I-Nicotinamide Riboside: Izinzuzo, Imiphumela emibi kanye Nesilinganiso

-Delile

• Iyini iNicotinamide Riboside?
• Izinzuzo Ezingaba khona
• Iguqulwe kalula ibe yi-NAD +
• Yenza kusebenze ama-enzyme angakhuthaza ukuguga okunempilo
• Kwangathi Kungasiza Ukuvikela Amaseli Obuchopho
• Kwangathi Ingozi Yezifo Zenhliziyo Ephansi
• Ezinye Izinzuzo Ezingaba khona
• Izingozi Ezingaba Khona Nemiphumela engemihle
• Isikali nezincomo
• Okusemqoka

Njalo ngonyaka, abaseMelika basebenzisa izigidigidi zamaRandi kwimikhiqizo elwa nokuguga.

Ngenkathi imikhiqizo eminingi elwa nokuguga izama ukuguqula izimpawu zokuguga esikhunjeni sakho, i-nicotinamide riboside - ebizwa nangokuthi i-niagen - ihlose ukubuyisa izimpawu zokuguga ngaphakathi komzimba wakho.

Ngaphakathi komzimba wakho, i-nicotinamide riboside iguqulwa ibe yi-NAD +, i-molecule yomsizi ekhona ngaphakathi kwamaseli akho futhi isekela izici eziningi zokuguga okunempilo.

Lo mbhalo uchaza konke odinga ukukwazi mayelana ne-nicotinamide riboside, kufaka phakathi izinzuzo zayo, imiphumela emibi kanye nomthamo.

Iyini iNicotinamide Riboside?

INicotinamide riboside, noma i-niagen, iyenye indlela kavithamini B3, ebizwa nangokuthi i-niacin.

Njengezinye izinhlobo zikavithamini B3, i-nicotinamide riboside iguqulwa ngumzimba wakho ibe yi-nicotinamide adenine dinucleotide (NAD +), i-coenzyme noma i-molecule yomsizi.

I-NAD + isebenza njengophethiloli wezinqubo eziningi eziyinhloko zebhayoloji, njenge (,):

• Ukuguqula ukudla kube ngamandla
• Ilungisa i-DNA elimele
• Ukuqinisa amaseli wokuvikela amaseli
• Ukusetha iwashi lomzimba wakho langaphakathi noma isigqi se-circadian

Kodwa-ke, inani le-NAD + emzimbeni wakho ngokwemvelo lehla ngobudala ().

Amazinga aphansi e-NAD + axhunyaniswe nokukhathazeka kwezempilo njengokuguga nezifo ezingalapheki, njengesifo sikashukela, isifo senhliziyo, isifo se-Alzheimer kanye nokulahleka kombono ().

Kuyathakazelisa ukuthi ucwaningo lwezilwane luthole ukuthi ukukhulisa amazinga e-NAD + kungasiza ekuguquleni izimpawu zokuguga futhi kwehlise ubungozi bezifo eziningi ezingamahlalakhona (,,).

Izithasiselo zeNicotinamide riboside - njenge-niagen - sezidume ngokushesha ngoba zibonakala zisebenza kakhulu ekukhuliseni amazinga we-NAD + ().

INicotinamide riboside nayo itholakala ngamanani wokulandelela obisini lwezinkomo, imvubelo nobhiya ().

INicotinamide riboside, noma i-niagen, iyenye indlela kavithamini B3. Kukhuthazwa njengesengezo sokulwa nokuguga ngoba kukhulisa amazinga womzimba wakho we-NAD +, asebenza njengophethiloli wezinqubo eziningi eziyinhloko zebhayoloji.

Izinzuzo Ezingaba khona

Ngoba ucwaningo oluningi nge-nicotinamide riboside ne-NAD + luvela ezifundweni zezilwane, azikho iziphetho ezicacile ezingenziwa mayelana nokusebenza kwaso kubantu.

Lokho kusho, nazi ezinye izinzuzo zezempilo ze-nicotinamide riboside.

Iguqulwe kalula ibe yi-NAD +

I-NAD + iyi-coenzyme, noma i-molecule yomsizi, ebamba iqhaza ekuphenduleni okuningi kwezinto eziphilayo.

Yize kubalulekile empilweni efanelekile, ucwaningo lukhombisa ukuthi amazinga e-NAD + ayaqhubeka ukwehla ngokukhula. Amazinga aphansi e-NAD + axhumene nokuguga okuncane kanye nezifo ezahlukahlukene eziyingozi (,).

