I-Aimovig (erenumab-aooe)

-Delile

• Kuyini u-Aimovig?
• Uhlobo olusha lomuthi
• I-Aimovig ejwayelekile
• Imiphumela emibi ye-Aimovig
• Imiphumela emibi ejwayelekile
• Imiphumela emibi kakhulu
• Ukusabela okweqile
• Ukwehla kwesisindo / ukuzuza kwesisindo
• Imiphumela yesikhathi eside
• Ukuqunjelwa
• Ukulahleka kwezinwele
• Isicanucanu
• Ukukhathala
• Uhudo
• Ukuqwasha
• Ubuhlungu bemisipha
• Ukulunywa
• Izindleko ze-Aimovig
• Usizo lwezezimali
• I-Aimovig isebenzisa
• I-Aimovig yezinhlungu zekhanda ze-migraine
• Ukusetshenziswa okungavunyelwe
• Isilinganiso se-Aimovig
• Amafomu namandla
• Isilinganiso se-migraine
• Kuthiwani uma ngiphuthelwa umthamo?
• Ngabe kuzodingeka ngisebenzise lesi sidakamizwa isikhathi eside?
• Ezinye izindlela ze-Aimovig
• Abaphikisi be-CGRP
• I-Aimovig vs. ezinye izidakamizwa
• I-Aimovig vs. Ajovy
• I-Aimovig vs. Botox
• I-Aimovig vs. Emgality
• I-Aimovig vs. Topamax
• I-Aimovig notshwala
• Ukusebenzisana kwe-Aimovig
• I-Aimovig ihlanganiswa kanjani
• Imiyalo yokuthi ungayithatha kanjani i-Aimovig
• Ungayijova kanjani
• Isikhathi
• Ukuthatha i-Aimovig ngokudla
• Isitoreji
• Isebenza kanjani i-Aimovig
• Kuthatha isikhathi esingakanani ukusebenza?
• I-Aimovig nokukhulelwa
• I-Aimovig nokuncelisa ibele
• Imibuzo ejwayelekile nge-Aimovig
• Ingabe ukumisa i-Aimovig kudala ukuhoxa?
• Ingabe i-Aimovig yi-biologic?
• Ungayisebenzisa i-Aimovig ukwelapha i-migraine?
• Ngabe i-Aimovig iyayelapha yini i-migraine?
• I-Aimovig yehluke kanjani kwezinye izidakamizwa ze-migraine?
• Uma ngithatha i-Aimovig, ngingayeka ukuthatha eminye imithi yami yokuvikela?
• Ukudlula ngokweqile kwe-Aimovig
• Izimpawu zokudlula ngokweqile
• Okufanele ukwenze uma kwenzeka ukweqisa ngokweqile
• Izexwayiso ze-Aimovig
• Ukuphelelwa yisikhathi nokugcinwa kwe-Aimovig
• Imininingwane yobungcweti ye-Aimovig
• Indlela yokusebenza
• I-Pharmacokinetics ne-metabolism
• Izimo
• Isitoreji

Kuyini u-Aimovig?

I-Aimovig umuthi kadokotela osetshenziswayo ukuvimbela ukuphathwa yikhanda kubantu abadala. Ifika ngepeni le-autoinjector eligcwalisiwe. Usebenzisa i-autoinjector ukuze uzinike umjovo ekhaya kanye ngenyanga. I-Aimovig ingabekwa kumthamo owodwa kwezimbili: 70 mg ngenyanga noma i-140 mg ngenyanga.

I-Aimovig iqukethe i-erenumab yezidakamizwa. I-Erenumab iyi-anti-monoclonal antibody, okuwuhlobo lomuthi owenziwe elebhu. Ama-antibody e-monoclonal yizidakamizwa ezenziwe ngamaseli omzimba omzimba. Zisebenza ngokuvimba ukusebenza kwamaprotheni athile emzimbeni wakho.

I-Aimovig ingasetshenziselwa ukuvimbela kokubili i-episodic migraine kanye ne-chronic migraine headaches. I-American Headache Society incoma i-Aimovig kubantu:

• ayikwazi ukunciphisa inani labo lezinyanga zonke le-migraine ikhanda elanele nezinye izidakamizwa
• ayikwazi ukuthatha eminye imishanguzo ye-migraine ngenxa yemiphumela emibi noma ukuhlangana kwezidakamizwa

I-Aimovig ikhonjisiwe ukuthi iyasebenza ezifundweni zokwelashwa. Kubantu abane-episodic migraine, phakathi kwamaphesenti angama-40 kanye namaphesenti angama-50 alabo abathathe i-Aimovig izinyanga eziyisithupha banciphisa inani labo lezinsuku ze-migraine okungenani uhhafu. Futhi kubantu abane-migraine engapheli, cishe amaphesenti angama-40 alabo abathathe i-Aimovig banciphisa inani labo lezinsuku ze-migraine ngesigamu noma ngaphezulu.

Uhlobo olusha lomuthi

I-Aimovig iyingxenye yesigaba esisha semithi ebizwa ngabaphikisi be-calcitonin ephathelene nezakhi zofuzo (CGRP). Lolu hlobo lomuthi lwenzelwe ukuvimbela ukuphathwa yikhanda elibuhlungu.

U-Aimovig wathola imvume yeFood and Drug Administration (FDA) ngoMeyi 2018. Kwakuwumuthi wokuqala ukuvunywa esigabeni sabaphikisi be-CGRP.

Eminye imithi emibili kulesi sigaba semithi yamukelwa ngemuva kwe-Aimovig: Emgality (galcanezumab) no-Ajovy (fremanezumab). Umuthi wesine, obizwa nge-eptinezumab, okwamanje ufundwa ekuhlolweni kwemitholampilo.

I-Aimovig ejwayelekile

I-Aimovig ayitholakali ngendlela ejwayelekile. Kuza kuphela njengomuthi wegama lomkhiqizo.

I-Aimovig iqukethe i-erenumab yezidakamizwa, ebizwa nangokuthi i-erenumab-aooe. Isiphetho "-aooe" kwesinye isikhathi siyangezwa ukukhombisa ukuthi umuthi wehlukile emithini efanayo engadalwa ngokuzayo. Eminye imishanguzo yama-anti-monoclonal antibody nayo inezakhiwo zamagama ezinjengalezi.

Imiphumela emibi ye-Aimovig

I-Aimovig ingadala imiphumela emibi noma emibi. Uhlu olulandelayo luqukethe eminye yemiphumela emibi engase ivele ngenkathi uthatha i-Aimovig. Lolu hlu alufaki yonke imiphumela emibi engaba khona.

Ngeminye imininingwane ngemiphumela engemihle ye-Aimovig, noma amathiphu wokuthi ungabhekana kanjani nemiphumela emibi ekhathazayo, khuluma nodokotela wakho noma usokhemisi.

Qaphela: Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kulandelela imiphumela emibi yezidakamizwa abazivumile. Uma ungathanda ukubika kwi-FDA imiphumela eseceleni obukade unayo nge-Aimovig, ungakwenza lokho ngeMedWatch.

Imiphumela emibi ejwayelekile

Imiphumela emibi ejwayelekile ye-Aimovig ingafaka:

• ukuphendula kwesiza somjovo (ubomvu, isikhumba esilumayo, ubuhlungu)
• ukuqunjelwa
• amajaqamba
• ukuphazamiseka kwemisipha

Iningi lalemiphumela emibi ingahle ihambe ngemuva kwezinsuku ezimbalwa noma amasonto ambalwa. Shayela udokotela wakho noma usokhemisi uma unemiphumela emibi kakhulu noma imiphumela engapheli.

Imiphumela emibi kakhulu

Imiphumela emibi ebucayi evela ku-Aimovig ingenzeka, kepha ayijwayelekile. Umphumela oyingozi omkhulu we-Aimovig ukusabela okweqile okunzima. Bona ngezansi ukuthola imininingwane.

Ukusabela okweqile

Abanye abantu banokungazwani ngemuva kokuthatha i-Aimovig. Lolu hlobo lokuphendula kungenzeka ngemithi eminingi. Izimpawu zokuphendula okuncane komzimba zingafaka:

• ukuba nokuqubuka esikhunjeni sakho
• ukuzwa ukulunywa
• ukufutha (ukufudumala nokubomvu esikhumbeni sakho)

Imvamisa, ukusabela okweqile komzimba kungenzeka. Izimpawu zokuphendula okweqile zingafaka:

• ukuvuvukala ngaphansi kwesikhumba sakho (ngokuvamile ezinkalweni zakho, izindebe, izandla, noma izinyawo)
• ukuzizwa uphelelwa umoya noma unenkinga yokuphefumula
• ukuvuvukala olimini lwakho, emlonyeni, nasemphinjeni

Shayela udokotela wakho khona manjalo uma ucabanga ukuthi unenkinga yokungezwani komzimba ne-Aimovig. Shayela u-911 uma izimpawu zakho zizizwa zisongela impilo noma uma unezimo eziphuthumayo zezokwelapha.

Ukwehla kwesisindo / ukuzuza kwesisindo

Ukwehla kwesisindo nokuzuza kwesisindo akubikwanga ezifundweni zokwelashwa ze-Aimovig. Kodwa-ke, abanye abantu bangabona ushintsho kusisindo sabo ngesikhathi sokwelashwa kwe-Aimovig. Lokhu kungahle kube ngenxa ye-migraine uqobo kune-Aimovig.

Abanye abantu kungenzeka bangazizwa belambile ngaphambi, ngesikhathi, noma ngemuva kwekhanda le-migraine. Uma lokhu kwenzeka kaningi ngokwanele, kungaholela ekulahlekelweni kwesisindo okungafuneki. Uma ulahlekelwa isifiso sokudla lapho unekhanda le-migraine, sebenzisana nodokotela wakho ukwakha uhlelo lokudla oluqinisekisa ukuthi uthola zonke izakhamzimba ozidingayo.

Ngakolunye uhlangothi lwe-spectrum, ukukhuluphala kwesisindo noma ukukhuluphala kuvamile kubantu abane-migraine. Futhi izifundo zomtholampilo zikhombisile ukuthi ukukhuluphala ngokweqile kungaba yingcuphe yokuqaqanjelwa yikhanda elibuhlungu noma ukuqaqanjelwa yikhanda okuvamile.

