Injection yeMethotrexate

-Delile

• Ngaphambi kokuthola umjovo we-methotrexate,
• I-Methotrexate ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

IMethotrexate ingadala imiphumela emibi kakhulu, esongela impilo. Kufanele uthole umjovo we-methotrexate kuphela ukwelapha umdlavuza osongela impilo, noma ezinye izimo ezinzima kakhulu futhi ezingakwazi ukwelashwa ngeminye imithi. Khuluma nodokotela wakho ngezingozi zokuthola umjovo we-methotrexate wesimo sakho.

Tshela udokotela wakho uma uke waba nakho uketshezi oludlulele esiswini sakho noma endaweni ezungeze amaphaphu akho futhi uma uke waba nesifo sezinso noma wake waba naso. Tshela nodokotela wakho uma uthatha izidakamizwa ezingezona ukuvuvukala (ama-NSAID) njenge-aspirin, i-choline magnesium trisalicylate (iTricosal, Trilisate), ibuprofen (Advil, Motrin), i-magnesium salicylate (iDoan's), naproxen (Aleve, Naprosyn), noma salsalate. Lezi zimo nemithi kungakhuphula ubungozi bokuthi uzoba nemiphumela emibi kakhulu ye-methotrexate. Udokotela wakho uzokuqapha ngokucophelela futhi angadinga ukukunikeza umthamo ophansi we-methotrexate noma ayeke ukwelashwa kwakho nge-methotrexate.

I-Methotrexate ingadala ukwehla kwenani lamaseli egazi enziwe ngomnkantsha wakho. Tshela udokotela wakho uma ngabe uke waba nenombolo ephansi yanoma yiluphi uhlobo lwamaseli egazi noma enye inkinga ngamaseli akho egazi. Shayela udokotela wakho ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo: umphimbo obuhlungu, amakhaza, umkhuhlane, ukukhwehlela okuqhubekayo nokucinana, noma ezinye izimpawu zokutheleleka; ukulimaza noma ukopha okungavamile; ukukhathala okungajwayelekile noma ubuthakathaka; isikhumba esiphaphathekile; noma ukuphefumula okuncane.

I-Methotrexate ingadala ukulimala kwesibindi, ikakhulukazi uma iphuzwa isikhathi eside. Tshela udokotela wakho uma uphuza noma uke waphuza utshwala obuningi noma uma uke waba nesifo sesibindi. Udokotela wakho kungenzeka angafuni ukuthi uthole umjovo we-methotrexate ngaphandle kokuthi ube nomdlavuza osongela impilo ngoba kunengozi enkulu yokuthi uzolimala isibindi. Ingozi yokuthi uzoba nokulimala kwesibindi ingaphakama futhi uma usumdala, ukhuluphele noma unesifo sikashukela. Buza udokotela wakho mayelana nokusetshenziswa okuphephile kweziphuzo ezidakayo ngenkathi uthola umjovo we-methotrexate. Tshela udokotela wakho uma ngabe uthatha noma imuphi wale mithi elandelayo: i-acitretin (Soriatane), azathioprine (Imuran), isotretinoin (Accutane), sulfasalazine (Azulfidine), noma i-tretinoin (Vesanoid). Shayela udokotela wakho ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo: isicanucanu, ukukhathala ngokweqile, ukungabi namandla, ukulahlekelwa isifiso sokudla, ubuhlungu engxenyeni engaphezulu kwesokudla yesisu, ukuphuzi kwesikhumba noma kwamehlo, noma izimpawu ezifana nomkhuhlane. Udokotela wakho angalawula ama-biopsies wesibindi (ukususwa kocezu oluncane lwezicubu zesibindi ukuze kuhlolwe elabhorethri) ngaphambi nangesikhathi sokwelashwa kwakho nge-methotrexate.

I-Methotrexate ingadala ukulimala kwamaphaphu. Tshela udokotela wakho uma uke waba nesifo samaphaphu noma wake waba naso. Shayela udokotela wakho ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo: ukukhwehlela owomile, umkhuhlane noma ukuphefumula okuncane.

I-Methotrexate ingadala umonakalo emgqeni womlomo wakho, isisu noma amathumbu. Tshela udokotela wakho uma uke waba nezilonda zesisu noma i-ulcerative colitis (isimo esidala ukuvuvukala nezilonda kulolwelwesi lwekholoni [amathumbu amakhulu] ne-rectum). Shayela udokotela wakho ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo: izilonda zomlomo, isifo sohudo, okumnyama, okulindile, noma indle enegazi, nokuhlanza, ikakhulukazi uma ukuhlanza kunegazi noma kufana nezindawo zekhofi.

Ukusebenzisa i-methotrexate kungandisa ubungozi bokuthi uzoba ne-lymphoma (umdlavuza oqala kumaseli amasosha omzimba). Uma uthuthukisa i-lymphoma, ingahle ihambe ngaphandle kokwelashwa lapho uyeka ukuthatha i-methotrexate, noma kungadinga ukwelashwa nge-chemotherapy.

