Yini i-DAO? Kuchazwa Izithako ze-Diamine Oxidase

-Delile

• Yini i-DAO?
• Ukushoda kwe-DAO kanye ne-Histamine Intolerance
• Izinzuzo Ezingaba khona Zokuxhaswa yi-DAO
• Izimpawu zokugaya ukudla
• Ukuhlaselwa Kwe-Migraine Nekhanda Elibuhlungu
• Isikhumba Rash
• Hhayi Ikhambi
• Izindlela Zokudla Ezinempilo Zokushoda Kwe-DAO
• Ithuthukisa Umsebenzi we-DAO
• Ukudla Okufanele Kugwenywe
• Ukuqapha kanye nezincomo zesilinganiso
• Okusemqoka

I-Diamine oxidase (i-DAO) iyi-enzyme kanye nesengezo sokudla okunempilo esisetshenziswa kakhulu ekwelapheni izimpawu zokungabekezelelani kwe-histamine.

Ukwengeza nge-DAO kungaba nezinzuzo ezithile, kepha ucwaningo lukhawulelwe.

Lo mbhalo ubuyekeza izengezo ze-DAO, kufaka phakathi izinzuzo zazo, isilinganiso, nokuphepha.

Yini i-DAO?

I-Diamine oxidase (i-DAO) iyi-enzyme yokugaya ekhiqizwa ezinso zakho, i-thymus, kanye nolwelwesi lwamathumbu lwendlela yakho yokugaya ukudla.

Umsebenzi wawo oyinhloko ukwephula i-histamine eyeqile emzimbeni wakho (1).

I-Histamine iyinhlanganisela eyenzeka ngokwemvelo esiza ukulawula imisebenzi ethile yamasistimu akho wokugaya ukudla, ama-nervous and immune.

Uma uke wahlangabezana nokungezwani komzimba, mhlawumbe ujwayelene nezimpawu ezijwayelekile ezihambisana namazinga aphakeme we-histamine, njengokucinana kwamakhala, isikhumba esilumayo, ikhanda elibuhlungu nokuthimula.

Ungangena futhi i-histamine ngokudla kwakho. Kwenzeka ngokwemvelo ekudleni okuthile - ikakhulukazi lokho okugugile, okuphulukisiwe, noma okubilisiwe njengoshizi, iwayini, ukhukhamba, nenyama ebhemayo (1).

I-DAO igcina amazinga e-histamine ebangeni eliphilile ukugwema izimpawu ezingathandeki ezibangelwa yi-histamine.

IDiamine oxidase (i-DAO) iyi-enzyme esiza ukwehlisa i-histamine eyeqile emzimbeni wakho, ngaleyo ndlela inciphise izimpawu ezingathandeki, njengokucinana kwamakhala, isikhumba esilumayo, ikhanda elibuhlungu nokuthimula.

Ukushoda kwe-DAO kanye ne-Histamine Intolerance

Ukungabekezelelani komlando kuyisimo sezokwelapha esenzeka njengomphumela wamazinga aphezulu e-histamine.

Enye yezimbangela ezisolwayo zokungabekezelelani kwe-histamine ukushoda kwe-DAO ().

Lapho amazinga akho e-DAO ephansi kakhulu, kunzima ngomzimba wakho ukuthi usebenze kahle futhi ukhiphe i-histamine eyeqile. Ngenxa yalokhu, amazinga e-histamine ayakhuphuka, aholele kwizimpawu ezahlukahlukene zomzimba.

Izimpawu zokungabekezelelani kwe-histamine zivame ukufana nalokho okusabela okweqile. Zingahle zihlukane kusuka kokumnene ziye kokubi futhi zifaka ():

• ukuminyana kwamakhala
• ikhanda
• isikhumba esilumayo, ukuqubuka, kanye nesifuba
• ukuthimula
• isifuba somoya nobunzima bokuphefumula
• ukushaya kwenhliziyo okungajwayelekile (arrhythmia)
• isifo sohudo, ubuhlungu besisu, nokucindezeleka kokugaya ukudla
• isicanucanu nokuhlanza
• umfutho wegazi ophansi (hypotension)

Izici ezahlukahlukene zingaba nomthelela ekwehliseni umsebenzi we-DAO noma ukukhiqizwa ngokweqile kwe-histamine, kufaka phakathi ukuguqulwa kwezakhi zofuzo, ukusetshenziswa kotshwala, imithi ethile, ukwanda kwamabhaktheriya emathunjini, nokudla ukudla okuningi okuqukethe i-histamine ().

