Ketoconazole

-Delile

• Ngaphambi kokuthatha i-ketoconazole,
• I-Ketoconazole ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Lezi zimpawu ezilandelayo azivamile, kepha uma uhlangabezana nenye yazo noma leyo ebhalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Ketoconazole kufanele isetshenziselwe kuphela ukwelapha ukutheleleka uma eminye imithi ingatholakali noma ingenakubekezelelwa.

I-Ketoconazole ingadala ukulimala kwesibindi, kwesinye isikhathi ibe yimbi ngokwanele ukudinga ukufakelwa kwesibindi noma ibangele ukufa. Ukulimala kwesibindi kungenzeka kubantu abangenaso isifo sesibindi noma ezinye izimo ezandisa ubungozi bokuthi bazohlaselwa ukulimala kwesibindi. Tshela udokotela wakho uma uphuza noma wake waphuza utshwala obuningi nokuthi unesifo sesibindi noma wake waba naso. Ungaphuzi noma iziphi iziphuzo ezidakayo ngesikhathi sokwelashwa kwakho ne-ketoconazole ngoba ukuphuza iziphuzo ezidakayo kungandisa ubungozi bokuthi uzolimala isibindi.Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukukhathala ngokweqile, ukulahlekelwa isifiso sokudla, ukuncipha komzimba, isicanucanu, ukuhlanza, ukuphuzi kwesikhumba noma kwamehlo, umchamo ophuzi omnyama, izitulo eziphaphathekile, ubuhlungu engxenyeni engaphezulu kwesokudla isisu, umkhuhlane, noma ukuqubuka.

I-Ketoconazole ingadala ukwandiswa kwe-QT (isigqi senhliziyo esingajwayelekile esingaholela ekuphelelweni amandla, ekulahlekelweni ukwazi, ekuqulekeni, noma ekufeni okungazelelwe). Ungathathi i-disopyramide (Norpace), dofetilide (Tikosyn), dronedarone (Multaq), pimozide (Orap), quinidine (Quinidex, Quinaglute), cisapride (Propulsid; ayisatholakali e-US), methadone (Dolophine, Methadose), kanye i-ranolazine (Ranexa) ngenkathi uthatha i-ketoconazole. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, yeka ukuthatha i-ketoconazole bese ufonela udokotela wakho ngokushesha: ukushesha, ukushaya ngamandla, noma ukushaya kwenhliziyo okungajwayelekile; ukuquleka; isiyezi; ikhanda elikhanyayo; noma ukulahlekelwa ukwazi.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ukuze ahlole impendulo yomzimba wakho ku-ketoconazole.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-ketoconazole futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokuthatha i-ketoconazole.

I-Ketoconazole isetshenziselwa ukwelapha ukutheleleka kwefungal lapho eminye imithi ingatholakali noma ingenakubekezelelwa. I-ketoconazole akufanele isetshenziselwe ukwelapha i-fungal meningitis (ukutheleleka kolwelwesi oluzungeze ubuchopho nentambo yomgogodla obangelwa yisikhunta) noma izifo zesipikili zefungal. I-Ketoconazole isekilasini lama-antifungal abizwa ngokuthi ama-imidazoles. Isebenza ngokunciphisa ukukhula kwesikhunta okubangela ukutheleleka.

I-Ketoconazole iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa kanye ngosuku Thatha i-ketoconazole ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-ketoconazole njengoba nje uqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Udokotela wakho angakhuphula umthamo wakho uma isimo sakho singathuthuki.

Ungadinga ukuthatha i-ketoconazole izinyanga eziyisithupha noma ngaphezulu ukwelapha ukutheleleka kwakho ngokuphelele. Qhubeka uphuze i-ketoconazole kuze kube yilapho udokotela akutshela ukuthi kufanele uyeke, noma ngabe uzizwa ungcono. Ungayeki ukuthatha i-ketoconazole ngaphandle kokukhuluma nodokotela wakho. Uma uyeka ukuthatha i-ketoconazole ngokushesha okukhulu, ukutheleleka kwakho kungabuya emuva kwesikhashana.