Enye indlela yokukhulisa amazinga we-NAD + ukusebenzisa i-NAD + eyandulelayo - amabhlogo wokwakha we-NAD + - njenge-nicotinamide riboside.

Ucwaningo lwezilwane lukhombisa ukuthi i-nicotinamide riboside inyusa amazinga e-NAD + egazi kufika ezikhathini ezi-2.7. Ngaphezu kwalokho, isetshenziswa kalula ngumzimba wakho kunabanye abangaphambi kwe-NAD + ().

Yenza kusebenze ama-enzyme angakhuthaza ukuguga okunempilo

INicotinamide riboside isiza ukukhulisa amazinga we-NAD + emzimbeni wakho.

Ukuphendula, i-NAD + isebenzisa ama-enzyme athile angahle akhuthaze ukuguga okunempilo.

Iqembu elilodwa ngama-sirtuins, abonakala enza ngcono impilo nempilo ephelele ezilwaneni. Ucwaningo lukhombisa ukuthi ama-sirtuin angalungisa i-DNA eyonakele, athuthukise ukumelana nengcindezi, anciphise ukuvuvukala futhi anikeze ezinye izinzuzo ezikhuthaza ukuguga okunempilo (,,).

Ama-Sirtuin nawo abhekele izinzuzo zokwehlisa isikhathi sokuphila zomkhawulo wekhalori ().

Elinye iqembu yiPoly (ADP-Ribose) polymerases (PARPs), elungisa i-DNA eyonakele. Izifundo zixhuma umsebenzi ophakeme we-PARP nomonakalo omncane we-DNA kanye nempilo ende (,).

Kwangathi Kungasiza Ukuvikela Amaseli Obuchopho

I-NAD + idlala indima ebalulekile ekusizeni amangqamuzana akho obuchopho ukuba akhule kahle.

Ngaphakathi kwamangqamuzana obuchopho, i-NAD + isiza ukulawula ukukhiqizwa kwe-PGC-1-alpha, iphrotheni ebonakala isiza ukuvikela amaseli ekucindezelekeni kwe-oxidative kanye nokusebenza kahle kwe-mitochondrial ().

Abaphenyi bakholelwa ukuthi zombili izingcindezi ze-oxidative nomsebenzi we-mitochondrial okhubazekile kuxhunyaniswe nezinkinga zobuchopho ezihlobene nobudala ezifana ne-Alzheimer's and Parkinson's disease (,,).

Kumagundane anesifo i-Alzheimer's, i-nicotinamide riboside iphakamise amazinga obuchopho we-NAD + nokukhiqizwa kwe-PGC-1-alpha kufika ku-70% no-50%, ngokulandelana. Ekupheleni kwesifundo, amagundane asebenze kangcono kakhulu emisebenzini esekwe kwimemori ().

Esifundweni se-test-tube, i-nicotinamide riboside iphakamise amazinga e-NAD + futhi yathuthukisa kakhulu ukusebenza kwe-mitochondrial kumaseli we-stem athathwe esigulini se-Parkinson's disease ().

Kodwa-ke, akukacaci ukuthi kusiza kangakanani ukukhulisa amazinga e-NAD + kubantu abanezinkinga zobuchopho ezihlobene nobudala. Kudingeka izifundo ezingaphezulu zabantu.

Kwangathi Ingozi Yezifo Zenhliziyo Ephansi

Ukuguga kuyimbangela enkulu yesifo senhliziyo, okuyimbangela yokufa okuhamba phambili emhlabeni ().

Kungadala ukuthi imithambo yegazi efana ne-aorta yakho ibe mkhulu, iqine futhi ingabi nezimo.

Izinguquko ezinjalo zingakhuphula amazinga egazi futhi zenze inhliziyo yakho isebenze kanzima.

Ezilwaneni, ukukhulisa i-NAD + kusize ukuguqula ushintsho oluhlobene nobudala emithanjeni ().

Kubantu, i-nicotinamide riboside yaphakamisa amazinga e-NAD +, yasiza ekwehliseni ukuqina ku-aorta futhi yehlisa umfutho wegazi we-systolic kubantu abadala abasengozini yomfutho wegazi ophezulu (22).

Lokho kusho, ucwaningo olwengeziwe lomuntu luyadingeka.