Ukungabekezelelani komlando kungaba nzima ukuwuthola, ngoba izimpawu zawo ziyindida futhi ziyafana nezinye izimo zezokwelapha (1,).

Ngakho-ke, uma ucabanga ukuthi uhlangabezana nokungabekezelelani kwe-histamine, thintana nomhlinzeki wokunakekelwa kwezempilo ofanelekile ukuze aphenye kahle izimbangela zezimpawu zakho ngaphambi kokuzama ukuzihlola noma ukuzelapha.

Ukungabekezelelani kwe-Histamine kungakhula ngenxa yokuntuleka kwe-DAO futhi kuholele kwizimpawu ezahlukahlukene ezingathandeki ezivame ukulingisa ukusabela okweqile.

Izinzuzo Ezingaba khona Zokuxhaswa yi-DAO

Ukushoda kwe-DAO nokungabekezelelani kwe-histamine kungelashwa ngezindlela ezahlukahlukene, kufaka phakathi ukwengeza nge-DAO.

Ucwaningo lwakuqala luphakamisa ukuthi izengezo ze-DAO zinganciphisa izimpawu ezithile zokungabekezelelani kwe-histamine, kufaka phakathi ikhanda, ukuqubuka kwesikhumba, kanye nokucindezeleka kokugaya ukudla.

Izimpawu zokugaya ukudla

Ocwaningweni lwamaviki amabili kubantu abangu-14 abane-histamine ukungabekezelelani nezimpawu ezibandakanya ubuhlungu besisu, ukuqunjelwa, noma isifo sohudo, ama-93% ababambiqhaza babike ukuxazululwa okungenani uphawu olulodwa lokugaya ukudla ngemuva kokuthatha i-4.2 mg ye-DAO kabili ngosuku ().

Ukuhlaselwa Kwe-Migraine Nekhanda Elibuhlungu

Ucwaningo lwenyanga engu-1 kubantu abayi-100 abanokushoda kwe-DAO obekutholwe ngaphambili babona ukuthi ababambiqhaza abangezela nsuku zonke nge-DAO babhekana nokwehla okungama-23% esikhathini sokuhlaselwa yi-migraine, uma kuqhathaniswa neqembu le-placebo ().

Isikhumba Rash

Ucwaningo lwezinsuku ezingama-30 kubantu abangama-20 abane-urticaria engapheli (ukuqubuka kwesikhumba) nokushoda kwe-DAO kuqaphele ukuthi ababambiqhaza abathole isengezo kabili ngosuku bathola ukukhululeka okukhulu ezimpawu futhi badinga imishanguzo ye-antihistamine ().

Yize lezi zifundo ziphakamisa ukuthi ukwengeza nge-DAO kungaqeda noma kuthuthukise izimpawu zokushoda, asikho isiqinisekiso sokuthi sisebenza kuwo wonke umuntu.

Ekugcineni, kudingeka olunye ucwaningo ukuthola iziphetho ezicacile.

Ucwaningo lwakuqala luphakamisa ukuthi izithasiselo ze-DAO zingathuthukisa izimpawu ezithile ezihambisana nokushoda kwe-DAO nokungabekezelelani kwe-histamine, kufaka phakathi ukuhlaselwa yi-migraine, ukuqubuka kwesikhumba, nezinkinga zokugaya ukudla. Noma kunjalo, kudingeka izifundo eziningi.

Hhayi Ikhambi

Ukuqonda kwesayensi kokungabekezelelani kwe-histamine nokushoda kwe-DAO kusese sigaba sokuqala.

Izici ezahlukahlukene zingathinta ukukhiqizwa kwe-DAO ne-histamine ezingxenyeni ezihlukene zomzimba wakho. Ukubhekana nomsuka walezi zinkinga akulula njengokufaka i-DAO esikhundleni sokufaka (1,).

