I-Saquinavir

-Delile

• Ngaphambi kokuthatha i-saquinavir,
• I-Saquinavir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Saquinavir isetshenziswa ngokuhlangana ne-ritonavir (Norvir) kanye neminye imithi yokwelapha ukutheleleka nge-immunodeficiency virus (HIV). ISaquinavir isekilasini lemithi ebizwa ngama-protease inhibitors. Isebenza ngokunciphisa inani le-HIV egazini. Yize i-saquinavir ingayelaphi i-HIV, ingahle yehlise amathuba akho okuba ne-immunodeficiency syndrome (i-AIDS) kanye nezifo ezihlobene ne-HIV ezinjengezifo ezibucayi noma umdlavuza. Ukuthatha le mithi kanye nokwenza ucansi oluphephile nokwenza ezinye izinguquko kwimpilo yakho kunganciphisa ingozi yokudlulisela igciwane lesandulela ngculaza kwabanye abantu.

ISaquinavir iza njengephilisi nethebhulethi engayithatha ngomlomo. Imvamisa ithathwa ngasikhathi sinye ne-ritonavir (Norvir) kabili ngosuku ngosuku phakathi kwamahora amabili ngemuva kokudla okugcwele. Kungaba lula ukukhumbula ukuthatha i-saquinavir uma uyithatha ngokudla. Thatha i-saquinavir ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-saquinavir njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; musa ukuhlafuna, noma ukuchoboza.

Uma ungakwazi ukugwinya lonke iphilisi, ungathatha i-saquinavir ngokuvula i-capsule bese uxuba okuqukethwe nesiraphu yoshukela, i-sorbitol, noma ujamu. Ukulungiselela umthamo ngamunye, engeza amathisipuni ama-3 (15 ml) wesiraphu kashukela, i-sorbitol, noma ujamu esitsheni esingenalutho. Vula i-saquinavir capsule bese ufaka okuqukethwe esitsheni. Hlanganisa ingxube imizuzwana engama-30 kuye kwangama-60. Uma usebenzise isiraphu ebandayo, i-sorbitol, noma ujamu, linda ingxube ifike ekamelweni lokushisa ngaphambi kokudla. Qiniseka ukuthi udla yonke ingxube ukuze uthole umthamo ophelele.

Qhubeka uphuze i-saquinavir noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-saquinavir ngaphandle kokukhuluma nodokotela wakho. Uma uphuthelwa imithamo, thatha ngaphansi komthamo obekiwe noma uyeke ukuthatha i-saquinavir, isimo sakho singaba nzima ukwelashwa.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-saquinavir futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

