Ukwelapha iMigraines ngama-Antidepressants

-Delile

• Yiziphi izinhlobo ezahlukahlukene?
• I-serotonin reuptake inhibitors ekhethiwe (SSRIs)
• I-Serotonin-norepinephrine reuptake inhibitors (SNRIs)
• I-Tricyclic antidepressants
• I-Monoamine oxidase inhibitors (MAOIs)
• Imithi elwa nokucindezelwa ivimbela kanjani i-migraines?
• Iyini imiphumela emibi ye-anti-depressants?
• Ingabe i-anti-depressants iphephile?
• Isifo se-Serotonin
• Okubalulekile

Yini ama-anti-depressants?

Ama-anti-depressants yimithi esiza ekwelapheni izimpawu zokudangala. Iningi labo liguqula uhlobo lwamakhemikhali abizwa ngokuthi yi-neurotransmitter. Lezi ziphethe imiyalezo phakathi kwamaseli asebuchosheni bakho.

Ngaphandle kwegama labo, ama-anti-depressants angaphatha izimo ezahlukahlukene ngaphandle kokucindezeleka, kufaka phakathi:

• ukukhathazeka nokukhathazeka
• ukuphazamiseka kokudla
• ukuqwasha
• ubuhlungu obungapheli
• ukushisa okushisayo

Ama-anti-depressants nawo angavimbela ngempumelelo imigraines. Qhubeka ufunde ukuze ufunde kabanzi.

Yiziphi izinhlobo ezahlukahlukene?

Kunezinhlobo ezine eziyinhloko ze-anti-depressants:

I-serotonin reuptake inhibitors ekhethiwe (SSRIs)

Ama-SSRI akhulisa inani le-serotonin ye-neurotransmitter ebuchosheni bakho. Odokotela bavame ukunquma lokhu kuqala ngoba kubangela imiphumela emibi kakhulu.

I-Serotonin-norepinephrine reuptake inhibitors (SNRIs)

Ama-SNRI akhulisa inani le-serotonin ne-norepinephrine ebuchosheni bakho.

I-Tricyclic antidepressants

Le mithi, eyaziwa nangokuthi i-cyclic antidepressants, inyusa inani le-serotonin ne-norepinephrine.

I-Monoamine oxidase inhibitors (MAOIs)

I-Serotonin, i-norepinephrine, ne-dopamine konke kungama-monoamine. Umzimba wakho ngokwemvelo udala i-enzyme ebizwa ngokuthi i-monoamine oxidase ewonakalisayo. Ama-MAOIs asebenza ngokuvimba le enzyme ekusebenzeni kuma-monoamine ebuchosheni bakho.

Ama-MAOI awavamile ukunikezwa ngoba abangela imiphumela emibi kakhulu.

Imithi elwa nokucindezelwa ivimbela kanjani i-migraines?

Ochwepheshe abaqiniseki ukuthi yini ebangela i-migraines. Ngokusho kweMayo Clinic, ukungalingani kuma-neurotransmitters kungadlala indima. Amazinga weSerotonin nawo ehla ngesikhathi se-migraine. Lokhu kungahle kuchaze ukuthi kungani ama-anti-depressants abonakala esiza ekuvimbeleni.

I-Tricyclic antidepressants ingenye yemithi ebekwa kakhulu yokuvikela i-migraine. Kodwa-ke, ucwaningo olukhona luthole ama-SSRI nama-SNRI asebenza ngokufanayo. Lokhu kutholakala kubalulekile ngoba ama-SSRIs nama-SNRI athambekele ekubangeleni imiphumela emibi embalwa kune-tricyclic antidepressants.

Ngenkathi izifundo ezishiwo kulokhu kubuyekezwa zithembisa, ababhali bayaqaphela ukuthi izifundo eziningi ezinkulu, ezilawulwayo ziyadingeka ukuqonda ngokugcwele ukuthi imishanguzo yokucindezela iyithinta kanjani imigraines.

Uma uthola i-migraines ejwayelekile engaphendulanga kwezinye izindlela zokwelashwa, buza udokotela wakho ngokuzama ama-anti-depressants. Khumbula ukuthi ama-anti-depressants asetshenziselwa ukuvimbela i-migraines, hhayi ukwelapha asebenzayo.

Iyini imiphumela emibi ye-anti-depressants?

Ama-anti-depressants angadala imiphumela emibi eminingi. Ama-SSRI ngokuvamile adala imiphumela emibi kakhulu, ngakho-ke udokotela wakho angase asikisele ukuzama lolu hlobo kuqala.