Uma ukhathazekile ngokuthi isisindo sakho sithinta kanjani ikhanda lakho le-migraine, khuluma nodokotela wakho ngezindlela zokuphatha isisindo sakho.

Imiphumela yesikhathi eside

I-Aimovig ngumuthi osanda kuvunywa esigabeni esisha semithi. Ngenxa yalokhu, kuncane kakhulu ucwaningo lwesikhathi eside olutholakalayo ekuphepheni kuka-Aimovig, futhi kuncane okwaziwayo ngemiphumela yaso yesikhathi eside.

Esifundweni esisodwa sesikhathi eside sokuphepha esadonsa cishe iminyaka emithathu, imiphumela emibi kakhulu ebikwe ne-Aimovig yile:

• ukuhlungu obusemhlane
• izifo eziphezulu zokuphefumula (njengokubanda okuvamile noma ukutheleleka kwesono)
• izimpawu ezinjengomkhuhlane

Uma unale miphumela emibi futhi ubucayi noma ungapheli, khuluma nodokotela wakho.

Ukuqunjelwa

Ukuqunjelwa kwenzeke kubantu abangafika kumaphesenti ama-3 abathathe i-Aimovig ezifundweni zokwelashwa.

Lo mphumela ohlangothini ungabangelwa ukuthi i-Aimovig ithinta kanjani i-peptide ehlobene nohlobo lwe-calcitonin (CGRP) emzimbeni wakho. I-CGRP yiprotheni engatholakala emathunjini futhi idlala indima ekunyakazeni okujwayelekile kwamathumbu. I-Aimovig ivimba umsebenzi we-CGRP, futhi lesi senzo singavimbela ukunyakaza kwamathumbu okujwayelekile ukuthi kungenzeki.

Uma uhlangabezana nokuqunjelwa ngesikhathi sokwelashwa no-Aimovig, khuluma nodokotela wakho noma usokhemisi ngamakhambi angasiza ukukhulula.

Ukulahleka kwezinwele

Ukulahleka kwezinwele akuyona imphumela eseceleni exhunywe ne-Aimovig. Uma uthola ukuthi ulahlekelwa yizinwele, khuluma nodokotela wakho ngezimbangela ezingaba khona kanye nokwelashwa.

Isicanucanu

I-nausea ayiwona umthelela oseceleni obikwe ngokusetshenziswa kwe-Aimovig. Kodwa-ke, abantu abaningi abane-migraine bangazizwa benesicanucanu ngesikhathi sekhanda le-migraine.

Uma uzizwa unesicanucanu ngesikhathi sekhanda le-migraine, kungasiza ukuhlala egumbini elimnyama, elinokuthula, noma ukuphuma phandle ukuze uthole umoya opholile. Ungabuza futhi udokotela wakho noma usokhemisi ngemithi engasiza ukuvimbela noma ukwelapha isicanucanu.

Ukukhathala

Ukukhathala (ukungabi namandla) akuyona imiphumela eseceleni exhunywe ne-Aimovig. Kodwa ukuzwa ukhathele kuyisibonakaliso esivamile se-migraine abantu abaningi abazizwa ngaphambi, ngesikhathi, noma ngemuva kokuba ikhanda le-migraine livele.

Ucwaningo olulodwa lomtholampilo lubonise ukuthi abantu abane-migraine abanekhanda elibuhlungu kakhulu kungenzeka ukuthi bazizwe bekhathele.

Uma ukhathazwa ukukhathala, khuluma nodokotela wakho ngezindlela zokuthuthukisa amazinga akho wamandla.

Uhudo

Uhudo akuwona umphumela oseceleni obikwe ngokusetshenziswa kwe-Aimovig. Kodwa-ke, kuyisibonakaliso esingavamile se-migraine. Kungase kube nokuxhumana phakathi kwe-migraine nesifo sokuvuvukala kwamathumbu nezinye izifo zesisu.

Uma unesifo sohudo esihlala isikhathi eside kunezinsuku ezimbalwa, khuluma nodokotela wakho.

Ukuqwasha

Ukuqwasha (ukunenkinga yokulala) akuwona umphumela oseceleni otholakele ezifundweni zokwelashwa ze-Aimovig. Kodwa-ke, isifundo esisodwa somtholampilo sathola ukuthi abantu abane-migraine abanokuqwasha bavame ukuba nekhanda elibuhlungu njalo. Eqinisweni, ukungabikho kokulala kungaba yimbangela yezinhlungu ze-migraine futhi kwandise ingozi yokuthola i-migraine engapheli.

Uma unesifo sokuqwasha futhi ucabanga ukuthi kungathinta ikhanda lakho le-migraine, khuluma nodokotela wakho ngezindlela zokulala kangcono.

Ubuhlungu bemisipha

Ezifundweni zokwelashwa, abantu abathole i-Aimovig ababuzwanga ubuhlungu obujwayelekile bemisipha. Abanye babenamajaqamba nemisipha, futhi esifundweni sokuphepha sesikhathi eside, abantu abathatha u-Aimovig babuzwa ubuhlungu emuva.

Uma unezinhlungu zemisipha ngenkathi uthatha i-Aimovig, kungahle kube ngenxa yezinye izimbangela. Isibonelo, ubuhlungu bemisipha entanyeni kungaba uphawu lwe-migraine kwabanye abantu. Futhi, ukuphendula kwesiza somjovo, kufaka phakathi ubuhlungu endaweni ezungeze umjovo, kungazizwa njengobuhlungu bemisipha. Lolu hlobo lobuhlungu kufanele luphele ezinsukwini ezimbalwa zomjovo.

Uma unezinhlungu zemisipha ezingapheli noma ezithinta izinga lakho lempilo, khuluma nodokotela wakho ngezinketho zokunciphisa izinhlungu.

Ukulunywa

Ukulunywa okujwayelekile akuyona imiphumela eseceleni ebonwe ezifundweni zokwelashwa ze-Aimovig. Kodwa-ke, isikhumba esilumayo endaweni lapho kufakwa khona i-Aimovig kuvame ukubikwa.

Isikhumba esilumayo eduze kwesiza somjovo kufanele sihambe zingakapheli izinsuku ezimbalwa. Uma une-itchiness engapheli, noma uma ukuluma kunzima, khuluma nodokotela wakho.

Izindleko ze-Aimovig

Njengayo yonke imithi, amanani we-Aimovig angahluka.

Izindleko zakho zangempela zizoxhomeka kumshwalense wakho, indawo okuyo nasekhemisi oyisebenzisayo.

Usizo lwezezimali

Uma udinga uxhaso lwezezimali ukukhokhela i-Aimovig, usizo luyatholakala.

U-Amgen no-Novartis, abakhiqizi be-Aimovig, banikela ngohlelo lwe-Aimovig Ally Access Card olungakusiza ukuthi ukhokhe imali encane ngokugcwaliswa kabusha kwemithi ngayinye. Ukuthola eminye imininingwane nokuthola ukuthi uyafaneleka yini, shayela ku-833-246-6844 noma uvakashele iwebhusayithi yohlelo.

I-Aimovig isebenzisa

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuvumela imishanguzo kadokotela efana ne-Aimovig ukwelapha noma ukuvimbela izimo ezithile.

I-Aimovig yezinhlungu zekhanda ze-migraine

I-Aimovig igunyazwe yi-FDA ukuvimbela i-migraine ikhanda kubantu abadala. Lezi zinhlungu zekhanda ezinzima yizimpawu ezivame kakhulu ze-migraine, okuyisimo sezinzwa.

Ezinye izimpawu zingenzeka ngekhanda le-migraine, njenge:

• isicanucanu
• ukuhlanza
• ukuzwela ekukhanyeni nasemsindweni
• kunzima ukukhuluma

I-Migraine ingahlukaniswa njenge-episodic noma engapheli, ngokusho kwe-International Headache Society. I-Aimovig ivunyelwe ukuvimbela kokubili i-episodic migraine kanye ne-chronic migraine headaches. Umehluko phakathi kwalezi zinhlobo ze-migraine yile:

• i-episodic migraine ibangela ikhanda elingaphansi kwezingu-15 noma izinsuku ezingama-migraine ngenyanga
• i-migraine engapheli ibangela izinsuku eziyi-15 noma ngaphezulu zekhanda ngenyanga esikhathini esingangezinyanga ezintathu, okungenani izinsuku eziyisishiyagalombili kwezinsuku kuyizinsuku ze-migraine

Ukusetshenziswa okungavunyelwe

I-Aimovig nayo ingasetshenziswa ngaphandle kwelebula ngezinye izimo. Ukusetshenziswa okungekho kwelebula kulapho kunqunywa umuthi ovunyelwe ukwelapha umbandela owodwa ukwelapha isimo esihlukile.

I-Aimovig yamakhanda eqoqo

I-Aimovig ayivunyelwe yi-FDA ukuvimbela ikhanda le-cluster, kepha ingasetshenziswa ngaphandle kwelebula ngale njongo. Okwamanje akwaziwa ukuthi i-Aimovig iyasebenza yini ekuvikeleni ikhanda le-cluster.

Ukuphathwa yikhanda le-Cluster yizinhlungu ezibuhlungu ezenzeka ngamaqoqo (izinhlungu zekhanda eziningi esikhathini esifushane). Zingaba ngama-episodic noma ezingapheli. Amakhanda eqoqo le-episodic anezinkathi ezinde zesikhathi phakathi kwamaqoqo ekhanda. Izinhlungu ze-cluster ezingapheli zinezikhathi ezimfishane phakathi kwamaqoqo ekhanda.

I-Aimovig ayizange ihlolwe ukuvikela ikhanda le-cluster ezifundweni zokwelashwa. Kodwa-ke, ezinye izidakamizwa ezisesigabeni esifanayo semithi njenge-Aimovig, kufaka phakathi i-Emgality ne-Ajovy, sezihloliwe.

Kwesinye isifundo somtholampilo, i-Emgality yatholakala isiza ukuvimbela ikhanda le-episodic cluster. Kepha esivivinyweni sasemtholampilo sika-Ajovy, umkhiqizi wezidakamizwa wamisa ucwaningo kusenesikhathi ngoba u-Ajovy wayengasebenzeli ukunciphisa inani lamakhanda eqoqo lamahlalakhona elingapheli kubantu abasesifundweni.