Uma uthatha i-methotrexate ukwelapha umdlavuza, ungahle ube nezinkinga ezithile ezingaba zimbi kakhulu noma ezisongela impilo njengoba i-methotrexate isebenza ukuqeda amangqamuzana omdlavuza. Udokotela wakho uzokuqapha ngokucophelela futhi aphathe lezi zinkinga uma zenzeka.

I-Methotrexate ingadala ukusabela kwesikhumba okungathi sína noma okusongela ukuphila. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: umkhuhlane, ukuqubuka, amabhamuza, noma isikhumba esikhanyayo.

IMethotrexate inganciphisa ukusebenza kwamasosha akho omzimba, futhi ungahlaselwa izifo ezimbi. Tshela udokotela wakho uma unanoma yiluphi uhlobo lokutheleleka futhi uma ngabe uke waba nanoma yisiphi isimo esithinta amasosha akho omzimba. Udokotela wakho angakutshela ukuthi akufanele uthole i-methotrexate ngaphandle uma unomdlavuza osongela impilo. Uma uhlangabezana nezimpawu zokutheleleka ezifana nomphimbo obuhlungu, ukukhwehlela, imfiva, noma amakhaza, shayela udokotela wakho ngokushesha.

Uma uthola i-methotrexate ngenkathi uphathwa ngemithi yokwelashwa ngemisebe yomdlavuza, i-methotrexate ingakhuphula ubungozi bokuthi ukwelashwa ngemisebe kuzolimaza isikhumba sakho, amathambo, noma ezinye izingxenye zomzimba wakho.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi, ngesikhathi, nangemva kokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-methotrexate nokwelapha imiphumela engemihle ngaphambi kokuba ibe nzima.

Tshela udokotela wakho uma wena noma umlingani wakho ukhulelwe noma uhlela ukukhulelwa. Uma ungowesifazane, kuzodingeka wenze ukuhlolwa kokukhulelwa ngaphambi kokuthola i-methotrexate. Sebenzisa indlela ethembekile yokulawula ukubeletha ukuze wena noma umlingani wakho ungakhulelwa ngesikhathi noma ngemuva nje kokwelapha kwakho. Uma ungowesilisa, wena nozakwenu kufanele niqhubeke nokusebenzisa inzalo izinyanga ezintathu ngemuva kokuyeka ukusebenzisa i-methotrexate. Uma ungowesifazane, kufanele uqhubeke nokusebenzisa ukubeletha uze ube nesikhathi esisodwa sokuya esikhathini esiqale ngemuva kokuyeka ukusebenzisa i-methotrexate. Uma wena noma umlingani wakho ukhulelwa, shayela udokotela wakho ngokushesha. I-Methotrexate ingadala ingozi noma ukufa embungwini.

Umjovo weMethotrexate usetshenziswa wedwa noma uhlanganiswe neminye imithi yokwelapha izicubu ze-gestational trophoblastic (uhlobo lwesimila oluba ngaphakathi kwesibeletho sowesifazane ngenkathi ekhulelwe), umdlavuza webele, umdlavuza wamaphaphu, eminye imidlavuza yekhanda nentamo; izinhlobo ezithile ze-leukemia (umdlavuza wamangqamuzana amhlophe egazi), kufaka phakathi i-acute lymphocytic leukemia (BONKE) ne-meningeal leukemia (umdlavuza osembozweni wentambo yomgogodla nobuchopho); izinhlobo ezithile ze-non-Hodgkin's lymphoma (izinhlobo zomdlavuza eziqala ngohlobo lwamaseli amhlophe egazi ngokuvamile alwa nokutheleleka); i-T-cell lymphoma enqamulelayo (i-CTCL, iqembu lomdlavuza wamasosha omzimba aqala ukuvela njengokuqubuka kwesikhumba); ne-osteosarcoma (umdlavuza owakhiwa emathanjeni) ngemuva kokuhlinzwa ukukhipha isimila. Umjovo weMethotrexate usetshenziselwa ukwelapha i-psoriasis enamandla (isifo sesikhumba lapho kwakhiwa khona amabala abomvu, anezikhala ezindaweni ezithile zomzimba) ezingalawulwa ngezinye izindlela zokwelapha. Umjovo weMethotrexate ubuye usetshenziswe kanye nokuphumula, ukwelashwa ngokomzimba futhi kwesinye isikhathi eminye imithi yokwelapha i-rheumatoid arthritis (RA; isimo lapho umzimba uhlasela khona amalunga ayo, ubangele ubuhlungu, ukuvuvukala, nokulahleka komsebenzi) ongalawulwa eminye imithi ethile. IMethotrexate isekilasini lemithi ebizwa ngama-antimetabolites. IMethotrexate yelapha umdlavuza ngokunciphisa ukukhula kwamangqamuzana omdlavuza. IMethotrexate iphatha i-psoriasis ngokubambezela ukukhula kwamaseli esikhumba ukumisa izikali ekwakheni. I-Methotrexate ingaphatha isifo samathambo ngokunciphisa ukusebenza kwesistimu yomzimba.

