Umdlavuza Webele Othuthukile Ngaphambi Nangemva Kokuya Esikhathini

-Delile

• 1.Yikuphi ukwelashwa okuyisisekelo komdlavuza webele we-hormone receptor-positive metastatic?
• 2. Uphathwa kanjani umdlavuza webele we-metastatic kwabesifazane abangaphambi kokuya esikhathini?
• 3. Yikuphi ukwelashwa okunqunyiwe kwabesifazane abase-postmenopausal?
• 4. Ngabe i-chemotherapy noma izindlela zokwelashwa eziqondisiwe zisetshenziselwa ukwelapha umdlavuza webele we-metastatic?

Ukubuka konke

Umdlavuza webele we-Metastatic (obizwa nangokuthi umdlavuza webele osezingeni eliphakeme) kusho ukuthi umdlavuza ususabalele kusukela ebeleni uye kwezinye izindawo emzimbeni. Kusabhekwa njengomdlavuza webele ngoba ama-metastase anohlobo olufanayo lwamaseli womdlavuza.

Izinketho zokwelashwa zixhomeke ezicini ezithile zesimila, njengokuthi zine-receptor receptor ye-hormone nokuthi iyi-HER2-positive. Ezinye izinto zibandakanya impilo yamanje, noma yikuphi ukwelashwa oke wakuthola phambilini, nokuthi umdlavuza uwuthathe isikhathi esingakanani ukubuya.

Ukwelashwa futhi kuya ngokuthi usakazeke kangakanani umdlavuza nokuthi udlulile esikhathini sokuya esikhathini. Nayi eminye imibuzo ongayibuza udokotela wakho mayelana nomdlavuza webele osezingeni eliphezulu njengoba uhlobene nokunqamuka kokuya esikhathini.

1.Yikuphi ukwelashwa okuyisisekelo komdlavuza webele we-hormone receptor-positive metastatic?

Ukwelashwa kweHormonal, noma i-endocrine therapy, imvamisa kuyisisekelo esiyinhloko sokwelashwa kwabesifazane abanomdlavuza webele we-hormone receptor-positive metastatic. Kwesinye isikhathi ibizwa ngokuthi yi-anti-hormone treatment ngoba isebenza njengokuphambene nokwelashwa ngama-hormone therapy (HRT).

Umgomo ukwehlisa amazinga e-estrogen ne-progesterone emzimbeni ukuvimba lawa mahormone ukuthi angafiki kumaseli womdlavuza futhi athole i-estrogen ayidingayo ukuthi ikhule.

Ukwelashwa kwehormonal kungasetshenziselwa ukuphazamisa ithonya lamahomoni ekukhuleni kwamaseli nokusebenza kukonke. Uma ama-hormone evinjiwe noma ekhishwa, amangqamuzana omdlavuza mancane amathuba okuthi aphile.

Ukwelashwa kweHormonal kubuye kumise amaseli webele aphilile ekutholeni ama-hormone angakhuthaza amangqamuzana anomdlavuza ukuba abuyele ngaphakathi kwesifuba noma kwenye indawo.

2. Uphathwa kanjani umdlavuza webele we-metastatic kwabesifazane abangaphambi kokuya esikhathini?

Ukwelashwa komdlavuza webele we-Metastatic kwabesifazane be-premenopausal abanomdlavuza we-hormone receptor-positive ngokuvamile kubandakanya ukucindezelwa kwe-ovari. Le nqubo yehlisa amazinga ama-hormone emzimbeni ukuze incishe isimila se-estrogen esidinga ukukhula.

Ukucindezelwa kwe-Ovarian kungatholakala ngenye yezindlela ezimbili:

• Izidakamizwa zingavimba ama-ovari ekwenzeni i-estrogen, ethinta ukunqamuka kokuya esikhathini isikhathi esithile.
• Inqubo yokuhlinza ebizwa nge-oophorectomy ingasusa ama-ovari futhi imise ukukhiqizwa kwe-estrogen unomphela.

I-aromatase inhibitor ingabekwa kwabesifazane be-premenopausal ngokuhlangana nokucindezelwa kwe-ovari. I-Aromatase inhibitors ingafaka:

• i-anastrozole (i-Arimidex)
• i-exemestane (i-Aromasin)
• i-letrozole (Femara)

I-Tamoxifen, i-antiestrogen, ibuye isetshenziselwe ukwelapha umdlavuza webele we-metastatic kwabesifazane be-premenopausal. Kungavimbela umdlavuza ukuthi ubuye noma usabalale kwenye indawo.

I-Tamoxifen kungenzeka ingabi inketho uma umdlavuza uthuthuka phakathi nokwelashwa kwangaphambilini kwe-tamoxifen. Ukuhlanganisa ukucindezelwa kwama-ovari kanye ne-tamoxifen kutholakale kuthuthukisa ukusinda kuqhathaniswa ne-tamoxifen kuphela.

3. Yikuphi ukwelashwa okunqunyiwe kwabesifazane abase-postmenopausal?

Ukucindezelwa kwe-Ovarian akudingekile kwabesifazane be-postmenopausal. Amaqanda abo asevele eyekile ukwenza inani elikhulu le-estrogen. Benza inani elincane kuphela kwizicubu zabo ezinamafutha nezindlala ze-adrenal.

Ukwelashwa kwe-Postmenopausal hormone ngokuvamile kufaka i-aromatase inhibitor. Le mithi yehlisa inani le-estrogen emzimbeni ngokumisa izicubu nezitho ngaphandle kwama-ovari ekwenzeni i-estrogen.

Imiphumela emibi ejwayelekile ye-aromatase inhibitors ifaka phakathi:

• ukushisa okushisayo
• isicanucanu
• ukuhlanza
• amathambo noma amalunga abuhlungu

Imiphumela emibi kakhulu ifaka phakathi ukuncipha kwamathambo nokwanda kwe-cholesterol.

Abesifazane be-Postmenopausal bangabekwa i-tamoxifen iminyaka eminingana, imvamisa emihlanu noma ngaphezulu. Uma umuthi usetshenziselwa isikhathi esingaphansi kweminyaka emihlanu, i-aromatase inhibitor ivame ukunikezwa iminyaka esele.

Eminye imishanguzo engabhalwa ifaka phakathi ama-CDK4 / 6 inhibitors noma i-fulvestrant.

4. Ngabe i-chemotherapy noma izindlela zokwelashwa eziqondisiwe zisetshenziselwa ukwelapha umdlavuza webele we-metastatic?

I-Chemotherapy iyindlela yokwelashwa eyinhloko yomdlavuza webele webele wesithathu (i-hormone receptor-negative ne-HER2-negative). I-Chemotherapy nayo ingasetshenziswa ngokuhlangana nezindlela eziqondiswe ku-HER2 zomdlavuza webele we-HER2-positive.

I-Chemotherapy ingasetshenziswa ezimweni ezibucayi kakhulu zomdlavuza we-hormone receptor-positive, i-HER2-negative cancer.

Uma umuthi wokuqala we-chemotherapy, noma inhlanganisela yezidakamizwa, iyeka ukusebenza futhi umdlavuza usakazeka, umuthi wesibili noma wesithathu ungasetshenziswa.

Ukuthola ukwelashwa okulungile kungathatha iphutha. Okulungele omunye umuntu ngeke kulunge kuwe. Landela uhlelo lwakho lwezokwelapha bese uxhumana nodokotela wakho. Bazise uma okuthile kusebenza noma kungasebenzi.

Ungaba nezinsuku ezinzima ezizayo, kepha kuyasiza ukwazi zonke izindlela zakho zokwelashwa.