I-Topiramate

-Delile

• Ukuthatha amaphilisi wokufafaza noma ama-capsule akhishwe isikhathi eside (uhlobo lweQudexy XR kuphela) ngokudla, landela lezi zinyathelo:
• Ngaphambi kokuthatha i-topiramate,
• I-Topiramate ingadala eminye imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Topiramate isetshenziswa yodwa noma ngeminye imithi yokwelapha izinhlobo ezithile zokuquleka okubandakanya ukuquleka okuyisisekelo okujwayelekile kwe-tonic-clonic (okwakubizwa ngokuthi ukuqubuka okukhulu; ukubanjwa okubandakanya umzimba wonke) nokuquleka kokuqala (ukubanjwa okubandakanya ingxenye eyodwa kuphela ubuchopho). I-Topiramate isetshenziswa futhi neminye imithi yokulawula ukuqubuka kubantu abane-Lennox-Gastaut syndrome (okuyisifo esidala ukuquleka nokubambezeleka kwentuthuko). I-Topiramate nayo isetshenziselwa ukuvimbela ukuphathwa yikhanda le-migraine kodwa hhayi ukudambisa ubuhlungu bekhanda elibuhlungu lapho livela. I-Topiramate isekilasini lemithi ebizwa ngama-anticonvulsants. Isebenza ngokunciphisa injabulo engavamile ebuchosheni.

I-Topiramate iza njengethebhulethi, i-capsule yokufafaza (i-capsule equkethe ubuhlalu obuncane bemithi engafafazwa ekudleni), kanye ne-capsule ekhishwe isikhathi eside (esebenza isikhathi eside) ezothathwa ngomlomo. Amaphilisi kanye nama-capsules afafaza ngokuvamile athathwa ngokudla noma ngaphandle kokudla kanye noma kabili ngosuku. Ama-capsules akhululwa enwetshiwe avame ukuthathwa nokudla noma ngaphandle kokudla kanye ngosuku. Thatha i-topiramate cishe ngesikhathi esifanayo (ama) nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-topiramate njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Kukhona omunye umuthi onegama elifana negama lomkhiqizo le-topiramate. Kufanele uqiniseke ukuthi uthola i-topiramate hhayi umuthi ofanayo njalo lapho ugcwalisa incwadi kadokotela. Qiniseka ukuthi incwadi kadokotela akunikeza yona icacile futhi ifundeka kalula. Khuluma nosokhemisi wakho ukuze uqiniseke ukuthi unikezwa i-topiramate. Uma ucabanga ukuthi unikezwe umuthi ongafanele, khuluma nosokhemisi wakho. Ungathathi noma imuphi umuthi ngaphandle uma uqinisekile ukuthi ngumuthi owunikwe udokotela wakho.

Amaphilisi e-Topiramate anokunambitheka okumunyu ngakho kufanele uwagwinye ephelele. Kubaluleke kakhulu ukuthi ungathathi amaphilisi e-topiramate aphukile nganoma yisiphi isikhathi eside ngoba amaphilisi aphukile angalahlekelwa ukusebenza kwawo ngokuhamba kwesikhathi.

Amaphilisi afafazayo nakhishwa isikhathi eside (Qudexy XR brand kuphela) angagwinywa aphelele noma avulwe futhi athelwe phezu kokudla okuthambile. Ama-capsules akhishwe isikhathi eside (i-Trokendi XR kuphela); ungahlukanisi, ungahlafuni, noma ufafaze ukudla.

Ukuthatha amaphilisi wokufafaza noma ama-capsule akhishwe isikhathi eside (uhlobo lweQudexy XR kuphela) ngokudla, landela lezi zinyathelo:

1. Lungisa isipuni sokudla okuthambile njenge-appleauce, i-custard, u-ayisikhilimu, i-oatmeal, i-pudding, noma i-yogurt.
2. Bamba i-capsule ime mpo phezu kokudla.
3. Sonta phezulu kwesihloko sephilisi bese uthele konke okuqukethwe kusipuni sokudla.
4. Gwinya yonke ingxube ngokushesha ngaphandle kokuhlafuna.
5. Phuza uketshezi ngemuva nje kokugwinya ukuze ugeze leyo ngxube futhi uqiniseke ukuthi uyayigwinya yonke.

Udokotela wakho mhlawumbe uzokuqala ngomthamo ophansi we-topiramate futhi akhuphule kancane umthamo wakho, hhayi ngaphezu kwesisodwa njalo ngesonto.

