I-Erenumab: lapho ikhonjisiwe nokuthi ungayisebenzisela kanjani i-migraine

-Delile

• Isebenza kanjani i-erenumab
• Isetshenziswa kanjani
• Imiphumela emibi engaba khona
• Ngubani ongafanele asebenzise

I-Erenumab yinto esebenzayo esebenzayo, ekhiqizwa ngendlela yomjovo, eyenzelwe ukuvimbela nokunciphisa ukuqina kobuhlungu be-migraine kubantu abaneziqephu ezi-4 noma ngaphezulu ngenyanga. Lesi sidakamizwa siyi-antibody yokuqala ne-monoclonal yokuqala eyenzelwe ngqo ukuvimbela i-migraine futhi imakethwa ngaphansi kwegama elithi Pasurta.

I-Migraine ibonwa yikhanda elibuhlungu nelishayayo elingathinta uhlangothi olulodwa kuphela, futhi lingahle lihambisane nezinye izimpawu ezinjengesicanucanu, ukuhlanza, isiyezi, ukuzwela ekukhanyeni, ubuhlungu entanyeni nobunzima bokugxila. Funda kabanzi mayelana nezimpawu ze-migraine.

I-Erenumab ivumela ukwehliswa kwesigamu senani lemigraines kanye nobude beziqephu zobuhlungu, ngamanani we-70 mg no-140 mg.

Isebenza kanjani i-erenumab

I-Erenumab i-anti-monoclonal antibody yomuntu esebenza ngokuvimba i-peptide receptor ehlobene ne-calcitonin gene, eyinhlanganisela yamakhemikhali ekhona ebuchosheni futhi ethintekayo ekusebenzeni kwe-migraine nobude besikhathi sobuhlungu.

I-peptide ehlobene nohlobo lwe-calcitonin kukholakala ukuthi idlala indima ebalulekile kwi-pathophysiology ye-migraine, ngesixhumanisi nama-receptors ayo abandakanyeka ekudluliseni ubuhlungu be-migraine. Kubantu abane-migraine, amazinga ale peptide akhuphuka ekuqaleni kwesiqephu, abuyele kokujwayelekile ngemuva kokudambisa izinhlungu, ngokwelashwa ngezidakamizwa ezisetshenziselwa ukwelapha i-migraine, noma lapho ukuhlaselwa kudamba.

Ngakho-ke, i-erenumab ayikwazi ukunciphisa kuphela iziqephu ze-migraine, kepha futhi inganciphisa ukuphuza imishanguzo esetshenziselwa ukwelapha i-migraines, enemiphumela emibi eminingi.

Isetshenziswa kanjani

I-Pasurta kufanele ijojowe ngaphansi kwesikhumba kusetshenziswa isipetu noma ipeni eligcwaliswe ngaphambili, elingalawulwa ngumuntu ngemuva kokuthola ukuqeqeshwa okwanele.

Umthamo onconywayo ungama-70 mg njalo emavikini amane, ngomjovo owodwa. Kwezinye izimo, kungadingeka ukuphatha umthamo ka-140 mg njalo emavikini amane.

Imiphumela emibi engaba khona

Imiphumela emibi kakhulu engenzeka ngesikhathi sokwelashwa nge-erenumab ukusabela endaweni yomjovo, ukuqunjelwa, ukuphazamiseka kwemisipha nokunwaya.

Ngubani ongafanele asebenzise

I-Pasurta iyaphikiswa kubantu abane-hypersensitive kunoma yiziphi izinto ezikhona kwifomula futhi akunconywa abesifazane abakhulelwe noma abesifazane abancelisayo.