Isifo sebele sikaPaget: siyini, izimpawu nokwelashwa

-Delile

• Izimpawu zesifo sebele sikaPaget
• Ukuxilongwa kwenziwa kanjani
• Ukuxilongwa okuhlukile
• Ukwelashwa kwesifo sebele sikaPaget

Isifo sikaPaget sesifuba, noma i-DPM, uhlobo olungajwayelekile lwesifo sebele esivame ukuhlobene nezinye izinhlobo zomdlavuza webele. Lesi sifo akuvamile ukuthi sivele kubantu besifazane ngaphambi kweminyaka engama-40, sitholakala kaningi phakathi kweminyaka engama-50 nengu-60. Yize kungavamile, isifo sikaPaget sesifuba singavela futhi emadodeni.

Ukuxilongwa kwesifo sesifuba sikaPaget kwenziwa yi-mastologist ngokusebenzisa ukuhlolwa kokuxilongwa nokuhlolwa kwezimpawu, njengobuhlungu engonweni, ukucasuka kanye nokuchithwa kwendawo kanye nobuhlungu nokunwaya engonweni.

Izimpawu zesifo sebele sikaPaget

Izimpawu zesifo sikaPaget zivame ukwenzeka ebeleni elilodwa kuphela futhi zivame kakhulu kwabesifazane abaneminyaka engaphezu kwengu-50, okuyizona eziyinhloko:

• Ukucasuka kwasendaweni;
• Ubuhlungu engonweni;
• Ukuchazwa kwesifunda;
• Ukushintshwa kwesimo sengono;
• Ubuhlungu nokulunywa engonweni;
• Ukushisa okushisayo endaweni;
• Ukuqina kwe-areola;
• Ukwenza mnyama isayithi, ezimweni ezivamile.

Ezimweni ezithuthuke kakhulu zesifo sikaPaget, kungahle kube nokubandakanyeka kwesikhumba ezungeze i-areola, ngaphezu kokuhoxa, ukuguqa nokulimala kwengono, ngakho-ke kubalulekile ukuthi ukwelashwa kuqalwe ngokushesha okukhulu.

Udokotela ofanele kakhulu ukuxilonga nokuqondisa ukwelashwa kwesifo sebele yi-mastologist, kepha ukukhonjwa nokwelashwa kwalesi sifo kunganconywa ngudokotela wesikhumba nodokotela wezifo zabesifazane. Kubalulekile ukuthi ukuxilongwa kwenziwe ngokushesha okukhulu, ngoba ngale ndlela kungenzeka ukwelashwa ngendlela efanele, kube nemiphumela emihle.

Ukuxilongwa kwenziwa kanjani

Ukuxilongwa kwesifo sebele sikaPaget kwenziwa ngudokotela ngokuhlola izimpawu nezimpawu zesifuba sowesifazane, ngaphezu kokuhlolwa kwe-imaging, njenge-breast ultrasound kanye ne-magnetic resonance imaging, ngokwesibonelo. Ngaphezu kwalokho, i-mammography ikhonjisiwe ukuze kubhekwe ubukhona bezigaxa noma ukwakheka okuncane kwesifuba okungakhombisa i-carcinoma engahlaseli.

Ngaphezu kokuhlolwa kwe-imaging, udokotela uvame ukucela ingono ye-biopsy, ukuze aqinisekise izici zamaseli, ngaphezu kokuhlolwa kwe-immunohistochemical, okuhambelana nohlobo lokuhlolwa kwelabhoratri lapho ukutholakala noma ukungabikho kwama-antigen kuqinisekiswa khona ezingasichaza lesi sifo, njenge-AE1, AE3, i-CEA kanye ne-EMA ezinesifo sikaPaget sesifuba.

Ukuxilongwa okuhlukile

Ukuxilongwa okwehlukanisayo kwesifo sesifuba sikaPaget kwenziwa ikakhulukazi nge-psoriasis, i-basal cell carcinoma kanye ne-eczema ngokwesibonelo, kwehlukaniswa kokugcina ngenxa yokuba munye nokungalunywa okunamandla. Ukuxilongwa okwehlukile kungenziwa futhi kucatshangelwa impendulo ekwelashweni, ngoba kwisifo sikaPaget, ukwelashwa ngezihloko kungadambisa izimpawu kepha akunamphumela ocacile, okuphindayo.

Ngaphezu kwalokho, isifo sesifuba sikaPaget, lapho sinebala, kufanele sihlukaniswe ne-melanoma, futhi lokhu kwenzeka ikakhulukazi ngokuhlolwa kwe-histopathological, okwenziwa ukuhlola amaseli webele, kanye ne-immunohistochemistry, lapho kukhona khona i-HMB-45, Ama-antigen e-MelanA ne-S100 ku-melanoma kanye nokungabikho kwama-antigen e-AE1, AE3, CEA kanye ne-EMA, okuvame ukuba khona esifweni sikaPaget sesifuba, awekho.

Ukwelashwa kwesifo sebele sikaPaget

Ukwelashwa okuvezwe ngudokotela ngesifo sesifuba sikaPaget kuvame ukuba yi-mastectomy okulandelwa yisikhathi se-chemotherapy noma i-radiation therapy, ngoba lesi sifo sihlala sihlobene ne-carcinoma ehlaselayo. Ezimweni ezingaphansi kakhulu, ukukhonjiswa kokuhlinzwa kwesifunda esilimele kungakhonjiswa, kulondoloze lonke ibele. Ukuxilongwa kusenesikhathi kubalulekile ukuvikela hhayi kuphela ukuqhubekela phambili kwezifo, kepha futhi nokwelashwa ngokuhlinzwa.

Kwezinye izimo, udokotela angakhetha ukwenza ukwelashwa ngaphandle kokuqinisekisa ukuxilongwa, okukhombisa ukusetshenziswa kwemithi yokwenziwa ngezihloko. Inkinga ehlobene nalolu hlobo lokuziphatha ukuthi le mithi inganciphisa izimpawu, noma kunjalo ayithikamezi ukuqhubeka kwesifo.