Isivivinyo se-Antimitochondrial Antibody (AMA)

-Delile

• Kungani ukuhlolwa kwe-AMA kuyaliwe?
• Kwenziwa kanjani ukuhlolwa kwe-AMA?
• Ziyini izingozi zokuhlolwa kwe-AMA?
• Ukuqonda imiphumela yakho yokuhlolwa kwe-AMA

Kuyini ukuhlolwa kwe-antimitochondrial antibody?

I-mitochondria idala amandla ukuze amaseli asemzimbeni wakho awasebenzise. Zibucayi ekusebenzeni okujwayelekile kwawo wonke amaseli.

Ama-antibodies e-Antimitochondrial (AMAs) ayisibonelo sempendulo yokuzimela eyenzeka lapho umzimba uphambana namaseli, izicubu kanye nezitho zomzimba. Uma lokhu kwenzeka, amasosha omzimba ahlasela umzimba kube sengathi uyisifo.

Ukuhlolwa kwe-AMA kukhomba amazinga aphakeme ala ma-antibody egazini lakho. Ukuhlolwa kuvame ukusetshenziselwa ukuthola isimo se-autoimmune esaziwa njenge-primary biliary cholangitis (PBC), esaziwa ngaphambili njenge-cirrhosis eyinhloko ye-biliary.

Kungani ukuhlolwa kwe-AMA kuyaliwe?

I-PBC ibangelwa ukuhlaselwa kwamasosha omzimba emibhedeni emincane yenyongo ngaphakathi kwesibindi. Amapayipi e-bile owonakele abangela isibazi, okungaholela ekuhlulekeni kwesibindi. Lesi simo siletha nengozi yokuba nomdlavuza wesibindi.

Izimpawu ze-PBC zifaka:

• ukukhathala
• isikhumba esilumayo
• ukuphuzi kwesikhumba, noma i-jaundice
• ubuhlungu esiswini esingenhla kwesokudla
• ukuvuvukala, noma i-edema yezandla nezinyawo
• uketshezi esiswini
• umlomo owomile namehlo
• ukuncipha komzimba

Ukuhlolwa kwe-AMA kusetshenziselwa ukusiza ukuqinisekisa ukuxilongwa kwemitholampilo kadokotela kwe-PBC. Ukuhlolwa okungajwayelekile kwe-AMA kukodwa akwenele ukuthola isifo. Uma lokhu kungenzeka, udokotela wakho anga-oda ezinye izivivinyo, kufaka phakathi okulandelayo:

Amasosha omzimba alwa nenuzi (ANA): Ezinye iziguli ezine-PBC nazo zivivinya ukuthi zinalo la ma-antibodies.

Izinguquko: Ama-enzyme alanine transaminase ne-aspartate transaminase aqondene nesibindi. Ukuhlola kuzokhomba amanani aphakeme, okuvame ukuba uphawu lwesifo sesibindi.

I-Bilirubin: Lokhu kuyinto ekhiqizwa ngumzimba lapho amaseli abomvu egazi ehla. Ikhishwa ngomchamo kanye nendle. Amanani aphezulu angabonisa isifo sesibindi.

I-albhamuin: Le yiprotheni elenziwe esibindini. Amazinga aphansi angakhombisa ukulimala kwesibindi noma isifo.

Amaprotheni asebenza ngo-C: Lokhu kuhlolwa kuvame uku-oda ukuxilonga isifo se-lupus noma senhliziyo, kepha futhi kungakhombisa ezinye izimo ezizimele.

Amasosha omzimba alwa nobushelelezi (i-ASMA): Lokhu kuhlolwa kuvame ukuphathwa kanye nokuhlolwa kwe-ANA futhi kuyasiza ekutholeni i-autoimmune hepatitis.

Ukuhlolwa kwe-AMA kungasetshenziswa futhi ukukuhlolela i-PBC uma ukuhlolwa kwegazi okujwayelekile kukhombisa ukuthi unamazinga aphezulu we-alkaline phosphatase (ALP) kunokujwayelekile. Izinga eliphakeme le-ALP kungaba uphawu lwe-bile duct noma isifo se-gallbladder.

Kwenziwa kanjani ukuhlolwa kwe-AMA?

Ukuhlolwa kwe-AMA ukuhlolwa kwegazi. Umhlengikazi noma uchwepheshe uzodonsa igazi lakho emthanjeni oseduze kwendololwane yakho noma esandleni. Leli gazi lizoqoqwa kushubhu bese lithunyelwa ebhodini ukuze liyohlaziywa.

Udokotela wakho uzokuthinta akuchaze ngemiphumela yakho uma isitholakala.

Ziyini izingozi zokuhlolwa kwe-AMA?

Ungase ube nokungaphatheki kahle lapho kudonswa isampula yegazi. Kungaba nobuhlungu endaweni yokubhoboza ngesikhathi sokuhlolwa noma ngemuva kokuhlolwa. Ngokuvamile, izingozi zokudonswa kwegazi zincane.

Izingozi ezingaba khona zifaka:

• ubunzima bokuthola isampula, okuholela kuzinti eziningi zezinaliti
• ukopha ngokweqile endaweni yenaliti
• ukuquleka ngenxa yokopha
• ukuqoqwa kwegazi ngaphansi kwesikhumba, okwaziwa njenge-hematoma
• ukutheleleka endaweni yokubhoboza

Akukho ukulungiselela okudingekayo kulolu vivinyo.

Ukuqonda imiphumela yakho yokuhlolwa kwe-AMA

Imiphumela yokuhlolwa ejwayelekile ayinayo i-AMA. I-AMA enhle isho ukuthi kunamazinga atholakala ama-antibody egazini. Yize ukuhlolwa okuhle kwe-AMA kuvame ukuhlotshaniswa ne-PBC, kungaba futhi ne-autoimmune hepatitis, i-lupus, i-rheumatoid arthritis, nesifo se-graft-versus-host. La ma-antibody ayingxenye eyodwa yesimo sokuzivikela komzimba esikhiqizwa ngumzimba.

Uma unemiphumela emihle, mhlawumbe uzodinga ukuhlolwa okwengeziwe ukuqinisekisa ukuxilongwa kwakho. Ikakhulu, udokotela wakho angalawula i-biopsy yesibindi ukuthi athathe isampula esibindini. Udokotela wakho angaphinde a-ode i-CT noma i-MRI yesibindi sakho.