I-Doxorubicin

-Delile

• Ngaphambi kokuthola umjovo we-doxorubicin,
• I-Doxorubicin ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Doxorubicin kufanele ifakwe kuphela emthanjeni. Kodwa-ke, ingahle ivuze izicubu eziseduze ezibangele ukucasuka okukhulu noma ukulimala. Udokotela wakho noma umhlengikazi uzoqapha indawo yakho yokuphatha ngale ndlela. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ubuhlungu, ukulunywa, ubomvu, ukuvuvukala, amabhamuza, noma izilonda endaweni lapho umjovo wafakwa khona.

I-Doxorubicin ingadala izinkinga zenhliziyo ezinkulu noma ezisongela impilo nganoma yisiphi isikhathi phakathi nokwelashwa kwakho noma izinyanga kuya eminyakeni ngemuva kokuphela kokwelashwa kwakho. Udokotela wakho uzo-oda ukuhlolwa ngaphambi nangesikhathi sokwelashwa kwakho ukuze abone ukuthi inhliziyo yakho isebenza kahle ngokwanele yini ukuthola i-doxorubicin ngokuphepha. Lezi zivivinyo zingafaka i-electrocardiogram (ECG; ukuhlolwa okurekhoda umsebenzi kagesi wenhliziyo) kanye ne-echocardiogram (ukuhlolwa okusebenzisa amaza omsindo ukukala amandla enhliziyo yakho okumpompa igazi). Udokotela wakho angakutshela ukuthi akufanele uthole le mithi uma unesilinganiso esingajwayelekile senhliziyo noma uma ukuhlolwa kukhombisa ukuthi amandla enhliziyo yakho okumpompa igazi anciphile. Tshela udokotela wakho uma uke waba nanoma yiluphi uhlobo lwesifo senhliziyo, isifo senhliziyo, noma ukwelashwa ngemisebe (x-ray) endaweni yesifuba. Tshela udokotela kanye nosokhemisi wakho uma uthatha noma wake wathola imithi ethile yokwelashwa ngamakhemikhali njenge-cyclophosphamide (Cytoxan), i-daunorubicin (i-Cerubidine, i-DaunoXome), i-epirubicin (i-Ellence), i-idarubicin (i-Idamycin), i-mitoxantrone (i-Novantrone), i-paclitaxel (i-Abraxane I-Onxol), i-trastuzumab (i-Herceptin), noma i-verapamil (i-Calan, i-Isoptin). Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukuphefumula okuncane; ukuphefumula kanzima; ukuvuvukala kwezandla, izinyawo, amaqakala noma imilenze engezansi; noma ukushaya kwenhliziyo okusheshayo, okungajwayelekile, noma okushaya ngamandla.

I-Doxorubicin ingadala ukwehla okukhulu kwenani lamaseli egazi emnkantsheni wakho. Udokotela wakho uzo-oda izivivinyo zaselebhu njalo ngaphambi nangesikhathi sokwelashwa kwakho. Ukwehla kwenani lamaseli egazi emzimbeni wakho kungadala izimpawu ezithile futhi kungakhuphula ubungozi bokuthi uzoba nokutheleleka okunzima noma ukopha. Tshela udokotela kanye nosokhemisi wakho uma uthatha noma uthole i-azathioprine (Imuran), cyclosporine (Neoral, Sandimmune), methotrexate (Rheumatrex), noma i-progesterone (Provera, Depo-Provera). Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: umkhuhlane, umphimbo obuhlungu, ukukhwehlela okuqhubekayo nokuminyana, noma ezinye izimpawu zokutheleleka; ukopha okungavamile noma ukulimaza; ezinegazi noma ezimnyama, izitulo zokulinda; ukuhlanza kwegazi; noma ukugabha igazi noma okokusundu okufana nezindawo zekhofi.

I-Doxorubicin ingakhuphula ubungozi bokuthola i-leukemia (umdlavuza wamangqamuzana amhlophe egazi), ikakhulukazi uma inikezwa ngemithamo ephezulu noma kanye neminye imishanguzo yokwelashwa ngamakhemikhali ne-radiation (x-ray) therapy.

Tshela udokotela wakho uma uke waba nesifo sesibindi noma wake waba naso. Udokotela wakho angakutshela ukuthi akufanele uthole le mithi noma angashintsha umthamo wakho uma unesifo sesibindi.

I-Doxorubicin kufanele inikezwe kuphela ngaphansi kokuqondisa kukadokotela onolwazi ekusetshenzisweni kwemithi yokwelapha ngamakhemikhali.

I-Doxorubicin isetshenziswa ngokuhlangana neminye imithi yokwelapha izinhlobo ezithile zesinye, isifuba, amaphaphu, isisu nomdlavuza we-ovari; I-Hodgkin's lymphoma (isifo sikaHodgkin) kanye ne-non-Hodgkin's lymphoma (umdlavuza oqala kumaseli amasosha omzimba); nezinhlobo ezithile ze-leukemia (umdlavuza wamaseli amhlophe egazi), kufaka phakathi i-acute lymphoblastic leukemia (ALL) kanye ne-acute myeloid leukemia (AML, ANLL). I-Doxorubicin nayo isetshenziswa yodwa futhi ihlanganiswe neminye imithi yokwelapha izinhlobo ezithile zomdlavuza wegilo nezinhlobo ezithile zezicubu ezithambile noma i-bone sarcomas (umdlavuza owakhiwa yimisipha namathambo). Ibuye isetshenziselwe ukwelapha i-neuroblastoma (umdlavuza oqala kumaseli ezinzwa futhi uvele ikakhulukazi ezinganeni) nesimila sikaWilms (uhlobo lomdlavuza wezinso olwenzeka ezinganeni). IDoxorubicin isekilasini lemithi ebizwa ngama-anthracyclines. Isebenza ngokunciphisa noma ukumisa ukukhula kwamangqamuzana omdlavuza emzimbeni wakho.