Imiphumela emibi ejwayelekile ezinhlotsheni ezahlukene ze-anti-depressants ifaka:

• umlomo owomile
• isicanucanu
• uvalo
• ukungahlaliseki
• ukuqwasha
• izinkinga zocansi, njengokungasebenzi kahle kwe-erectile noma ukubambezeleka kwe-ejaculation

I-Tricyclic antidepressants, kufaka phakathi i-amitriptyline, ingadala imiphumela emibi eyengeziwe, efana nale:

• ukungaboni kahle
• ukuqunjelwa
• kwehla umfutho wegazi lapho umile
• ukugcinwa komchamo
• ukozela

Imiphumela emibi iyahlukahluka phakathi kwemithi, ngisho nangaphakathi kohlobo olufanayo lwe-antidepressant. Sebenza nodokotela wakho ukukhetha i-antidepressant enikeza inzuzo enkulu ngemiphumela emibi kakhulu. Kungadingeka ukuthi uzame okumbalwa ngaphambi kokuthola okusebenzayo.

Ingabe i-anti-depressants iphephile?

Ama-anti-depressants ngokuvamile aphephile. Kodwa-ke, ukuthatha imishanguzo yokulwa nengcindezi yokwelapha i-migraines kubhekwa njengokusetshenziswa kwelebula. Lokhu kusho ukuthi abenzi be-anti-depressant abenzanga izivivinyo ezinzima ezifanayo ukuqinisekisa ukuphepha nokusebenza kahle uma kuziwa ekwelapheni i-migraines. Odokotela abaningi abayiniki imithi yokusetshenziswa ngaphandle kwelebula ngaphandle uma ezinye izindlela zokwelapha zehlulekile.

Udokotela wakho angakusiza ukuthi ulinganise izinzuzo nezingozi zokusebenzisa imishanguzo elwa nemithi yokuqaqanjelwa ikhanda.

Ama-anti-depressants nawo angaxhumana neminye imithi, ngakho-ke tshela udokotela wakho ngayo yonke i-over-the-counter (OTC) nemithi oyinikezwa ngudokotela. Lokhu kufaka amavithamini nezithako.

Kufanele futhi utshele udokotela wakho uma une:

• cholesterol ephezulu
• umlando wesifo senhliziyo
• ingozi eyengeziwe yokuhlaselwa yisifo senhliziyo noma isifo sohlangothi
• i-glaucoma
• i-prostate ekhulisiwe

Isifo se-Serotonin

I-Serotonin syndrome yisimo esingavamile kodwa esibi esenzekayo lapho amazinga akho e-serotonin ephakeme kakhulu. Kuvame ukwenzeka lapho uthatha imishanguzo yokulwa nokudangala, ikakhulukazi ama-MAOIs, neminye imishanguzo, izithasiselo, noma izidakamizwa ezingekho emthethweni ezandisa amazinga akho e-serotonin.

Ungathathi imishanguzo yokulwa nengcindezi uma usuvele uthathe noma imiphi yale mithi elandelayo ye-migraines:

• i-almotriptan (Axert)
• i-naratriptan (Amerge)
• i-sumatriptan (Imitrex)

Ezinye izinto ezingasebenzisana nama-anti-depressants futhi zibangele i-serotonin syndrome zifaka:

• i-dextromethorphan, isithako esivamile emithini ebandayo neyokukhwehlela ye-OTC
• izithako zemithi, kufaka phakathi i-ginseng neSt
• amanye ama-anti-depressants
• izidakamizwa ezingekho emthethweni, kufaka phakathi i-ecstasy, i-cocaine, nama-amphetamine

Funa ukwelashwa okuphuthumayo uma uhlangabezana nanoma yimiphi yale miphumela emibi ngenkathi uthatha imishanguzo yokucindezela:

• ukudideka
• ukuphazamiseka kwemisipha nokuthuthumela
• ukuqina kwemisipha
• ngiqhaqhazela
• ukushaya kwenhliziyo okusheshayo
• ukucabanga okweqile
• abafundi abahlanzekile
• isithuthwane
• ukungaphenduli

Okubalulekile

Ukwelashwa kwe-Migraine kungenye yezindlela ezisetshenziswa kakhulu ezingekho kwelebula zemithi elwa nokudangala. Ngenkathi kudingeka izilinganiso ezinkulu kakhulu, ezisezingeni eliphakeme, ucwaningo olukhona lukhombisa ukuthi imishanguzo yokucindezela ingasebenza ekuvikeleni uma umuntu engaphenduli kahle kwezinye izindlela zokwelashwa. Uma uthola njalo i-migraines engaphenduli kwezinye izindlela zokwelashwa, khuluma nodokotela wakho ngokuzama ama-anti-depressants.