I-Dermatitis Herpetiformis kanye ne-Gluten Intolerance

-Delile

• Izithombe ze-dermatitis herpetiformis
• Yini ebangela i-dermatitis herpetiformis?
• Ngubani osengozini ye-dermatitis herpetiformis?
• Ziyini izimpawu ze-dermatitis herpetiformis?
• Ngabe i-dermatitis herpetiformis itholakala kanjani?
• Yiziphi izindlela zokwelapha ezitholakalayo ze-dermatitis herpetiformis?
• Yiziphi izinkinga ze-dermatitis herpetiformis?
• Uyini umbono wesikhathi eside we-dermatitis herpetiformis?

Kuyini i-dermatitis herpetiformis?

Ukuqhuma kwesikhumba, ukugqabhuka, ukushisa kwesikhumba, i-dermatitis herpetiformis (DH) yisimo esinzima ukuhlala naso. Ukuqubuka nokunwaya kwenzeka ezindololwaneni, emadolweni, esikhunjeni, emuva nasezinqeni. Lokhu kuqhuma kungenzeka kukhombise ukungabekezelelani kwe-gluten, okungahle kuhlobene nesimo esibi kakhulu esaziwa njengesifo se-celiac. I-DH kwesinye isikhathi ibizwa ngokuthi isifo sikaDuhring noma ukuqubuka kwe-gluten. Abantu abanalesi simo badinga ukugcina ukudla okuqinile okungenayo i-gluten.

Izithombe ze-dermatitis herpetiformis

Yini ebangela i-dermatitis herpetiformis?

Ngomsindo wegama, abantu abaningi bacabanga ukuthi lokhu kuqubuka kubangelwa uhlobo oluthile lwegciwane le-herpes. Lokhu akunjalo, ngoba akuhlangene ne-herpes. I-dermatitis herpetiformis ivela kubantu abanesifo se-celiac. Isifo se-Celiac (esibizwa nangokuthi i-celiac sprue, ukungabekezelelani kwe-gluten, noma i-enteropathy ezwela nge-gluten) yisifo esizimele esibonakala ngokungabekezelelani ne-gluten. I-Gluten yiprotheni etholakala kukolweni, i-rye nebhali. Futhi kwesinye isikhathi kutholakala kuma-oats asetshenzisiwe ezitshalweni eziphatha ezinye izinhlamvu.

Ngokusho kweNational Institutes of Health (NIH), amaphesenti ayi-15 kuye kwangama-25 abantu abanesifo se-celiac bane-DH. Isifo seCeliac singadala nobuhlungu obukhulu besisu, ukuqunjelwa, isicanucanu nokuhlanza. Abantu abane-DH ngokuvamile abanazo izimpawu zamathumbu. Kodwa-ke, noma ngabe bengazitholi izimpawu zamathumbu, amaphesenti angama-80 noma ngaphezulu abantu abane-DH basenomonakalo wamathumbu, ikakhulukazi uma bedla ukudla okune-gluten eningi, ngokusho kweNational Foundation for Celiac Awareness (NFCA).

Ukulimala kwamathumbu nokuqubuka kubangelwa ukusabela kwamaprotheni e-gluten nohlobo olukhethekile lwe-antibody ebizwa nge-immunoglobulin A (IgA). Umzimba wakho wenza amasosha omzimba we-IgA ahlasele amaprotheni e-gluten. Lapho amasosha omzimba e-IgA ehlasela i-gluten, alimaza izingxenye zamathumbu ezikuvumela ukuthi umunce amavithamini nezakhi zomzimba. Lokhu kuzwela ku-gluten kuvame ukugijima emindenini.

Izakhiwo ezakhiwe lapho i-IgA inamathela ku-gluten bese ingena egazini, lapho iqala khona ukuvala imithambo yegazi emincane, ikakhulukazi leyo esikhumbeni. Amaseli amhlophe egazi adonswa kulawa ma-clogs. Amaseli egazi amhlophe akhipha ikhemikhali elibizwa ngokuthi "umphelelisi" elibanga ukuqubuka okunukayo, okuqhamukayo.

Ngubani osengozini ye-dermatitis herpetiformis?

Isifo seCeliac singathinta noma ngubani, kepha sithambekele kakhulu kubantu abanelinye ilungu lomndeni elinesifo se-celiac noma i-DH.

Yize abesifazane abaningi kunabesilisa betholakala ukuthi banesifo se-celiac, abesilisa banamathuba amaningi okuthuthukisa i-DH kunabesifazane, ngokusho kwe-NIH. Ukuqhuma kuvame ukuqala kuma-20s akho noma ama-30s, noma kungaqala ebuntwaneni. Isimo sivame ukwenzeka kubantu bomdabu waseYurophu. Akuvamile ukuthinta abantu abadabuka e-Afrika noma e-Asia.

Ziyini izimpawu ze-dermatitis herpetiformis?

I-DH ingesinye seziqubu ezimbi kakhulu. Izindawo ezivamile zokuqhuma zihlanganisa:

• Izindololwane
• amadolo
• emuva emuva
• izinwele
• emuva kwentamo
• emahlombe
• izinqa
• isikhumba sekhanda

Ukuqubuka kuvame ukuba ngosayizi nokuma okufanayo ezinhlangothini zombili zomzimba futhi kuvame ukufika kudlule.