I-Topiramate ingalawula ukuquleka noma i-migraines yakho kepha ngeke iselaphe isimo sakho. Qhubeka uthathe i-topiramate noma uzizwa uphilile. Ungayeki ukuthatha i-topiramate ngaphandle kokukhuluma nodokotela wakho, noma ngabe uhlangabezana nemiphumela emibi njengokushintsha okungajwayelekile kokuziphatha noma kwemizwelo. Uma ngokungazelelwe uyeka ukuthatha i-topiramate, ungahle ube nokuquleka okukhulu, noma ngabe awukaze ube nokuquleka phambilini. Udokotela wakho mhlawumbe uzokwehlisa umthamo wakho kancane kancane.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-topiramate futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs) noma iwebhusayithi yomkhiqizi ukuthola uMhlahlandlela Wezokwelapha.

I-Topiramate nayo isetshenziselwa ukuphathwa kokuncika kotshwala. Khuluma nodokotela wakho ngezingozi zokusebenzisa lo muthi ngesimo sakho.

Lo muthi ungabekelwa okunye ukusetshenziswa. Buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-topiramate,

• Tshela udokotela wakho kanye nosokhemisi uma uxabana ne-topiramate, noma imiphi eminye imithi, noma yiziphi izithako kumaphilisi e-topiramate, ufafaza ama-capsule, nama-capsule akhishwe isikhathi eside. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• tshela udokotela wakho uma une-metabolic acidosis (ukuphazamiseka kokulinganisela kwe-acid-base komzimba okuholela ekubeni ne-asidi ngokweqile egazini) futhi uthatha i-metformin (i-Fortamet, i-Glucophage, i-Riomet, abanye). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-metformin uma une-metabolic acidosis futhi usebenzisa le mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: i-acetazolamide (Diamox); amitriptyline; ama-anticoagulants (’ama-thinner egazi’) afana ne-warfarin (Coumadin); imishanguzo; ama-antihistamine; i-aspirin neminye imishanguzo yokulwa nokuvuvukala (ama-NSAID) njenge-ibuprofen (Advil, Motrin) ne-naproxen (Aleve, Naprosyn); i-digoxin (i-Lanoxin); izindlela zokuvimbela inzalo zamahomoni (amaphilisi okulawula inzalo, amabala, izindandatho, okufakelwa emzimbeni noma imijovo); i-hydrochlorothiazide (i-Microzide, i-Oretic); i-lamotrigine (iLamictal); i-lithium (i-Lithobid); imithi yokugula okunyakazayo, izilonda, noma izinkinga zomchamo; metformin (Fortamet, Glucophage, Riomet, abanye); eminye imishanguzo yokuquleka efana ne-carbamazepine (Epitol, Equetro, Tegretol, Teril), phenytoin (Dilantin, Phenytek), valproic acid (Depakene), ne-zonisamide (Zonegran); kanye ne-pioglitazone (Actos, ku-Actoplus Met ER). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• tshela udokotela wakho uma wena noma amanye amalungu omndeni enake noma ake aba namatshe ezinso, nokuthi ngabe wake wacabanga ukuzibulala noma wazama ukwenza kanjalo. Phinda utshele udokotela wakho uma uke waba noma uke waba ne-metabolic acidosis (ukuphazamiseka kubhalansi ye-acid-base yomzimba okuholela ekubeni ne-asidi ngokweqile egazini); i-osteopenia, i-osteomalacia, noma i-osteoporosis (izimo lapho amathambo ethambile khona noma ephuka futhi angahle aphuke kalula); isifo sikashukela; i-glaucoma (uhlobo lwesifo samehlo); noma yisiphi isifo esithinta ukuphefumula kwakho njengesifuba somoya noma isifo samaphaphu esingapheliyo (COPD); ukucindezeleka noma imizwa engavamile; inkinga yokukhula; noma isifo sesibindi noma sezinso. Tshela nodokotela wakho uma unesifo sohudo noma uhlaselwa yisisu ngesikhathi sokwelashwa kwakho.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwe noma uhlela ukukhulelwa, udokotela wakho angakunikeza umuthi ohlukile esikhundleni se-topiramate ngoba i-topiramate ingalimaza umbungu. Uma ungahleleli ukukhulelwa, kufanele usebenzise ukuvimbela ukukhulelwa ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nge-topiramate. Khuluma nodokotela wakho mayelana nokuthi yiluphi uhlobo lokulawulwa kokuzalwa okufanele ulusebenzise, ​​ngoba ukuthatha i-topiramate kunganciphisa ukusebenza kwezinye izinhlobo zokulawulwa kokubeletha. Uma ukhulelwa ngenkathi uthatha i-topiramate, biza udokotela wakho khona manjalo, kepha ungayeki ukuthatha i-topiramate ngaphambi kokukhuluma nodokotela wakho.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-topiramate.