I-Saquinavir kwesinye isikhathi isetshenziswa ne-ritonavir (i-Norvir) kanye neminye imithi yokusiza ukuvikela ukutheleleka kubasebenzi bezokunakekelwa kwezempilo noma abanye abantu abachayeke ku-HIV. Khuluma nodokotela wakho ngezingozi zokuthatha le mithi ngesimo sakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-saquinavir,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-saquinavir, noma imiphi eminye imithi, i-lactose, noma ezinye izithako kumaphilisi we-saquinavir noma amaphilisi. Udokotela wakho angakutshela ukuthi ungathathi i-saquinavir. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• utshele udokotela wakho uma uthatha noma iyiphi yale mithi elandelayo: i-alfuzosin (i-Uroxatral); atazanavir (Reyataz, e-Evotaz); i-clarithromycin (i-Biaxin, ku-Prevpac); i-clozapine (iClozaril, iFazaclo, iVersacloz); i-dasatinib (i-Sprycel); imithi ye-ergot efana ne-dihydroergotamine (i-DHE 45, i-Migranal), i-ergoloid mesylates (i-Hydergine), i-ergonovine (i-Ergotrate), i-ergotamine (i-Ergomar, eCafergot, eMigergot, abanye), ne-methylergonovine (Methergine); i-erythromycin (E.E.S., E-mycin, Erythrocin, abanye); i-halofantrine; i-haloperidol (iHaldol); imithi ethile yokushaya kwenhliziyo okungajwayelekile njenge-amiodarone (Nexterone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), flecainide (Tambocor), lidocaine (Xylocaine), propafenone (Rhythmol), ne-quinidine (eNuedexta); i-lovastatin (Altoprev); i-lurasidone (Latuda); imithi yokugula ngengqondo kanye nesicanucanu njenge-chlorpromazine, ne-thioridazine; i-midazolam ngomlomo; ipentamidine (Nebupent, Pentam); ipimozide (i-Orap); i-quinine (i-Qualaquin); i-rifampin (i-Rifadin, i-Rimactane, e-Rifamate, i-Rifater); i-sildenafil (uphawu lwe-Revatio kuphela olusetshenziselwa isifo samaphaphu); simvastatin (iZocor, Flolopid, eVytorin); i-sunatinib (i-Sutent); i-tacrolimus (i-Astagraf XL, i-Envarsus XR, i-Prograf); i-trazodone; i-triazolam (iHalcion); noma i-ziprasidone (Geodon). Phinda utshele udokotela noma usokhemisi wakho uma uthatha i-rilpivirine (i-Edurant, eJuluca, i-Odefsey, i-Complera) noma uma uyekile ukuyithatha emasontweni amabili edlule. Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-saquinavir uma uthatha eyodwa noma ngaphezulu yale mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: ama-anticoagulants (’ama-thinner egazi’) njenge-warfarin (i-Coumadin, i-Jantoven); imishanguzo efana ne-itraconazole (i-Onmel, i-Sporanox) ne-ketoconazole benzodiazepines efana ne-alprazolam (i-Xanax), i-clorazepate (i-Gen-Xene, i-Tranxene), i-diazepam (i-Diastat, i-Valium) ne-flurazepam; ama-beta blocker anjenge-atenolol (Tenormin, in Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, eDutoprol, eLoressor HCT), nadolol (Corgard, eCorzide), kanye nepropranolol (Hemangeol, Inderal, Innopran); i-bosentan (iTracleer); ama-calcium channel blocker anjenge-amlodipine (Norvasc, eCaduet, Lotrel, abanye), diltiazem (Cardizem, Cartia, Tiazac, others), felodipine, isradipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab CR, Procardia), nimodipine (Nymalize ), nisoldipine (Sular), ne-verapamil (Calan, Verelan, eTarka); imithi ethile yokwehlisa i-cholesterol (ama-statins) njenge-atorvastatin (Lipitor, eCaduet); i-cobicistat (iTybost, e-Evotaz, eGenvoya, Prezcobix, naseStribild); i-corticosteroids efana ne-betamethasone, i-budesonide (i-Entocort, i-Pulmicort, i-Uceris, e-Symbicort), i-ciclesonide (i-Alvesco, i-Zetonna, i-Omnaris), i-dexamethasone, i-fluticasone (i-Arnuity Ellipta, i-Flonase, i-Flovent, e-Advair, abanye), i-methylprednisone (i-Asmana ), i-prednisone (i-Rayos), ne-triamcinolone (i-Kenalog); i-colchicine (Colcrys, Mitigare); i-digoxin (i-Lanoxin); fentanyl (Abstral, Actiq, Duragesic, abanye); ama-immunosuppressants athile afana ne-cyclosporine (Gengraf, Neoral, Sandimmune), ne-sirolimus (Rapamune); imishanguzo yokwelapha i-HIV noma i-AIDS okubandakanya i-indinavir (Crixivan), i-lopinavir ene-ritonavir (Kaletra), i-maraviroc (i-Selzentry), i-nelfinavir (i-Viracept), noma i-tipranavir ene-ritonavir (i-Aptivus); imithi ethile yokushaya kwenhliziyo okungajwayelekile njenge-ibutilide (Corvert), ne-sotalol (iBetapace, iSorine, iSotylize); imithi yokwelapha ukuquleka okufana ne-carbamazepine (Carbatrol, Epitol, Tegretol, abanye), phenytoin (Dilantin, Phenytek), ne phenobarbital; i-methadone (i-Dolophine, i-Methadose); nefazodone; omeprazole (Prilosec, eYosprela, Zegerid); i-phosphodiesterase (PDE5) inhibitors efana ne-sildenafil (Viagra), i-tadalafil (i-Adcirca, i-Cialis), ne-vardenafil (i-Levitra, i-Staxyn); i-quetiapine (iSeroquel); i-quinupristin ne-dalfopristin (iSynercid); i-rifabutin (i-Mycobutin); i-salmeterol (iSerevent, e-Advair); kanye nezidambisi ezithile ze-tricyclic ezibandakanya i-amitriptyline, i-clomipramine (i-Anafranil), i-imipramine (iSurmontil, iTofranil), ne-maprotiline. Eminye imishanguzo ingaxhumana ne-saquinavir, ngakho-ke qiniseka ukuthi utshela udokotela kanye nosokhemisi ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi yimiphi imikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha, ikakhulukazi iSt John's wort, namaphilisi kagalikhi.
• Tshela udokotela wakho uma uphuza noma wake waphuza utshwala obuningi, futhi uma wena noma omunye emndenini wakho uke waba nesifo sikashukela noma wake waba naso. Tshela nodokotela wakho uma uke waba nokushaya kwenhliziyo okungajwayelekile, i-cholesterol ephezulu noma i-triglycerides (amafutha egazini); i-hemophilia (isifo sokopha); izimo lapho umzimba ungakwazi ukukhiqiza i-lactase eyanele noma ungabekezeleli i-lactose, noma isifo senhliziyo noma sezinso.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uma ukhulelwa ngenkathi uthatha i-saquinavir, shayela udokotela wakho. Akufanele uncelise ibele uma utheleleke nge-HIV noma uthatha i-saquinavir.
• kufanele wazi ukuthi i-saquinavir inganciphisa ukusebenza kahle kwezindlela zokuvimbela inzalo zamahomoni (amaphilisi okulawula inzalo, amabala, izindandatho noma imijovo). Khuluma nodokotela wakho ngokusebenzisa enye indlela yokulawula ukubeletha.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-saquinavir.
• kufanele wazi ukuthi amafutha omzimba wakho angakhuphuka noma ahambele ezindaweni ezahlukahlukene zomzimba wakho, njengasemhlane wakho ongaphezulu, entanyeni (’’ inyathi ’), amabele, nasesizungeze isisu sakho. Ungaqaphela ukulahleka kwamafutha omzimba ebusweni bakho, emilenzeni nasezingalweni.
• kufanele wazi ukuthi ungathola i-hyperglycemia (iyanda kushukela wakho wegazi) ngenkathi uthatha lo muthi, noma ngabe awunaso vele isifo sikashukela. Tshela udokotela wakho ngokushesha uma unezinye zalezi zimpawu ezilandelayo ngenkathi uthatha i-saquinavir: ukoma ngokweqile, ukuchama kaningi, ukulamba ngokweqile, ukungaboni kahle, noma ubuthakathaka. Kubaluleke kakhulu ukubiza udokotela wakho ngokushesha uma unezinye zalezi zimpawu, ngoba ushukela wegazi ongelashwa ungadala isimo esibi esibizwa nge-ketoacidosis. I-Ketoacidosis ingasongela impilo uma ingelashwa kusenesikhathi. Izimpawu ze-ketoacidosis zifaka phakathi umlomo owomile, isicanucanu nokuhlanza, ukuphefumula okuncane, ukuphefumula okunuka izithelo, nokuncipha kokwazi.
• kufanele wazi ukuthi ngenkathi uthatha imishanguzo yokwelapha ukutheleleka nge-HIV, amasosha omzimba wakho angaqina futhi aqale ukulwa nezinye izifo ezazivele zisemzimbeni wakho noma zidale ukuthi ezinye izimo zivele. Lokhu kungadala ukuthi uthuthukise izimpawu zalezo zifo noma izimo. Uma unezimpawu ezintsha noma eziya ziba zimbi ngemuva kokuqala ukwelashwa nge-saquinavir, qiniseka ukuthi utshela udokotela wakho.