Umjovo weMethotrexate uza njengempuphu ezoxutshwa noketshezi oluzofakwa ngaphakathi (emsipheni), ngemithambo (emthanjeni), ngaphakathi (emthanjeni), noma ngaphakathi (esikhaleni esigcwele uketshezi somgogodla womgogodla ). Ubude bokwelashwa buxhomeke ezinhlotsheni zemithi oyiphuzayo, ukuthi umzimba wakho uphendula kahle kangakanani kuyo, nohlobo lomdlavuza noma isimo onaso.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

I-Methotrexate kwesinye isikhathi isetshenziswa ngokuhlangana neminye imithi yokwelapha umdlavuza wesinye. Kwesinye isikhathi kuyasetshenziswa ukwelapha isifo sikaCrohn (isimo lapho amasosha omzimba ehlasela ulwelwesi lwendlela yokugaya ukudla, edala ubuhlungu, isifo sohudo, ukwehla kwesisindo nomkhuhlane) nezinye izifo ezizimele (izimo ezikhula lapho amasosha omzimba ehlasela amaseli anempilo umzimba ngephutha). Buza udokotela wakho ngezingozi zokusebenzisa lo muthi ngesimo sakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-methotrexate,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-methotrexate, noma imiphi eminye imithi, noma yiziphi izithako zomjovo we-methotrexate. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imishanguzo ebhalwe esigabeni ESIBALULEKILE SESEXWAYISO nanoma yikuphi okulandelayo: ama-antibiotic athile afana ne-chloramphenicol (Chloramycetin), ama-penicillin, ne-tetracylcines; i-folic acid (etholakala yodwa noma njengesithako kwamanye amavithamini); eminye imishanguzo yesifo samathambo; i-phenytoin (iDilantin); ama-probenecid (i-Benemid); ama-proton pump inhibitors (ama-PPIs) afana ne-esomeprazole (Nexium), omeprazole (Prilosec, Prilosec OTC, Zegerid), pantoprazole (Protonix); i-sulfonamides efana ne-co-trimoxazole (Bactrim, Septra), sulfadiazine, sulfamethizole (Urobiotic), kanye ne-sulfisoxazole (Gantrisin); kanye ne-theophylline (Theochron, Theolair). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma ngabe uke waba nanoma yimiphi imibandela eshiwo esigabeni ESIBALULEKILE SESEXWAYISO noma izinga eliphansi le-folate egazini lakho.
• ungancelisi ibele ngenkathi uthola umjovo we-methotrexate.
• kufanele wazi ukuthi i-methotrexate ingadala isiyezi noma ikwenze uzizwe usozela. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.
• hlela ukugwema ukuvezwa ukukhanya kwelanga okungadingekile noma isikhathi eside noma ukukhanya kwe-ultraviolet (imibhede yokushuka kanye nezibani zelanga) nokugqoka izimpahla zokuzivikela, izibuko zelanga, kanye nesikrini selanga. IMethotrexate ingenza isikhumba sakho sizwele ekukhanyeni kwelanga noma ekukhanyeni kwe-ultraviolet. Uma une-psoriasis, izilonda zakho zingase zibe zimbi kakhulu uma ubeka isikhumba sakho elangeni ngenkathi uthola i-methotrexate.
• awunayo imigomo ngesikhathi sokwelashwa kwakho nge-methotrexate ngaphandle kokukhuluma nodokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

I-Methotrexate ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ubuhlungu obuhlangene noma besisipha
• amehlo abomvu
• izinsini ezivuvukile
• ukulahleka kwezinwele

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuhlanza
• ukungaboni kahle noma ukulahleka kombono kungazelelwe
• umkhuhlane ongazelelwe, ikhanda elibi, nentamo elukhuni
• isithuthwane
• ukudideka noma ukulahleka kwememori
• ubuthakathaka noma ubunzima bokuhambisa uhlangothi olulodwa noma zombili zomzimba
• ukuhamba kanzima noma ukuhamba ungagxilile
• ukulahlekelwa ukwazi
• inkulumo engakhubazekile
• ukuncipha kokuchama
• ukuvuvukala kobuso, izingalo, izandla, izinyawo, amaqakala noma imilenze engezansi
• isifuba
• ukulunywa
• ukuqubuka kwesikhumba
• ukuphefumula kanzima noma ukugwinya

I-Methotrexate ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• izilonda emlonyeni nasemphinjeni
• umphimbo obuhlungu, amakhaza, umkhuhlane, ukukhwehlela okuqhubekayo nokucinana, noma ezinye izimpawu zokutheleleka
• ukulimaza noma ukopha okungavamile
• ezimnyama nezilindayo noma ezinezihlalo ezinegazi
• ukuhlanza okunegazi
• okokuhlanza okubukeka njengezizathu zekhofi

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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