I-Aimovig yekhanda le-vestibular

I-Aimovig ayivunyelwe yi-FDA ukuvimbela noma ukwelapha ikhanda le-vestibular. Amakhanda e-Vestibular ahlukile kunekhanda lakudala le-migraine ngoba imvamisa alibuhlungu. Abantu abanekhanda le-vestibular bangazizwa benesiyezi noma bezwa i-vertigo. Lezi zimpawu zingahlala imizuzwana kuya emahoreni.

Izifundo zomtholampilo azenzelwanga ukukhombisa ukuthi ngabe i-Aimovig iyasebenza ekuvikeleni noma ekwelapheni ikhanda le-vestibular. Kepha abanye odokotela basengakhetha ukubeka umuthi ongekho kulebula ngalesi simo.

Isilinganiso se-Aimovig

Isilinganiso se-Aimovig udokotela wakho asinqumayo sizoxhomeka ezicini eziningana. Lokhu kufaka phakathi ubunzima besimo osisebenzisayo ukwelapha i-Aimovig.

Imvamisa, udokotela wakho uzokuqala ngomthamo ophansi futhi awulungise ngokuhamba kwesikhathi ukufinyelela umthamo okulungele wena. Ekugcineni bazonquma isilinganiso esincane kunazo zonke esihlinzeka ngomphumela oyifunayo.

Imininingwane elandelayo ichaza imithamo esetshenziswa kakhulu noma enconywayo. Kodwa-ke, qiniseka ukuthatha isilinganiso udokotela wakho akubekela sona. Udokotela wakho uzonquma isilinganiso esihle kakhulu ukuhlangabezana nezidingo zakho.

Amafomu namandla

I-Aimovig iza ngomthamo owodwa, i-autoinjector efakiwe esetshenziselwa ukunikeza umjovo ongaphansi (umjovo ohamba ngaphansi kwesikhumba). I-autoinjector iza ngamandla owodwa: 70 mg ngomjovo ngamunye. I-autoinjector ngayinye yenzelwe ukuthi isetshenziswe kanye kuphela bese ilahlwa.

Isilinganiso se-migraine

I-Aimovig ingabekwa ngemithamo emibili: 70 mg noma i-140 mg. Noma ngabe umthamo uphuzwa kanye ngenyanga.

Uma udokotela wakho ekunika ama-70 mg, uzozinika umjovo owodwa ngenyanga (usebenzisa i-autoinjector eyodwa). Uma udokotela wakho ekunika u-140 mg, uzozinika imijovo emibili ngenyanga, eyodwa ilandelana (usebenzisa ama-autoinjectors amabili).

Udokotela wakho uzoqala ukwelashwa kwakho ngama-70 mg ngenyanga. Uma lokhu kulinganiswa kunganciphisi inani lakho lezinsuku ze-migraine ngokwanele, udokotela wakho angakhuphula isilinganiso sakho sibe ngu-140 mg ngenyanga.

Kuthiwani uma ngiphuthelwa umthamo?

Thatha umthamo ngokushesha lapho ubona ukuthi uphuthelwe owodwa. Umthamo wakho olandelayo kufanele ube yinyanga eyodwa ngemuva kwaleyo. Khumbula usuku olusha ukuze ukwazi ukuhlela amanani akho esikhathi esizayo.

Ngabe kuzodingeka ngisebenzise lesi sidakamizwa isikhathi eside?

Uma i-Aimovig isebenza kahle ekuvimbeleni i-migraine ekhanda kuwe, wena nodokotela wakho ninganquma ukuqhubeka nokwelashwa nge-Aimovig isikhathi eside.

Ezinye izindlela ze-Aimovig

Eminye imishanguzo iyatholakala ukusiza ukuvimbela i-migraine ekhanda. Abanye bangakusebenzela kangcono kunabanye. Uma unentshisekelo yokuzama ukwelashwa ngaphandle kwe-Aimovig, khuluma nodokotela wakho ukuze ufunde kabanzi ngezinye izidakamizwa ezingakusebenzela kahle.

Izibonelo zeminye imithi evunyelwe yi-FDA yokuvimbela i-migraine ikhanda ifaka:

• ezinye izimbangi ze-peptide ezihlobene nohlobo lwe-calcitonin (CGRP):
• i-fremanezumab-vrfm (Ajovy)
• galcanezumab-gnlm (Ubungqabavu)
• imithi ethile yokubamba, njenge:
• i-divalproex sodium (Depakote)
• i-topiramate (i-Topamax, iTrokendi XR)
• i-neurotoxin onabotulinumtoxinA (Botox)
• i-beta-blocker propranolol (Inderal, Inderal LA)

Eminye imishanguzo isetshenziswa ngaphandle kwelebula ukuvimbela ikhanda elibuhlungu le-migraine. Le mithi ihlanganisa:

• amanye ama-anti-depressants, njenge-amitriptyline noma i-venlafaxine (i-Effexor XR)
• eminye imithi yokubamba, njenge-valproate sodium
• amanye ama-beta-blocker, afana ne-metoprolol (Lopressor, Toprol XL) noma i-atenolol (Tenormin)

Abaphikisi be-CGRP

I-Aimovig iyingxenye yesigaba esisha semithi ebizwa ngokuthi yi-calcitonin peptide ehlobene nohlobo lwe-peptide (CGRP). I-Aimovig yamukelwa yi-FDA ngo-2018 ukuvimbela ukuphathwa yikhanda elibuhlungu. Abanye abaphikisi ababili be-CGRP ababizwa nge-Ajovy and Emgality nabo basanda kuvunywa. Umuthi wesine kulesi sigaba (eptinezumab) kulindeleke ukuthi uvunyelwe kungekudala.

Basebenza kanjani

Abaphikisi abavunyelwe be-CGRP basebenza ngezindlela ezifanayo ukuvimbela ikhanda le-migraine.

I-CGRP yiprotheni emzimbeni wakho exhunywe nokuvuvukala kanye ne-vasodilation (ukunwetshwa kwemithambo yegazi) ebuchosheni. Lokhu kuvuvukala kanye ne-vasodilation kungaholela ebuhlungwini obuvela ekhanda le-migraine. Ukwenza le miphumela, i-CGRP idinga ukubopha (ukunamathisela) kuma-receptors ayo, okuyizindawo ezingaphansi kwamanye amaseli akho obuchopho.

I-Ajovy ne-Emgality zombili zisebenza ngokuzibophezela ku-CGRP uqobo. Ngenxa yalokho, i-CGRP ayikwazi ukubophezela kuma-receptors ayo. Ngokungafani nezinye izidakamizwa ezimbili kulesi sigaba, i-Aimovig isebenza ngokuzibophezela kuma-receptor cell cell. Lokhu kuvimba i-CGRP ekwenzeni lokhu.

Ngokuvimba i-CGRP ekusebenzisaneni ne-receptor yayo, yomithathu le mithi isiza ukumisa ukuvuvukala kanye ne-vasodilation. Lokhu kungasiza ekuvimbeleni i-migraine ikhanda.

Icala ngecala

Ishadi elingezansi liqhathanisa ulwazi oluyisisekelo mayelana nemithi emithathu evunyelwe yi-FDA kuleli klasi esetshenziselwa ukuvimbela ukuphathwa ikhanda kwe-migraine. Ukuze ufunde kabanzi mayelana nokuthi i-Aimovig iqhathanisa kanjani nalezi ezinye izidakamizwa, bheka isigaba esilandelayo ("Aimovig vs. other drug").

Amanani angahluka ngokuya ngendawo okuyo, ikhemisi elisetshenzisiwe, ukumbozwa komshuwalense wakho, nezinhlelo zosizo zabakhiqizi.

I-Aimovig vs. ezinye izidakamizwa

Ungase uzibuze ukuthi i-Aimovig iqhathanisa kanjani neminye imithi enqunyelwe ukusetshenziswa okufanayo. Ngezansi kukhona ukuqhathanisa phakathi kwe-Aimovig nemithi eminingana.

I-Aimovig vs. Ajovy

I-Aimovig iqukethe i-erenumab yezidakamizwa, eyi-antibody monoclonal. I-Ajovy iqukethe i-fremanezumab yezidakamizwa, nayo eyi-antibody monoclonal. Ama-antibody e-monoclonal yimithi eyenziwe elebhu. Le mithi yenziwa ngamaseli omzimba. Zisebenza ngokuvimba ukusebenza kwamaprotheni athile emzimbeni wakho.

U-Aimovig no-Ajovy bobabili bayayeka ukusebenza kweprotheni ebizwa nge-calcitonin peptide ehlobene nohlobo (CGRP). I-CGRP ibangela ukuvuvukala kanye ne-vasodilation (ukunwetshwa kwemithambo yegazi) ebuchosheni, okungaholela ekhanda le-migraine. Ukuvimba i-CGRP kusiza ukuvimbela i-migraine ekhanda.

Isebenzisa

I-Aimovig ne-Ajovy zombili zivunyelwe yi-FDA ukuvimbela i-migraine ikhanda kubantu abadala.

Amafomu nokuphathwa

I-Aimovig ne-Ajovy bobabili beza ngendlela ejojelwayo enikezwa ngaphansi kwesikhumba sakho (ngaphansi kwesikhumba). Ungazinikeza umjovo ekhaya. Yomibili le mithi ingazilimaza ezindaweni ezithile, njenge:

• isisu sakho
• ngaphambili kwamathanga akho
• ngemuva kwezingalo zakho ezingaphezulu

I-Aimovig inikezwa njenge-autoinjector ekhethwe ngomthamo owodwa. Imvamisa inikezwa njengomjovo we-70-mg kanye ngenyanga. Kodwa-ke, abanye abantu banikezwa umthamo ophakeme ka-140 mg inyanga ngayinye.

I-Ajovy ihlinzekwa njengesirinji egcwaliswe ngomthamo owodwa. Inganikezwa njengomjovo owodwa we-225 mg kanye ngenyanga. Noma inganikezwa njengemijovo emithathu ka-225 mg kanye ezinyangeni ezintathu.

Imiphumela emibi kanye nezingozi

I-Aimovig ne-Ajovy zisebenza ngezindlela ezifanayo futhi zidala imiphumela emibi efanayo. Imiphumela emibi ejwayelekile futhi emibi yezidakamizwa zombili ingezansi.

