I-Harvoni (ledipasvir / sofosbuvir)

-Delile

• Yini iHarvoni?
• IHarvoni ejwayelekile
• Imiphumela emibi ye-Harvoni
• Imiphumela emibi ejwayelekile
• Imiphumela emibi kakhulu
• Ukuvimbela ukuzibulala
• Imiphumela emibi yesikhathi eside
• Imiphumela emibi ngemuva kokwelashwa
• Ukwehla kwesisindo noma ukuzuza kwesisindo
• Izimpawu zokuhoxa
• Ubuhlungu obuhlangene
• Imiphumela yamehlo
• Ukulahleka kwezinwele
• Ukuqhuma / ukulunywa
• Uhudo
• Ukucindezeleka
• Ukukhathala
• Ukuqwasha (kunzima ukulala)
• Ubuhlungu bekhanda
• Umdlavuza wesibindi / umdlavuza
• Izindleko ze-Harvoni
• Usizo lwezezimali nolomshuwalense
• UHarvoni usebenzisa
• Isilinganiso se-Harvoni
• Amafomu wezidakamizwa namandla
• Isikali se-hepatitis C
• Isikhathi sokwelashwa
• Kuthiwani uma ngiphuthelwa umthamo?
• Ukunamathela kuhlelo lwakho lokwelashwa kweHarvoni
• IHarvoni notshwala
• IHarvoni ene-ribavirin
• Imiphumela emibi ye-Ribavirin
• I-Ribavirin nokukhulelwa
• I-Ribavirin nokuncelisa
• Ukusebenzisana kweHarvoni
• Harvoni neminye imithi
• IHarvoni ne-ribavirin
• IHarvoni ne-omeprazole noma amanye ama-PPIs
• IHarvoni namakhambi nezithako
• IHarvoni nekhofi
• Ezinye izindlela eziya eHarvoni
• IHarvoni vs. ezinye izidakamizwa
• IHarvoni vs. Epclusa
• IHarvoni noMavyret
• IHarvoni vs. Sovaldi
• IHarvoni vs. Zepatier
• Ungamthatha kanjani uHarvoni
• Isikhathi
• Ukuthatha uHarvoni ngokudla
• Ngabe iHarvoni ingachotshozwa?
• Isebenza kanjani iHarvoni
• Mayelana ne-hepatitis C
• I-Harvoni ilapha kanjani i-hepatitis C?
• Kuthatha isikhathi esingakanani ukusebenza?
• Harvoni nokukhulelwa
• IHarvoni nokuncelisa ibele
• Imibuzo ejwayelekile ngeHarvoni
• Ngabe ngidinga ukulandela ukudla okukhethekile ngenkathi ngithatha iHarvoni?
• Kuzothatha isikhathi esingakanani uHarvoni ukususa i-hepatitis C yami?
• Lithini inani lokwelashwa kweHarvoni?
• Ngabe i-hepatitis C ingabuya ngemuva kokuthatha iHarvoni?
• Iyini i-genotype ye-hepatitis C?
• Ukudlula ngokweqile kweHarvoni
• Izimpawu zokudlula ngokweqile
• Okufanele ukwenze uma kwenzeka ukweqisa ngokweqile
• Izexwayiso zikaHarvoni
• Isexwayiso se-FDA: Ukuvuselelwa kwegciwane le-hepatitis B
• Ezinye izexwayiso
• Ukuphelelwa yisikhathi kweHarvoni
• Imininingwane yobungcweti yeHarvoni
• Indlela yokusebenza
• I-Pharmacokinetics ne-metabolism
• Izimo
• Isitoreji

Yini iHarvoni?

I-Harvoni ngumuthi kadokotela osetshenziswayo ukwelapha i-hepatitis C. I-Harvoni iqukethe imishanguzo emibili: i-ledipasvir ne-sofosbuvir. Kuza njengethebhulethi evame ukuthathwa kanye nsuku zonke amasonto ayi-12.

IHarvoni uhlobo lomuthi obizwa nge-direct-acting antiviral (DAA). Kwavunywa yi-FDA ngo-2014 ukwelapha ama-genotypes ahlukahlukene, noma amafomu, e-hepatitis C.

I-Harvoni ivunyelwe ukwelapha i-hepatitis C:

• kubantu abane-hepatitis C genotypes 1, 4, 5, no-6
• kubantu abane-cirrhosis noma abangenayo
• kubantu abaye bafakelwa isibindi
• kubantu abadala noma izingane ezineminyaka engu-12 noma ngaphezulu noma ezinesisindo okungenani esingamakhilogremu angama-77

Ezifundweni eziningi zemitholampilo zeHarvoni, izinga lokuphumelela lokwelapha i-hepatitis C lalilikhulu kunamaphesenti angama-90.Lokhu kusho ukuthi cishe bonke abantu abathathe iHarvoni bathole impendulo eqhubekayo ye-virologic (SVR). I-SVR isho ukuthi babengenalo igciwane elitholakele emzimbeni wabo amasonto ayi-12 noma ngaphezulu ngemuva kokuphela kokwelashwa.

IHarvoni ejwayelekile

I-Harvoni iqukethe izidakamizwa ezimbili kuthebhulethi eyodwa: i-ledipasvir ne-sofosbuvir. Okwamanje awekho amafomu ejwayelekile womuthi ohlangene noma umuthi ngamunye. I-Harvoni itholakala kuphela njengomuthi kadokotela wegama lomuthi.

Kodwa-ke, uhlobo olujwayelekile lweHarvoni kulindeleke ukuthi lukhishwe ekuqaleni kuka-2019.

Imiphumela emibi ye-Harvoni

IHarvoni ingadala imiphumela emibi noma emibi. Uhlu olulandelayo luqukethe eminye yemiphumela emibi engase ivele ngenkathi uthatha iHarvoni. Lolu hlu alubandakanyi yonke imiphumela emibi engaba khona.

Ukuthola eminye imininingwane ngemiphumela emibi engaba khona yeHarvoni noma amathiphu wokuthi ungabhekana kanjani nemiphumela emibi ekhathazayo, khuluma nodokotela wakho noma usokhemisi.

Uma udokotela wakho futhi ekuyalela ukuthi usebenzise i-ribavirin noHarvoni, ungaba neminye imiphumela emibi. (Bheka i- "Harvoni ne-ribavirin" ngezansi.)

Imiphumela emibi ejwayelekile

Imiphumela emibi ejwayelekile yeHarvoni ingafaka:

• ukukhathala
• ikhanda
• isicanucanu
• isifo sohudo
• ukuqwasha (kunzima ukulala)
• ukukhwehlela
• ubuthakathaka
• ubuhlungu bemisipha
• i-dyspnea (ukuphefumula okuncane)
• ukucasuka
• isiyezi

Kwezinye izimo, iHarvoni ingadala ukusabela okuncane kokungezwani komzimba. Izimpawu zingafaka ukuqubuka kwesikhumba, ukulunywa, nokushaywa (ukufudumala kwesikhumba nokubomvu, imvamisa ebusweni nasentanyeni).

Iningi lalemiphumela emibi ingahle ihambe ezinsukwini ezimbalwa noma emasontweni ambalwa. Uma zinzima kakhulu noma zingahambi, khuluma nodokotela wakho noma usokhemisi.

Imiphumela emibi kakhulu

Imiphumela emibi ebucayi evela eHarvoni ayijwayelekile, kepha ingenzeka. Shayela udokotela wakho ngokushesha uma unemiphumela emibi kakhulu. Shayela u-911 uma izimpawu zakho zizizwa zisongela impilo noma uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha.

Imiphumela emibi kanye nezimpawu zayo zingafaka okulandelayo:

• Ukuvuselelwa kwe-Hepatitis B kubantu abane-hepatitis C ne-hepatitis B. Abanye abantu abanesifo sokusha kwesibindi kohlobo C kanye nesifo sokusha kwesibindi kohlobo B babone ukuvuselelwa kwegciwane le-hepatitis B lapho beqala ukwelashwa noHarvoni. Ukuvuselelwa kabusha kusho ukuthi igciwane lisebenza futhi. Ukuvuselelwa kwegciwane le-hepatitis B kungaholela ekulimaleni kwesibindi, ukwehluleka kwesibindi noma ukufa. Ngaphambi kokuba uqale ukwelashwa noHarvoni, udokotela wakho uzokuhlolela i-hepatitis B. Ungadinga ukuthatha imithi yokwelapha i-hepatitis B.
• Ukusabela okweqile komzimba. Ezimweni ezingavamile, iHarvoni ingadala ukusabela okweqile komzimba. Izimpawu zingafaka:
• i-angioedema (ukuvuvukala ngaphansi kwesikhumba sakho, imvamisa ezinkalweni zakho, izindebe, izandla, noma izinyawo)
• ukuvuvukala komphimbo wakho, umlomo nolimi
• inkinga yokuphefumula
• Imicabango yokuzibulala. Ezimweni ezingavamile, i-Harvoni ingadala imicabango yokuzibulala noma isenzo lapho ithathwa ihlanganiswe ne-ribavirin noma i-pegylated interferon / ribavirin.

Ukuvimbela ukuzibulala

• Uma wazi othile osengozini ngokushesha yokuzilimaza, ukuzibulala noma ukulimaza omunye umuntu:
• Shayela ku-911 noma inombolo ephuthumayo yendawo.
• Hlala nalo muntu kuze kufike usizo lochwepheshe.
• Susa noma yiziphi izikhali, imithi, noma ezinye izinto ezingaba yingozi.
• Lalela umuntu ngaphandle kokwahlulela.
• Uma wena noma umuntu omaziyo enemicabango yokuzibulala, ucingo lwenombolo yokuvimbela lungasiza. INational Suicide Prevention Lifeline itholakala amahora angama-24 ngosuku ngo-1-800-273-8255.

Imiphumela emibi yesikhathi eside

Imiphumela emibi yesikhathi eside ayikabikwa ngokusetshenziswa kweHarvoni.

Kodwa-ke, abantu abane-cirrhosis (isibazi sesibindi) bangaqhubeka nokuba nezimpawu zokulimala kwesibindi ngemuva kokuphulukiswa kwe-hepatitis C yabo. Uma une-cirrhosis, udokotela wakho uzofuna ukuhlola ukusebenza kwesibindi sakho njalo nangemva kokwelashwa noHarvoni.

Imiphumela emibi ngemuva kokwelashwa

Imiphumela emibi ngemuva kokwelashwa kweHarvoni ayikabikwa ezifundweni zokwelashwa.