Ngaphambi kokuqubuka okuphelele kokuqubuka, ungazizwa isikhumba sendawo esivele sisheshiswe ukushisa noma silume. Amaqhuqhuva abukeka njengezinduna agcwele uketshezi olucacile aqala ukwakheka. Lokhu kuklwebheka ngokushesha. Amaqhuqhuva ayaphola kungakapheli izinsuku ezimbalwa bese eshiya uphawu olububende oluhlala amasonto. Kepha amaqhubu amasha ayaqhubeka nokwakheka njengoba amadala elapha. Le nqubo ingaqhubeka iminyaka, noma ingangena ekuxolelweni bese ibuya.

Ngenkathi lezi zimpawu zivame ukuhlotshaniswa ne-dermatitis herpetiformis, zingabangelwa nezinye izimo zesikhumba ezifana ne-atopic dermatitis, i-irritant noma i-allergen contact dermatitis, i-psoriasis, i-pemphigoid, noma utwayi.

Ngabe i-dermatitis herpetiformis itholakala kanjani?

I-DH itholakala kangcono nge-biopsy yesikhumba. Udokotela uthatha isampula elincane lesikhumba bese elihlola ngaphansi kwesibonakhulu. Kwesinye isikhathi, kwenziwa ukuhlolwa okuqondile kwe-immunofluorescence, lapho isikhumba esizungeze ukuqubuka sigcwele udayi ozokhombisa ubukhona bamadiphozithi omzimba we-IgA. I-biopsy yesikhumba nayo ingasiza ekunqumeni ukuthi ngabe izimpawu zibangelwa esinye isimo sesikhumba.

Ukuhlolwa kwegazi ukubheka la ma-antibody egazini nakho kungenziwa. I-biopsy yamathumbu ingenziwa ukuqinisekisa ukutholakala komonakalo ngenxa yesifo se-celiac.

Uma ukuxilongwa kungaqinisekile, noma okunye ukuxilongwa kungenzeka, okunye ukuhlolwa kungenziwa. Ukuhlolwa kwe-Patch kuyindlela engcono kakhulu yokuhlonza i-allergen contact dermatitis, okuyimbangela ejwayelekile yezimpawu ezifana ne-dermatitis herpetiformis.

Yiziphi izindlela zokwelapha ezitholakalayo ze-dermatitis herpetiformis?

I-DH ingelashwa nge-antibiotic ebizwa nge-dapsone. IDapsone ngumuthi onamandla onemiphumela emibi kakhulu. Umthamo kufanele unyuswe kancane ezinyangeni ezimbalwa ngaphambi kokuba usebenze ngokugcwele.

Iningi labantu libona ukukhululeka ekuthatheni i-dapsone, kepha imiphumela emibi ingafaka:

• izinkinga zesibindi
• ukuzwela ekukhanyeni kwelanga
• i-anemia
• ubuthakathaka bemisipha
• i-peripheral neuropathy

I-Dapsone ingahle ibe nokuxhumana okungalungile neminye imithi, njenge-aminobenzoate potassium, i-clofazimine, noma i-trimethoprim.

Eminye imishanguzo engasetshenziswa ifaka i-tetracycline, i-sulfapyridine, kanye neminye imishanguzo yokuvikela umzimba. Lokhu akusebenzi kangako kune-dapsone.

Ukwelashwa okuphumelela kakhulu okungenayo imiphumela emibi ukunamathela ngokuqinile ekudleni okungenalutho kwe-gluten. Lokhu kusho ukuthi kufanele ugweme ngokuphelele ukudla, isiphuzo, noma imithi equkethe okulandelayo:

• ukolweni
• rye
• ibhali
• oats

Yize lokhu kudla kungaba nzima ukukulandela, kuzoba nomthelela omuhle kakhulu empilweni yakho uma unesifo se-celiac. Noma yikuphi ukwehliswa kokudla kwe-gluten kungasiza ekunciphiseni inani lemithi oyodinga ukuyithatha.

Yiziphi izinkinga ze-dermatitis herpetiformis?

Abantu abanesifo se-DH kanye ne-celiac esingalashiwe bangaba nengozi enkulu yomdlavuza wamathumbu ngenxa yokuvuvukala okungapheli emathunjini. Ukushoda kwamavithamini kanye ne-anemia nakho kungaba yinkinga uma amathumbu engamunci izakhi kahle.

Njengoba i-DH iyi-autoimmune disease, ithole ukuthi ibuye ihlotshaniswe nezinye izinhlobo ezahlukahlukene zezifo ezizimele. Lokhu kufaka phakathi:

• i-hypothyroidism
• i-vitiligo
• thayipha 1 sikashukela mellitus
• myasthenia gravis
• Isifo seSjögren
• isifo samathambo

Uyini umbono wesikhathi eside we-dermatitis herpetiformis?

I-DH yisifo sempilo yonke. Ungangena ekuthethelelweni, kepha noma kunini lapho uvezwa ku-gluten, ungahle ube nokuqubuka kokuqubuka. Ngaphandle kokwelashwa, i-DH nesifo se-celiac kungaholela emiphumeleni eminingi emibi yezempilo, kufaka phakathi ukuswelakala kwamavithamini, i-anemia nomdlavuza wamathumbu.

Ukwelashwa nge-dapsone kungalawula izimpawu zokuqubuka ngokushesha okukhulu. Kodwa-ke, ukulimala kwamathumbu okubangelwa yisifo se-celiac kungalashwa kuphela ngokugcina ukudla okuqinile okungenayo i-gluten. Qiniseka ukuthi uxoxa ngokudla okuthile nodokotela wakho noma isazi sokudla okunempilo.