Inaliti ye-Fludarabine

-Delile

• Ngaphambi kokuthola umjovo we-fludarabine,
• Umjovo we-Fludarabine ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka:

Umjovo we-Fludarabine kufanele unikezwe ngaphansi kweso lodokotela onolwazi lokunikeza imishanguzo yamakhemikhali yokwelashwa komdlavuza.

Umjovo we-Fludarabine ungadala ukwehla kwenani lamaseli egazi enziwe ngomnkantsha wakho. Lokhu kwehla kungadala ukuthi ube nezimpawu eziyingozi futhi kungakhuphula ubungozi bokutheleleka okuyingozi noma okusongela ukuphila. Udokotela wakho angakunikeza eminye imithi ukunciphisa ubungozi bokuthi uzoba nokutheleleka okunzima ngesikhathi sokwelashwa kwakho. Tshela udokotela wakho uma ngabe uke waba nenombolo ephansi yanoma yiluphi uhlobo lwamangqamuzana egazi egazini lakho noma kunoma isiphi isimo esithinta amasosha akho omzimba nokuthi ngabe wake waba nokutheleleka ngenxa yokuthi amazinga akho amangqamuzana egazi ayephansi kakhulu. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukuphefumula okuncane; ukushaya kwenhliziyo okusheshayo; ikhanda; isiyezi; isikhumba esiphaphathekile; ukukhathala ngokweqile; ukopha okungavamile noma ukulimaza; isitulo esimnyama, sokulinda, noma esinegazi; hlanza okunegazi noma okubukeka njengezizathu zekhofi; nomkhuhlane, amakhaza, ukukhwehlela, umphimbo obuhlungu, ukuchama okunzima, okubuhlungu, noma okuvamile, noma ezinye izimpawu zokutheleleka.

Umjovo we-Fludarabine nawo ungadala ukulimala ohlelweni lwezinzwa. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukuquleka, ukuphazamiseka, ukudideka, kanye ne-coma (ukulahlekelwa ukwazi isikhathi esithile).

Umjovo we-Fludarabine ungadala izimo ezinzima noma ezisongela impilo lapho umzimba uhlasela futhi uqede amaseli awo egazi. Tshela udokotela wakho uma wake wahlakulela lolu hlobo lwesimo ngemuva kokuthola i-fludarabine esikhathini esedlule. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: umchamo omnyama, isikhumba esiphuzi, amachashazi amancane abomvu noma ansomi esikhunjeni, ukuphuma kwamakhala, ukopha okunzima ukuya esikhathini, igazi emchameni, ukukhwehlela igazi, noma ukuphefumula kanzima ngenxa yokopha emphinjeni.

Esifundweni somtholampilo, abantu abane-lymphocytic leukemia engapheli abasebenzisa umjovo we-fludarabine kanye ne-pentostatin (Nipent) babesengozini enkulu yokuthola umonakalo omkhulu wamaphaphu. Kwezinye izimo, lokhu kulimala kwamaphaphu kwabangela ukufa. Ngakho-ke, udokotela wakho ngeke anikeze umjovo we-fludarabine okufanele unikezwe kanye ne-pentostatin (Nipent).

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ukuze ahlole impendulo yomzimba wakho kumjovo we-fludarabine.

Khuluma nodokotela wakho ngezingozi zokuthola umjovo we-fludarabine.

Umjovo we-Fludarabine usetshenziselwa ukwelapha i-lymphocytic leukemia (CLL; uhlobo lomdlavuza wamaseli amhlophe egazi) kubantu abadala asebevele belashwa okungenani ngomunye umuthi futhi abangakabi ngcono. Umjovo we-Fludarabine usesigabeni semithi ebizwa ngama-purine analogs. Isebenza ngokunciphisa noma ukumisa ukukhula kwamangqamuzana omdlavuza emzimbeni wakho.

Umjovo we-Fludarabine uza njengempuphu ezokwengezwa oketshezini futhi ijojowe ngaphezu kwemizuzu engama-30 ngemithambo (emthanjeni) ngudokotela noma umhlengikazi osehhovisi lezokwelapha noma emtholampilo wabangalaliswa esibhedlela. Imvamisa ijovwa kanye ngosuku izinsuku ezi-5 zilandelana. Le nkathi yokwelashwa ibizwa ngokuthi umjikelezo, futhi umjikelezo ungaphindwa njalo ezinsukwini ezingama-28 ngemijikelezo eminingana.

Udokotela wakho angadinga ukubambezela ukwelashwa kwakho noma alungise umthamo wakho uma uhlangabezana nemiphumela ethile emibi. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho ngomjovo we-fludarabine.