Kodwa-ke, ngemuva kokuqeda ukwelashwa ngeHarvoni, abanye abantu bangathola izimpawu ezinjengomkhuhlane, njengokuqaqamba kwemisipha, ukugodola, ukukhathala, nenkinga yokulala. Le miphumela emibi kungenzeka ibangelwe ukuthi umzimba wakho ululame ngemuva kokuba igciwane le-hepatitis C selisuliwe.

Uma unezimpawu ezinjengomkhuhlane ngemuva kokuqeda ukwelashwa noHarvoni, khuluma nodokotela wakho.

Ukwehla kwesisindo noma ukuzuza kwesisindo

Izinguquko zesisindo ngesikhathi sokwelashwa kweHarvoni azange zibikwe ezifundweni zomtholampilo. Kodwa-ke, abanye abantu banciphile njengophawu lwe-hepatitis C. Uma unezinguquko ezinzima esisindweni, khuluma nodokotela wakho.

Izimpawu zokuhoxa

Ukuyeka ukwelashwa ngeHarvoni akubanga zimpawu zokuhoxa ezifundweni zokwelashwa.

Abanye abantu bangathola izimpawu ezifana nokuhoxa, njengomkhuhlane onjengomkhuhlane, ikhanda elibuhlungu nezinhlungu zemisipha. Kodwa-ke, akucaci ukuthi ngabe lezi zimpawu zihlobene nokumisa ukwelashwa kweHarvoni.

Ubuhlungu obuhlangene

Ubuhlungu obuhlangene babungewona umphumela ohlangothini lukaHarvoni ezifundweni zokwelashwa.

Abantu abaningi abane-hepatitis C bathola ubuhlungu obuhlangene njengophawu lwegciwane, noma kunjalo. Lokhu kungaba umphumela wokuvuvukala okungapheli noma inqubo yokuzimela ehlasela amalunga akho.

Uma unezinhlungu emajoyintini akho, khuluma nodokotela wakho ngezindlela zokukulawula.

Imiphumela yamehlo

Ezifundweni zokwelashwa zaseHarvoni, abantu abathatha lesi sidakamizwa abaze babhekana nezinkinga zamehlo. Kepha kukhona umbiko owodwa wokulahleka kombono wesikhashana ngemuva kokusebenzisa iHarvoni nomuthi i-ribavirin. Futhi omunye umuntu ubike ukuvuvukala kwamehlo nokubona okufiphele ngemuva kokusebenzisa i-sofosbuvir (omunye wemithi eHarvoni) ne-ribavirin.

Kodwa-ke, akucaci ukuthi iHarvoni noma izithako zayo kubangele izinkinga zamehlo kulezi zimo. Futhi, ucwaningo lwango-2019 luthole ukuthi le mithi efanayo ayibanga izinkinga zamehlo kubantu abane-hepatitis C.

Kunoma ikuphi, uma uhlangabezana nemiphumela yamehlo ngenkathi uthatha uHarvoni, khuluma nodokotela wakho khona manjalo.

Ukulahleka kwezinwele

Ukulahleka kwezinwele akuzange kubikwe njengomphumela wecala ezifundweni zokwelashwa zaseHarvoni. Abanye abantu babike ukuthi balahlekelwa yizinwele ngenkathi bedla umuthi, kodwa akucaci ukuthi ngabe uHarvoni wayeyimbangela yokulahleka kwezinwele zabo.

Kubalulekile ukuqaphela ukuthi ukulahleka kwezinwele kungaba uphawu lwe-hepatitis C. Igciwane le-hepatitis C (HCV) livimbela isibindi sakho ekusebenzeni kahle. Udinga isibindi esinempilo ukuze uthole izakhamzimba ekudleni okudlayo. Ngakho-ke uma ungakwazi ukuthola izakhamzimba ezidingwa ngumzimba wakho, ungahle ulahlekelwe yizinwele.

Uma ukhathazekile ngokulahleka kwezinwele, khuluma nodokotela wakho.

Ukuqhuma / ukulunywa

Ukuqubuka kwesikhumba kwabikwa kwabanye abantu abathathe iHarvoni ezifundweni zokwelashwa, kodwa akucaci ukuthi babevame kangakanani. Kwezinye izimo, abantu babenamabhamuza nokuvuvukala kwesikhumba, futhi. Lokhu kungabangelwa ukusabela okweqile ku-Harvoni.

Isikhumba sokulunywa nokuqubuka nakho kuyizimpawu zegciwane le-hepatitis C. Ngaphezu kwalokho, zingaba yizimpawu zokulimala okukhulu kwesibindi. Khuluma nodokotela wakho uma uhlangabezana nokuqubuka noma isikhumba esikhathazayo.

Uhudo

Ezifundweni zokwelashwa zaseHarvoni, phakathi kwamaphesenti ama-3 namaphesenti ayi-7 wabantu abahlangabezana nohudo ngesikhathi belashwa. Uhudo lungaphela ngokusetshenziswa okuqhubekayo komuthi.

Uma unesifo sohudo esibi, noma isifo sohudo esihlala isikhathi esingaphezu kwezinsuku ezimbalwa, khuluma nodokotela wakho khona manjalo.

Ukucindezeleka

Ukudangala kungumphumela wecala ongavamile weHarvoni. Ezifundweni zokwelashwa, ngaphansi kwamaphesenti ama-5 abantu abathathe uHarvoni babhekana nokudangala. Ngaphezu kwalokho, imicabango yokuzibulala yenzeke ngaphansi kwamaphesenti ama-1 wabantu abathathe iHarvoni nge-ribavirin noma i-pegylated interferon / ribavirin.

Abantu abaningi abane-hepatitis C bangazizwa becindezelekile ngenxa yokuxilongwa kwabo. Uma uzizwa ucindezelekile, khuluma nodokotela wakho ngezindlela zokuthuthukisa imizwa yakho. Futhi uma unemicabango yokuzilimaza, shayela udokotela wakho ngokushesha.

Ukukhathala

Ukukhathala, noma ukungabi namandla, kungumphumela ojwayelekile weHarvoni. Ezifundweni zokwelashwa, kuze kufike kumaphesenti ayi-18 abantu abathathe uHarvoni ababhekene nokukhathala.

Ukukhathala kungaphela ngokusetshenziswa okuqhubekayo kweHarvoni. Kodwa-ke, uma ukukhathala kwakho kunzima futhi kuthinta impilo yakho, khuluma nodokotela wakho.

Ukuqwasha (kunzima ukulala)

Ezifundweni zokwelashwa, ukuqwasha kwenzeka kubantu abangafika kumaphesenti ayisithupha abantu abathathe iHarvoni. Lo mphumela ohlangothini ungaphela ngokusetshenziswa okuqhubekayo komuthi.

Izindlela zokuthuthukisa ukulala kwakho zibandakanya ukulandela uhlelo olujwayelekile lokulala nokugcina izinto ze-elekthronikhi, ezinjengama-smartphone, ngaphandle kwegumbi lakho lokulala. Uma ukuqwasha kwakho kukukhathaza futhi kungapheli, khuluma nodokotela wakho ngezinye izindlela zokukusiza ulale.

Ubuhlungu bekhanda

Ubuhlungu bekhanda bungumphumela ojwayelekile we-Harvoni. Ezifundweni zomtholampilo, abantu abangafika kumaphesenti angama-29 abathathe uHarvoni babhekana nekhanda. Uma unekhanda ngenkathi uthatha iHarvoni, khuluma nodokotela wakho ngezindlela zokukusiza ukuzilawula.

Umdlavuza wesibindi / umdlavuza

UHarvoni umuthi obizwa nge-direct-acting antiviral (DAA). Ukwelapha i-hepatitis C ngama-DAA kusiza ukuvimbela imiphumela yesikhathi eside, njengomdlavuza wesibindi. Kodwa-ke, kuye kwaba nemibiko yomdlavuza wesibindi kubantu abelapheke i-hepatitis C yokwelashwa kwe-Harvoni.

Olunye ucwaningo lomtholampilo lwathola ukuthi abantu abane-cirrhosis abaphathwa nge-DAA babenobungozi obukhulu bokuba nomdlavuza wesibindi uma kuqhathaniswa nalabo abangenayo i-cirrhosis. Kodwa-ke, abantu abangenayo i-cirrhosis basengathola umdlavuza wesibindi.

Uma ukhathazekile ngengozi yokuba nomdlavuza wesibindi, khuluma nodokotela wakho.

Izindleko ze-Harvoni

Njengayo yonke imithi, izindleko zeHarvoni zingahluka.

Izindleko zakho zangempela zizoxhomeka kumshuwalense wakho.

Usizo lwezezimali nolomshuwalense

Uma udinga ukwesekwa kwezezimali ukukhokhela iHarvoni, noma uma udinga usizo lokuqonda ukutholakala komshuwalense wakho, usizo luyatholakala.

IGilead Sciences, Inc., umkhiqizi weHarvoni, unikela ngohlelo olubizwa ngeHarvoni Support Path. Ngeminye imininingwane nokuthola ukuthi uyakufanelekela yini ukwesekwa, shayela ku-855-769-7284 noma uvakashele iwebhusayithi yohlelo.

UHarvoni usebenzisa

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuvumela imishanguzo kadokotela efana neHarvoni ukwelapha izimo ezithile.

I-Harvoni ivunyiwe yi-FDA ekwelapheni igciwane le-hepatitis C (HCV). IHarvoni ingabekelwa lokhu:

• Abantu abadala nezingane (abaneminyaka engu-12 nangaphezulu noma abanesisindo okungenani esingamakhilogremu angama-77):
• une-HCV genotype 1, 4, 5, noma 6. Ama-genotypes yizinhlobo ezahlukene zegciwane.
• unayo noma anginaso isinxephezelo sokuqina kwesibindi. I-Cirrhosis yisibazi esibi esibindi esivimbela ukuthi sisebenze kahle. I-cirrhosis ekhokhelwe i-cirrhosis ngokuvamile engabangeli izimpawu.
• Abantu abadala aba:
• une-genotype 1 ne-cirrhosis ebolile. I-cirrhosis ebolile lapho isibindi sehluleka futhi sidala izingqinamba ezinkulu zezempilo. Abantu abane-cirrhosis ebolile bazodinga ukuthatha i-Harvoni ngomuthi wesibili, i-ribavirin (i-Rebetol).
• ngine-genotype 1 noma 4 futhi ngibe nokufakelwa kwesibindi.

Leli thebula likhombisa ukuthi ngubani ofanele ukwelashwa i-Harvoni:

Isilinganiso se-Harvoni

I-Harvoni inqunywe njengomthamo owodwa: Ithebhulethi equkethe i-90 mg ye-ledipasvir kanye no-400 mg we-sofosbuvir, ethathwa kanye ngosuku.

