I-Colchicine

-Delile

• Ngaphambi kokuthatha i-colchicine,
• I-Colchicine ingadala imiphumela emibi. Tshela udokotela wakho uma ngabe kukhona kulezi zimpawu ezilandelayo ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nalezi zimpawu ezilandelayo, yeka ukuthatha i-colchicine bese ushayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka:

I-Colchicine isetshenziselwa ukuvimbela ukuhlaselwa yi-gout (ngokungazelelwe, ubuhlungu obukhulu kwilungu elilodwa noma ngaphezulu okubangelwa amazinga aphezulu ngokungavamile entweni ebizwa nge-uric acid egazini) kubantu abadala. IColchicine (Colcrys) nayo isetshenziselwa ukudambisa ubuhlungu bokuhlaselwa yi-gout lapho kwenzeka. IColchicine (Colcrys) ibuye isetshenziselwe ukwelapha imfiva yomndeni iMedithera (FMF; isimo esingokwemvelo esidala iziqephu zomkhuhlane, izinhlungu nokuvuvukala kwesisu, amaphaphu namalunga) kubantu abadala kanye nezingane ezineminyaka engu-4 nangaphezulu. IColchicine ayisona isiqabu sobuhlungu futhi ayinakusetshenziswa ukwelapha ubuhlungu obungabangelwa yi-gout noma i-FMF. IColchicine isekilasini lemithi ebizwa ngama-anti-gout agents. Isebenza ngokumisa izinqubo zemvelo ezibangela ukuvuvukala nezinye izimpawu ze-gout ne-FMF.

IColchicine iza njengethebhulethi nesisombululo (uketshezi; iGloperba) ukuthatha ngomlomo ngokudla noma ngaphandle kokudla. Lapho i-colchicine isetshenziselwa ukuvimbela ukuhlaselwa yi-gout noma ukwelapha i-FMF, imvamisa iphuzwa kanye noma kabili ngosuku. Lapho i-colchicine (Colcrys) isetshenziselwa ukudambisa ubuhlungu bokuhlaselwa yi-gout, umthamo owodwa uvame ukuthathwa kusibonakaliso sokuqala sobuhlungu kanti okwesibili, umthamo omncane uvame ukuthathwa ngemuva kwehora elilodwa. Uma ungatholi ukukhululeka noma uhlaselwa futhi ezinsukwini ezimbalwa ngemuva kokwelashwa, khuluma nodokotela wakho ngaphambi kokuthatha imithamo eyengeziwe yemithi. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-colchicine njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Kubalulekile ukusebenzisa isirinji yomlomo (ithuluzi lokulinganisa) ukukala ngokunembile inani elifanele liketshezi kumthamo ngamunye; ungasebenzisi isipuni sasekhaya.

Uma uthatha i-colchicine (Colcrys) ukwelapha i-FMF, udokotela wakho angakuqala ngomthamo ophansi futhi akhuphule kancane umthamo wakho. Udokotela wakho anganciphisa umthamo wakho uma uba nemiphumela emibi.

Uma uthatha i-colchicine ukuvimbela ukuhlaselwa yi-gout, shayela udokotela wakho ngokushesha uma uhlangabezana nokuhlaselwa yi-gout ngesikhathi sokwelashwa kwakho. Udokotela wakho angakutshela ukuthi uthathe umthamo owengeziwe we-colchicine, ulandelwe umthamo omncane ngemuva kwehora elilodwa. Uma uthatha imithamo eyengeziwe ye-colchicine ukwelapha ukuhlaselwa yi-gout, akufanele uthathe umthamo wakho olandelayo ohleliwe we-colchicine kuze kudlule okungenani amahora ayi-12 selokhu uthathe imithamo eyengeziwe.