• kufanele wazi ukuthi i-topiramate ingakwenza ukozele, ube nesiyezi, udideke, noma ungakwazi ukugxila. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.
• uma uthatha i-topiramate ukulawula ukuqubuka, kufanele wazi ukuthi ungaqhubeka nokuquleka ngesikhathi sokwelashwa kwakho. Ungadinga ukugwema imisebenzi enjengokubhukuda, ukushayela, nokukhuphuka ukuze ungazilimazi wena noma abanye uma ulahlekelwa ukwazi ngesikhathi sokubamba.
• utshele udokotela wakho uma uphuza utshwala. Akufanele uphuze utshwala kungakapheli amahora ayisithupha ngaphambi kwamahora ayisithupha ngemuva kokuthatha amaphilisi akhishwa isikhathi eside (uhlobo lweTrokendi XR kuphela). Udokotela wakho uzokutshela ukuthi ungaphuzi utshwala ngenkathi uthatha i-topiramate.
• kufanele wazi ukuthi i-topiramate ingakuvimbela ekujulukeni futhi yenze kube nzima ngomzimba wakho ukuphola lapho kushisa kakhulu. Lokhu kwenzeka kaningi esimweni sezulu esifudumele nasezinganeni ezithatha i-topiramate. Gwema ukuchayeka ekushiseni, phuza uketshezi oluningi bese utshela udokotela wakho uma unemfiva, ikhanda elibuhlungu, amajaqamba, noma isisu esidumbile, noma uma ungajuluki njengenjwayelo.
• kufanele wazi ukuthi ungahle ube nethuba lokuthuthukisa itshe lezinso ngenkathi uthatha i-topiramate. Phuza izingilazi zamanzi eziyisithupha kuya kweziyisishiyagalombili nsuku zonke ukuvimbela amatshe ezinso ukuthi angakheki.
• kufanele wazi ukuthi impilo yakho yengqondo ingashintsha ngezindlela ezingalindelekile futhi ungazibulala (ucabanga ngokuzilimaza noma ukuzibulala noma ukuhlela noma ukuzama ukwenza kanjalo) ngenkathi uthatha i-topiramate yokwelashwa kwesifo sokuwa, ukugula kwengqondo, noma ezinye izimo. Inani elincane labantu abadala nezingane ezineminyaka engu-5 nangaphezulu (cishe umuntu oyedwa kwabangu-500) abathathe ama-anticonvulsants afana ne-topiramate ukwelapha izimo ezahlukahlukene phakathi kwezifundo zokwelashwa baba nokuzibulala ngesikhathi belashwa. Abanye balaba bantu bahlakulele imicabango yokuzibulala nokuziphatha kusasele isonto eli-1 ngemuva kokuqala ukuphuza umuthi. Kunobungozi bokuthi ungathola ushintsho empilweni yakho yengqondo uma uthatha umuthi we-anticonvulsant onjenge-topiramate, kepha kungahle kube nengozi yokuthi uzohlangabezana nezinguquko empilweni yakho yengqondo uma isimo sakho singelashwa. Wena nodokotela wakho nizonquma ukuthi izingozi zokuthatha umuthi we-anticonvulsant zinkulu yini kunezingozi zokungawuthathi umuthi. Wena, umndeni wakho, noma umnakekeli wakho kufanele ushayele udokotela wakho ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo: ukwethuka; ukuphazamiseka noma ukungahlaliseki; ukucasuka okusha noma okuya kuba kubi, ukukhathazeka, noma ukucindezeleka; ukwenza izinkanuko eziyingozi; ubunzima bokulala noma ukulala; ulaka, intukuthelo, noma ukuziphatha okunodlame; i-mania (i-frenzied, imood ejabule ngokungavamile); ukukhuluma noma ukucabanga ngokufuna ukuzilimaza noma ukuqeda impilo yakho; ukuhoxa kubangani nomndeni; ukukhathazeka ngokufa nokufa; ukuphana ngezinto eziyigugu; noma olunye uguquko olungajwayelekile ekuziphatheni noma emoyeni. Qiniseka ukuthi umndeni wakho noma umnakekeli wakho uyazi ukuthi yiziphi izimpawu ezingaba zimbi kakhulu ukuze bakwazi ukubiza udokotela uma ungakwazi ukuzifunela ukwelashwa wedwa.

Khuluma nodokotela wakho ngokwandisa inani lokudla okudlayo uma ulahlekelwa isisindo ngenkathi uthatha i-topiramate.

Khuluma nodokotela wakho ngaphambi kokushintsha indlela odla ngayo noma uqale noma yiluphi uhlobo lohlelo lokwehlisa isisindo. Ungalandeli ukudla okune-ketogenic (ukudla okunamafutha amaningi, okunama-carbohydrate amancane asetshenziselwa ukulawula ukuqubuka) noma yikuphi okunye ukudla okunamafutha aphezulu, okunama-carbohydrate amancane, njengokudla kwe-Atkins, ngenkathi uthatha lo muthi.