Ezimweni ezithile, udokotela wakho angakunikeza umuthi wesibili ozowuthatha noHarvoni. Isibonelo, ungahle unikezwe i-ribavirin (iRebetol) ngokuhlanganiswa neHarvoni.

Lokhu kungenzeka uma usuqedile ukubola kwesibindi (izimpawu ezinzima zesifo sesibindi esithuthukile) noma uma uthathe imishanguzo ethile ukwelapha isifo sokusha kwesibindi kohlobo C esikhathini esedlule. Umthamo wakho we-ribavirin uzoya ngesisindo sakho, ukusebenza kwezinso, nezinye izimo zempilo.

Imininingwane elandelayo ichaza isilinganiso esinconyiwe seHarvoni.

Amafomu wezidakamizwa namandla

IHarvoni itholakala ngamandla owodwa. Iza kuthebhulethi ehlanganisiwe equkethe i-90 mg ye-ledipasvir kanye ne-400 mg ye-sofosbuvir.

Isikali se-hepatitis C

Umthamo wokwelapha i-hepatitis C yithebulethi elilodwa (90 mg ledipasvir / 400 mg sofosbuvir), ethathwa kanye ngosuku.

Isikhathi sokwelashwa

Uthatha isikhathi esingakanani uHarvoni kuzoxhomeka kuhlobo lwakho lwe-hepatitis C (uhlobo lwegciwane). Kuzophinde futhi kuncike ekusebenzeni kwesibindi sakho, kanye nanoma ikuphi ukwelashwa kwe-hepatitis C oke wakuzama esikhathini esedlule.

Iningi labantu lithatha i-Harvoni amasonto ayi-12, kepha ukwelashwa nakho kungahlala amasonto ayi-8 noma angama-24. Udokotela wakho uzokunquma isikhathi esifanele sokwelashwa kwakho.

Kuthiwani uma ngiphuthelwa umthamo?

Kubalulekile ukuthatha i-Harvoni nsuku zonke isikhathi esigcwele udokotela wakho akushoyo. Ukulahleka noma ukweqa imithamo kungadala ukuthi igciwane lingazweli kuHarvoni. Ukumelana kusho ukuthi umuthi awusasebenzi kuwe.

Ukusebenzisa ithuluzi lesikhumbuzo kungakusiza ukuthi ukhumbule ukuthatha iHarvoni nsuku zonke.

Uma uphuthelwa umthamo, wuthathe ngokushesha lapho ukhumbula. Uma ungakhumbuli kuze kube usuku olulandelayo, ungathathi imithamo emibili yeHarvoni ngasikhathi sinye. Lokhu kungakhuphula ubungozi bemiphumela emibi. Mane uthathe umthamo wakho ojwayelekile weHarvoni.

Ukunamathela kuhlelo lwakho lokwelashwa kweHarvoni

Kubaluleke kakhulu ukuthi uthathe amaphilisi wakho we-Harvoni njengoba udokotela wakho ekuyalela. Lokhu kungenxa yokuthi ukulandela uhlelo lwakho lokwelashwa kwandisa amathuba akho okwelapha i-hepatitis C (HCV) yakho. Kuyasiza futhi ukunciphisa ingozi yakho yemiphumela yesikhathi eside ye-HCV, efaka isifo sokuqina kwesibindi nomdlavuza wesibindi.

Imithamo elahlekile ingenza iHarvoni ingasebenzi kahle ekwelapheni i-HCV yakho. Kwezinye izimo, uma uphuthelwa imithamo, i-HCV yakho kungenzeka ingalapheki.

Qiniseka ukuthi ulandela imiyalo kadokotela wakho bese uthatha ithebhulethi eyodwa ye-Harvoni nsuku zonke ngobude obugcwele bokwelashwa kwakho. Ukusebenzisa ithuluzi lesikhumbuzo kungakusiza uqiniseke ukuthi uthatha iHarvoni nsuku zonke.

Uma unemibuzo noma ukukhathazeka mayelana nokwelashwa kwakho, khuluma nodokotela wakho. Bangakusiza ekuxazululeni noma yiziphi izingqinamba futhi bakusize uthole ukwelashwa okuphumelela kakhulu kwesifo sakho sokusha kwesibindi kohlobo C.

IHarvoni notshwala

Ukuphuza utshwala ngenkathi uthatha iHarvoni kungakhuphula ubungozi bemiphumela emibi ethile evela eHarvoni. Le miphumela emibi ifaka phakathi:

• ukukhathala
• ikhanda
• isicanucanu
• isifo sohudo

Ngaphezu kwalokho, kokubili ukusha kwesibindi kohlobo C nokusetshenziswa kotshwala ngokweqile kubangela ukusha nokuvuvukala esibindini sakho. Ukuhlanganisa lezi zimbili kwandisa ubungozi bokuqina kwesibindi nokuhluleka kwesibindi.

Utshwala bungakwenza futhi ukuthi ungakwazi ukuthatha imithi yakho njengokuyalelwa ngudokotela wakho. Isibonelo, kungadala ukuthi ukhohlwe ukuthatha imishanguzo yakho ngesikhathi esifanele. Imithamo elahlekile yeHarvoni ingenza ingasebenzi kahle ekwelapheni i-HCV yakho.

Kuzo zonke lezi zizathu, kufanele ugweme ukuphuza utshwala lapho unesifo sokusha kwesibindi kohlobo C. Lokhu kuyiqiniso ikakhulukazi lapho welashwa noHarvoni. Uma unenkinga yokugwema utshwala, khuluma nodokotela wakho.

IHarvoni ene-ribavirin

I-Harvoni ivame ukuthathwa yodwa ukwelapha i-hepatitis C. Kodwa-ke, kwezinye izimo, ithathwa ngomunye umuthi obizwa nge-ribavirin (Rebetol).

Udokotela wakho anganikeza i-ribavirin neHarvoni uma:

• babe nokubola kwesibindi
• ngibe nokufakelwa kwesibindi
• ngithole ukwelashwa okungaphumelelanga ngeminye imishanguzo yesifo sokusha kwesibindi kohlobo C esikhathini esedlule

I-Harvoni ne-ribavirin zisetshenziswa ndawonye kubantu kulezi zimo ngoba izifundo zomtholampilo zikhombise izinga eliphakeme lokulapha ngemithi ehlanganisiwe kunakuHarvoni kuphela.

Ukwelashwa nge-ribavirin ngokuvamile kuthatha amasonto ayi-12. I-Ribavirin iza njengephilisi oyiphuza kabili ngosuku. Umthamo owuthathayo uzoncika kusisindo sakho. Kungase futhi kusekelwe ekusebenzeni kwakho kwezinso namazinga e-hemoglobin.

Imiphumela emibi ye-Ribavirin

I-Ribavirin ingadala imiphumela emibi eminingi ejwayelekile futhi emibi. Kuza nezixwayiso ezibalulekile.

Isixwayiso esibhokisi

URibavirin unesixwayiso esibhokisi esivela ku-FDA. Isexwayiso esibhokisini luhlobo oluqine kakhulu lwesexwayiso oludingwa yi-FDA. Isexwayiso sebhokisi likaRibavirin seluleka ukuthi:

• I-Ribavirin akufanele isetshenziswe yodwa ukwelapha i-hepatitis C ngoba ayisebenzi ngokwayo.
• I-Ribavirin ingadala uhlobo lwesifo segazi esibizwa nge-hemolytic anemia. Lesi simo singaholela ekuhlaselweni yinhliziyo noma ekufeni. Ngenxa yale ngozi, abantu abanesifo senhliziyo esibi noma esingazinzile akufanele bathathe i-ribavirin.
• Lapho i-ribavirin isetshenziswa kwabesifazane abakhulelwe, ingadala ingozi enkulu noma ibulale umbungu. I-Ribavirin akufanele ithathwe ngabesifazane abakhulelwe noma abalingani babo besilisa ngesikhathi sokukhulelwa. Ukukhulelwa kufanele futhi kugwenywe okungenani izinyanga eziyisithupha ngemuva kokuphela kokwelashwa kwe-ribavirin. Ngalesi sikhathi, cabanga ukusebenzisa indlela eyisipele yokuvimbela inzalo (ukulawulwa kokuzalwa).

Eminye imiphumela emibi

I-Ribavirin nayo ingadala imiphumela emibi ejwayelekile, njenge:

• ukukhathala
• ukuzizwa ngikhathazekile
• imfiva
• ikhanda
• ukuzwa ukucasuka
• ukulahlekelwa isifiso sokudla
• ubuhlungu bemisipha noma ubuthakathaka
• isicanucanu
• ukuhlanza

Imiphumela emibi ejwayelekile kodwa ebucayi ebonwe ezifundweni zokwelashwa ibandakanya i-anemia, isifo samaphaphu, ne-pancreatitis. Zazihlanganisa nezinkinga zamehlo, njengokutheleleka nokungaboni kahle.

I-Ribavirin nokukhulelwa

Bheka “Isexwayiso esibhokisi” ngenhla.

I-Ribavirin nokuncelisa

Akwaziwa ukuthi i-ribavirin idlula ubisi lwebele lomuntu. Ucwaningo ezilwaneni lukhombisa ukuthi i-ribavirin ethathwe ngumama ingaba yingozi ekunceliseni izingane. Kodwa-ke, izifundo zezilwane azihlali zibikezela ukuthi kuzokwenzekani kubantu.

Uma ucabanga ukwelashwa kwe-ribavirin ngenkathi uncelisa, khuluma nodokotela wakho. Bangancoma ukuthi uyeke ukuncelisa noma ugweme ukwelashwa kwe-ribavirin.

Ukusebenzisana kweHarvoni

IHarvoni ingaxhumana neminye imithi eminingana. Ingabuye ihlanganyele nezithako ezithile nokudla.

Ukuxhumana okuhlukile kungadala imiphumela ehlukile. Isibonelo, ezinye zingaphazamisa ukuthi usebenza kanjani umuthi, kanti ezinye zingadala imiphumela emibi eyengeziwe.

Harvoni neminye imithi

Ngezansi kunohlu lwemithi engasebenzisana noHarvoni. Lolu hlu aluqukethe yonke imishanguzo engasebenzisana noHarvoni.

Ngaphambi kokuthatha iHarvoni, qiniseka ukuthi utshela udokotela kanye nosokhemisi ngayo yonke imishanguzo kadokotela, i-counter-counter, nezinye izidakamizwa oziphuzayo. Batshele futhi nganoma yimaphi amavithamini, amakhambi, nezithako ozisebenzisayo. Ukwabelana ngalolu lwazi kungakusiza ugweme ukuhlangana okungenzeka.

