Kungenzeka Yini ukuthi Uhlobo Lwesibili Sikashukela Luguquke lube Uhlobo 1?

-Delile

• Ngabe uhlobo lwesifo sikashukela 2 lungaphenduka uhlobo 1?
• Ingabe ungaxilongwa kabi ngohlobo lwesifo sikashukela sohlobo 2?
• Siyini isifo sikashukela esizimele sabantu abadala (i-LADA)?
• Uyini umehluko phakathi kohlobo 2 sikashukela kanye ne-LADA?
• Uyini umugqa waphansi?

Uyini umehluko phakathi kohlobo 1 nohlobo 2 sikashukela?

Uhlobo lwe-1 sikashukela luyisifo esizimele. Kwenzeka lapho amangqamuzana e-islet akhiqiza i-insulin emanyikwe ecekelwe phansi ngokuphelele, ngakho umzimba awukwazi ukukhiqiza noma iyiphi i-insulin.

Kuhlobo lwesifo sikashukela sohlobo 2, amangqamuzana esiqhingi asasebenza. Kodwa-ke, umzimba umelana ne-insulin. Ngamanye amagama, umzimba awusayisebenzisi kahle i-insulin.

Uhlobo lwesifo sikashukela sohlobo 1 aluvamile kakhulu kunohlobo lwesi-2. Sasibizwa ngokuthi yisifo sikashukela esentsha ngoba lesi sifo sitholakala sisencane.

Uhlobo lwesifo sikashukela sohlobo lwe-2 luvame ukutholakala kubantu abadala, yize manje sesibona izingane eziningi ngokwengeziwe zitholwa zinalesi sifo. Kuvame ukubonakala kulabo abakhuluphele ngokweqile noma abakhuluphele.

Ngabe uhlobo lwesifo sikashukela 2 lungaphenduka uhlobo 1?

Uhlobo lwesifo sikashukela sohlobo lwe-2 alunakuphenduka uhlobo lwesifo sikashukela sohlobo 1, ngoba lezi zimo ezimbili zinezimbangela ezihlukile.

Ingabe ungaxilongwa kabi ngohlobo lwesifo sikashukela sohlobo 2?

Kungenzeka ukuthi umuntu onesifo sikashukela sohlobo lwe-2 angatholakali kahle. Bangaba nezimpawu eziningi zesifo sikashukela sohlobo lwe-2, kepha empeleni banesinye isimo esingahle sihlobene kakhulu nohlobo 1 lwesifo sikashukela. Lesi simo sibizwa ngokuthi yi-latent autoimmune diabetes kubantu abadala (i-LADA).

Abaphenyi balinganisela ukuthi phakathi kwamaphesenti amane kuya kwayi-14 abantu abatholwe benesifo sikashukela sohlobo 2 kungenzeka babe ne-LADA. Odokotela abaningi abakasazi lesi simo futhi bazocabanga ukuthi umuntu unesifo sikashukela sohlobo 2 ngenxa yeminyaka nezimpawu zakhe.

Ngokuvamile, ukuxilongwa okungalungile kungenzeka ngoba:

• zombili i-LADA nohlobo lwesifo sikashukela esingu-2 zivame ukukhula kubantu abadala
• izimpawu zokuqala ze-LADA - njengokoma ngokweqile, ukungaboni kahle, noshukela ophakeme wegazi - zilingisa lezo zohlobo lwesifo sikashukela sohlobo 2
• odokotela abajwayele ukwenza izivivinyo ze-LADA lapho bethola isifo sikashukela
• ekuqaleni, amanyikwe kubantu abane-LADA asakhipha i-insulin ethile
• ukudla, ukuzivocavoca, kanye nezidakamizwa zomlomo ngokuvamile ezisetshenziselwa ukwelapha uhlobo lwesifo sikashukela sohlobo 2 zisebenza kahle kubantu abane-LADA ekuqaleni

Kusukela manje, kusenokungaqiniseki okuningi mayelana nokuthi ingachazwa kanjani kahle i-LADA nokuthi ibangelwa yini ukuthi ithuthuke. Imbangela ngqo ye-LADA ayaziwa, kepha abacwaningi bathole izakhi ezithile zofuzo ezingadlala indima.

I-LADA ingasolwa kuphela ngemuva kokuthi udokotela wakho abone ukuthi awuphenduli (noma awusaphenduli) kahle emithini yomlomo yesifo sikashukela yomlomo, ukudla, nokuzivocavoca umzimba.

