Kuyini i-B-Cell Lymphoma?
-Delile
- Yimaphi ama-subtypes we-B-cell lymphoma?
- Isiteji
- Ziyini izimpawu?
- Ilashwa kanjani?
- Imisebe
- Ukwelashwa ngamakhemikhali
- Ukwelashwa komzimba
- Ukufakelwa kwe-stem cell
- Ingabe zikhona izinkinga ezingaba khona?
- Kunjani ukululama?
- Umbono
Ukubuka konke
I-Lymphoma uhlobo lomdlavuza oqala kuma-lymphocyte. Ama-lymphocyte amangqamuzana kumasosha omzimba. I-Hodgkin's kanye ne-non-Hodgkin's lymphoma yizinhlobo ezimbili eziyinhloko ze-lymphoma.
I-T-cell lymphoma ne-B-cell lymphoma yizinhlobo ezimbili ze-non-Hodgkin's lymphoma. Kukhona nohlobo olungandile olubizwa nge-NK-cell lymphoma.
Phakathi kwabantu abane-non-Hodgkin lymphoma, cishe amaphesenti angama-85 ane-B-cell lymphoma.
Ukwelashwa kwe-B-cell lymphomas kusekelwe kuhlobo oluthile lwesigaba nesifo.
Yimaphi ama-subtypes we-B-cell lymphoma?
Kunezinhlayiya eziningi ze-B-cell lymphoma, zombili ezikhula kancane (ezingasebenzi) futhi ezikhula ngokushesha (ezinolaka), kufaka phakathi:
| I-B-cell subtype | Izici |
| Ukusabalalisa i-B-cell lymphoma enkulu (DLBCL) | Lolu uhlobo oluvame kakhulu lwe-non-Hodgkin's lymphoma. Kungumdlavuza onolaka kodwa owelaphekayo ongafaka ama-lymph node nezinye izitho. |
| I-lymphoma elandelayo | Lolu uhlobo lwesibili oluvame kakhulu kwi-non-Hodgkin's lymphoma. Iyakhula kancane futhi imvamisa iqala kuma-lymph node. |
| I-Mantel cell lymphoma | Ngokuvamile kuhilela ama-lymph node, umnkantsha, ubende, nesistimu yamathumbu. |
| I-lymphocytic leukemia engapheli (CLL) / i-lymphocytic lymphoma (SLL) encane | Lolu hlobo alunqeni futhi luthinta kakhulu umnkantsha wegazi nethambo (CLL), noma ama-lymph node ne-spleen (SLL). |
| Isistimu eyinhloko ye-nervous central lymphoma | Lolu hlobo luvame ukuqala ebuchosheni noma emgogodleni. Ihambisana nezinkinga zokuzivikela ezifweni ezibangelwa ingculaza noma imishanguzo yokulwa nokwaliwa esetshenziswe ngokulandela ukufakelwa komzimba. |
| Indawo eseceleni kwe-Splenic B-cell lymphoma | Lolu uhlobo olukhula kancane oluqala ebuchosheni nasemnkantsheni wethambo. |
| Indawo eseceleni kwe-B-cell lymphoma ye-MALT | Lolu hlobo luvame ukufaka isisu. Kungenzeka futhi nasemaphashini, esikhunjeni, endlaleni yegilo, endlaleni yesisu, noma esweni. |
| Indawo eseceleni kweNodal B-cell lymphoma | Lolu uhlobo olungajwayelekile, olukhula kancane olutholakala ikakhulukazi kuma-lymph node. |
| IBurkitt lymphoma | Lolu uhlobo olukhula ngokushesha oluvame kakhulu ezinganeni. |
| I-leukemia yeseli lezinwele | Lolu uhlobo olukhula kancane oluthinta ubende, ama-lymph node, negazi. |
| I-Lymphoplasmacytic lymphoma (iWaldenstrom macroglobulinemia) | Lokhu kuyi-lymphoma engavamile, ekhula kancane yomnkantsha wethambo, ubende, nama-lymph node. |
| I-primary effusion lymphoma | Lolu uhlobo olungajwayelekile nolunolaka oluvame ukwenzeka kubantu abanamasosha omzimba abuthakathaka. |
Isiteji
Umdlavuza uhlelwe ngokusho ukuthi ususabalale kangakanani ukusuka endaweni yokuqala. I-non-Hodgkin's lymphoma ihlelwe kusuka ku-1 kuye ku-4, kuthi i-4 ibe yiyona ethuthuke kakhulu.
Ziyini izimpawu?
Izimpawu ziyahlukahluka ngohlobo lwe-B-cell lymphoma nokuthi iphambili kangakanani. Lezi ngezinye zezimpawu eziyinhloko:
- ama-lymph node avuvukile entanyeni yakho, emakhwapheni, noma emgodini
- ubuhlungu besisu noma ukuvuvukala
- ubuhlungu besifuba
- ukukhwehlela
- ubunzima bokuphefumula
- umkhuhlane nokujuluka ebusuku
- ukuncipha komzimba
- ukukhathala
Ilashwa kanjani?
Izinhlobo ezithile ze-lymphoma ezingaqondakali futhi ezingavumi azidingi ukwelashwa. Udokotela wakho angakutusa ngokuthi kwaziwa ngokuthi “ukulinda ngokuqapha.” Lokho kusho ukuthi uzolandelela njalo ezinyangeni ezimbalwa ukuqinisekisa ukuthi umdlavuza awuqhubeki. Kwezinye izimo, lokhu kungaqhubeka iminyaka.