Uma unemibuzo mayelana nokuhlangana kwezidakamizwa okungakuthinta, buza udokotela wakho noma usokhemisi.

Ama-Antacids

Ukuthatha i-Harvoni ngama-antacids, njenge-Mylanta noma i-Tums, kunganciphisa inani le-Harvoni elibanjwa ngumzimba wakho. Lokhu kungenza iHarvoni ingasebenzi kahle. Ukuvimbela lokhu kuhlangana, hlukanisa umthamo weHarvoni kanye nama-antacids okungenani amahora amane.

Ama-H2 blocker

Ukuthatha i-Harvoni ngezidakamizwa ezibizwa nge-H2 blockers kunganciphisa inani le-Harvoni eligxile emzimbeni wakho. Lokhu kungadala ukuthi iHarvoni ingasebenzi kahle ekulweni negciwane le-hepatitis C.

Uma udinga ukuthatha i-H2 blocker eneHarvoni, kufanele ubathathe ngasikhathi sinye noma ubathathe amahora ayi-12 behlukene. Ukuyithatha ngasikhathi sinye kuvumela ukuthi izidakamizwa zincibilike futhi zimunzwe ngumzimba wakho ngaphambi kokuba imiphumela ye-H2 blocker ingene. Ukuzihlukanisa amahora ayi-12 futhi kuvumela umuthi ngamunye ukuthi umunce umzimba wakho ngaphandle kokuxhumana nomunye umuthi.

Izibonelo ze-H2 blockers zifaka i-famotidine (Pepcid) ne-cimetidine (Tagamet HB).

Amiodarone

Ukuthatha i-Harvoni nge-amiodarone (i-Pacerone, i-Nexterone) kungadala ukushaya kwenhliziyo okuhamba kancane ngokuyingozi, okubizwa nge-bradycardia. Eminye imibiko isho ukuthi abantu abathathe i-amiodarone neHarvoni ndawonye badinga umshini wokushaya inhliziyo ukuze ugcine ukushaya kwenhliziyo njalo. Baphinde babika ukuthi abanye abantu babulawa yisifo senhliziyo.

Ukuthatha i-amiodarone ne-Harvoni ndawonye akunconyiwe. Uma kufanele uthathe i-Harvoni ne-amiodarone ndawonye, ​​udokotela wakho uzoqapha eduze ukusebenza kwenhliziyo yakho.

I-Digoxin

Ukuthatha i-Harvoni nge-digoxin (i-Lanoxin) kungakhuphula inani le-digoxin emzimbeni wakho. Amazinga we-Digoxin aphakeme kakhulu angaholela emiphumeleni emibi eyingozi.

Uma udinga ukuthatha i-Harvoni ne-digoxin ndawonye, ​​udokotela wakho uzoqapha kakhulu amazinga akho e-digoxin. Bangaguqula umthamo wakho we-digoxin ukwehlisa ubungozi bemiphumela emibi.

Imithi yokuquleka

Ukuthatha iHarvoni ngemithi ethile yokuquleka kunganciphisa inani leHarvoni elibanjwa ngumzimba wakho. Lokhu kunganciphisa ukusebenza kweHarvoni. Ngalesi sizathu, akufanele uthathe i-Harvoni ngale mithi yokubanjwa.

Izibonelo zemithi yokuthwebula okufanele uyigweme ngenkathi uthatha iHarvoni ifaka:

• i-carbamazepine (Carbatrol, Equetro, Tegretol)
• i-phenytoin (Dilantin, Phenytek)
• lindokuhle
• i-oxcarbazepine (i-Trileptal)

Imithi elwa namagciwane

Imithi ethile yama-antibiotic inganciphisa amazinga we-Harvoni emzimbeni wakho. Lokhu kungenza iHarvoni ingasebenzi kahle. Ukuvimbela lokhu kuhlangana, gwema ukuthatha iHarvoni ngama-antibiotic alandelayo:

• i-rifabutin (Mycobutin)
• i-rifampin (i-Rifadin, i-Rimactane)
• i-rifapentine (Priftin)

Imithi ye-HIV

Ukuthatha iHarvoni ngemithi ethile ye-HIV kungashintsha amazinga omzimba wakho we-Harvoni noma imishanguzo ye-HIV. Lokhu kusebenzisana kungenza ukuthi izidakamizwa zingasebenzi kahle noma kwandise ubungozi bemiphumela emibi.

I-Tenofovir disoproxil fumarate

Ukuthatha iHarvoni ngemithi equkethe i-tenofovir disoproxil fumarate kungakhuphula amazinga e-tenofovir emzimbeni wakho. Lokhu kuzokwandisa ubungozi bemiphumela emibi evela ku-tenofovir, njengokulimala kwezinso. Uma udinga ukuthatha i-Harvoni ngemithi equkethe i-tenofovir disoproxil fumarate, udokotela wakho uzokuqapha kakhulu ngemiphumela emibi.

Izibonelo zemithi equkethe i-tenofovir disoproxil fumarate ifaka:

• i-tenofovir (Viread)
• i-tenofovir ne-emtricitabine (iTruvada)
• i-tenofovir, i-elvitegravir, i-cobicistat, ne-emtricitabine (iStribild)
• i-tenofovir, i-emtricitabine, ne-rilpivirine (i-Complera)

I-Tipranavir ne-ritonavir

Ukuthatha iHarvoni ngemishanguzo ye-HIV tipranavir (Aptivus) noma i-ritonavir (Norvir) kungehlisa amazinga eHarvoni emzimbeni wakho. Lokhu kungenza iHarvoni ingasebenzi kahle. Ukuthatha i-Harvoni nge-tipranavir ne-ritonavir akunconyiwe.

Imithi ye-cholesterol

Ukuthatha iHarvoni ngemithi ye-cholesterol ebizwa ngama-statins kungakhuphula amazinga ama-statins emzimbeni wakho. Lokhu kwandisa ubungozi bemiphumela emibi ye-statin, njengobuhlungu bemisipha nokulimala.

Izitatimende zifaka phakathi izidakamizwa ezifana ne-rosuvastatin (Crestor), i-atorvastatin (Lipitor), ne-simvastatin (i-Zocor). Uma uthatha iHarvoni nge-statin, udokotela wakho uzokuqapha eduze ngezibonakaliso ze-rhabdomyolysis (ukwehla kwemisipha).

I-Rosuvastatin ne-Harvoni akufanele zithathwe ndawonye. Ezinye izitatimende kufanele zisetshenziswe ngokucophelela ngeHarvoni.

I-Warfarin

IHarvoni ingathinta amandla omzimba wakho okwenza amahlule egazi. Uma udinga ukuthatha i-warfarin (i-Coumadin) ngenkathi uphathwa ne-Harvoni, udokotela wakho angahlola igazi lakho kaningi. Kungadinga nokuthi bandise noma banciphise umthamo wakho we-warfarin.

IHarvoni ne-ribavirin

Akukho ukuxhumana phakathi kweHarvoni ne-ribavirin (iRebetol). IHarvoni iphephile ukuyithatha nge-ribavirin. Eqinisweni, iHarvoni ivunyelwe yi-FDA ukuthi ithathwe nge-ribavirin kubantu abanemilando ethile yezokwelapha.

Udokotela wakho angakunikeza i-ribavirin ongayithatha noHarvoni uma:

• babe nokubola kwesibindi
• ngibe nokufakelwa kwesibindi
• baye bahluleka ukwelashwa ngeminye imithi ethile ye-hepatitis C esikhathini esidlule

I-Harvoni ne-ribavirin zisetshenziswa ndawonye kubantu abanalezizimo ngoba izifundo zomtholampilo zikhombise izinga eliphakeme lokwelapha ngemithi ehlanganisiwe.

IHarvoni ne-omeprazole noma amanye ama-PPIs

Ukuthatha iHarvoni nge-omeprazole (Prilosec) noma amanye ama-proton pump inhibitors (ama-PPIs) kunganciphisa inani le-Harvoni emzimbeni wakho. Lokhu kungenza iHarvoni ingasebenzi kahle.

Uma kungenzeka, gwema ukuthatha uHarvoni nalesi sigaba semithi. Uma udinga i-PPI ngenkathi uthatha iHarvoni, kufanele uthathe i-Harvoni ne-PPI ngasikhathi sinye esiswini esingenalutho.

Izibonelo zamanye ama-PPIs zifaka:

• i-esomeprazole (Nexium)
• I-lansoprazole (Prevacid)
• i-pantoprazole (Protonix)

IHarvoni namakhambi nezithako

Ukuthatha iHarvoni ngeSt.I-wort kaJohn inganciphisa inani le-Harvoni emzimbeni wakho. Lokhu kungenza iHarvoni ingasebenzi kahle. Ukugwema lokhu kuhlangana, ungathathi iHarvoni neSt.

Amanye amakhambi noma izithasiselo ezinganciphisa inani leHarvoni emzimbeni wakho zifaka:

• kava kava
• ubisi lwameva
• inhlaba
• sibongile

Ngesikhathi sokwelashwa kwakho noHarvoni, hlola udokotela wakho ngaphambi kokuthatha noma yimaphi amakhambi amasha noma izithasiselo.

IHarvoni nekhofi

Akukho ukuxhumana okubikiwe phakathi kweHarvoni nekhofi. Kodwa-ke, eminye imiphumela emibi yeHarvoni ingase ibe yimbi kakhulu uma uphuza ikhofi eliningi noma i-caffeine. Isibonelo, ukuphuza ikhofi ntambama noma kusihlwa kungenza izinkinga zakho zokulala zibe zimbi kakhulu. Futhi i-caffeine ingabhebhethekisa ikhanda.

Uma uphuza ikhofi noma udla i-caffeine njalo, khuluma nodokotela wakho ukuthi ngabe lokhu kuphephile yini kuwe ngesikhathi sokwelashwa kwakho neHarvoni.

Ezinye izindlela eziya eHarvoni

Eminye imishanguzo iyatholakala engelapha isifo sokusha kwesibindi kohlobo C. Eminye ingakulungela kangcono kunabanye. Uma unentshisekelo yokuthola enye indlela ye-Harvoni, khuluma nodokotela wakho ukuze ufunde kabanzi ngeminye imithi engakusebenzela kahle.

I-Hepatitis C ingelashwa ngokusebenzisa ezinye izidakamizwa eziningana noma inhlanganisela yezidakamizwa. Imithi yokwelashwa udokotela akhethela yona izoncika kuhlobo lwakho lwe-hepatitis C, ukusebenza kwesibindi sakho, nokuthi ngabe wake wakuthola ukwelashwa kwesifo sokusha kwesibindi kohlobo C esikhathini esedlule.