Imiphumela emibi ejwayelekile

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi ejwayelekile engenzeka nge-Aimovig, ne-Ajovy, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

• Kungenzeka nge-Aimovig:
• ukuqunjelwa
• amajaqamba noma ama-spasms
• ukutheleleka okuphezulu kokuphefumula (njengokubanda okuvamile noma ukutheleleka kwesono)
• izimpawu ezinjengomkhuhlane
• ukuhlungu obusemhlane
• Kungenzeka nge-Ajovy:
• akukho nemiphumela engejwayelekile eyehlukile
• Kungenzeka ngamabili i-Aimovig ne-Ajovy:
• ukuphendula kwesiza somjovo njengobuhlungu, ukulunywa, noma ukubomvu

Imiphumela emibi kakhulu

Umphumela oyisisekelo obalulekile we-Aimovig ne-Ajovy ukusabela okweqile okunzima. Ukusabela okunjalo akuvamile, kodwa kungenzeka. (Ngeminye imininingwane, bheka “Ukusabela okweqile” ngaphansi kwe- “Aimovig side effects” ngenhla).

Ukusabela komzimba

Ekuvivinyweni komtholampilo okwenzelwe bobabili u-Aimovig no-Ajovy, inani elincane labantu lalinokuphendula komzimba emithini. Lokhu kusabela kubangele ukuthi imizimba yabo ithuthukise amasosha omzimba ngokumelene nemithi.

Ama-antibody amaprotheni enziwa amasosha omzimba ukulwa nezinto zangaphandle emzimbeni wakho. Umzimba wakho ungakha amasosha omzimba kunoma iyiphi into yangaphandle, kufaka phakathi ama-antibody monoclonal. Uma umzimba wakho wenza amasosha omzimba ku-Aimovig noma ku-Ajovy, umuthi kungenzeka ungabe usakusebenzela.

Ezivivinyweni zomtholampilo ze-Aimovig, abantu abangaphezu kwamaphesenti ayisithupha abantu bakhiqize amasosha omzimba omuthi. Ezifundweni zokwelashwa eziqhubekayo, bangaphansi kwamaphesenti amabili abantu abenze amasosha omzimba ku-Ajovy.

Ngenxa yokuthi i-Aimovig ne-Ajovy zavunyelwa ngonyaka we-2018, kusesekuseni kakhulu ukuthi wazi ukuthi lo mphumela ungavama kangakanani nokuthi ungathinta kanjani ukuthi abantu bayisebenzisa kanjani le mithi ngokuzayo.

Ukusebenza ngempumelelo

I-Aimovig ne-Ajovy zombili ziyasebenza ekuvikeleni ikhanda le-migraine, kepha azizange ziqhathaniswe ngqo ezivivinyweni zomtholampilo.

Kodwa-ke, imihlahlandlela yokwelashwa kwe-migraine incoma noma yisiphi isidakamizwa njengenketho kubantu abathile. Lokhu kufaka phakathi abantu:

• azikwazi ukunciphisa izinsuku zabo zenyanga ze-migraine ngokwanele ngeminye imithi
• ayikwazi ukubekezelela eminye imithi ngenxa yemiphumela emibi noma ukuhlangana kwezidakamizwa

I-episodic migraine

Ucwaningo oluhlukile luka-Aimovig no-Ajovy lukhombise ukusebenza kahle ekuvimbeleni i-episodic migraine headaches.

• Ezifundweni zomtholampilo ze-Aimovig, cishe amaphesenti angama-40 abantu abane-episodic migraine abathole ama-70 mg omuthi nyangazonke basika izinsuku zabo ze-migraine okungenani isigamu sezinyanga eziyisithupha. Kuze kube ngamaphesenti ama-50 wabantu abathola i-140 mg bathola imiphumela efanayo.
• Esifundweni somtholampilo sika-Ajovy, cishe amaphesenti angama-48 abantu abane-episodic migraine abathola ukwelashwa nyangazonke ngomuthi besika izinsuku zabo ze-migraine okungenani isigamu sezinyanga ezintathu. Cishe amaphesenti angama-44 abantu abathola i-Ajovy njalo ezinyangeni ezintathu babe nemiphumela efanayo.

I-migraine engapheli

Ucwaningo oluhlukile luka-Aimovig no-Ajovy lukhombise nokusebenza ekuvikeleni ikhanda elingapheliyo le-migraine.

• Esifundweni semitholampilo sezinyanga ezintathu se-Aimovig, cishe amaphesenti angama-40 abantu abane-migraine engapheli abathola i-70 mg noma i-140 mg yesidakamizwa nyangazonke babenezinsuku eziyizinsuku eziningi zemigraine noma ezimbalwa.
• Esifundweni semitholampilo sezinyanga ezintathu sika-Ajovy, cishe amaphesenti angama-41 abantu abane-migraine engapheli abathola ukwelashwa kwe-Ajovy nyangazonke babenezinsuku eziyizigamu eziningi ze-migraine ngemuva kokwelashwa noma ezimbalwa. Kubantu abathola i-Ajovy njalo ezinyangeni ezintathu, cishe amaphesenti angama-37 athola imiphumela efanayo.

Izindleko

I-Aimovig ne-Ajovy yomibili imishanguzo enegama lomkhiqizo. Azikho izinhlobo ezijwayelekile zomuthi otholakalayo. Imithi enegama lomkhiqizo ngokuvamile ibiza ngaphezu kwamafomu ejwayelekile.

Ngokuya ngesilinganiso esivela kuGoodRx.com, i-Aimovig ne-Ajovy zibiza cishe inani elifanayo. Intengo yangempela ongayikhokhela noma yimuphi umuthi izoncika ohlelweni lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo. Intengo yakho ye-Aimovig nayo izoncika kumthamo wakho.

I-Aimovig vs. Botox

I-Aimovig iqukethe i-antioclonal antibody ebizwa nge-erenumab. I-anti-monoclonal antibody wuhlobo lomuthi owenziwe elebhu. Le mithi yenziwa ngamaseli omzimba. I-Aimovig isebenza ukuvimbela ukuphathwa yikhanda le-migraine ngokuvimba ukusebenza kweprotheni ethile engayibangela.

I-Botox iqukethe umuthi onabotulinumtoxinA. Lo muthi ungowesigaba semithi esibizwa ngama-neurotoxin. IBotox isebenza ngokukhubaza okwesikhashana imisipha efakwe kuyo. Lo mphumela uvimbela amasignali obuhlungu emisipheni ukuthi angasebenzi.Kucatshangwa ukuthi le nqubo isiza ukuvimbela ikhanda le-migraine ngaphambi kokuba liqale.

Isebenzisa

I-Aimovig ivunyelwe yi-FDA ukuvimbela i-episodic noma engapheli ikhanda le-migraine kubantu abadala.

I-Botox ivunyiwe yi-FDA ukuvimbela ikhanda elingapheliyo le-migraine kubantu abadala. I-Botox nayo ivunyelwe ukuphatha ezinye izimo eziningana, njenge:

• i-dystonia yomlomo wesibeletho (intamo esontekile ebuhlungu)
• ukuqhuma kwejwabu leso
• isinye esisebenza ngokweqile
• ukuqina kwemisipha
• ukujuluka okweqile

Amafomu nokuphathwa

I-Aimovig iza njenge-autoinjector ekhethwe ngomthamo owodwa. Unikezwa njengomjovo ngaphansi kwesikhumba sakho (ongaphansi kwesikhumba) ongazinikeza wona ekhaya. Inikezwa ngomthamo we-70 mg noma i-140 mg ngenyanga.

I-Aimovig ingajovwa ezindaweni ezithile zomzimba. Lezi izi:

• isisu sakho
• ngaphambili kwamathanga akho
• ngemuva kwezingalo zakho ezingaphezulu

I-Botox inikezwa kuphela ehhovisi likadokotela. Ijojowe ngesirinji emsipheni (ngaphakathi kwemisipha), imvamisa njalo emavikini ayi-12. Izindawo ezijwayelekile zomjovo zifaka:

• esiphongweni sakho
• ngemuva kwentamo yakho namahlombe
• ngenhla futhi eduze nezindlebe zakho
• eduze kwezinwele zakho ezansi kwentamo yakho

Udokotela wakho uzokunikeza imijovo emincane engama-31 kulezi zindawo ngesikhathi ngasinye.

Imiphumela emibi kanye nezingozi

I-Aimovig neBotox zombili zisetshenziselwa ukuvimbela ukuphathwa yikhanda elibuhlungu, kodwa zisebenza ngezindlela ezahlukene. Ngakho-ke, banemiphumela emibi efanayo futhi abanye bahlukile.

Imiphumela emibi ejwayelekile

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi engaba khona ne-Aimovig, neBotox, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

• Kungenzeka nge-Aimovig:
• ukuqunjelwa
• amajaqamba
• imisipha
• ukuhlungu obusemhlane
• ukutheleleka okuphezulu kokuphefumula (njengokubanda okuvamile noma ukutheleleka kwesono)
• Kungenzeka ngeBotox:
• ikhanda noma i-migraine ebuhlungu
• ijwabu leso ligobekile
• ukukhubazeka kwemisipha ebusweni
• ubuhlungu bentamo
• ukuqina kwemisipha
• ubuhlungu bemisipha nobuthakathaka
• Kungenzeka ngamabili i-Aimovig neBotox:
• ukuphendula kwesiza somjovo
• izimpawu ezinjengomkhuhlane

Imiphumela emibi kakhulu

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi engaba khona ne-Aimovig, neBotox, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

• Kungenzeka nge-Aimovig:
• nemiphumela engemihle embalwa eyingqayizivele
• Kungenzeka ngeBotox:
• ukusabalala kokukhubazeka emisipha eseduzane *
• Inkinga yokugwinya nokuphefumula
• ukutheleleka okungathi sína
• Kungenzeka ngamabili i-Aimovig neBotox:
• ukusabela okweqile komzimba

I-Botox inesixwayiso esibhokisi esivela ku-FDA ngokusabalala kokukhubazeka kuya emisipha eseduze kulandela ukujova. Isexwayiso esibhakeleni yisixwayiso esiqine kakhulu esidingwa yi-FDA. Kwazisa odokotela neziguli ngemiphumela yezidakamizwa engaba yingozi.

Ukusebenza ngempumelelo

Isimo okuwukuphela kwaso ukuthi i-Aimovig neBotox zisetshenziselwa ukuvimbela yizinhlungu ezingapheli ze-migraine.

Imihlahlandlela yokwelashwa incoma i-Aimovig njengenketho kubantu abangakwazi ukunciphisa inani labo lezinsuku ze-migraine ngokwanele ngeminye imishanguzo. Kuyanconywa futhi kubantu abangakwazi ukuthatha eminye imithi ngenxa yemiphumela emibi noma ukuhlangana kwezidakamizwa.