IColchicine ingavimbela ukuhlaselwa yi-gout futhi ilawule i-FMF kuphela uma uthatha umuthi. Qhubeka uthathe i-colchicine noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-colchicine ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa. Buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-colchicine,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-colchicine, noma imuphi omunye umuthi, noma iziphi izithako ezibhebheni ze-colchicine noma isixazululo. Buza udokotela wakho noma usokhemisi noma uhlole umhlahlandlela wemithi ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela nemishanguzo ongayinikiwe, amavithamini, imikhiqizo yokudla okunomsoco, kanye nezithasiselo zamakhambi ozithathayo, ozithathile ezinsukwini eziyi-14 ezedlule, noma uhlela ukuzithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ama-antibiotic afana ne-azithromycin (Zithromax), i-clarithromycin (i-Biaxin), i-erythromycin (i-E.E.S., i-E-Mycin), i-telithromycin (i-Ketek; ayitholakali e-U.S.); ama-antifungals afana ne-fluconazole (i-Diflucan), i-itraconazole (i-Sporanox), i-ketoconazole (i-Nizoral), ne-posaconazole (i-Noxafil); i-aprepitant (Hlela); imithi yokwehlisa i-cholesterol (ama-statins) njenge-atorvastatin (Lipitor), i-fluvastatin (i-Lescol), i-lovastatin (i-Mevacor), i-pravastatin (i-Pravachol), ne-simvastatin (i-Zocor); i-cyclosporine (GenGraf, Neoral, Sandimmune); i-digoxin (i-Digitek, i-Lanoxin); i-diltiazem (Cardizem, Dilacor, Tiazac, abanye); ama-fibrate afana ne-bezafibrate, i-fenofibrate (i-Antara, i-Lipofen), ne-gemfibrozil (i-Lopid); imishanguzo ye-HIV noma i-AIDS efana ne-amprenavir (Agenerase), atazanavir (Reyataz), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (eKaletra, Norvir), ne-saquinavir (Invirase); nefazodone; i-ranolazine (Ranexa); kanye ne-verapamil (Calan, Covera, Isoptin, Verelan). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingase futhi ihlanganyele ne-colchicine, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• Tshela udokotela wakho uma uke waba nesifo sezinso noma sesibindi. Udokotela wakho uzokutshela ukuthi ungathathi i-colchicine uma uthatha eminye imithi noma uma unezinso zombili zezinso nezesibindi.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-colchicine, shayela udokotela wakho.

Ungadli i-grapefruit noma uphuze ijusi lamagilebhisi ngesikhathi sokwelashwa kwakho nge-colchicine.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Uma uthatha i-colchicine njalo futhi sekusondele isikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

Kodwa-ke, uma uthatha i-colchicine (Colcrys) ukwelapha ukuhlaselwa i-gout okwenzeka ngenkathi uthatha i-colchicine ukuvimbela ukuhlaselwa yi-gout futhi ukhohlwe ukuthatha umthamo wesibili, thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Ngemuva kwalokho linda okungenani amahora ayi-12 ngaphambi kokuthatha umthamo wakho olandelayo ohleliwe we-colchicine.

I-Colchicine ingadala imiphumela emibi. Tshela udokotela wakho uma ngabe kukhona kulezi zimpawu ezilandelayo ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• isifo sohudo
• isisu noma ubuhlungu besisu

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nalezi zimpawu ezilandelayo, yeka ukuthatha i-colchicine bese ushayela udokotela wakho ngokushesha:

• ubuhlungu bemisipha noma ubuthakathaka
• ukuba ndikindiki noma ukuncinza eminweni noma ezinzwaneni
• ukulimaza noma ukopha okungavamile
• umphimbo obuhlungu, umkhuhlane, amakhaza nezinye izimpawu zokutheleleka
• ubuthakathaka noma ukukhathala
• ukuphaphatheka noma ubumpunga bezindebe, ulimi, noma izintende

IColchicine inganciphisa ukuzala emadodeni. Khuluma nodokotela wakho ngezingozi zokuthatha i-colchicine.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, iya egumbini lezimo eziphuthumayo esibhedlela eliseduze ngokushesha. Ukuthatha i-colchicine eningi kakhulu kungadala ukufa.

Izimpawu zokudlula ngokweqile zingafaka:

• ubuhlungu besisu
• isicanucanu
• ukuhlanza
• isifo sohudo
• ukulimaza noma ukopha okungavamile
• umphimbo obuhlungu, umkhuhlane, amakhaza nezinye izimpawu zokutheleleka
• ukuphaphatheka noma ubumpunga bezindebe, ulimi, noma izintende
• ukuphefumula kancane
• yehlisa noma yamisa ukushaya kwenhliziyo

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho angalawula izivivinyo ezithile zebhu ukuze ahlole impendulo yakho ku-colchicine.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Colcrys^®
• IGloperba^®