I-Ponesimod

-Delile

• I-Ponesimod isetshenziselwa ukuvimbela iziqephu zezimpawu futhi yehlise ukwanda kokukhubazeka kubantu abadala abanamafomu abuyela emuva e-multiple sclerosis (MS; isifo lapho izinzwa zingasebenzi kahle futhi abantu bangathola ubuthakathaka, ukuba ndikindiki, ukulahleka kokuhlangana kwemisipha, izinkinga ngombono, ukukhuluma, nokulawula isinye), kufaka phakathi: I-Ponesimod isekilasini lemithi ebizwa nge-sphingosine l-phosphate receptor modulators. Isebenza ngokunciphisa isenzo samaseli omzimba angadala ukulimala kwezinzwa.
• Ngaphambi kokuthatha i-ponesimod,
• I-Ponesimod ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka:

I-Ponesimod isetshenziselwa ukuvimbela iziqephu zezimpawu futhi yehlise ukwanda kokukhubazeka kubantu abadala abanamafomu abuyela emuva e-multiple sclerosis (MS; isifo lapho izinzwa zingasebenzi kahle futhi abantu bangathola ubuthakathaka, ukuba ndikindiki, ukulahleka kokuhlangana kwemisipha, izinkinga ngombono, ukukhuluma, nokulawula isinye), kufaka phakathi: I-Ponesimod isekilasini lemithi ebizwa nge-sphingosine l-phosphate receptor modulators. Isebenza ngokunciphisa isenzo samaseli omzimba angadala ukulimala kwezinzwa.

• i-syndrome ehlukanisiwe nomtholampilo (i-CIS; isiqephu sesifo sezinzwa sokuqala esihlala okungenani amahora angama-24),
• isifo esibuyisa emuva (isifo esiyisifo lapho izimpawu zivela khona ngezikhathi ezithile),
• isifo esisebenzayo esiqhubekayo sesibili (isigaba sesifo esizayo ngokuqhubeka nokuba zimbi kwezimpawu.)

I-Ponesimod iza njengethebhulethi ukuthatha ngomlomo. Imvamisa kuthathwa kanye ngosuku noma ngaphandle kokudla. Thatha i-ponesimod ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-ponesimod njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Udokotela wakho mhlawumbe uzokuqala ngomthamo ophansi we-ponesimod futhi akhuphule kancane umthamo wakho ezinsukwini zokuqala eziyi-15.

I-Ponesimod ingadala ukushaya kwenhliziyo ukuthi kwehle, ikakhulukazi phakathi namahora amane okuqala ngemuva kokuthatha umthamo wakho wokuqala. Uzothatha umthamo wakho wokuqala we-ponesimod ehhovisi likadokotela wakho noma kwenye indawo yezokwelapha. Uzothola i-electrocardiogram (ECG; ukuhlolwa okurekhoda umsebenzi kagesi wenhliziyo) ngaphambi kokuthatha umthamo wakho wokuqala futhi futhi namahora ama-4 ngemuva kokuthatha umthamo. Uzodinga ukuhlala esikhungweni sezokwelapha okungenani amahora ama-4 ngemuva kokudla umuthi ukuze ubhekwe. Ungadinga ukuhlala esikhungweni sezokwelapha isikhathi esingaphezu kwamahora ama-4 noma ubusuku bonke uma unemibandela ethile noma uthatha imishanguzo ethize ekhulisa ubungozi bokuthi ukushaya kwenhliziyo yakho kuzokwehla noma uma ukushaya kwenhliziyo yakho kuhamba kancane kunalokho obekulindelwe noma kuqhubeka ukwehla ngemuva kwe-4 yokuqala amahora. Kungase kudingeke nokuthi uhlale esikhungweni sezokwelapha okungenani amahora angu-4 ngemuva kokuthatha umthamo wakho wesibili uma ukushaya kwenhliziyo yakho kwehla kakhulu lapho uthatha umthamo wakho wokuqala. Tshela udokotela wakho uma uba nesiyezi, ukhathala, ubuhlungu besifuba, noma ukushaya kwenhliziyo okuhamba kancane noma okungajwayelekile nganoma yisiphi isikhathi lapho welashwa.