I-Botox inconywa yi-American Academy of Neurology njengenketho yokwelashwa kubantu abane-migraine engapheli.

Ukusebenza kwale mithi akukaze kuqhathaniswe ngqo ezifundweni zokwelashwa. Kodwa-ke, ezifundweni ezihlukene, u-Aimovig noBotox bobabili bathole imiphumela ephumelelayo ekuvimbeleni ikhanda elingapheliyo le-migraine.

• Esifundweni somtholampilo se-Aimovig, cishe amaphesenti angama-40 abantu abane-migraine engapheli abathola i-70 mg noma i-140 mg babenezinsuku ezingama-migraine noma ngaphansi kwezinyanga ezintathu.
• Ezifundweni zokwelashwa zabantu abane-migraine engapheli, iBotox inciphise inani lezinsuku zekhanda kuze kube yizinsuku eziyi-9.2 ngokwesilinganiso ngenyanga, ngaphezu kwamasonto angama-24. Kwesinye isifundo, cishe amaphesenti angama-47 abantu anciphise inani labo lezinsuku zekhanda okungenani uhhafu.

Izindleko

I-Aimovig neBotox yomibili iyimithi enegama lomkhiqizo. Okwamanje awekho amafomu ejwayelekile atholakala kunoma imuphi umuthi.

Ngokwezibalo ezivela kwaGoodRx.com, iBotox imane ibize kancane kune-Aimovig. Intengo yangempela ongayikhokhela noma yimuphi umuthi izoncika kumthamo wakho, uhlelo lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

I-Aimovig vs. Emgality

I-Aimovig iqukethe i-antioclonal antibody ebizwa nge-erenumab. Ubungqabavu buqukethe i-antibody monoclonal ebizwa nge-galcanezumab. I-anti-monoclonal antibody wuhlobo lomuthi owenziwe elebhu. Le mithi yenziwa ngamaseli omzimba. Zisebenza ngokuvimba umsebenzi wamaprotheni athile emzimbeni wakho.

I-Aimovig ne-Emgality zombili zivimba umsebenzi weprotheyini emzimbeni wakho obizwa ngokuthi yi-calcitonin peptide ehlobene nohlobo (CGRP). I-CGRP ibangela ukuvuvukala kanye ne-vasodilation (ukunwetshwa kwemithambo yegazi) ebuchosheni, okungaholela ekhanda le-migraine. Ngokuvimba umsebenzi we-CGRP, le mithi isiza ukumisa ukuvuvukala kanye ne-vasodilation. Lokhu kusiza ukuvimbela i-migraine ikhanda.

Isebenzisa

I-Aimovig ne-Emgality zombili zivunyelwe yi-FDA ukuvimbela ukuphathwa ikhanda kwe-migraine kubantu abadala.

Amafomu nokuphathwa

I-Aimovig inikezwa nge-single-dose preinjector egcwaliswe ngomthamo owodwa. Ubuningi bunikezwa ngesirinji ekhethwe ngomthamo owodwa nepeni eligcwalisiwe lomthamo owodwa. Yomibili le mithi inikezwa njengomjovo ongaphansi (umjovo ngaphansi kwesikhumba). Ungazinikeza imijovo yakho ekhaya kanye ngenyanga.

Yomibili le mithi ingajovwa ngaphansi kwesikhumba ezindaweni ezithile emzimbeni wakho. Lezi izi:

• isisu sakho
• ngaphambili kwamathanga akho
• ngemuva kwezingalo zakho ezingaphezulu

Ukuqina kungabuye kujovwe ngaphansi kwesikhumba sezinqa zakho.

I-Aimovig inqunywe njengomjovo wanyanga zonke we-70-mg noma i-140-mg. Ubunzima bunqunywa njengomjovo wenyanga ongu-120-mg.

Imiphumela emibi kanye nezingozi

I-Aimovig ne-Emgality yizidakamizwa ezifanayo ezibanga imiphumela efanayo efanayo nebi kakhulu. Ngezansi kunezibonelo zale miphumela emibi.

Imiphumela emibi ejwayelekile

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi engaba khona ne-Aimovig, ne-Emgality, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

• Kungenzeka nge-Aimovig:
• ukuqunjelwa
• amajaqamba
• imisipha
• izimpawu ezinjengomkhuhlane
• Kungenzeka nge-Emgality:
• Umphimbo obuhlungu
• Kungenzeka ngamabili i-Aimovig ne-Emgality:
• ukuphendula kwesiza somjovo
• ukuhlungu obusemhlane
• ukutheleleka okuphezulu kokuphefumula (okufana nomkhuhlane ovamile noma ukutheleleka kwesono)

Imiphumela emibi kakhulu

Ukusabela okweqile komzimba kungumphumela omubi ongajwayelekile we-Aimovig ne-Emgality. (Ngeminye imininingwane, bheka “Ukusabela okweqile” ngaphansi kwe- “Aimovig side effects” ngenhla).

Ukusabela komzimba

Ekuvivinyweni komtholampilo ngomuthi ngamunye, inani elincane labantu lalinokuphendula komzimba ku-Aimovig naku-Emgality. Ngalolu hlobo lokuphendula, amasosha omzimba akha izivikeli mzimba ezilwa nemithi.

Amasosha omzimba angamaprotheni kumasosha akho omzimba alwa nezinto zangaphandle emzimbeni wakho. Umzimba wakho ungenza ama-antibody kunoma iyiphi into yangaphandle, kufaka phakathi ama-antibody monoclonal njenge-Aimovig ne-Emgality.

Uma umzimba wakho uba nama-antibody komunye wale mithi, kungenzeka ukuthi umuthi ngeke usasebenza ukuvikela ikhanda le-migraine kuwe.

Ezifundweni zokwelashwa ze-Aimovig, ngaphezu kwamaphesenti ayisithupha abantu abasebenzisa lesi sidakamizwa abenze amasosha omzimba kuso. Futhi ezifundweni zomtholampilo ze-Emgality, cishe amaphesenti ama-5 wabantu athuthukisa amasosha omzimba ku-Emgality.

Ngoba i-Aimovig ne-Emgality zivunyelwe ku-2018, kusesekuseni kakhulu ukwazi ukuthi bangaki abantu abangaba nalolu hlobo lokuphendula. Kusesekuseni kakhulu ukwazi ukuthi kungathinta kanjani ukuthi abantu bayisebenzisa kanjani le mithi ngokuzayo.

Ukusebenza ngempumelelo

I-Aimovig ne-Emgality azange ziqhathaniswe nezifundo zomtholampilo, kepha zombili ziyasebenza ekuvimbeleni ukuphathwa yikhanda elibuhlungu.

Imihlahlandlela yokwelashwa incoma i-Aimovig ne-Emgality njengezinketho zabantu abane-episodic noma i-migraine engapheli abathi:

• ayikwazi ukuthatha eminye imithi ngenxa yemiphumela emibi noma ukuhlangana kwezidakamizwa
• ayikwazi ukunciphisa inani labo lezinsuku zenyanga ze-migraine ngokwanele ngeminye imithi

I-episodic migraine

Ucwaningo oluhlukile lwe-Aimovig ne-Emgality lukhombisile ukuthi yomibili le mithi iyasebenza ekuvikeleni ikhanda le-episodic migraine.

• Ezifundweni zokwelashwa ze-Aimovig, kuze kufike kumaphesenti angama-50 abantu abane-episodic migraine abathola i-140 mg yesidakamizwa banciphisa izinsuku zabo ze-migraine okungenani uhhafu ngaphezu kwezinyanga eziyisithupha. Cishe amaphesenti angama-40 abantu abathole ama-70 mg babone imiphumela efanayo.
• Ezifundweni zomtholampilo ze-Emgality zabantu abane-episodic migraine, cishe amaphesenti ama-60 wabantu anciphise inani labo lezinsuku ze-migraine okungenani uhhafu ngaphezu kwezinyanga eziyisithupha zokwelashwa kwe-Emgality. Kuze kube ngamaphesenti ayi-16 abengenayo i-migraine ngemuva kwezinyanga eziyisithupha zokwelashwa.

I-migraine engapheli

Ucwaningo oluhlukile lwe-Aimovig ne-Emgality lubonise ukuthi yomibili le mithi iyasebenza ekuvikeleni ikhanda elingapheliyo le-migraine:

• Esifundweni semitholampilo sezinyanga ezintathu sabantu abane-migraine engapheli, cishe amaphesenti angama-40 abantu abathathe i-70 mg noma i-140 mg ye-Aimovig babenezinsuku ezinhlanu zezinsuku ze-migraine noma abambalwa ngokwelashwa.
• Ocwaningweni lwezinyanga ezintathu lwezemitholampilo lwabantu abane-migraine engapheli, cishe amaphesenti angama-30 wabantu abathathe i-Emgality izinyanga ezintathu babenezinsuku eziyizigamu eziningi zemigraine noma abambalwa ngokwelashwa.

Izindleko

I-Aimovig ne-Emgality yomibili imishanguzo enegama lomkhiqizo. Okwamanje awekho amafomu ejwayelekile atholakala kunoma imuphi umuthi. Izidakamizwa ezibizwa ngegama lomkhiqizo ngokuvamile zibiza ngaphezu kwama-generic.

Ngokuya ngokulinganisela okuvela ku-GoodRx.com, i-Aimovig ne-Emgality zibiza cishe inani elifanayo. Intengo yangempela ongayikhokhela noma yimuphi umuthi izoncika kumthamo wakho, uhlelo lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

I-Aimovig vs. Topamax

I-Aimovig iqukethe i-antioclonal antibody ebizwa nge-erenumab. I-anti-monoclonal antibody wuhlobo lomuthi owenziwe ngamaseli omzimba. Izidakamizwa zalolu hlobo zenziwa elebhu. I-Aimovig isiza ukuvimbela ukuphathwa yikhanda le-migraine ngokumisa ukusebenza kwamaprotheni athile awabangelayo.

I-Topamax iqukethe i-topiramate, uhlobo lomuthi obuye usetshenziselwe ukwelapha ukuquleka. Akuqondakali kahle ukuthi iTopamax isebenza kanjani ukuvimbela ikhanda elibuhlungu be-migraine. Kucatshangwa ukuthi lesi sidakamizwa sinciphisa amaseli emizwa asebenzayo ngokweqile ebuchosheni angadala ikhanda le-migraine.