Siyini isifo sikashukela esizimele sabantu abadala (i-LADA)?

Odokotela abaningi babheka i-LADA uhlobo lwabantu abadala besifo sikashukela sohlobo 1 ngoba futhi yisimo sokuzimela.

Njengesifo sikashukela sohlobo 1, amaseli we-islet kuma-pancreas abantu abane-LADA ayabhujiswa. Noma kunjalo, le nqubo yenzeka kancane kakhulu. Uma isiqalile, kungathatha izinyanga ezimbalwa kuze kube yiminyaka eminingana amanyikwe ayeke ukukwazi ukwenza i-insulin.

Abanye ochwepheshe babheka i-LADA kwenye indawo phakathi kohlobo 1 nohlobo 2 futhi bayibize ngokuthi “thayipha 1.5” isifo sikashukela. Laba bacwaningi bakholelwa ukuthi isifo sikashukela singenzeka nxazonke.

Abaphenyi basazama ukuthola imininingwane, kepha ngokujwayelekile, i-LADA yaziwa ngo:

• athuthuke ebudaleni
• ube nenkambo yokuhamba kancane kunohlobo lwesifo sikashukela sohlobo 1
• kuvame ukuvela kubantu abangakhuluphali ngokweqile
• kuvame ukuvela kubantu abangenazo ezinye izingqinamba ze-metabolic, ezifana nomfutho wegazi ophakeme kanye ne-triglycerides ephezulu
• kuphumela ekuhlolweni okuhle kwama-antibodies ngokumelene namaseli we-islet

Izimpawu ze-LADA ziyefana nezesifo sikashukela sohlobo 2, kufaka phakathi:

• ukoma ngokweqile
• ukuchama ngokweqile
• ukungaboni kahle
• amazinga aphezulu kashukela egazini
• amazinga aphezulu kashukela emchameni
• isikhumba esomile
• ukukhathala
• ukuluma ezandleni noma ezinyaweni
• ukutheleleka njalo kwesinye nesikhumba

Ngaphezu kwalokho, izinhlelo zokwelashwa ze-LADA nohlobo 2 lwesifo sikashukela ziyafana ekuqaleni. Ukwelashwa okunjalo kufaka:

• ukudla okufanele
• ukuzivocavoca umzimba
• ukulawula isisindo
• imithi yesifo sikashukela ngomlomo
• ukwelashwa kokushintshwa kwe-insulin
• ukuqapha amazinga akho e-hemoglobin A1c (HbA1c)

Uyini umehluko phakathi kohlobo 2 sikashukela kanye ne-LADA?

Ngokungafani nabantu abanesifo sikashukela sohlobo lwe-2 abangaze badinge i-insulin futhi abangasibuyisela emuva isifo sikashukela ngokushintsha kwendlela yokuphila kanye nokwehlisa isisindo, abantu abane-LADA abakwazi ukuguqula isimo sabo.

Uma une-LADA, ekugcineni kuzodingeka ukuthi uthathe i-insulin ukuze uhlale uphilile.

Uyini umugqa waphansi?

Uma usanda kutholakala unesifo sikashukela sohlobo 2, qonda ukuthi isimo sakho ngeke sigcine siphenduke isifo sikashukela sohlobo 1. Kodwa-ke, kukhona okuncane okungenzeka ukuthi uhlobo lwakho lwesifo sikashukela sohlobo lwe-2 empeleni luyi-LADA, noma uthayiphe isifo sikashukela esingu-1.5.

Lokhu kuyiqiniso ikakhulukazi uma unesisindo esinempilo noma uma unomlando womndeni wezifo ezizimele, ezinjengesifo sikashukela sohlobo 1 noma isifo samathambo (RA).

Kubalulekile ukuxilonga kahle i-LADA ngoba uzodinga ukuqala kuma-insulin shots kusenesikhathi ukulawula isimo sakho. Ukuxilongwa ngokungafanele kungakhungathekisa futhi kudideke. Uma unanoma yikuphi ukukhathazeka mayelana nohlobo lwakho lwesifo sikashukela sohlobo lwakho, bheka udokotela wakho.

Ukuphela kwendlela yokuhlonza kahle i-LADA ukuhlola amasosha omzimba akhombisa ukuhlaselwa okuzenzakalelayo kumaseli akho e-islet. Udokotela wakho angalawula ukuhlolwa kwegazi le-antibody ye-GAD ukuthola ukuthi unaso yini leso simo.