I-Ponesimod ingasiza ekulawuleni i-multiple sclerosis kepha ngeke iyelaphe. Ungayeki ukuthatha i-ponesimod ngaphandle kokukhuluma nodokotela wakho.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-ponesimod futhi isikhathi ngasinye ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-ponesimod,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-ponesimod, noma imiphi eminye imithi, noma iziphi izithako ezibhebheni ze-ponesimod. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: alemtuzumab (Campath, Lemtrada); i-amiodarone (i-Nexterone, i-Pacerone); ama-beta-blocker anjenge-atenolol (Tenormin, in Tenoretic), carteolol, labetalol (Trandate), metoprolol (Lopressor, Toprol-XL, in Dutoprol, in Lopressor HCT), nadolol (Corgard, eCorzide), nebivolol (Bystolic, in Byvalson ), propranolol (Inderal LA, Innopran XL), sotalol (Betapace, Sorine, Sotylize) kanye ne-timolol; carbamazepine (Carbatrol, Equetro, Tegretol, abanye); i-digoxin (i-Lanoxin); i-diltiazem (Cardizem, Cartia, Tiazac, abanye); i-modafinil (i-Provigil); i-phenytoin (iDilantin); procainamide; i-quinidine (ku-Nuedexta); i-rifampin (Rifadin, Rimactane, eRifamate, abanye); kanye ne-verapamil (Calan, Verelan, eTarka). Phinda utshele udokotela wakho uma ngabe usebenzisa noma iyiphi yale mithi elandelayo, noma uma uke wayisebenzisa esikhathini esedlule: i-corticosteroids efana ne-dexamethasone, i-methylprednisolone (i-Medrol) ne-prednisone (i-Rayos); imithi yomdlavuza; nemithi yokwenziwa buthaka noma yokulawula amasosha omzimba njenge-glatiramer acetate (Copaxone, Glatopa) ne-interferon beta (Betaseron, Extavia, Plegridy). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-ponesimod, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• Tshela udokotela wakho uma uke waba nanoma iyiphi yalezi zimo ezinyangeni eziyisithupha ezedlule: isifo senhliziyo, i-angina (ubuhlungu besifuba), isifo sohlangothi noma ukushaywa unhlangothi, noma ukwehluleka kwenhliziyo. Phinda utshele udokotela wakho uma unesigqi senhliziyo esingajwayelekile noma izinhlobo ezithile zebhlokhi yenhliziyo, ngaphandle uma une-pacemaker. Udokotela wakho angakutshela ukuthi ungathathi i-ponesimod.
• utshele udokotela wakho uma unomkhuhlane noma ukutheleleka noma uma unesifo esiza futhi sidlule noma esingapheli. Futhi, tshela udokotela wakho uma uke wahlaselwa yinhliziyo, wahlaselwa isifo sohlangothi, waba nesifo sohlangothi, isifo sikashukela, waphefumula ubuthongo (isimo lapho uyeka khona ukuphefumula kaningi ebusuku) noma ezinye izinkinga zokuphefumula, umfutho wegazi ophakeme, uveitis (ukuvuvukala kweso) noma ezinye izinkinga zamehlo, umdlavuza wesikhumba, noma isifo senhliziyo noma sesibindi. Phinda utshele udokotela wakho uma une-QT syndrome ende (isimo esandisa ingozi yokuhlaselwa ukushaya kwenhliziyo okungajwayelekile, okungadala ukuquleka noma ukufa ngokuzuma), isigqi senhliziyo esingajwayelekile, noma uma usanda kuthola umuthi wokugoma.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa, noma uncelisa.Kufanele usebenzise ukulawulwa kokubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho futhi okungenani isonto elilodwa ngemuva komthamo wakho wokugcina. Uma ukhulelwa ngenkathi uthatha i-ponesimod noma kungakapheli isonto elilodwa ngemuva komthamo wakho wokugcina, shayela udokotela wakho. I-Ponesimod ingalimaza umbungu.
• awunawo umuthi wokugoma inyanga engu-1 ngaphambi kokuqala ukwelashwa kwakho nge-ponesimod, ngesikhathi sokwelashwa kwakho, nangesonto elingu-1 kuya kwele-2 ngemuva komthamo wakho wokugcina ngaphandle kokukhuluma nodokotela wakho. Khuluma nodokotela wakho ngemigomo ongayidinga ukuyithola ngaphambi kokuqala ukwelashwa kwakho nge-ponesimod.
• Tshela udokotela wakho uma ungakaze ube nochoko futhi awutholanga umuthi wokugomela ubungu. Udokotela wakho angayalela ukuhlolwa kwegazi ukuze abone ukuthi ngabe uchayekile yini ekubhekaneni nenkukhu. Ungadinga ukuthola umuthi wokugomela umkhuhlane bese ulinda amasonto ama-4 ngaphambi kokuqala ukwelashwa kwakho nge-ponesimod.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa izinsuku ezi-1 ukuya kwezi-3 ze-ponesimod ngesikhathi sokubhaliswa (iphakethe lezinsuku eziyi-14), thatha ithebhulethi ephuthelwe ngokushesha nje lapho ukhumbula bese uqhubeka nokwelashwa kwakho ngokuthatha ithebhulethi eyodwa ngosuku ku-starter pack njengoba kuhlelwe. Uma uphuthelwa ukuthatha izinsuku ezi-4 noma ngaphezulu zilandelana ze-ponesimod ngesikhathi sokubhaliswa (iphakethe lezinsuku eziyi-14), shayela udokotela wakho njengoba uzodinga ukuqala kabusha ukwelashwa ngephakethe elisha lezinsuku eziyi-14. Uma unezimo ezithile zenhliziyo, kungadingeka ukuthi ubhekwe ngudokotela wakho okungenani amahora angu-4 lapho uthatha umthamo wakho olandelayo.