Khuluma nodokotela wakho ngokudla isithelo samagilebhisi nokuphuza ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Saquinavir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• ubuhlungu besisu
• isicanucanu
• ukuhlanza
• ukuqunjelwa
• ukukhathala
• ukuhlungu obusemhlane
• izindebe noma isikhumba esomile
• imfiva

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuqubuka, ukulunywa, ukuvuvukala kwamehlo, ubuso, umlomo, umphimbo, noma izindebe, ubunzima bokuphefumula noma ukugwinya
• isikhumba esishayayo noma esikhanyayo
• ukuphuzi kwesikhumba noma kwamehlo, ukungathandi ukudla, umkhuhlane njengezimpawu, ukukhathala ngokweqile, umchamo onombala omnyama, izitulo ezinombala okhanyayo, ubuhlungu engxenyeni engaphezulu yesisu
• isiyezi, ikhanda elikhanyayo, ukushaya kwenhliziyo okuhamba kancane, okungajwayelekile, noma okushaya ngamandla, ukuquleka

I-Saquinavir ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ubuhlungu bomphimbo

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-saquinavir. Udokotela wakho angaphinde ahlele i-electrocardiogram (ECG; ukuhlolwa okulinganisa umsebenzi kagesi enhliziyweni) ngaphambi nangesikhathi sokwelashwa kwakho.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-invirase^®