Imithamo ephezulu ye-ketoconazole kwesinye isikhathi isetshenziselwa ukwelapha i-Cushing syndrome (isimo esenzeka lapho kune-hormone eningi kakhulu ye-corticosteroid emzimbeni) nomdlavuza wesibeletho osezingeni eliphakeme (umdlavuza wendlala yokuzala yowesilisa). I-Ketoconazole ayiboniswanga ukuthi iphephile noma iyasebenza kulokhu kusetshenziswa. Khuluma nodokotela wakho ngokusebenzisa i-ketoconazole yesimo sakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-ketoconazole,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-ketoconazole noma yimuphi omunye umuthi noma ezinye izithako ezisemaphilisi e-ketoconazole. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma uthatha i-alprazolam (Niravam, Xanax); i-eplerenone (Inspra); ama-ergot alkaloids afana ne-ergotamine (Ergomar, eCafergot, eMigergot), i-dihydroergotamine (i-D.H.E 45, i-Migranal), ne-methylergonovine (Methergine); i-felodipine (Plendil); i-irinotecan (iCamptosar); i-lovastatin (Mevacor); i-lurasidone (Latuda); i-midazolam (iVesi); nisoldipine (Sular); simvastatin (iZocor); i-tolvaptan (iSamsca); kanye ne-triazolam (Halcion). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-ketoconazole uma uthatha eyodwa noma ngaphezulu yale mithi noma noma yimiphi imithi ebhalwe esigabeni ESIBALULEKILE SEXWAYISO.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo. Qiniseka ukuthi uyayisho imithi efakwe kuhlu esigabeni ESIBALULEKILE SESEXWAYISO nanoma yikuphi okulandelayo: i-aliskiren (Tekturna, eValturna, e-Amturnide); ama-anticoagulants (’ama-thinner egazi’) afana ne-dabigatran (Pradaxa), i-rivaroxaban powder (i-Xarelto) ne-warfarin (i-Coumadin); i-aprepitant (Hlela); i-aripiprazole (Abilify); i-atorvastatin (Lipitor); i-bosentan (iTracleer); i-budesonide (i-Uceris); ibuspirone (BuSpar); carbamazepine (Tegretol); ama-calcium channel blocker afana ne-amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac), nicardipine (Cardene), nifedipine (Adalat, Procardia), kanye ne-verapamil (Calan, Covera, Isoptin, Verelan); imishanguzo yomdlavuza efana ne-bortezomib (Velcade); busulfan (Myleran); i-dasatinib (i-Sprycel); i-docetaxel (Taxotere), i-erlotinib (iTarceva); ixabepilone (Ixempra); i-lapatinib (iTykerb); nilotinib (Tasigna); paclitaxel (Taxol), trimetrexate (Neutrexin), vincristine (Vincasar), vinblastine, ne-vinorelbine (Navelbine); i-ciclesonide (i-Alvesco); i-cilostazol (i-Pletal); i-cinacalcet (i-Sensipar); i-colchicine (Colcrys, ku-Col-Probenecid); i-dexamethasone; i-digoxin (i-Lanoxin); i-eletriptan (i-Relpax); i-fentanyl (Abstral, Actiq, Duragesic, Fentora, Lazanda, Onsolis); i-fesoterodine (Toviaz); i-fluticasone (i-Flonase, i-Flovent); i-haloperidol (iHaldol); Imithi ye-HIV efana ne-darunavir (Prezista), efavirenz (Sustiva), fosamprenavir (Lexiva), indinavir (Crixivan), maraviroc (Selzentry), nevirapine (Viramune), ritonavir (Norvir), kanye ne-saquinavir (Invirase, Fortovase); ama-immunosuppressants afana ne-cyclosporine (Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune), kanye ne-tacrolimus (Prograf); imatinib (Gleevec); imishanguzo yokungasebenzi kahle kwe-erectile njenge-sildenafil (Viagra), i-tadalafil (i-Cialis), ne-vardenafil (i-Levitra); imithi ye-indigestion, isilungulela, noma izilonda ezifana ne-cimetidine (Tagamet), i-famotidine (i-Pepcid), i-lansoprazole (i-Prevacid), i-nizatidine (i-Axid), i-omeprazole (i-Prilosec), ne-ranitidine (i-Zantac); imithi yokwelapha isifo sofuba njenge-isoniazid (INH, Nydrazid), i-rifabutin (i-Mycobutin), i-rifampin (i-Rifadin, i-Rimactane); i-methylprednisolone (iMedrol); i-nadolol (Corgard); i-oxycodone (i-Oxecta, i-Oxy Contin, ePercocet, abanye); i-phenytoin (iDilantin); i-praziquantel (i-Biltricide); i-quetiapine (iSeroquel); i-ramelteon (iRozerem); i-repaglinide (Prandin, ePrandiMet); i-risperidone (i-Risperdal); i-salmeterol (iSerevent, e-Advair); i-saxagliptin (i-Onglyza); i-solifenacin (i-Vesicare); ama-immunosuppressants afana ne-cyclosporine (Neoral, Sandimmune), sirolimus (Rapamune), ne-tacrolimus (Prograf); i-tamsulosin (i-Flomax, eJalyn); i-telithromycin (Ketek); kanye ne-tolterodine (Detrol). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-ketoconazole, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• uma uthatha i-antacid equkethe i-aluminium, i-calcium, noma i-magnesium (Maalox, Mylanta, Tums, others), thatha ihora eli-1 ngaphambi noma ngemuva kwamahora amabili uthathe i-ketoconazole.
• Tshela udokotela wakho uma ngabe uke waba nezimo ezishiwo esigabeni ESIBALULEKILE SESEXWAYISO noma ukungasebenzi kahle kwe-adrenal (isimo lapho izindlala ze-adrenal zingenzi ama-hormone anele we-steroid).
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-ketoconazole, shayela udokotela wakho.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-ketoconazole.
• kufanele wazi ukuthi ukuphuza iziphuzo ezidakayo (kufaka phakathi iwayini, ubhiya, nemithi equkethe utshwala njengesiraphu sokukhwehlela) ngenkathi uthatha i-ketoconazole kwandisa ubungozi bokuthi uzohlaselwa ukulimala kwesibindi futhi kungadala izimpawu ezingezinhle njengokufutha, ukuqhuma, isicanucanu, ikhanda, nokuvuvukala kwezandla, izinyawo, amaqakala, noma imilenze ephansi uma uphuza utshwala ngenkathi uthatha i-ketoconazole.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Ketoconazole ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• ubuhlungu besisu
• isifo sohudo
• ukuqunjelwa
• isilungulela
• igesi
• shintsha emandleni okunambitha ukudla
• umlomo owomile
• shintsha ngombala wolimi
• ubunzima bokulala noma ukulala
• uvalo
• ukuba ndikindiki, ukushiswa, noma ukushaywa izandla noma izinyawo
• ubuhlungu bemisipha
• ukulahleka kwezinwele
• ukuqhuma
• Ukugodola
• ukuzwela ekukhanyeni
• ukuphuma kwamakhala
• ukukhuliswa kwebele kwabesilisa
• ukwehla kwekhono lezocansi

Eminye imiphumela emibi ingaba mibi. Lezi zimpawu ezilandelayo azivamile, kepha uma uhlangabezana nenye yazo noma leyo ebhalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuqubuka
• isifuba
• ukulunywa
• ukuvuvukala kwamehlo, ubuso, izindebe, ulimi, izandla, izinyawo, amaqakala noma imilenze engezansi
• ukushaqeka
• ukuphefumula kanzima noma ukugwinya
• ukukhathala noma ubuthakathaka

I-Ketoconazole ingadala ukwehla kwenani lesidoda (amaseli okuzala abesilisa) akhiqizwayo, ikakhulukazi uma ethathwa ngemithamo ephezulu. Khuluma nodokotela wakho ngezingozi zokuphuza lo muthi uma uyindoda futhi ungathanda ukuba nezingane.

I-Ketoconazole ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ngaphambi kokwenza noma yiluphi uvivinyo lwe-laboratory, tshela udokotela wakho kanye nabasebenzi be-laboratory ukuthi uthatha i-ketoconazole.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho uma unemibuzo mayelana nokugcwalisa imishanguzo yakho. Uma usenezimpawu zokutheleleka ngemuva kokuqeda i-ketoconazole, shayela udokotela wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Nizoral^®