Uma uthatha amaphilisi e-topiramate noma ufafaza amaphilisi, thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma kungaphansi kwamahora angu-6 ngaphambi kokuba uhlelelwe ukuthatha umthamo wakho olandelayo, weqa umthamo ongabanjwanga bese uqhubeka nesimiso sakho sokulinganisa okujwayelekile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

Uma uthatha amaphilisi wokukhishwa okwandisiwe we-topiramate, thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi sedosi yakho elandelayo, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile. Uma uphuthelwe umthamo ongaphezu kowodwa, xhumana nodokotela wakho.

I-Topiramate ingadala eminye imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuba ndikindiki, ukushiswa, noma ukuncinza ezandleni noma ezinyaweni
• ukusabela okwephuzile
• uvalo
• ikhanda
• ukozela
• ubuthakathaka
• ukuzamazama okungalawuleki kwengxenye yomzimba
• ukunyakaza kwamehlo okungalawuleki
• ukuncipha komzimba
• ukuqunjelwa
• isilungulela
• shintsha emandleni okunambitha ukudla
• umlomo owomile
• ekhaleni
• izinyembezi noma amehlo omile
• emuva, imisipha, umlenze, noma ubuhlungu bethambo
• uphuthelwe yizikhathi zokuya esikhathini
• ukopha ngokweqile kokuya esikhathini
• ukopha okungajwayelekile noma ukulinyazwa

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, shayela udokotela wakho ngokushesha:

• ukuqubuka, amabhamuza esikhumba, noma ukuxebuka kwesikhumba
• ukungaboni kahle
• ukulahleka kombono
• ukubona kabili
• ubuhlungu beso
• ukubomvu kwamehlo
• ukwanda kokuquleka
• ukuzwa ukubanda, ukubanda, noma ukushisa komzimba okuphansi
• ubunzima bokugxila
• izinkinga zokukhuluma, ikakhulukazi ubunzima bokucabanga ngamagama athile
• ukudideka
• izinkinga zememori
• ukulahleka kokuxhumanisa
• ukushaya kwenhliziyo okushaya ngamandla noma okungajwayelekile
• ubuhlungu besifuba
• ukuphelelwa umoya
• ukuphefumula kanzima
• ukushesha, ukuphefumula okungajulile
• ukungakwazi ukuphendula izinto ezikuzungezile
• ukukhathala ngokweqile
• isifo sohudo
• isicanucanu
• ukuhlanza
• ubuhlungu besisu
• ukulahlekelwa isifiso sokudla
• ubuhlungu obukhulu emuva noma ohlangothini
• umchamo onegazi, onamafu, noma onuka kabi
• isidingo sokuchama njalo
• ubunzima bokuchama noma ubuhlungu lapho uchama
• umkhuhlane noma ezinye izimpawu zokutheleleka

I-Topiramate ingadala i-osteoporosis (isimo lapho amathambo engaphuka khona kalula) kubantu abadala kanye namarikethi (ukukhula okungavamile, kwamathambo agobile) ezinganeni. I-Topiramate nayo inganciphisa ukukhula kwezingane futhi inganciphisa ukuphakama kokugcina okutholwa yizingane. Khuluma nodokotela wakho ngezingozi zokuthatha i-topiramate.

I-Topiramate ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Amathebulethi nama-capsule akhishwa isikhathi eside kufanele agcinwe ekamelweni lokushisa futhi kude nokushisa okwedlulele nomswakama (hhayi endlini yangasese). Amaphilisi wefafaza kufanele agcinwe noma ngaphansi kwama-77 ° F (25 ° C). Ungalokothi ugcine amaphilisi aphukile, amaphilisi, noma imixube yama-sprinkle nokudla okuthambile. Lezi kufanele zisetshenziswe ngokushesha noma zilahlwe.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• isithuthwane
• ukozela
• izinkinga zokukhuluma
• ukungaboni kahle
• ukubona kabili
• unenkinga yokucabanga
• ukukhathala
• ukulahleka kokuxhumanisa
• ukulahlekelwa ukwazi
• isiyezi
• ubuhlungu besisu
• ukuhlanza
• ukuyaluza
• ukudana
• ukulahlekelwa isifiso sokudla
• ukushaya kwenhliziyo okushaya ngamandla noma okungajwayelekile
• ukushesha, ukuphefumula okungajulile

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zebhu ukuze ahlole impendulo yomzimba wakho ku-topiramate.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Qudexy XR^®
• I-Topamax^®
• I-Trokendi XR^®