Izithako ze-DAO zisebenza ukwephula i-histamine engena emzimbeni wakho ngaphandle, njengokudla noma iziphuzo.

Ukuthatha lesi sithasiselo ngeke kuthinte amazinga e-histamine akhiqizwa ngaphakathi, njengoba lolu hlobo lwe-histamine ludilizwa i-enzyme ehlukile ebizwa nge-N-methyltransferase ().

Yize izithasiselo ze-DAO zinganciphisa izimpawu ngokunciphisa ukuvezwa kwe-histamine yangaphandle, ucwaningo olukhombisa ukuthi bangakwazi ukwelapha ukungabekezelelani kwe-histamine noma ukushoda kwe-DAO kuyashoda.

Uma utholwe unokubekezelelana kwe-histamine noma usola ukuthi ungaba nakho, thintana nodokotela ofanelekayo wezempilo ukuze wakhe uhlelo olwenzelwe wena ngokuya ngezidingo zakho ezihlukile kanye nezinhloso zezempilo.

Kuze kube manje, alukho ucwaningo lwesayensi olukhombisa ukuthi izithasiselo ze-DAO zingalapha ukushoda kwe-DAO noma ukungabekezelelani kwe-histamine.

Izindlela Zokudla Ezinempilo Zokushoda Kwe-DAO

Ukungabekezelelani kwe-Histamine nokushoda kwe-DAO yizimo eziyinkimbinkimbi ezinezici eziningi ezinomthelela ebukhali bezimpawu ezihambisanayo.

Njengamanje, enye yezindlela eziyinhloko zokwelapha lezi zimo kungukudla.

Ngoba ukudla okuthile kwaziwa ukuthi kuqukethe amazinga e-histamine ahlukahlukene, ukuguqulwa kokudla okuthile kungathuthukisa izimpawu zokungabekezelelani kwe-histamine ngokunciphisa ukuvezwa kwemithombo yokudla ye-histamine nokudla okudlayo okungavimba ukusebenza kwe-DAO.

Ithuthukisa Umsebenzi we-DAO

Ukwelashwa kokudla okunempilo okwenzelwe ukuthuthukisa ukubekezelelana kwe-histamine nomsebenzi we-DAO ufuna ukuqinisekisa ukutholwa okwanele kwezakhamzimba okubandakanyekile ekwehliseni i-histamine, kufaka phakathi ithusi namavithamini B6 no-C ().

Olunye ucwaningo luphakamisa nokuthi ukudla okwanele kwamafutha enempilo nezinye izakhi zomzimba - njenge phosphorus, zinc, magnesium, iron, kanye no vitamin B12 - kungadlala indima ekuthuthukiseni umsebenzi weDAO ().

Ukudla ikakhulukazi ukudla kwe-histamine ephansi kunganciphisa ukuvezwa kwe-histamine futhi kwehlise ukuqongelela kwakho emzimbeni wakho. Ukudla okuphansi kwe-histamine kufaka:

• inyama nenhlanzi entsha
• amaqanda
• imifino eminingi emisha - ngaphandle kwesipinashi, utamatisi, ukwatapheya nesitshalo seqanda
• izithelo ezintsha - ngaphandle kwezithelo ezisawolintshi namanye amajikijolo
• amafutha anjengokakhukhunathi namafutha omnqumo
• okusanhlamvu, kufaka phakathi irayisi, i-quinoa, ummbila, i-teff, namabele

Ukudla Okufanele Kugwenywe

Ukunciphisa noma ukususa ukudla okuphezulu kwi-histamine noma lokho okubangela ukukhiqizwa kwe-histamine elinye isu lokulawula izimpawu zokungabekezelelani kwe-histamine nokukhiqizwa kwe-DAO okuphansi.

