kwezinwele
• ukushisa okushisayo (ukuqhuma okungazelelwe kokushisa komzimba okuncane noma okukhulu)
• izinguquko esikhathini sokuya esikhathini (ukuphuma kwegazi ngokungajwayelekile noma ukubona, ukuphuma kancane noma ukungabikho nhlobo, ukunciphisa ubude bezikhathi)
• ikhanda
• ukuzuza kwesisindo
• ubuhlungu obuhlangene
• izinguquko ezifisweni zocansi
• ukozela noma ukukhathala

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuphuzi kwesikhumba noma kwamehlo
• ukulimaza noma ukopha okungavamile
• ukulahlekelwa isifiso sokudla
• ukukhathala ngokweqile, ubuthakathaka, noma ukungabi namandla
• umchamo onombala omnyama
• isitulo esinombala okhanyayo
• ubuhlungu engxenyeni engenhla kwesokudla yesisu
• isicanucanu
• ukuhlanza
• ukuvuvukala kwezandla, izinyawo, noma imilenze engezansi

Ukuhlanganiswa kwe-elagolix, i-estradiol, ne-norethindrone kungadala noma kubhebhethekise i-osteoporosis. Kunganciphisa ukuminyana kwamathambo akho futhi kwandise amathuba okuphuka kwamathambo nokuqhekeka. Khuluma nodokotela wakho ngezingozi zokuthatha lo muthi.

I-Elagolix, i-estradiol, ne-norethindrone kungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka:

• isicanucanu
• ukuhlanza
• isisa sebele
• ubuhlungu besisu
• ukozela noma ukukhathala
• ukopha esithweni sangasese

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-elagolix, estradiol, naku-norethindrone.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• U-Oriahnn^®

• Norethisterone