Izibonelo zezinye izidakamizwa ezingasetshenziswa ukwelapha i-hepatitis C zifaka:

• I-Epclusa (velpatasvir, sofosbuvir)
• I-Mavyret (glecaprevir, pibrentasvir)
• I-Viekira Pak (paritaprevir, ombitasvir, ritonavir, dasubuvir)
• I-Vosevi (velpatasvir, sofosbuvir, voxilaprevir)
• I-Zepatier (elbasvir, grazoprevir)
• I-Rebetol (ribavirin), esetshenziswa ngokuhlangana nezinye izidakamizwa

Ama-interferon yimithi emidala eyayikade isetshenziswa kakhulu ukwelapha isifo sokusha kwesibindi kohlobo C. Kodwa-ke, imishanguzo emisha efana neHarvoni idala imiphumela emibi embalwa futhi inamazinga aphezulu okwelapha kunama-interferon. Ngenxa yalezi zizathu, namuhla ama-interferon awavamile ukusetshenziselwa ukwelapha i-hepatitis C.

IHarvoni vs. ezinye izidakamizwa

Ungase uzibuze ukuthi uHarvoni uqhathanisa kanjani neminye imithi enikezwe ukusetshenziswa okufanayo. Ngezansi ukuqhathanisa phakathi kweHarvoni nemithi eminingana.

IHarvoni vs. Epclusa

IHarvoni iqukethe imishanguzo emibili kuphilisi elilodwa: i-ledipasvir ne-sofosbuvir. I-Epclusa iqukethe nemithi emibili kuphilisi elilodwa: i-velpatasvir ne-sofosbuvir.

Yomibili le mithi iqukethe i-sofosbuvir yezidakamizwa, ebhekwa “njengomgogodla” wokwelashwa. Lokhu kusho ukuthi uhlelo lokwelashwa lususelwa kumuthi womgogodla, neminye imithi ifakwa ngokuhlangana.

Isebenzisa

IHarvoni ne-Epclusa bobabili bavunyelwe yi-FDA ukwelapha i-hepatitis C. IHarvoni ingaphatha i-hepatitis C genotypes 1, 4, 5, no-6, kuyilapho i-Epclusa ingaphatha zonke izinhlobo eziyisithupha zofuzo.

Zombili lezi zidakamizwa zivunyelwe ukwelapha abantu ngaphandle kwesifo sokuqina kwesibindi, noma nge-cirrhosis enxephezelwe noma ebolile. Kunokwehluka okuncane ekutheni ngubani anqunyelwe yena, kuya nge-genotype, ukusebenza kwesibindi, nomlando wezokwelapha.

I-Harvoni ivunyelwe yi-FDA ukwelapha i-hepatitis C ezinganeni ezineminyaka engu-12 nangaphezulu noma ezinesisindo okungenani esingamakhilogremu angama-77. I-Epclusa ayivunyelwe ukwelapha i-hepatitis C ezinganeni.

Amafomu wezidakamizwa nokuphathwa

IHarvoni ne-Epclusa bobabili bathathwa njengethebhulethi eyodwa kanye ngosuku. Zingathathwa ngokudla noma esiswini esingenalutho.

Isikhathi sokwelashwa kweHarvoni kungaba amasonto ayi-8, 12, noma ama-24. Uthatha isikhathi esingakanani uHarvoni kuzoxhomeka kuhlobo lwakho lofuzo, noma uhlobo lwe-hepatitis C nokusebenza kwesibindi sakho. Kuzophinda futhi kuncike ekwelashweni kwakho kwe-hepatitis C okudlule.

Isikhathi sokwelashwa kwe-Epclusa amasonto ayi-12.

Imiphumela emibi kanye nezingozi

IHarvoni ne-Epclusa zombili izidakamizwa ezibizwa ngama-antivirals asebenza ngqo futhi zinemiphumela efanayo emzimbeni. Ngenxa yalokhu, zidala imiphumela emibi efanayo. Ngezansi kunezibonelo ezithile zale miphumela emibi.

Imiphumela emibi ejwayelekile

Imiphumela emibi ejwayelekile engenzeka ngeHarvoni ne-Epclusa ifaka:

Imiphumela emibi kakhulu

Imiphumela emibi engaba khona ngeHarvoni ne-Epclusa ifaka:

• ukuvuselelwa kwesifo sokusha kwesibindi kohlobo B (lapho ukutheleleka kwangaphambilini sekuqala ukusebenza futhi), okungaholela ekuhlulekeni kwesibindi noma ekufeni (bheka “Izexwayiso Ezibhokisiwe” ngezansi)
• ukusabela okweqile komzimba, okunezimpawu ezingafaka inkinga yokuphefumula kanye ne-angioedema (ukuvuvukala ngaphansi kwesikhumba sakho, ikakhulukazi ezinkophe zakho, izindebe, izandla, noma izinyawo)

Izexwayiso ezingamabhokisi

UHarvoni no-Epclusa bobabili banesixwayiso esibhokisi esivela ku-FDA. Isexwayiso esibhakeleni yisixwayiso esiqine kakhulu esidingwa yi-FDA.

Isexwayiso sichaza ingozi yokuvuselelwa kwesifo sokusha kwesibindi kohlobo B ngemuva kokuqala ukwelashwa nganoma yisiphi isidakamizwa. Ukuvuselelwa kwesifo sokusha kwesibindi kohlobo B kungaholela ekulimaleni okukhulu kwesibindi, ukwehluleka kwesibindi noma ukufa.

Udokotela wakho uzokuhlolela i-hepatitis B ngaphambi kokuba uqale ukuthatha iHarvoni noma i-Epclusa. Uma kutholakala ukuthi une-hepatitis B, kungadingeka ukuthi uthathe imithi ukuyelapha.

Ukusebenza ngempumelelo

Ngokuya ngemikhombandlela yokwelashwa, uHarvoni no-Epclusa zombili izindlela zokukhetha umuthi zokwelashwa kwe-hepatitis C genotypes 1, 4, 5, no-6.Izincomo ezingeziwe zifaka okulandelayo:

• I-Harvoni iyindlela yokuqala yokukhetha ukwelapha ama-genotypes 1, 4, 5, no-6 ezinganeni ezineminyaka engu-12 nangaphezulu (noma ezinesisindo esingamakhilogremu angama-77 nangaphezulu).
• I-Epclusa inketho yokuqala yokwelashwa kwama-genotypes 2 no-3.

UHarvoni no-Epclusa baye bafaniswa ezifundweni zokwelashwa. Zombili zitholakale zisebenza kakhulu ekwelapheni isifo sokusha kwesibindi kohlobo C. Kodwa-ke, i-Epclusa ingaphulukisa amaphesenti amakhulu abantu kunoHarvoni.

Kokunye ukuhlola komtholampilo, ngaphezu kwamaphesenti angama-93 abantu abathola i-ledipasvir ne-sofosbuvir, izingxenye ze-Harvoni, belashwa i-hepatitis C. Izinga lokwelashwa kwabantu abathola i-velpatasvir ne-sofosbuvir, izingxenye ze-Epclusa, lalilikhulu kunamaphesenti angama-97.

Ucwaningo lwesibili lwathola imiphumela efanayo kubantu abane-cirrhosis yesibindi. Olunye ucwaningo luye lwathola nokuthi i-Epclusa yelapha i-hepatitis C kumaphesenti amakhulu abantu kunoHarvoni.

Kuzo zontathu izifundo, i-SVR yayiphakeme kancane ku-Epclusa kuneHarvoni. I-SVR imele impendulo eqhubekayo ye-virologic, okusho ukuthi igciwane ngeke lisatholakala emzimbeni wakho.

Izindleko

UHarvoni no-Epclusa bobabili bayimithi enegama lomkhiqizo. Okwamanje azikho izinhlobo ezijwayelekile zomuthi. Imithi enegama lomkhiqizo ngokuvamile ibiza ngaphezu kwama-generic.

Ngokuya ngokulinganiselwa ku-GoodRx.com, iHarvoni ibiza kakhulu kune-Epclusa. Inani langempela olikhokhela noma yisiphi isidakamizwa lizoya ngohlelo lwakho lomshuwalense nasekhemisi oyisebenzisayo.

Qaphela: Izinhlobo ezijwayelekile zemithi yomibili kulindeleke ukuthi ikhishwe ekuqaleni kuka-2019. Umkhiqizi ulinganisela ukuthi izindleko zesifundo somuthi ngamunye zizoba ngama- $ 24,000. Le ntengo incane kakhulu kunentengo yezinguqulo zegama lomkhiqizo.

IHarvoni noMavyret

IHarvoni iqukethe imishanguzo emibili kuphilisi elilodwa: i-ledipasvir ne-sofosbuvir. IMavyret iqukethe nezidakamizwa ezimbili kupilisi elilodwa: i-glecaprevir ne-pibrentasvir.

Isebenzisa

UHarvoni noMavyret bobabili bavunyelwe yi-FDA ukwelapha isifo sokusha kwesibindi kohlobo C. Kodwa-ke, zisetshenziselwa ukwelapha ama-genotypes ahlukene ezimweni ezahlukahlukene:

• I-Harvoni ivunyelwe ukuphatha i-hepatitis C genotypes 1, 4, 5, no-6. UMavyret uvunyelwe ukwelapha wonke ama-genotypes ayisithupha amakhulu.
• Yomibili le mithi isetshenziselwa ukwelapha abantu abakhokhele i-cirrhosis. IHarvoni nayo ingasetshenziswa kubantu abane-cirrhosis ebolile, kepha uMavyret akakwazi.
• Zombili zingasetshenziswa kubantu abaye bafakelwa isibindi.
• I-Mavyret ingasetshenziswa kubantu abanesifo esibi sezinso noma ngemuva kokufakelwa kwezinso, kepha iHarvoni ayivunyelwe kulokhu kusetshenziswa.
• I-Harvoni ivunyelwe ukwelapha i-hepatitis C ezinganeni ezineminyaka engu-12 nangaphezulu noma ezinesisindo okungenani esingamakhilogremu angama-77. IMavyret ivunyelwe kuphela ukusetshenziswa kubantu abadala.
• Yomibili le mithi ivunyelwe ukwelapha abantu abazame imishanguzo ethile ye-hepatitis C esikhathini esedlule.

Amafomu wezidakamizwa nokuphathwa

UHarvoni noMavyret bobabili beza njengamathebulethi owaphuzayo kanye ngosuku. Kodwa-ke, ngenkathi uthatha ithebhulethi eyodwa yeHarvoni ngosuku, uphuza amaphilisi amathathu eMavyret ngosuku.