IDoxorubicin iza njengesisombululo (uketshezi) noma njengempuphu ezoxutshwa noketshezi oluzofakwa ngaphakathi (emthanjeni) ngudokotela noma umhlengikazi esikhungweni sezokwelapha. Imvamisa inikezwa kanye ezinsukwini ezingama-21 kuya kwezingama-28. Ubude bokwelashwa buxhomeke ezinhlotsheni zemithi oyiphuzayo, ukuthi umzimba wakho uphendula kahle kangakanani kuyo, nohlobo lomdlavuza onawo.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

I-Doxorubicin kwesinye isikhathi isetshenziselwa ukwelapha umdlavuza wesibeletho, i-endometrium (ulwelwesi lwesibeletho), nomlomo wesibeletho (ukuvulwa kwesibeletho); umdlavuza wendlala yabesilisa (umdlavuza wesitho sowesilisa sokuzala); umdlavuza we-pancreatic; umdlavuza we-adrenocortical (umdlavuza kuzindlala ze-adrenal); umdlavuza wesibindi; I-Kaposi’s sarcoma ehlobene nesifo se-immunodeficiency syndrome (i-AIDS); I-Ewing’s sarcoma (uhlobo lomdlavuza wamathambo) ezinganeni; mesothelioma (umdlavuza emgqeni wesifuba noma wesisu); i-myeloma eminingi (uhlobo lomdlavuza womnkantsha wethambo); kanye ne-lymphoblastic leukemia (CLL; uhlobo lomdlavuza wamaseli amhlophe egazi). Khuluma nodokotela wakho ngezingozi zokusebenzisa lo muthi ngesimo sakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-doxorubicin,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-doxorubicin, i-daunorubicin (i-Cerubidine, i-DaunoXome), i-epirubicin (i-Ellence), i-idarubicin (i-Idamycin), noma imiphi eminye imithi, noma iziphi izithako zomjovo we-doxorubicin. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imishanguzo ebhalwe esigabeni ESIBALULEKILE SESEXWAYISO nanoma yikuphi okulandelayo: imishanguzo ethile yamakhemikhali afana ne-cytarabine (DepoCyt), dexrazoxane (Zinecard), mercaptopurine (Purinethol), streptozocin (Zanosar); i-phenobarbital (i-Luminal Sodium); noma i-phenytoin (i-Dilantin). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo nayo ingaxhumana ne-doxorubicin, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• tshela udokotela wakho uma ngabe uke waba nanoma yiziphi ezinye izimo zezokwelapha.
• kufanele wazi ukuthi i-doxorubicin ingaphazamisa umjikelezo ojwayelekile wokuya esikhathini (isikhathi) kwabesifazane futhi ingamisa ukukhiqizwa kwesidoda emadodeni. Kodwa-ke, akufanele ucabange ukuthi awukwazi ukukhulelwa noma ukuthi awukwazi ukukhulelisa omunye umuntu. Abesifazane abakhulelwe noma abancelisayo kufanele batshele odokotela babo ngaphambi kokuba baqale ukuthola lo muthi. Akufanele ukhulelwe noma uncelise ibele ngenkathi uthola umjovo we-doxorubicin. Uma ukhulelwa ngenkathi uthola i-doxorubicin, shayela udokotela wakho. Sebenzisa indlela ethembekile yokulawula inzalo ukuvimbela ukukhulelwa. I-Doxorubicin ingalimaza umbungu.
• ungenayo imigomo ngaphandle kokukhuluma nodokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

I-Doxorubicin ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• izilonda emlonyeni nasemphinjeni
• ukulahlekelwa ukudla (nokulahlekelwa isisindo)
• ukuzuza kwesisindo
• ubuhlungu besisu
• isifo sohudo
• ukoma okwandisiwe
• ukukhathala okungajwayelekile noma ubuthakathaka
• isiyezi
• ukulahleka kwezinwele
• ukwehlukaniswa kenzipho noma uzipho embhedeni wezipikili
• amehlo alumayo, abomvu, anamanzi noma acasukile
• ubuhlungu beso
• ubuhlungu, ukushisa, noma ukuncinza ezandleni noma ezinyaweni
• ukuguqulwa okubomvu komchamo (izinsuku eziyi-1 kuya kwezi-2 ngemuva komthamo)

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• isifuba
• ukuqubuka kwesikhumba
• ukulunywa
• ukuphefumula kanzima noma ukugwinya
• isithuthwane

I-Doxorubicin ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• izilonda emlonyeni nasemphinjeni
• umkhuhlane, umphimbo obuhlungu, amakhaza, noma ezinye izimpawu zokutheleleka
• ukopha okungajwayelekile noma ukulinyazwa
• indle emnyama neyokulinda
• igazi elibomvu endle
• ukuhlanza okunegazi
• okokuhlanza okubukeka njengezizathu zekhofi

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ukuze ahlole impendulo yomzimba wakho ku-doxorubicin.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Adriamycin^®¶
• I-Rubex^®¶

• I-Hydroxydaunomycin Hydrochloride
• I-Hydroxydoxorubicin Hydrochloride

^¶ Lo mkhiqizo onophawu alusekho emakethe. Ezinye izindlela ezijwayelekile zingatholakala.