Ezinye Izinzuzo Ezingaba khona

Ngaphezu kwalokho, i-nicotinamide riboside ingahlinzeka ngezinye izinzuzo eziningana:

• Kwangathi kungasiza ukunciphisa umzimba: INicotinamide riboside isize ukusheshisa imetabolism yamagundane. Kodwa-ke, akucaci noma kuzoba nomphumela ofanayo kubantu nokuthi unamandla kangakanani lo mphumela ().
• Kunganciphisa ingozi yomdlavuza: Amazinga aphezulu e-NAD + asiza ukuvikela ukulimala kwe-DNA kanye nengcindezi ye-oxidative, exhunywe nokuthuthuka komdlavuza (,).
• Kungasiza ekwelapheni i-jet lag: I-NAD + isiza ukulawula iwashi langaphakathi lomzimba wakho, ngakho-ke ukuthatha i-niagen kungasiza ekwelapheni i-jet lag noma okunye ukuphazamiseka kwesigqi se-circadian ngokusetha kabusha iwashi langaphakathi lomzimba wakho).
• Kwangathi kungakhuthaza ukuguga kwemisipha okunempilo: Ukukhulisa amazinga we-NAD + kusize ekuthuthukiseni ukusebenza kwemisipha, amandla nokukhuthazela kumagundane amadala (,).

INicotinamide riboside inyusa amazinga e-NAD +, axhumene nezinzuzo zezempilo ezingaba khona maqondana nokuguga, impilo yobuchopho, ingozi yesifo senhliziyo nokuningi.

Izingozi Ezingaba Khona Nemiphumela engemihle

INicotinamide riboside kungenzeka iphephe ngemiphumela emibi - uma ikhona -.

Ezifundweni zabantu, ukuthatha i-1,000-2,000 mg ngosuku akubanga nemiphumela emibi (,).

Kodwa-ke, izifundo eziningi zabantu zifushane ngesikhathi futhi zinabahlanganyeli abambalwa kakhulu. Ukuze uthole umbono onembe ngokwengeziwe wokuphepha kwayo, kudingeka izifundo ezinamandla zabantu.

Abanye abantu babike imiphumela emibi ethambile kuya kokumaphakathi, njengokucanuzela kwenhliziyo, ukukhathala, ikhanda elibuhlungu, isifo sohudo, ukungaphatheki kahle esiswini kanye nokugaya ukudla ().

Ezilwaneni, ukuthatha ama-300 mg nge-kg yesisindo somzimba (i-136 mg ngekhilogremu) nsuku zonke izinsuku ezingama-90 akubanga nemiphumela eyingozi ().

Ngaphezu kwalokho, ngokungafani nezithasiselo zevithamini B3 (niacin), i-nicotinamide riboside akufanele idale ukuqhuma ebusweni ().

INicotinamide riboside ibonakala iphephile ngemiphumela emibi embalwa. Kodwa-ke, imiphumela yayo yesikhathi eside kubantu ayisaziwa.

Isikali nezincomo

I-Nicotinamide riboside iyatholakala kuthebhulethi noma kwifomu le-capsule futhi ibizwa kakhulu nge-niagen.

Itholakala ezitolo ezikhethiwe zokudla okunempilo, e-Amazon noma kubathengisi abaku-inthanethi.

Izithako zeNiagen ngokuvamile ziqukethe i-nicotinamide riboside kuphela, kepha abanye abakhiqizi bayayihlanganisa nezinye izithako ezifana nePterostilbene, eyi-polyphenol - i-antioxidant efana namakhemikhali afana ne-resveratrol ().

Imikhiqizo eminingi yokwengeza ye-niagen incoma ukuthatha ama-250-300 mg ngosuku, okulingana namaphilisi ayi-1-2 ngosuku kuye ngohlobo lomkhiqizo.

Iningi labakhiqizi be-niagen batusa ukuthatha ama-250-300 mg we-nicotinamide riboside ngosuku.

Okusemqoka

INicotinamide riboside ingenye indlela kavithamini B3 enemiphumela emibi embalwa. Kuvame ukuthengiswa njengomkhiqizo olwa nokuguga.

Umzimba wakho uwuguqula ube yi-NAD +, obhebhethekisa wonke amaseli akho. Ngenkathi amazinga e-NAD + ewela ngokwemvelo ngokukhula, ukukhulisa amazinga we-NAD + kungaguqula izimpawu ezimbalwa zokuguga.

Kodwa-ke, ucwaningo oluningi lwe-nicotinamide riboside ne-NAD + lusezilwaneni. Kudingeka izifundo zabantu ezisezingeni eliphakeme ngaphambi kokuncoma njengokwelashwa.