IHarvoni ingathathwa nokudla noma ngaphandle kokudla, kepha iMavyret kufanele ithathwe ngokudla.

IHarvoni ingahle inqunyelwe ukwelashwa amasonto ayi-8, 12, noma ama-24. Isikhathi sokwelashwa kukaMavyret singaba amasonto ayi-8, 12, noma ama-16. Ubude bokwelashwa okuyalelwa ngudokotela buzosuselwa kuhlobo lwakho lwe-hepatitis C, ukusebenza kwesibindi, kanye nomlando wokwelashwa kwe-hepatitis C edlule.

Imiphumela emibi kanye nezingozi

IHarvoni neMavyret zinemiphumela efanayo emzimbeni. Lokhu kusho ukuthi nazo zidala imiphumela emibi efanayo. Ngezansi kunezibonelo zeminye yale miphumela engemihle.

Imiphumela emibi ejwayelekile

Imiphumela emibi ejwayelekile engenzeka ngeHarvoni neMavyret ifaka:

Imiphumela emibi kakhulu

Imiphumela emibi engaba khona ngeHarvoni neMavyret ifaka:

• ukuvuselelwa kwesifo sokusha kwesibindi kohlobo B (lapho ukutheleleka kwangaphambilini sekuqala ukusebenza futhi), okungaholela ekulimaleni okukhulu kwesibindi, ukwehluleka kwesibindi, noma ukufa (bheka “Izexwayiso Ezibhokisi” ngezansi)
• ukusabela okweqile komzimba, okunezimpawu ezingafaka inkinga yokuphefumula kanye ne-angioedema (ukuvuvukala ngaphansi kwesikhumba sakho, ikakhulukazi ezinkophe zakho, izindebe, izandla, noma izinyawo)

Izexwayiso ezingamabhokisi

UHarvoni noMavyret bobabili banezixwayiso zesibhakela ezivela ku-FDA. Isexwayiso esibhakeleni yisixwayiso esiqine kakhulu esidingwa yi-FDA.

Isexwayiso sichaza ingozi yokuvuselelwa kwesifo sokusha kwesibindi kohlobo B ngemuva kokuqala ukwelashwa nganoma yisiphi isidakamizwa. Ukuvuselelwa kwe-Hepatitis B kungaholela ekulimaleni okukhulu kwesibindi, ukwehluleka kwesibindi, noma ukufa.

Udokotela wakho uzokuhlolela i-hepatitis B ngaphambi kokuba uqale ukuthatha iHarvoni noma iMavyret. Uma kutholakala ukuthi une-hepatitis B, kungadingeka ukuthi uthathe imithi ukuyelapha.

Ukusebenza ngempumelelo

UHarvoni noMavyret abakaze baqhathaniswe nezifundo zomtholampilo, kepha zombili ziyasebenza ekwelapheni i-hepatitis C.

Ngokweziqondiso zokwelashwa, iHarvoni neMavyret zombili izindlela zokwelashwa ezingakhethwa kuqala ze-hepatitis C genotypes 1, 4, 5, kanye no-6. izimo ezithile zezokwelapha lapho umuthi owodwa unganconywa ngaphezu komunye:

• Izingane ezineminyaka engu-12 nangaphezulu noma ezinesisindo esingamakhilogremu angama-77 noma ngaphezulu: I-Harvoni inketho yokuqala yokwelapha lezi zingane ngama-genotypes 1, 4, 5, no-6. I-Mavyret ayinconywa ukuthi isetshenziswe ezinganeni.
• Isifo sezinso esibi: I-Mavyret iyindlela yokuqala yokukhetha ukwelashwa kwesifo sokusha kwesibindi kohlobo C kubantu abanalesi simo. I-Harvoni ayinconywa kubantu abanesifo esibi sezinso.
• Isifo sokuqina kwesibindi esinciphile: Kubantu abane-cirrhosis ebolile, iHarvoni inconywa ukuthi isetshenziswe ne-ribavirin. I-Mavyret ayinconyelwe abantu abanalesi simo.
• Ukufakelwa kwezinso: Kubantu abathole ukufakelwa izinso, zombili lezi zidakamizwa zinconywa njengezinketho zomugqa wokuqala kubantu abane-genotypes 1 noma 4. (I-Harvoni isetshenziswa ngaphandle kwelebula ngale njongo.) I-Mavyret nayo inconyelwa abantu abane-genotypes 2 , 3, 5, noma 6 abathole ukufakelwa izinso, kepha uHarvoni akayona.
• Ukufakelwa kwesibindiIzincomo zokwelashwa zokusetshenziswa kweHarvoni neMavyret zihlukile kubantu abanesibindi sokufakelwa kwesibindi. Zisekelwe ekusebenzeni kwe-genotype nesibindi.

Izindleko

UHarvoni noMavyret bobabili bayimithi enegama lomkhiqizo. Okwamanje azikho izinhlobo ezijwayelekile zomuthi otholakalayo. Imithi enegama lomkhiqizo ivame ukubiza ngaphezu kwama-generic.

Ngokuya ngokulinganiselwa ku-GoodRx.com, iHarvoni ibiza kakhulu kunoMavyret.Izindleko zangempela ozikhokhela noma yisiphi isidakamizwa zizoya ngohlelo lwakho lomshuwalense nasekhemisi oyisebenzisayo.

Qaphela: Uhlobo olujwayelekile lwe-Harvoni kulindeleke ukuthi lukhishwe ekuqaleni kuka-2019. Umkhiqizi ulinganisela ukuthi izindleko zomuthi othile zizoba ngama- $ 24,000. Le ntengo incane kakhulu kunentengo yohlobo lwegama lomkhiqizo.

IHarvoni vs. Sovaldi

IHarvoni neSovaldi zombili zisetshenziselwa ukwelapha isifo sokusha kwesibindi kohlobo C. IHarvoni iyinhlanganisela yethebhulethi equkethe imishanguzo emibili: i-ledipasvir ne-sofosbuvir. I-Sovaldi iqukethe umuthi owodwa: i-sofosbuvir.

Isebenzisa

I-Harvoni ivunyelwe yi-FDA ukwelapha isifo sokusha kwesibindi kohlobo C kubantu abadala abane-genotypes 1, 4, 5, noma 6. Ingasetshenziselwa ukwelapha izingane ezinala ma-genotypes aneminyaka engu-12 nangaphezulu noma anesisindo okungenani esingamakhilogremu angama-77.

I-Sovaldi nayo ivunyelwe ukwelapha i-hepatitis C, kepha isetshenziswa kubantu abadala abane-genotypes 1, 2, 3, noma 4. Ingasetshenziswa nasezinganeni ezine-genotypes 2 noma 3 ezineminyaka engu-12 noma ngaphezulu noma ezinesisindo esingamakhilogremu angama-77 noma ngaphezulu .

I-Sovaldi isetshenziswa ngokuhlangana neminye imithi yokwelapha i-hepatitis C. Ayivunyelwe i-FDA ukuthi isetshenziswe yodwa.

Amafomu wezidakamizwa nokuphathwa

UHarvoni noSovaldi bobabili beza njengamathebulethi owaphuzayo. I-Harvoni ithathwa kanye nsuku zonke amasonto ayi-8, 12, noma ama-24. ISovaldi ibuye ithathwe kanye ngosuku, kepha amasonto ayi-12 noma angama-24.

Yomibili le mithi iqukethe i-sofosbuvir, kepha iHarvoni iyinhlanganisela yemithi engasetshenziswa yodwa kwabanye abantu. I-Sovaldi ayisetshenziswanga yodwa ukwelapha i-hepatitis C. Inqunywe nezinye izidakamizwa, kufaka phakathi i-pegylated interferon ne-ribavirin (i-Rebetol). Uhlobo olujwayelekile lwe-Sovaldi luyatholakala nakweminye inhlanganisela yemithi ye-hepatitis C.

Imiphumela emibi kanye nezingozi

Yomibili le mithi iqukethe i-sofosbuvir, ngakho-ke izodala imiphumela emibi efanayo. Kodwa-ke, uSovaldi uhlala ethathwa ehlanganiswe neminye imithi, engasebenza ngokuhlukile kweHarvoni. Ngenxa yalokhu, imiphumela emibi ebonwa ngokwelashwa kwe-Sovaldi incike kumuthi osetshenziswe ngawo.

Imiphumela emibi ejwayelekile nebucayi yeHarvoni neSovaldi iboniswe ngezansi. Imiphumela engemihle kaSovaldi echaziwe iyabonakala lapho iSovaldi isetshenziswa nezinye izidakamizwa ze-hepatitis C ezifana ne-ribavirin kanye ne-pegylated interferon.

* UHarvoni noSovaldi bobabili banesixwayiso esibhokisi esivela ku-FDA sokuvuselelwa kwesifo sokusha kwesibindi kohlobo B. Isexwayiso esibhakeleni yisixwayiso esiqine kakhulu esidingwa yi-FDA. Kwazisa odokotela neziguli ngemiphumela yezidakamizwa engaba yingozi.

Ukusebenza ngempumelelo

I-Harvoni ne-Sovaldi zinokusetshenziswa okwehlukile okuvunyelwe yi-FDA, kodwa zombili zisetshenziselwa ukwelapha i-hepatitis C. Harvoni iyasebenza ukulwa negciwane uma isetshenziswa yodwa noma i-ribavirin. I-Sovaldi iyasebenza ekwelapheni i-hepatitis C kuphela uma isetshenziswe ngokuhlangana nezinye izidakamizwa, njenge-ribavirin ne-pegylated interferon.

Ngokuya ngemikhombandlela yokwelashwa, iHarvoni iyindlela yokuzikhethela yokuqala yokwelapha i-hepatitis C kubantu abane-genotypes 1, 4, 5, noma i-6.

I-Sovaldi ayisaphakanyiswa imihlahlandlela yokwelashwa njengenketho yokuzikhethela ekwelapheni i-hepatitis C. Lokhu kungenxa yokuthi imishanguzo emisha efana ne-Harvoni ibhekwa njengeyisebenza kakhulu. Imithi emisha nayo idala imiphumela emibi embalwa kakhulu.

Kodwa-ke, i-Sovaldi kwesinye isikhathi inconywa njengokwelashwa okukhethwa kukho kwesibili kubantu abathile, kepha kufanele isetshenziswe ngokuhlangana neminye imithi.

Izindleko

IHarvoni neSovaldi yimithi enegama lomkhiqizo. Okwamanje awekho amafomu ejwayelekile atholakala kunoma imuphi umuthi.

Ngokuya ngokulinganiselwa ku-GoodRx.com, iHarvoni ngokwejwayelekile ibiza kancane kuneSovaldi. Intengo yangempela oyikhokhela noma yisiphi isidakamizwa izoncika kumshwalense wakho nasekhemisi oyisebenzisayo.

