Ukuhlolwa kwe-BRAF Genetic

-Delile

• Luyini uvivinyo lwe-BRAF genetic?
• Kusetshenziselwa ini?
• Kungani ngidinga ukuhlolwa kofuzo kwe-BRAF?
• Kwenzekani ngesikhathi sokuhlolwa kofuzo kwe-BRAF?
• Ngabe kukhona engizodinga ukukwenza ukulungiselela isivivinyo?
• Ingabe zikhona izingozi esivivinyweni?
• Isho ukuthini imiphumela?
• Ngabe kukhona okunye engidinga ukukwazi mayelana nokuhlolwa kwe-BRAF?
• Izinkomba

Luyini uvivinyo lwe-BRAF genetic?

Ukuhlolwa kwezakhi zofuzo kwe-BRAF kubheka ushintsho, olwaziwa njengokuguquka kwezakhi zofuzo, kufuzo olubizwa nge-BRAF. Izakhi zofuzo yizingxenye eziyisisekelo zofuzo ezedluliswa zivela kumama nobaba wakho.

Uhlobo lwe-BRAF lwenza iprotheni esiza ukulawula ukukhula kwamaseli. Kuyaziwa njenge-oncogene. I-oncogene isebenza njengokuchezuka kwegesi emotweni. Imvamisa, i-oncogene ivula ukukhula kweseli njengoba kudingeka. Kepha uma unokuguquka kwe-BRAF, kufana nokuthi i-pedal yegesi ibhajwe phansi, futhi ufuzo alukwazi ukuvimba amaseli ukuthi angakhuli. Ukukhula kwamaseli okungalawulwa kungaholela kumdlavuza.

Ukuguqulwa kwe-BRAF kungazuzwa njengefa kubazali bakho noma kutholwe kamuva empilweni. Izinguquko ezenzeka kamuva empilweni zivame ukubangelwa yimvelo noma ngephutha elenzeka emzimbeni wakho ngesikhathi sokuhlukaniswa kwamaseli. Ukuguqulwa okuzuzwe njengefa kwe-BRAF akuvamile, kepha kungadala izinkinga ezinkulu zempilo.

Kutholakale (okwaziwa nangokuthi yi-somatic) ukuguqulwa kwe-BRAF kuvame kakhulu. Lezi zinguquko ziye zatholakala cishe engxenyeni yazo zonke izifo ze-melanoma, uhlobo lomdlavuza wesikhumba olubi kakhulu. Izinguquko ze-BRAF nazo zivame ukutholakala kokunye ukuphazamiseka nezinhlobo ezahlukahlukene zomdlavuza, kufaka phakathi umdlavuza wekholoni, i-thyroid, nama-ovari. Imdlavuza enokuguqulwa kwe-BRAF ivame ukuba yimbi kakhulu kunaleyo engenakuguqulwa.

Amanye amagama: Ukuhlaziywa kokuguqulwa kwezakhi zofuzo ze-BRAF, iMelanoma, ukuguqulwa kwe-BRAF V600, imfezi

Kusetshenziselwa ini?

Ukuhlolwa kuvame ukusetshenziselwa ukubheka ukuguqulwa kwe-BRAF ezigulini ezine-melanoma noma eminye imidlavuza ehlobene ne-BRAF. Imithi ethile yomdlavuza isebenza ikakhulukazi kubantu abanezinguquko ze-BRAF. Imithi efanayo ayisebenzi kangako futhi kwesinye isikhathi iyingozi kubantu abangenalo ushintsho.

Ukuhlolwa kwe-BRAF kungasetshenziselwa ukubona ukuthi ngabe usengozini yomdlavuza osuselwa kumlando womndeni kanye / noma kumlando wakho wezempilo.

Kungani ngidinga ukuhlolwa kofuzo kwe-BRAF?

Ungadinga ukuhlolwa kwe-BRAF uma utholakale une-melanoma noma olunye uhlobo lomdlavuza. Ukwazi ukuthi unoshintsho kungasiza umhlinzeki wakho anikeze ukwelashwa okufanele.

Ungadinga futhi lolu vivinyo ukubona ukuthi usengozini enkulu yokuthola umdlavuza. Izici zobungozi zifaka umlando womndeni womdlavuza kanye / noma ukuba nomdlavuza usemncane. Iminyaka ethile incike ohlotsheni lomdlavuza.

Kwenzekani ngesikhathi sokuhlolwa kofuzo kwe-BRAF?

Ukuhlolwa okuningi kwe-BRAF kwenziwa ngenqubo ebizwa nge-tumor biopsy. Ngesikhathi se-biopsy, umhlinzeki wezokunakekelwa kwempilo uzokhipha ucezu oluncane lwezicubu ngokusika noma ngokuklwebha ubuso besimila. Uma umhlinzeki wakho edinga ukuhlola izicubu zomzimba ngaphakathi komzimba wakho, angasebenzisa inaliti ekhethekile ukukhipha isampula.

Ngabe kukhona engizodinga ukukwenza ukulungiselela isivivinyo?

Imvamisa awudingi amalungiselelo akhethekile wokuhlolwa kwe-BRAF.

Ingabe zikhona izingozi esivivinyweni?

Ungaba nokulimala okuncane noma ukopha kusayithi le-biopsy. Ungase futhi ube nokungakhululeki okuncane esizeni usuku noma ezimbili.

Isho ukuthini imiphumela?

Uma une-melanoma noma olunye uhlobo lomdlavuza, futhi imiphumela ikhombisa ukuthi unokuguquka kwe-BRAF, umhlinzeki wakho angakunika imithi eyenzelwe ukukhomba ukuguquka. Le mithi ingasebenza kakhulu kunezinye izindlela zokwelapha.

Uma une-melanoma noma olunye uhlobo lomdlavuza, futhi imiphumela ikukhombisa ungenzi ube noshintsho, umhlinzeki wakho uzokunikeza izinhlobo ezahlukahlukene zemithi yokwelapha umdlavuza wakho.

Uma ungatholakali unomdlavuza futhi imiphumela yakho ikhombisa ukuthi unokuguqulwa kwezakhi zofuzo kwe-BRAF, akunjalo akunjalo kusho ukuthi unomdlavuza, kodwa unengozi enkulu yomdlavuza. Kepha ukuhlolwa kaningi komdlavuza, njengokuhlolwa kwesikhumba, kunganciphisa ubungozi bakho. Ngesikhathi sokuhlolwa kwesikhumba, umhlinzeki wezokunakekelwa kwempilo uzobheka ngokucophelela isikhumba emzimbeni wakho wonke ukuze ahlole izimvukuzane nokunye ukukhula okusolisayo.

Khuluma nomhlinzeki wakho ngezinye izinyathelo ongazithatha ukunciphisa ubungozi bakho.

Funda kabanzi mayelana nokuhlolwa kwelabhorethri, ububanzi bezinkomba, nemiphumela yokuqonda.

Ngabe kukhona okunye engidinga ukukwazi mayelana nokuhlolwa kwe-BRAF?

Ungase uzwe umhlinzeki wakho ekhuluma ngokuguqulwa kwe-V600E. Kunezinhlobo ezahlukahlukene zokuguqulwa kwe-BRAF. I-V600E uhlobo oluvame kakhulu lokuguqulwa kwe-BRAF.

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Imininingwane ekulesi siza akufanele isetshenziswe esikhundleni sezokunakekelwa kwezokwelapha noma iseluleko. Xhumana nomhlinzeki wezempilo uma unemibuzo ngempilo yakho.