Isebenzisa

Kokubili i-Aimovig ne-Topamax zivunyelwe yi-FDA ukuvimbela ukuphathwa ikhanda kwe-migraine. I-Aimovig ivunyelwe ukusetshenziswa kubantu abadala, kuyilapho iTopamax ivunyelwe ukusetshenziswa kubantu abadala nezingane ezineminyaka engu-12 nangaphezulu.

ITopamax nayo ivunyelwe ukwelapha isithuthwane.

Amafomu nokuphathwa

I-Aimovig iza ngomthamo owodwa ozenzakalelayo we-autoinjector. Unikezwa njengomjovo ngaphansi kwesikhumba sakho (ngaphansi kwesikhumba) ozinika sona ekhaya kanye ngenyanga. Umthamo ojwayelekile ungama-70 mg, kepha abanye abantu bangazuza kumthamo we-140-mg.

I-Topamax iza njenge-capsule yomlomo noma ithebhulethi yomlomo. Umthamo ojwayelekile ngu-50 mg othathwa kabili ngosuku. Ngokuya ngesincomo sikadokotela wakho, ungaqala ngomthamo ophansi bese uwukhuphukela kumthamo ojwayelekile ezinyangeni ezimbalwa.

Imiphumela emibi kanye nezingozi

I-Aimovig neTopamax zisebenza ngezindlela ezahlukene emzimbeni ngakho-ke zinemiphumela engemihle eyehlukene. Eminye yemiphumela emibi ejwayelekile futhi emibi yezidakamizwa zombili ingezansi. Uhlu olungezansi alubandakanyi yonke imiphumela emibi engaba khona.

Imiphumela emibi ejwayelekile

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi engaba khona ne-Aimovig, ne-Topamax, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

• Kungenzeka nge-Aimovig:
• ukuphendula kwesiza somjovo
• ukuhlungu obusemhlane
• ukuqunjelwa
• amajaqamba
• ukuphazamiseka kwemisipha
• izimpawu ezinjengomkhuhlane
• Kungenzeka nge-Topamax:
• Umphimbo obuhlungu
• ukukhathala
• i-paresthesia (ukuzwa "kwezikhonkwane nezinaliti")
• isicanucanu
• isifo sohudo
• ukuncipha komzimba
• ukulahlekelwa isifiso sokudla
• unenkinga yokugxila
• Kungenzeka ngamabili i-Aimovig ne-Topamax:
• ukutheleleka komgudu wokuphefumula (njengokubanda okuvamile noma ukutheleleka kwesono)

Imiphumela emibi kakhulu

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi engaba khona ne-Aimovig, ne-Topamax, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

• Kungenzeka nge-Aimovig:
• nemiphumela engemihle embalwa eyingqayizivele
• Kungenzeka nge-Topamax:
• izinkinga zombono, kufaka phakathi i-glaucoma
• ukunciphisa ukujuluka (ukungakwazi ukulawula ukushisa komzimba)
• i-metabolic acidosis
• imicabango yokuzibulala nezenzo
• izinkinga zokucabanga ezifana nokudideka nezinkinga zememori
• ukudana
• i-encephalopathy (isifo sobuchopho)
• amatshe ezinso
• ukuqubuka okwengeziwe lapho umuthi umiswa ngokuzumayo (lapho umuthi usetshenziselwa ukwelashwa kokuquleka)
• Kungenzeka ngamabili i-Aimovig ne-Topamax:
• ukusabela okweqile komzimba

Ukusebenza ngempumelelo

Inhloso kuphela i-Aimovig ne-Topamax evunyelwe yi-FDA ukuvimbela i-migraine.

Imihlahlandlela yokwelashwa incoma i-Aimovig njengenketho yokuvimbela i-episodic noma engapheli migraine ikhanda kubantu:

• ayikwazi ukuthatha eminye imithi ngenxa yemiphumela emibi noma ukuhlangana kwezidakamizwa
• ayikwazi ukunciphisa inani labo lezinyanga zonke zekhanda elibuhlungu elanele ngeminye imithi

Imihlahlandlela yokwelashwa incoma i-Topiramate njengenketho yokuvimbela i-episodic migraine headaches.

Izifundo zomtholampilo azizange ziqhathanise ngokuqondile ukusebenza kwalezi zidakamizwa ezimbili ekuvimbeleni ukuphathwa yikhanda elibuhlungu. Kepha izidakamizwa zifundwe ngokwehlukana.

I-episodic migraine

Ucwaningo oluhlukile lwe-Aimovig neTopamax lukhombisile ukuthi yomibili le mithi yayisebenza ekuvikeleni ikhanda le-episodic migraine.

• Ezifundweni zomtholampilo ze-Aimovig, kuze kufike kumaphesenti angama-50 abantu abane-episodic migraine abathola i-140 mg basike izinsuku zabo ze-migraine okungenani isigamu sezinyanga eziyisithupha zokwelashwa. Cishe amaphesenti angama-40 abantu abathole ama-70 mg babone imiphumela efanayo.
• Ezifundweni zomtholampilo zabantu abane-episodic migraine abathathe i-Topamax, labo abaneminyaka engu-12 nangaphezulu babenekhanda elincane elingaba mabili le-migraine njalo ngenyanga. Izingane ezineminyaka engu-12 kuya ku-17 ezine-episodic migraine zaziphathwa yikhanda elincane kathathu njalo ngenyanga.

I-migraine engapheli

Ucwaningo oluhlukile lwemithi lukhombise ukuthi bobabili i-Aimovig neTopamax babephumelela ekuvikeleni ikhanda elingapheliyo le-migraine:

• Esifundweni sezinyanga ezintathu sokuhlolwa komtholampilo se-Aimovig, cishe amaphesenti angama-40 abantu abanezinhlungu ezingapheli ze-migraine abathola i-70 mg noma i-140 mg babenezinsuku eziyizigamu eziningi zemigraine noma ezimbalwa ngemuva kokwelashwa.
• Esicwaningweni esibheke imiphumela yezilingo eziningana zemitholampilo kutholakale ukuthi kubantu abane-migraine engapheli, i-Topamax inciphise isibalo se-migraine ikhanda noma ikhanda cishe cishe emihlanu kuya kweziyisishiyagalolunye inyanga ngayinye.

Izindleko

I-Aimovig ne-Topamax yomibili iyimithi enegama lomkhiqizo. Imithi enegama lomkhiqizo imvamisa ibiza ngaphezu kwemithi ejwayelekile. I-Aimovig ayitholakali ngendlela ejwayelekile, kepha iTopamax iza njengejenerikhi ebizwa nge-topiramate.

Ngokwezibalo ezivela kwaGoodRx.com, iTopamax ingabiza kakhulu noma ngaphansi kuka-Aimovig, kuya ngomthamo wakho. Futhi i-topiramate, ifomu elijwayelekile le-Topamax, izobiza ngaphansi kune-Topamax noma i-Aimovig.

Intengo yangempela ongayikhokhela noma iyiphi yalezi zidakamizwa izoncika kumthamo wakho, uhlelo lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

I-Aimovig notshwala

Akukho ukuxhumana phakathi kwe-Aimovig notshwala.

Noma kunjalo, abanye abantu bangazizwa ukuthi umuthi awusebenzi kangako uma bephuza utshwala ngenkathi bethatha i-Aimovig. Lokhu kungenxa yokuthi utshwala bungaba yisisusa se-migraine kubantu abaningi. Ngisho notshwala obuncane bungadala i-migraine kubo.

Kufanele ugweme iziphuzo eziqukethe utshwala uma uthola ukuthi utshwala budala ikhanda elibuhlungu kakhulu noma elibuhlungu njalo.

Ukusebenzisana kwe-Aimovig

Izidakamizwa eziningi zingasebenzisana neminye imithi. Imiphumela ehlukene ingabangelwa ukuxhumana okuhlukile. Isibonelo, ukuxhumana okuthile kungaphazamisa ukuthi usebenza kanjani umuthi, kanti okunye kungadala imiphumela emibi eminingi.

I-Aimovig ngokuvamile ayinakho ukuxhumana kwezidakamizwa. Lokhu kungenxa yendlela i-Aimovig icutshungulwa ngayo emzimbeni wakho.

I-Aimovig ihlanganiswa kanjani

Izidakamizwa eziningi, amakhambi, nezithasiselo zenziwa umzimba (zicutshungulwe) ngama-enzyme esibindini sakho. Kodwa izidakamizwa ze-monoclonal antibody, njenge-Aimovig, azivame ukucubungulwa esibindini. Esikhundleni salokho, lolu hlobo lomuthi luyacutshungulwa ngaphakathi kwamanye amaseli emzimbeni wakho.

Ngoba i-Aimovig ayicutshungulwa esibindini njengezinye izidakamizwa eziningi, ngokuvamile ayihlangani nezinye izidakamizwa.

Uma unanoma ikuphi ukukhathazeka ngokuhlanganisa i-Aimovig neminye imithi ongase uyiphuze, khuluma nodokotela wakho. Futhi qiniseka ukubatshela ngayo yonke imishanguzo kadokotela, i-counter-counter, neminye imithi oyiphuzayo. Kufanele futhi ubatshele nganoma yimaphi amakhambi, amavithamini, nezithako zokudla okunomsoco ozisebenzisayo.

Imiyalo yokuthi ungayithatha kanjani i-Aimovig

I-Aimovig iza njengomjovo onikezwa ngaphansi kwesikhumba sakho (ngaphansi kwesikhumba). Uzinika umjovo ekhaya kanye ngenyanga. Isikhathi sokuqala lapho uthola khona incwadi kadokotela ye-Aimovig, umhlinzeki wakho wezokunakekelwa kwempilo uzochaza ukuthi ungazinika kanjani umjovo.

I-Aimovig iza ngomthamo owodwa (70 mg) autoinjector. I-autoinjector ngayinye iqukethe umthamo owodwa kuphela futhi yenzelwe ukuthi isetshenziswe kanye bese ilahlwa kude. (Uma udokotela wakho ekunika i-140 mg ngenyanga, uzosebenzisa ama-autoinjectors amabili inyanga ngayinye.)

Ngezansi kunemininingwane yokuthi ungasisebenzisa kanjani isirinji ekhethiwe. Ngeminye imininingwane, ividiyo, nezithombe zemiyalo yomjovo, bona iwebhusayithi yomkhiqizi.