Okunye ukudla okuqukethe amazinga aphezulu we-histamine futhi kungadala ukukhishwa kwe-histamine kufaka ():

• iziphuzo ezidakayo, ezifana nobhiya, iwayini, notshwala
• ukudla okubilisiwe, njenge-sauerkraut, ukhukhamba, iyogathi, ne-kimchi
• izimbaza
• okobisi
• ukudla okudala, njengoshizi kanye nenyama ebhemayo nephulukisiwe
• ukolweni
• amantongomane, njengamakinati namasheya
• izithelo ezithile, kufaka phakathi izithelo ezisawolintshi, ubhanana, upopo, kanye nama-strawberry
• imifino ethile, efaka utamatisi, isipinashi, isitshalo seqanda, nokwatapheya
• izithasiselo ezithile zokudla, ukufaka imibala, nokonga okonga

Ngoba ukukhetha kokudla okuvunyelwe ekudleni okuphansi kwe-histamine kungakhawulelwa, ungaba sengozini yokushoda kokudla okunempilo nekhwalithi yempilo encishisiwe (1,).

Ngakho-ke, ukudla okuqinile kwe-histamine okufanele kusetshenziswe kuphela okwesikhashana ukuhlola ukuzwela kokudla okuthile.

Abanye abantu abane-histamine ukungabekezelelani bangakubekezelela inani elincane lokudla okuphezulu kwe-histamine.

Ukudla kokuqeda kungasiza ekuboneni ukuthi yikuphi ukudla okubangela izimpawu eziningi futhi okufanele kugwenywe unomphela nalabo ongaqhubeka nokudla ngokuphepha ngamanani amancane.

Ngokufanelekile, le nqubo igcwaliswa ngaphansi kokuholwa ngumhlinzeki wezempilo ofanele ukuvimbela izinkinga.

Imithi yokwelashwa yokusekela ukusebenza kwe-DAO futhi inciphise ukuvezwa kwe-histamine ifaka phakathi ukuqeda izivumelwano zokudla nokudla okwanele kwezakhamzimba ezithile ezaziwa ukuthuthukisa ukusebenza kwe-DAO.

Ukuqapha kanye nezincomo zesilinganiso

Ayikho imiphumela emibi yezempilo eye yabikwa ezifundweni zezithasiselo ze-DAO.

Kodwa-ke, ucwaningo lusatholakali, ngakho-ke ukuvumelana okucacile maqondana nokufaka umthamo walesi sengezo esithile kusamele kusungulwe.

Ucwaningo oluningi olutholakalayo lusebenzise imithamo ka-4.2 mg we-DAO ngasikhathi kuze kube izikhathi ezi-2-3 nsuku zonke ngaphambi nje kokudla (,,).

Ngakho-ke, imithamo efanayo kungenzeka iphephile kubantu abaningi - kepha lokho akusho ukuthi ayinangozi engu-100%.

Amanye amazwe afana ne-United States awalawuli izithasiselo zokudla okunempilo. Ngakho-ke, kuwumqondo omuhle ukuqinisekisa ukuthi umkhiqizo wakho owukhethile uhlolwe ubumsulwa nekhwalithi ngumuntu wesithathu, njenge-U.S. Pharmacopeia Convention (USP).

Njalo thintana nomhlinzeki wakho wezokunakekelwa kwempilo ngaphambi kokufaka isengezo esisha ekudleni kwakho.

Imithamo ye-4.2 mg ye-DAO izikhathi ezingama-2-3 nsuku zonke ngaphambi kokudla kucwaningwe ngaphandle kwemibiko yokuphendula okubi. Kodwa-ke, ukuvumelana okucacile kokufakwa kwe-DAO akukatholakali.

Okusemqoka

Izithasiselo ze-DAO azikwazi ukwelapha ukungabekezelelani kwe-histamine noma i-DAO kepha zinganciphisa izimpawu ngokudiliza imithombo yangaphandle ye-histamine njengaleyo evela ekudleni naseziphuzweni.

Ucwaningo oluningi luyadingeka ukuze kutholakale ukusebenza kwabo, ukuphepha, kanye nomthamo, yize izifundo zamanje zingabiki imiphumela emibi.

Qiniseka ukuthi uthintana nokukhuluma nomhlinzeki wezempilo oqeqeshiwe ngaphambi kokungeza noma isiphi isengezo esisha noma umuthi enkambisweni yakho yempilo.