Qaphela: Uhlobo olujwayelekile lwe-Harvoni kulindeleke ukuthi lukhishwe ekuqaleni kuka-2019. Umkhiqizi ulinganisela ukuthi izindleko zomuthi othile zizoba ngama- $ 24,000. Le ntengo incane kakhulu kunentengo yohlobo lwegama lomkhiqizo.

IHarvoni vs. Zepatier

IHarvoni iqukethe izidakamizwa ledipasvir ne-sofosbuvir kwiphilisi elilodwa. I-Zepatier iqukethe nezidakamizwa ezimbili kupilisi elilodwa: i-elbasvir ne-grazoprevir.

Isebenzisa

IHarvoni neZepatier bobabili bavunyelwe yi-FDA ukwelapha igciwane le-hepatitis C kubantu abadala abane-genotypes 1 noma 4. I-Harvoni nayo ivunyelwe ukwelapha ama-genotypes 5 no-6 kubantu abadala, kanye ne-genotypes 1, 4, 5, noma 6 ezinganeni ezineminyaka engu-12 noma ngaphezulu. noma ngubani onesisindo okungenani esingamaphawundi angama-77. I-Zepatier ayivunyelwe ukusetshenziswa ezinganeni.

I-Harvoni ivunyelwe ukwelapha igciwane le-hepatitis C kubantu abadala abane-cirrhosis ebolile noma abaye bafakelwa isibindi. Ngalezi zimo, udokotela wakho kungenzeka anikeze i-ribavirin neHarvoni.

I-Zepatier ayivunyelwe ukusetshenziswa kubantu abanezifo zesibindi ezilinganiselwe noma ezinzima, i-cirrhosis ebolile, noma ngemuva kokufakelwa kwesibindi.

I-Zepatier ivunyiwe yi-FDA ukuthi isetshenziswe kubantu abane-genotypes 1 no-4 abanesimo esibizwa nge-polymorphism. Ngalesi simo, umuntu unokuhlukahluka okuthile kofuzo (okwenza izakhi zofuzo) okwenza igciwane limelane nemithi ethile. Lapho igciwane lingazweli, kunzima ukuselapha ngemithi ethile.

Udokotela wakho uzokwenza ukuhlolwa kwegazi abone ukuthi unayo yini enye yalezi zinguquko. Uma wenza kanjalo, kungadingeka ukuthi uthathe i-ribavirin noZepatier.

Amafomu wezidakamizwa nokuphathwa

UHarvoni noZepatier bobabili beza njengethebhulethi eyodwa ethathwa kanye nsuku zonke. Ngasinye singathathwa nokudla noma ngaphandle kokudla.

Ukwelashwa kwe-Harvoni kuhlala amasonto ayi-8, 12, noma ama-24. Ukwelashwa kwe-Zepatier kuhlala amasonto ayi-12 noma ayi-16. Isikhathi sokwelashwa okushiwo udokotela wakho kuzosuselwa kuhlobo lwakho lwezinhlobo zofuzo, ukusebenza kwesibindi, kanye nomlando wezindlela zokwelashwa kwesifo sokusha kwesibindi kohlobo C.

Imiphumela emibi kanye nezingozi

IHarvoni neZepatier yimithi efanayo nemiphumela yayo emzimbeni iyafana. Ngakho-ke, zidala imiphumela emibi efanayo. Ngezansi kunezibonelo ezithile zemiphumela yazo emibi.

* UHarvoni noZepatier bobabili banesixwayiso esibhokisi esivela ku-FDA sokuvuselelwa kwesifo sokusha kwesibindi kohlobo B. Isexwayiso esibhakeleni yisixwayiso esiqine kakhulu esidingwa yi-FDA. Kwazisa odokotela neziguli ngemiphumela yezidakamizwa engaba yingozi.

Ukusebenza ngempumelelo

UHarvoni noZepatier abakaze baqhathaniswe nezifundo zomtholampilo, kepha bobabili bayasebenza ekwelapheni i-hepatitis C.

Ngokweziqondiso zokwelashwa, bobabili uHarvoni noZepatier banconywa njengezinketho zokukhetha ukwelashwa kwesifo sokusha kwesibindi kohlobo C kubantu abadala abane-genotypes 1 no-4. I-Harvoni nayo iyindlela yokuqala yokwelapha i-genotypes 5 no-6, kodwa uZepatier akayona.

Izincomo zemihlahlandlela zeHarvoni neZepatier nazo ziyehluka ngezimo ezilandelayo:

• Izingane ezineminyaka engu-12 nangaphezulu noma ezinesisindo esingamakhilogremu angama-77 noma ngaphezulu: I-Harvoni iyindlela yokuzikhethela yokuqala yokwelapha lezi zingane ezine-genotypes 1, 4, 5, no-6. I-Zepatier ayinconyelwe ukusetshenziswa ezinganeni.
• Isifo sezinso esibi: I-Zepatier inconyelwa njengenketho yokuqala yokuzikhethela kubantu abanalesi simo, kuyilapho uHarvoni engekho.
• Isifo sokuqina kwesibindi esinciphile: Kubantu abane-cirrhosis ebolile, i-Harvoni inconywa njengenketho yokuqala. I-Zepatier ayinconyelwe abantu abanalesi simo.
• Ukufakelwa kwesibindi noma izinso: I-Harvoni iyindlela yokuqala yokukhetha ukwelashwa kwesifo sokusha kwesibindi kohlobo C kubantu abaye bafakelwa isibindi noma izinso. I-Zepatier ayinconyelwe abantu abanale mibandela.

Izindleko

IHarvoni neZepatier yimithi enegama lomkhiqizo. Okwamanje awekho amafomu ejwayelekile atholakala kunoma imuphi umuthi. Imithi enegama lomkhiqizo ivame ukubiza ngaphezu kwama-generic.

Ngokuya ngokulinganiselwa ku-GoodRx.com, iHarvoni ngokuvamile ibiza kakhulu kunoZepatier. Izindleko zangempela ozikhokhela noma yisiphi isidakamizwa zizoya ngohlelo lwakho lomshuwalense nasekhemisi oyisebenzisayo.

Qaphela: Uhlobo olujwayelekile lwe-Harvoni kulindeleke ukuthi lukhishwe ekuqaleni kuka-2019. Umkhiqizi ulinganisela ukuthi izindleko zomuthi othile zizoba ngama- $ 24,000. Le ntengo incane kakhulu kunentengo yohlobo lwegama lomkhiqizo.

Ungamthatha kanjani uHarvoni

Kufanele uthathe i-Harvoni ngokwemiyalo kadokotela wakho.

Isikhathi

IHarvoni ingathathwa nganoma yisiphi isikhathi sosuku. Kodwa-ke, kufanele uzame ukuthatha iHarvoni ngasikhathi sinye nsuku zonke. Lokhu kungakusiza ukuthi ukhumbule ukuyithatha futhi usize ukugcina inani elifanayo lomuthi kusistimu yakho.

Uma uhlangabezana nokukhathala phakathi nokwelashwa kwakho neHarvoni, zama ukuthatha umuthi ebusuku. Lokho kungakusiza ukuthi ugweme leyo miphumela emibi.

Ukuthatha uHarvoni ngokudla

I-Harvoni ingathathwa ngokudla noma ngaphandle kokudla. Uma uhlangabezana nesicanucanu ngemuva kokuthatha iHarvoni, ungawugwema lowomphumela wokudla ngokuthatha umuthi ngokudla.

Ngabe iHarvoni ingachotshozwa?

Akwaziwa ukuthi kuphephile yini ukuchoboza amaphilisi e-Harvoni, ngakho-ke kungcono ukugwema ukuwaphula. Uma unenkinga yokugwinya amaphilisi e-Harvoni, khuluma nodokotela wakho ngeminye imithi engakusebenzela kangcono.

Isebenza kanjani iHarvoni

I-Harvoni isetshenziselwa ukwelapha ukutheleleka ngegciwane le-hepatitis C (HCV).

Mayelana ne-hepatitis C

I-HCV idluliselwa ngegazi noma uketshezi lomzimba. Leli gciwane lihlasela amaseli esibindi sakho futhi libangele ukuvuvukala. Lokhu kuholela ezimpawu ezifana:

• ubuhlungu esiswini sakho (esiswini)
• imfiva
• umchamo onombala omnyama
• ubuhlungu obuhlangene
• i-jaundice (okuphuzi kwesikhumba sakho noma okumhlophe kwamehlo akho)

Amasosha omzimba abanye abantu angalwa ne-HCV ngaphandle kokwelashwa. Kodwa-ke, abantu abaningi badinga imishanguzo yokususa igciwane nokunciphisa imiphumela yesikhathi eside. Imiphumela ebucayi, yesikhathi eside ye-hepatitis C ifaka i-cirrhosis (isibazi sesibindi) nomdlavuza wesibindi.

I-Harvoni ilapha kanjani i-hepatitis C?

IHarvoni iyi-antiviral esebenza ngqo (i-DAA). Lezi zinhlobo zemithi zelapha i-HCV ngokuvimba igciwane ukuthi lingakhiqizi (lizenzele amakhophi alo). Amagciwane angenakukwazi ukwenza amakhophi agcina ngokufa futhi asuswe emzimbeni.

Ukusula igciwane emzimbeni wakho kuzonciphisa ukuvuvukala kwesibindi futhi kuvimbele isibazi esengeziwe sesibindi.

Kuthatha isikhathi esingakanani ukusebenza?

Abanye abantu baqala ukuzizwa bengcono ezinsukwini ezimbalwa noma emasontweni aqala ukwelashwa noHarvoni. Kodwa-ke, kusazodingeka uthathe i-Harvoni isikhathi sonke esinqunywe udokotela wakho.

Ezifundweni zokwelashwa, abantu abangaphezu kwamaphesenti angama-86 abathathe iHarvoni belashwa ngemuva kwezinyanga ezintathu belashwa.

Udokotela wakho uzohlola igazi lakho ukuthola igciwane ngaphambi nokwelashwa. Bazokuhlola futhi emasontweni ayi-12 ngemuva kokuqeda ukwelashwa. Uma lingekho igciwane elibonakalayo emzimbeni wakho emasontweni ayi-12 ngemuva kokuphela kokwelashwa kwakho, uzuze impendulo eqhubekayo ye-virologic (SVR). Ukufeza i-SVR kusho ukuthi ubhekwa njengokwelapha i-hepatitis C.