Ungayijova kanjani

Udokotela wakho uzonquma noma i-70 mg kanye ngenyanga noma i-140 mg kanye ngenyanga. Uma unqunywe u-70 mg njalo ngenyanga, uzozinika umjovo owodwa. Uma unqunywe u-140 mg njalo ngenyanga, uzozinika imijovo emibili ehlukene, enye emva kwenye.

Ilungiselela ukujova

• Thatha i-Aimovig autoinjector yakho esiqandisini imizuzu engama-30 ngaphambi kokuhlela ukwenza umjovo wakho. Lokhu kuzovumela umuthi ukuthi ufudumale ekamelweni lokushisa. Shiya ikepisi kudivayisi ye-autoinjector uze ulungele ukujova umuthi.
• Ungazami ukufudumeza i-autoinjector ngokushesha ngokuyigcina ngemayikhro microwave noma ukusebenzisa amanzi ashisayo phezu kwayo. Futhi, unganyakazisi i-autoinjector. Ukwenza lezi zinto kungenza i-Aimovig iphephe kakhulu futhi isebenze kahle.
• Uma ulahle ngephutha i-autoinjector, ungayisebenzisi. Izingxenye ezincane ze-autoinjector zingahle ziphulwe ngaphakathi, noma ngabe awukwazi ukubona noma yimuphi umonakalo.
• Ngenkathi ulinde i-Aimovig ukuthi ize ekamelweni lokushisa, thola ezinye izinto ozozidinga. Lokhu kufaka phakathi:
• ukusula utshwala
• ukotini amabhola noma gauze
• amabhandeshi okunamathela
• Isiqukathi sokulahla esishisayo
• Hlola i-autoinjector bese uqinisekisa ukuthi umuthi awubukeki unamafu. Kufanele ingabi nombala ophuzi okhanyayo kakhulu ngombala. Uma ibukeka ingekho umbala, inamafu, noma inezicucu eziqinile kuketshezi, ungayisebenzisi. Uma kudingeka, xhumana nodokotela wakho mayelana nokuthola okusha. Futhi, hlola usuku lokuphelelwa yisikhathi kudivayisi ukuze uqiniseke ukuthi umuthi awuphelelwe yisikhathi.
• Ngemuva kokugeza izandla zakho ngensipho namanzi, khetha indawo yokujova. I-Aimovig ingajovwa kulezi zindawo:
• isisu sakho (okungenani amasentimitha ama-2 kude nenkinobho yesisu sakho)
• ngaphambili kwamathanga akho (okungenani amasentimitha ama-2 ngaphezulu kwamadolo akho noma ama-intshi amabili ngaphansi kwe-groin yakho
• ngemuva kwezingalo zakho ezingaphezulu (uma omunye umuntu ekujova)
• Sebenzisa ukusula utshwala ukuhlanza indawo ohlela ukujova kuyo. Vumela utshwala bome ngokuphelele ngaphambi kokujova umuthi.
• Ungafaki i-Aimovig endaweni yesikhumba elimele, eqinile, ebomvu, noma ethambile.

Kusetshenziswa i-autoinjector

1. Donsa ikepisi elimhlophe uqonde ku-autoinjector. Ungakwenzi lokhu ngaphezu kwemizuzu emihlanu ngaphambi kokusebenzisa le divayisi.
2. Nweba noma uphine indawo yesikhumba lapho uhlela khona ukujova umuthi. Dala indawo eqinile yesikhumba cishe ngamasentimitha amabili ububanzi ngomjovo wakho.
3. Beka i-autoinjector esikhumbeni sakho nge-engela engu-90 degree. Cindezela ngokuqinile ungene esikhunjeni sakho lapho izofika khona.
4. Cindezela inkinobho yokuqala ephephuli phezulu kwe-autoinjector uze uzwe ukuchofoza.
5. Dedela inkinobho yokuqala ephephuli kodwa uqhubeke ubambe i-autoinjector yehle esikhunjeni sakho kuze kube yilapho iwindi ku-autoinjector liphenduka liphuzi. Ungase futhi uzwe noma uzizwe “uchofoze” Lokhu kungathatha amasekhondi angu-15. Kubalulekile ukwenza lesi sinyathelo ukuqinisekisa ukuthi uthola wonke umthamo.
6. Susa i-autoinjector esikhunjeni sakho bese uyilahla esitsheni sakho sokulahla esibukhali.
7. Uma kukhona igazi endaweni yokujova, cindezela ibhola likakotini noma i-gauze esikhunjeni, kodwa ungalihlikihli. Sebenzisa ibhandeshi lokunamathela uma kudingeka.
8. Uma umthamo wakho ungu-140 mg ngenyanga, phinda lezi zinyathelo nge-autoinjector yesibili. Ungasebenzisi isiza esifanayo somjovo njengomjovo wokuqala.

Isikhathi

I-Aimovig kufanele ithathwe kanye ngenyanga. Ingathathwa nganoma yisiphi isikhathi sosuku.

Uma uphuthelwa umthamo, thatha i-Aimovig ngokushesha okukhulu lapho ukhumbula khona. Umthamo olandelayo kufanele ube yinyanga eyodwa ngemuva kokuthatha lowo. Ukusebenzisa ithuluzi lesikhumbuzo semithi kungakusiza ukuthi ukhumbule ukuthatha i-Aimovig ngesikhathi.

Ukuthatha i-Aimovig ngokudla

I-Aimovig ingathathwa ngokudla noma ngaphandle kokudla.

Isitoreji

I-Aimovig kufanele igcinwe esiqandisini. Ingakhishwa esiqandisini kepha kufanele isetshenziswe kungakapheli izinsuku eziyisikhombisa. Ungayibeki esiqandisini uma isithathiwe futhi yalethwa ekamelweni lokushisa.

Ungamisi i-Aimovig. Futhi, yigcine ephaketheni layo langempela ukuyivikela ekukhanyeni.

Isebenza kanjani i-Aimovig

I-Aimovig yisidakamizwa esibizwa ngokuthi yi-monoclonal antibody. Lolu hlobo lomuthi lwenziwa elebhu kusuka kumaprotheni amasosha omzimba. I-Aimovig isebenza ngokumisa umsebenzi weprotheyini emzimbeni wakho obizwa ngokuthi yi-calcitonin peptide ehlobene nohlobo (CGRP). I-CGRP ingadala ukuvuvukala kanye ne-vasodilation (ukunwetshwa kwemithambo yegazi) ebuchosheni bakho.

Ukuvuvukala kanye ne-vasodilation okulethwe yi-CGRP kuyimbangela engaba khona yekhanda le-migraine. Eqinisweni, lapho ikhanda le-migraine liqala ukuvela, abantu banamazinga aphezulu we-CGRP egazini labo. I-Aimovig isiza ukuvimbela i-migraine ngokumisa umsebenzi we-CGRP.

Ngenkathi imithi eminingi isebenza ngokuthinta izinto eziningi emzimbeni wakho, ama-antibody monoclonal anjenge-Aimovig asebenza kwiprotheni elilodwa kuphela emzimbeni. Ngenxa yalokhu, i-Aimovig ingadala ukuhlangana okumbalwa kwezidakamizwa nemiphumela engemihle. Lokhu kungenza kube yindlela enhle yokwelashwa kubantu abangakwazi ukuthatha eminye imithi ngenxa yemiphumela emibi noma ukuxhumana.

I-Aimovig futhi ingaba yindlela enhle yokwelashwa kubantu abangatholanga omunye umuthi onganciphisa izinsuku zabo ze-migraine ngokwanele.

Kuthatha isikhathi esingakanani ukusebenza?

Ngemuva kokuthi uqale ukuthatha i-Aimovig, kungathatha amasonto ambalwa ukubona ukuthuthuka ekhanda lakho le-migraine. I-Aimovig ingasebenza ngokugcwele ngemuva kwezinyanga ezimbalwa.

Abantu abaningi abathathe i-Aimovig ngesikhathi sokuhlolwa komtholampilo babenezinsuku ezimbalwa ze-migraine kungakapheli inyanga eyodwa beqale lo muthi. Abantu babenezinsuku ezimbalwa ze-migraine ngemuva kokuqhubeka nokwelashwa ezinyangeni ezimbalwa.

I-Aimovig nokukhulelwa

Akuzange kube nezifundo ezanele ezenziwe ukwazi ukuthi ngabe i-Aimovig iphephile yini ukuyithatha ngesikhathi sokukhulelwa. Izifundo zezilwane azikhombisanga bungozi ekukhulelweni ngenkathi i-Aimovig inikezwa owesifazane okhulelwe. Kodwa-ke, izifundo zezilwane azihlali zibikezela ukuthi izidakamizwa zizophepha yini kubantu.

Uma ukhulelwe noma ucabanga ukukhulelwa, khuluma nodokotela wakho ukubona ukuthi i-Aimovig ikulungele yini. Kungase kudingeke ukuthi ulinde uze ungabe usakhulelwa ukuze usebenzise i-Aimovig.

I-Aimovig nokuncelisa ibele

Akwaziwa ukuthi i-Aimovig idlulela ebisini lwebele. Ngakho-ke, akucaci ukuthi i-Aimovig iphephile yini ukusebenzisa ngenkathi uncelisa.

Uma ucabanga ukwelashwa nge-Aimovig ngenkathi uncelisa ingane yakho, khuluma nodokotela wakho ngezinzuzo nezingozi. Ungadinga ukuyeka ukuncelisa uma uqala ukuthatha i-Aimovig.

Imibuzo ejwayelekile nge-Aimovig

Nazi izimpendulo zemibuzo ebuzwa njalo nge-Aimovig.

Ingabe ukumisa i-Aimovig kudala ukuhoxa?

Akubanga khona mibiko ngemiphumela yokuhoxa ngemuva kokumisa i-Aimovig. Kodwa-ke, i-Aimovig isanda kuvunywa yi-FDA, ngonyaka ka-2018. Isibalo sabantu abake basebenzisa futhi bayeke ukwelashwa kwe-Aimovig sisanqunyelwe.

Ingabe i-Aimovig yi-biologic?

Yebo. I-Aimovig iyi-anti-monoclonal antibody, okuluhlobo lwe-biologic. I-biologic yisidakamizwa esakhiwe kusuka kokuphilayo, kunamakhemikhali.