Uma uphuthelwa izinsuku ezi-1 ukuya kwezi-3 ze-ponesimod ngemuva kwesikhathi sokubamba (umthamo wesondlo) thatha ithebhulethi ephuthelwe ngokushesha okukhulu lapho ukhumbula khona bese uqhubeka nokwelashwa kwakho. Uma uphuthelwa ukuthatha izinsuku ezi-4 noma ngaphezulu zilandelana ze-ponesimod ngemuva kwesikhathi sokubamba (umthamo wesondlo), shayela udokotela wakho njengoba uzodinga ukuqala kabusha ukwelashwa ngephakethe elisha lezinsuku eziyi-14. Uma unezimo ezithile zenhliziyo, kungadingeka ukuthi ubhekwe ngudokotela wakho okungenani amahora angu-4 lapho uthatha umthamo wakho olandelayo.

I-Ponesimod ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isiyezi
• ukukhwehlela
• ubuhlungu ezandleni noma ezinyaweni

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukushaya kwenhliziyo okuhamba kancane
• umphimbo obuhlungu, ukuphefumula okuncane, ubuhlungu bomzimba, umkhuhlane, ukuvuthwa ukuchama, ukubanda, ukukhwehlela, nezinye izimpawu zokutheleleka ngesikhathi sokwelashwa futhi kuze kube amasonto ayi-1 kuya kwangu-2 ngemuva kokwelashwa kwakho
• ubuthakathaka ohlangothini olulodwa lomzimba noma ubuthakathaka bezingalo noma imilenze obuba bucayi ngokuhamba kwesikhathi; izinguquko emcabangweni wakho, ememori, noma ekulinganiseni; ukudideka noma izinguquko zobuntu; noma ukuphelelwa amandla
• ukufiphala, izithunzi, noma indawo engaboni maphakathi nombono wakho; ukuzwela ekukhanyeni; umbala ongavamile kumbono wakho noma ezinye izinkinga zombono
• isicanucanu, ukuhlanza, ukungathandi ukudla, ubuhlungu besisu, ukuphuzi kwesikhumba noma kwamehlo, noma umchamo omnyama
• ukuphefumula okusha noma okuya kuba kubi kakhulu

I-Ponesimod ingakhuphula ingozi yokuba nomdlavuza wesikhumba. Tshela udokotela wakho uma kukhona ushintsho kumvukuzane ekhona; indawo entsha emnyama esikhunjeni; izilonda ezingapholi; ukukhula kwesikhumba sakho okufana neqhubu elingacwebezela, libe mhlophe ngebala, libe nombala wesikhumba, noma lipinki, noma olunye uguquko esikhunjeni sakho. Udokotela wakho kufanele ahlole isikhumba sakho nganoma yiziphi izinguquko phakathi nokwelashwa nge-ponesimod. Nciphisa isikhathi osichitha ekukhanyeni kwelanga nokukhanya kwe-ultraviolet (UV). Gqoka izingubo zokuzivikela bese usebenzisa i-sunscreen enesici sokuvikela ilanga. Khuluma nodokotela wakho ngezingozi zokuthatha lo muthi.

I-Ponesimod ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Uma umuthi wakho ufike nephakethe le-desiccant (iphakethe elincane eliqukethe into edonsa umswakama ukugcina umuthi womile), shiya iphakethe ebhodleleni kodwa uqaphele ukuthi ungaligwinyi.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka:

• ukushaya kwenhliziyo okuphuzile noma okungajwayelekile

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu kanye nokuhlolwa kwamehlo, futhi uzoqapha umfutho wegazi lakho ngaphambi nangesikhathi sokwelashwa kwakho ukuze aqiniseke ukuthi kuphephile ukuthi uqale ukuthatha noma uqhubeke nokuthatha i-ponesimod.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Ponvory^®