Ukwelashwa kungaqala lapho kuvela izimpawu noma uma kunezimpawu zokuqhubeka kwesifo. I-B-cell lymphoma ivame ukufaka inhlanganisela yokwelashwa, engashintsha ngokuhamba kwesikhathi.
Imisebe
Kusetshenziswa imishayo yamandla aphezulu, ukwelashwa ngemisebe kusetshenziselwa ukubulala amangqamuzana omdlavuza nokunciphisa izicubu. Kudinga ukulala unganyakazi phezu kwetafula ngenkathi imishayo iqondiswe endaweni eqondile emzimbeni wakho.
Nge-lymphoma ekhula kancane, yasendaweni, ukwelashwa ngemisebe kungaba yikho konke okudingayo.
Imiphumela emibi ingafaka ukukhathala nokucasula isikhumba.
Ukwelashwa ngamakhemikhali
I-Chemotherapy yindlela yokwelashwa ehlelekile enganikezwa ngomlomo noma ngemithambo yegazi. Amanye ama-B-cell lymphomas anolaka angalapheka nge-chemotherapy, ikakhulukazi ezifweni zokuqala.
I-DLBCL wuhlobo olukhula ngokushesha olungaphathwa ngomuthi wokwelashwa ngamakhemikhali obizwa nge-CHOP (cyclophosphamide, doxorubicin, vincristine, ne-prednisone). Uma unikezwa kanye ne-monoclonal antibody rituximab (Rituxan), ibizwa nge-R-CHOP. Imvamisa inikezwa ngemijikelezo ngaphandle kwamasonto ambalwa. Kunzima enhliziyweni, ngakho-ke akuyona inketho uma unezinkinga zenhliziyo esezikhona.
Imiphumela emibi ye-chemotherapy ingabandakanya isicanucanu, ukukhathala nokulahleka kwezinwele.
Ukwelashwa komzimba
Izidakamizwa ze-biologic zisiza amasosha akho omzimba ukulwa nomdlavuza. I-Rituximab ihlose amaprotheni ebusweni bama-B-cell, okwenza kube lula kumasosha omzimba ukuwabona nokuwaqeda. Ngokunciphisa inani lamaseli we-B anomdlavuza futhi anempilo, umuthi wenza umzimba wakho ukhiqize ama-B-cell amasha aphilile. Lokhu kwenza kungabi namathuba amancane okuthi umdlavuza uphinde ubuye.
Imithi ye-radioimmunotherapy, efana ne-ibritumomab tiuxetan (i-Zevalin), yenziwa ngama-antibody monoclonal athwala isotopes enemisebe. Umuthi usiza amasosha omzimba anamathisele kumaseli womdlavuza ukulethwa okuqondile kwemisebe.
Imiphumela emibi yokwelashwa komzimba ingahlanganisa ukubalwa kwamaseli egazi amhlophe aphansi, ukukhathala, kanye nezifo.
Ukufakelwa kwe-stem cell
Ukufakelwa kabusha kwe-stem cell kufaka phakathi ukufaka umnkantsha wakho emnkantsheni ovela kumnikeli onempilo. Okokuqala, uzodinga i-chemotherapy ephezulu noma i-radiation ukucindezela amasosha akho omzimba, ukubhubhisa amangqamuzana omdlavuza, nokwenza isikhala somnkantsha omusha. Ukuze ufaneleke, kufanele ube nempilo eyenele ukumelana nalokhu kwelashwa.
Imiphumela emibi ingafaka izifo, i-anemia, kanye nokwenqatshelwa komnkantsha omusha.
Ingabe zikhona izinkinga ezingaba khona?
AmaLymphomas enza buthakathaka amasosha omzimba wakho, akwenze ube sengozini yokungenwa yizifo. Ezinye izindlela zokwelapha i-lymphoma zingadala izinkinga ezifana nalezi:
- ukungazali
- inhliziyo, amaphaphu, izinso nesifo se-thyroid
- isifo sikashukela
- umdlavuza wesibili
I-B-cell lymphomas ingakhula futhi isakaze ezithweni ezikude.
Kunjani ukululama?
Ezinye izinhlobo zama-B-cell lymphomas zingelashwa. Ukwelashwa kunganciphisa ukuqhubeka kwabanye. Uma kungenasibonakaliso somdlavuza ngemuva kokwelapha kwakho okuyinhloko, kusho ukuthi usuthethelelweni. Usazodinga ukulandelela iminyaka eminingana ukuqapha ukuphindeka.
Umbono
Isilinganiso seminyaka emihlanu sokusinda esihlobene ne-non-Hodgkin's lymphoma singamaphesenti angama-70. Lokhu kwehluka kakhulu ngokuya ngohlobo lwe-B-cell lymphoma kanye nesigaba sokuxilongwa. Okunye ukucatshangelwa yiminyaka yakho nempilo yonke.
Isibonelo, i-DLBCL iyelapheka cishe engxenyeni yabantu abanayo. Labo abaqala ukwelashwa ngezigaba zangaphambili banombono ongcono kunalabo abanezifo ezizayo.
Udokotela wakho angakunikeza ukubikezelwa kwakho siqu ngokuya ngephrofayili yakho ephelele yezempilo.
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