Ngenxa yokuthi basebenzisana namaseli namasosha omzimba akhethekile kakhulu, i-biologics efana ne-Aimovig kucatshangwa ukuthi inemiphumela emibi embalwa uma iqhathaniswa nezidakamizwa ezithinta uhla olubanzi lwezinhlelo zomzimba, njengoba ezinye izidakamizwa ze-migraine zenza.

Ungayisebenzisa i-Aimovig ukwelapha i-migraine?

Cha. I-Aimovig isetshenziselwa kuphela ukuvimbela ikhanda le-migraine ngaphambi kokuba liqale. Ngeke kusebenze ukwelapha i-migraine eseyiqalile.

Ngabe i-Aimovig iyayelapha yini i-migraine?

Cha, i-Aimovig ngeke ilaphe i-migraine. Ayikho imithi okwamanje etholakalayo yokwelapha i-migraine.

I-Aimovig yehluke kanjani kwezinye izidakamizwa ze-migraine?

I-Aimovig yehlukile kunezinye izidakamizwa eziningi ze-migraine ngoba kwakuyimithi yokuqala evunyelwe yi-FDA eyenziwe ngokukhethekile ukuvikela ukuphathwa yikhanda le-migraine. I-Aimovig iyingxenye yesigaba esisha semithi ebizwa ngokuthi yi-calcitonin peptide ehlobene nohlobo lwe-peptide (CGRP).

Iningi leminye imishanguzo esetshenziselwa ukuvimbela ukuphathwa yikhanda elibuhlungu empeleni lenzelwe ezinye izizathu, njengokulapha ukuquleka, umfutho wegazi ophakeme noma ukucindezeleka. Eziningi zalezi zidakamizwa zisetshenzisiwe ngaphandle kwelebula ukuvimbela ikhanda le-migraine.

Ukuba umjovo wanyanga zonke kwenza i-Aimovig yehluke kwezinye izidakamizwa eziningi zokuvimbela i-migraine. Iningi lalezi ezinye izidakamizwa ziza njengamaphilisi noma amaphilisi. I-Botox esinye isidakamizwa esiza njengomjovo. Kodwa-ke, kufanele inikezwe ehhovisi likadokotela kanye njalo ezinyangeni ezintathu. Ungazinikeza imijovo ye-Aimovig ekhaya.

Futhi ngokungafani nezinye izidakamizwa eziningi zokuvimbela i-migraine, i-Aimovig iyi-antibody monoclonal. Lolu uhlobo lwemithi olwenziwe ebhodini. Yenziwe ngamaseli omzimba omzimba.

Ama-antibody e-monoclonal aphukile ngaphakathi kwamaseli amaningi ahlukene emzimbeni. Eminye imishanguzo yokuvimbela i-migraine yehliswa yisibindi. Ngenxa yalomehluko, ama-antibody monoclonal anjenge-Aimovig ajwayele ukuba nokuhlangana okumbalwa kwezidakamizwa kuneminye imithi esetshenziselwa ukuvimbela ukuphathwa yikhanda elibuhlungu.

Uma ngithatha i-Aimovig, ngingayeka ukuthatha eminye imithi yami yokuvikela?

Mhlawumbe. Umzimba womuntu ngamunye uzophendula ku-Aimovig ngokuhlukile. Uma i-Aimovig inciphisa inani lezinhlungu ze-migraine onazo, ungakwazi ukuyeka ukuthatha eminye imithi yokuvikela. Kepha lapho uqala ukwelashwa, udokotela wakho mhlawumbe uzoncoma ukuthi uqale ukuthatha i-Aimovig kanye neminye imithi yokuvikela.

Ngemuva kokuthi uthathe u-Aimovig izinyanga ezimbili kuya kwezintathu, udokotela wakho uzokhuluma nawe ngokuthi umuthi usebenza kanjani kuwe. Wena nodokotela wakho ningaxoxa ngokumisa eminye imithi yokuvikela oyithathayo noma ukunciphisa umthamo wakho wale mithi.

Ukudlula ngokweqile kwe-Aimovig

Ukujova imithamo eminingi ye-Aimovig kungakhuphula ubungozi bokuphendulwa kwesiza somjovo. Uma uxabana no-Aimovig noma u-hypersensitive ku-Aimovig noma ku-latex (isithako esisezikhwameni ze-Aimovig), ungaba sengozini yokuphendula okubi kakhulu.

Izimpawu zokudlula ngokweqile

Izimpawu zokudlula ngokweqile zingabandakanya:

• ubuhlungu obukhulu, ukulunywa, noma ubomvu endaweni eseduze nomjovo
• ukuqhuma
• isifuba
• i-angioedema (ukuvuvukala ngaphansi kwesikhumba)
• ukuvuvukala kolimi, umphimbo, noma umlomo
• inkinga yokuphefumula

Okufanele ukwenze uma kwenzeka ukweqisa ngokweqile

Uma ucabanga ukuthi uthathe kakhulu lo muthi, shayela udokotela wakho noma funa ukuholwa yi-American Association of Poison Control Centers ku-800-222-1222 noma ngethuluzi labo eliku-inthanethi. Kepha uma izimpawu zakho zinzima, shayela ku-911 noma uye egumbini lezimo eziphuthumayo eliseduze ngokushesha.

Izexwayiso ze-Aimovig

Ngaphambi kokuthatha i-Aimovig, khuluma nodokotela wakho ngomlando wakho wezempilo. I-Aimovig kungenzeka ingakulungeli uma unezimo ezithile zezokwelapha. Lokhu kufaka phakathi:

• Ukungezwani komzimba nelatex. I-Aimovig autoinjector iqukethe uhlobo lwenjoloba olufana ne-latex. Lokhu kungadala ukusabela okweqile kubantu abane-aleji ku-latex. Uma unomlando wokusabela okunzima emikhiqizweni equkethe i-latex, i-Aimovig kungenzeka ingabi umuthi ofanele kuwe.

Ukuphelelwa yisikhathi nokugcinwa kwe-Aimovig

Lapho u-Aimovig ekhishwa ekhemisi, usokhemisi uzokwengeza usuku lokuphelelwa yisikhathi kwilebula esebhodleleni. Lolu suku luvame unyaka owodwa kusukela ngosuku okwakhishwa ngalo umuthi.

Inhloso yezinsuku zokuphelelwa isikhathi ezinjalo ukuqinisekisa ukusebenza komuthi ngalesi sikhathi. Isimo samanje se-Food and Drug Administration (i-FDA) ukugwema ukusebenzisa imishanguzo ephelelwe yisikhathi.

Ukuthi umuthi uhlala ulungile isikhathi eside kangakanani kungancika ezintweni eziningi, kufaka phakathi ukuthi umuthi ugcinwa kanjani futhi kuphi.

I-autoimjector efakwe i-Aimovig kufanele igcinwe esiqandisini. Ingagcinwa ngaphandle kwesiqandisi kuze kube yizinsuku eziyisikhombisa. Ungabuyeli esiqandisini uma sekufinyelele ekamelweni lokushisa.

Unganyakazisi noma ubambe iqhwa le-Aimovig autoinjector. Futhi gcina i-autoinjector emaphaketheni oqobo ukuyivikela ekukhanyeni.

Uma usebenzise umuthi ongasetshenziswanga osudlulile esikhathini sokuphelelwa yisikhathi, khuluma nosokhemisi wakho mayelana nokuthi usengakwazi yini ukuwusebenzisa.

Imininingwane yobungcweti ye-Aimovig

Imininingwane elandelayo inikezwa odokotela nabanye ochwepheshe bezempilo.

Indlela yokusebenza

I-Aimovig (erenumab) i-anti-monoclonal antibody ebopha i-calcitonin ephathelene ne-peptide (CGRP) receptor futhi ivimbele i-CGRP ligand ekusebenziseni i-receptor.

I-Pharmacokinetics ne-metabolism

I-Aimovig ilawulwa njalo ngenyanga futhi ifinyelela ekugxileni okuqinile ngemuva kwemithamo emithathu. Ukuhlushwa okukhulu kufinyelelwa ezinsukwini eziyisithupha. I-Metabolism ayenzeki ngezindlela ze-cytochrome P450.

Ukubophezela ku-CGRP kuyagcwaliseka futhi kuqhuba ukuqedwa ezindaweni ezinomqondo ophansi. Ezingxenyeni eziphakeme, i-Aimovig isuswa ngezindlela ezingezona ezehlukile ze-proteolytic. Ukukhubazeka kwe-renal noma i-hepatic akulindelekile ukuthi kuthinte izakhiwo ze-pharmacokinetic.

Izimo

Akukho ukuphikisana nokusetshenziswa kwe-Aimovig.

Isitoreji

I-autoinjector efakwe i-Aimovig kufanele igcinwe esiqandisini ezingeni lokushisa eliphakathi kuka-36⁰F no-46⁰F (2⁰C no-8⁰C). Ingasuswa esiqandisini futhi igcinwe ekamelweni lokushisa (kufika ku-77⁰F, noma ku-25⁰C) izinsuku eziyi-7.

Gcina i-Aimovig emaphaketheni oqobo ukuyivikela ekukhanyeni. Ungayibeki emuva esiqandisini uma sekufike ekamelweni lokushisa. Ungafaki iqhwa noma unyakazise i-Aimovig autoinjector.

Ukuzikhulula: IMedical News Namuhla yenze yonke imizamo yokuqinisekisa ukuthi yonke imininingwane iyiqiniso, iphelele futhi ihambisana nesikhathi. Kodwa-ke, le ndatshana akufanele isetshenziswe njengokungena esikhundleni solwazi nobungoti bochwepheshe bezokunakekelwa kwezempilo onelayisense. Kufanele uhlale uthintana nodokotela wakho noma omunye uchwepheshe wezokunakekelwa kwempilo ngaphambi kokuthatha noma imuphi umuthi. Imininingwane yezidakamizwa equkethwe lapha ingashintsha futhi ayihloselwe ukumboza konke ukusetshenziswa okungaba khona, izinkomba, izixwayiso, izexwayiso, ukuxhumana kwezidakamizwa, ukungezwani komzimba, noma imiphumela emibi. Ukungabikho kwezixwayiso noma olunye ulwazi lomuthi othile awukhombisi ukuthi inhlanganisela yezidakamizwa noma yezidakamizwa iphephile, iyasebenza, noma ilungele zonke iziguli noma konke ukusetshenziswa okuthile.