Umjovo we-Fludarabine kwesinye isikhathi usetshenziselwa ukwelapha i-non-Hodgkin's lymphoma (NHL; umdlavuza oqala ngohlobo lweseli elimhlophe elijwayele ukulwa nokutheleleka) kanye ne-mycosis fungoides (uhlobo lwe-lymphoma oluthinta isikhumba). Khuluma nodokotela wakho ngezingozi zokusebenzisa lo muthi ngesimo sakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-fludarabine,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-fludarabine, noma imiphi eminye imithi, noma yiziphi izithako zomjovo we-fludarabine. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imithi efakwe kuhlu esigabeni ESIBALULEKILE SESEXWAYISO noma i-cytarabine (Cytosar-U, DepoCyt). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho ukuthi uke waba nesifo sezinso noma wake waba naso yini futhi. Tshela udokotela wakho ngayo yonke eminye imithi yokwelashwa ngamakhemikhali oyitholile nokuthi uke waphathwa yini ngemithi yokwelashwa ngemisebe (ukwelashwa komdlavuza okusebenzisa amagagasi ezinhlayiya zamandla aphezulu ukubulala amangqamuzana omdlavuza ). Ngaphambi kokuthola i-chemotherapy noma i-radiation therapy ngokuzayo, tshela udokotela wakho ukuthi welashwe nge-fludarabine.
• kufanele wazi ukuthi umjovo we-fludarabine ungaphazamisa umjikelezo ojwayelekile wokuya esikhathini (isikhathi) kwabesifazane futhi ungamisa ukukhiqizwa kwesidoda emadodeni. Kodwa-ke, akufanele ucabange ukuthi wena noma umlingani wakho anikwazi ukukhulelwa. Uma ukhulelwe noma uncelisa, kufanele utshele udokotela wakho ngaphambi kokuba uqale ukuthola le mithi. Akufanele uhlele ukuba nezingane ngenkathi uthola umjovo we-fludarabine noma okungenani izinyanga eziyisithupha ngemuva kokwelashwa. Sebenzisa indlela ethembekile yokulawula ukubeletha ukuvimbela ukukhulelwa ngalesi sikhathi. Khuluma nodokotela wakho ukuthola eminye imininingwane. Umjovo we-Fludarabine ungalimaza umbungu.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthola umjovo we-fludarabine.
• kufanele wazi ukuthi umjovo we-fludarabine ungadala ukukhathala, ubuthakathaka, ukudideka, ukuyaluza, ukuquleka, kanye nezinguquko zombono. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.
• khuluma nodokotela wakho ngaphambi kokuba uthole noma yimiphi imigomo ngesikhathi sokwelashwa kwakho ngomjovo we-fludarabine.
• kufanele wazi ukuthi ungathola ukusabela okungathi sína noma okusongela impilo uma udinga ukuthola ukumpontshelwa igazi ngesikhathi sokwelashwa kwakho ngomjovo we-fludarabine noma nganoma yisiphi isikhathi ngemuva kokwelashwa kwakho. Qiniseka ukuthi utshela udokotela wakho ukuthi uthola noma uthole umjovo we-fludarabine ngaphambi kokumpontshelwa igazi.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Umjovo we-Fludarabine ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukulahlekelwa isifiso sokudla
• isicanucanu
• ukuhlanza
• ukuqunjelwa
• isifo sohudo
• izilonda zomlomo
• ukulahleka kwezinwele
• ukuba ndikindiki, ukushiswa, ubuhlungu, noma ukuncinza ezandleni, ezingalweni, ezinyaweni noma emilenzeni
• ubuhlungu bemisipha noma bamalunga
• ikhanda
• ukudana
• izinkinga zokulala

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• ubuhlungu besifuba noma ukungaphatheki kahle
• ukushaya kwenhliziyo okusheshayo noma okungajwayelekile
• ukulahlekelwa ukuzwa
• ubuhlungu ohlangothini lomzimba
• ukuvuvukala kwezingalo, izandla, izinyawo, amaqakala, noma imilenze engezansi
• ukuqubuka
• isifuba
• ukuphefumula kanzima noma ukugwinya
• isikhumba esihlabayo noma esishayayo

Umjovo we-Fludarabine ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka:

• ukulimaza noma ukopha okungavamile
• umkhuhlane, ukubanda, ukukhwehlela, umphimbo obuhlungu, noma ezinye izimpawu zokutheleleka
• ukubambezeleka okubambezelekile
• ikhoma

Buza udokotela wakho noma usokhemisi uma unemibuzo mayelana nomjovo we-fludarabine.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UFludara^®

• 2-Fluoro-ara-A Monophosphate, 2-Fluoro-ara AMP, FAMP