Harvoni nokukhulelwa

Akuzange kube nezifundo ezanele kubantu ukwazi ukuthi uHarvoni uphephile yini ukuthatha ngesikhathi sokukhulelwa. Ezifundweni zezilwane, kwakungekho monakalo kumbungu owabonwa lapho umama ethola uHarvoni. Kodwa-ke, izifundo zezilwane azihlali zibikezela ukuthi kuzokwenzekani kubantu.

Uma ukhulelwe noma uhlela ukukhulelwa, khuluma nodokotela wakho mayelana nokuthi uHarvoni ukufanele yini.

Qaphela: Uma uthatha i-Harvoni nge-ribavirin, leyo mithi ayiphephile ukuyisebenzisa ngesikhathi sokukhulelwa (bheka i- "Harvoni ne-ribavirin" ngenhla).

IHarvoni nokuncelisa ibele

Akwaziwa ukuthi uHarvoni udlulela ebisini lwebele lomuntu. Ezifundweni zezilwane, uHarvoni watholakala obisini lwebele kodwa akazange abangele imiphumela eyingozi enzalweni. Kodwa-ke, izifundo zezilwane azihlali zibikezela ukuthi kuzokwenzekani kubantu.

Uma uncelisa noma uhlela ukuncelisa, khuluma nodokotela wakho mayelana nobungozi kanye nezinzuzo zokuthatha i-Harvoni ngenkathi uncelisa.

Qaphela: Uma uthatha iHarvoni nge-ribavirin, kufanele ukhulume nodokotela wakho mayelana nokuthi ungaqhubeka nokuncelisa ingane ngokuphepha (bheka i- "Harvoni ne-ribavirin" ngenhla).

Imibuzo ejwayelekile ngeHarvoni

Nazi izimpendulo zemibuzo ebuzwa njalo ngeHarvoni.

Ngabe ngidinga ukulandela ukudla okukhethekile ngenkathi ngithatha iHarvoni?

Cha, akukho kudla okukhethekile okudingekayo ngenkathi uthatha iHarvoni.

Kodwa-ke, uma uhlangabezana nesicanucanu noma ubuhlungu besisu njengomphumela wecala likaHarvoni, kungasiza ukudla ukudla okuncane futhi ugweme ukudla okunamafutha, okubabayo noma okune-asidi. Ukuthatha i-Harvoni ngesiphuzo esincane nakho kunganciphisa isicanucanu.

Kuzothatha isikhathi esingakanani uHarvoni ukususa i-hepatitis C yami?

UHarvoni uzoqala ukusebenza ngokushesha ukulwa naleli gciwane. Kodwa-ke, ukuze ususe i-hepatitis C, kuzodingeka uthathe i-Harvoni isikhathi esigcwele esinqunyelwe udokotela wakho. Lokhu kungaba amasonto ayi-8, 12, noma ama-24, kuya ngomlando wakho wezokwelapha.

Ezifundweni zokwelashwa, cishe bonke abantu abathathe uHarvoni bathole impendulo eqhubekayo ye-virologic SVR) ngemuva kokwelapha okugcwele. I-SVR isho ukuthi igciwane belingasatholakali egazini labo. Lapho umuntu ethola i-SVR, kubhekwa njengokwelashwa kwesifo sokusha kwesibindi kohlobo C.

Lithini inani lokwelashwa kweHarvoni?

Izinga lokwelashwa kweHarvoni lincike ezicini ezithile zesifo sakho sokusha kwesibindi kohlobo C. Lokhu kufaka phakathi ukuthi unesifo sokuqina kwesibindi noma cha, yiziphi izindlela zokwelapha i-hepatitis C oke wazama esikhathini esidlule, nokuthi yiluphi uhlobo lwegciwane onalo.

Isibonelo, ezifundweni zokwelashwa zaseHarvoni, amaphesenti angama-96 abantu abahlangabezana nale ncazelo elandelayo baphulukiswa i-hepatitis C ngemuva kwamasonto ayi-12:

• ngine-genotype 1
• wayengenaso isifo sokuqina kwesibindi
• wayengenawo umlando wezinye izindlela zokwelapha i-hepatitis C.

Ezifundweni ezifanayo zomtholampilo, phakathi kwamaphesenti angama-86 kanye namaphesenti ayi-100 abantu abanemilando ehlukene yezokwelapha belashwa i-hepatitis C.

Ngabe i-hepatitis C ingabuya ngemuva kokuthatha iHarvoni?

Uma uthatha iHarvoni nsuku zonke njengokuyalelwa ngudokotela wakho futhi ugcina indlela yokuphila enempilo, igciwane akufanele libuye.

Kodwa-ke, kungenzeka ukuphinda ubuye (ukutheleleka kuvele futhi). Lokhu kwenzeka lapho umuthi uselaphe umuntu isifo sokusha kwesibindi kohlobo C, kepha ukuhlolwa kwegazi kuthola leli gciwane futhi ezinyangeni kuya eminyakeni ngemuva kokwelashwa. Ezivivinyweni zomtholampilo, kuze kufike kumaphesenti ayi-6 wabantu abaphathwe noHarvoni babuyela emuva.

Futhi, uma uvezwa i-hepatitis C futhi ngemuva kokuthatha noma imuphi umuthi we-hepatitis C, kufaka phakathi iHarvoni, ungaphinde utheleleke ngegciwane. Ukutheleleka kabusha kungenzeka ngendlela efanayo nokutheleleka kwasekuqaleni okwatholwa.

Ukwabelana ngezinaliti ezisetshenziselwa ukujova izidakamizwa nokuya ocansini ngaphandle kwekhondomu kungenzeka kube yimizila yokuphinda itheleleke. Ukugwema lezi zindlela zokuziphatha kungasiza ekuvimbeleni ukutheleleka kabusha nge-hepatitis C.

Iyini i-genotype ye-hepatitis C?

Kunezinhlobo eziyisithupha ezihlukene zamagciwane e-hepatitis C aziwa ngokuthelela abantu. Lezi zinhlobo zibizwa ngokuthi ama-genotypes.

Ama-genotypes akhonjwa ngokwehluka kwekhodi yezakhi zofuzo yamagciwane. Uhlobo oluvame kakhulu lwe-hepatitis C e-United States yi-genotype 1, kepha ezinye izinhlobo ziyabonakala lapha.

Udokotela wakho uzokuhlolela igazi ukuthola ukuthi yiluphi uhlobo lohlobo onalo. Uhlobo lwakho lwe-hepatitis C luzosiza udokotela wakho anqume ukuthi imuphi umuthi ofanele wena.

Ukudlula ngokweqile kweHarvoni

Uma uthatha iHarvoni eningi, wandisa ubungozi bemiphumela emibi kakhulu.

Izimpawu zokudlula ngokweqile

Izimpawu zokudlula ngokweqile kweHarvoni zingafaka:

• ukukhathala
• ikhanda elibi kakhulu
• isicanucanu nokuhlanza
• ubuthakathaka bemisipha
• ukuqwasha (kunzima ukulala)
• ukucasuka

Okufanele ukwenze uma kwenzeka ukweqisa ngokweqile

Uma ucabanga ukuthi uthathe kakhulu lo muthi, shayela udokotela wakho noma funa ukuholwa yi-American Association of Poison Control Centers ku-800-222-1222 noma ngethuluzi labo eliku-inthanethi. Kepha uma izimpawu zakho zinzima, shayela ku-911 noma uye egumbini lezimo eziphuthumayo eliseduze ngokushesha.

Izexwayiso zikaHarvoni

Lesi sidakamizwa siza nezixwayiso eziningana.

Isexwayiso se-FDA: Ukuvuselelwa kwegciwane le-hepatitis B

Lesi sidakamizwa sinesixwayiso esibhakeleni. Lesi yisexwayiso esibi kakhulu esivela ku-Food and Drug Administration (FDA). Isexwayiso sebhokisi sazisa odokotela neziguli ngemiphumela yezidakamizwa engaba yingozi.

• Lapho abantu abane-coinfected bobabili i-hepatitis C ne-hepatitis B beqala ukuthatha i-Harvoni, kunengozi yokuvuselelwa kwegciwane le-hepatitis B (HBV). Ukuvuselelwa kabusha kusho ukuthi igciwane lisebenza futhi. Ukuvuselelwa kwe-HBV kungaholela ekuhlulekeni kwesibindi noma ekufeni. Udokotela wakho uzokuhlolela i-HBV ngaphambi kokuqala ukwelashwa ngeHarvoni. Uma kutholakala ukuthi une-HBV, kungadingeka ukuthi uthathe imishanguzo ukuyelapha.

Ezinye izexwayiso

Ngaphambi kokuthatha uHarvoni, khuluma nodokotela wakho ngomlando wakho wezempilo. IHarvoni ingahle ingakulungeli uma unezimo ezithile zezokwelapha.

Akwaziwa ukuthi iHarvoni iphephile noma iyasebenza yini kubantu abanezifo ezinzima zezinso. Lokhu kufaka phakathi abantu abanokukhubazeka okukhulu kwezinso noma abanezifo zezinso zokugcina ezidinga i-hemodialysis. Kodwa-ke, abantu abanesifo esibi sezinso abathathe uHarvoni ocwaningweni lomtholampilo lwango-2018 baphathwa kahle futhi abanayo imiphumela emibi emibi.

Uma unesifo esibi sezinso, khuluma nodokotela wakho ukuthi ngabe uHarvoni ukufanele yini.

Ukuphelelwa yisikhathi kweHarvoni

Lapho uHarvoni ekhishwa ekhemisi, usokhemisi uzokwengeza usuku lokuphelelwa yisikhathi kwilebula esebhodleleni. Lolu suku luvame unyaka owodwa kusukela ngosuku okwakhishwa ngalo umuthi.

Inhloso yezinsuku zokuphelelwa isikhathi ezinjalo ukuqinisekisa ukusebenza komuthi ngalesi sikhathi. Isimo samanje se-Food and Drug Administration (i-FDA) ukugwema ukusebenzisa imishanguzo ephelelwe yisikhathi.

Ukuthi umuthi uhlala ulungile isikhathi eside kangakanani kungancika ezintweni eziningi, kufaka phakathi ukuthi umuthi ugcinwa kanjani futhi kuphi. Amaphilisi e-Harvoni kufanele agcinwe ngaphansi kuka-86⁰F (30⁰C) futhi agcinwe esitsheni abangene kuso.

Uma usebenzise umuthi ongasetshenziswanga osudlulile esikhathini sokuphela kwawo, khuluma nosokhemisi wakho mayelana nokuthi usengakwazi yini ukuwusebenzisa.

Imininingwane yobungcweti yeHarvoni

Imininingwane elandelayo inikezwa odokotela nabanye ochwepheshe bezempilo.

Indlela yokusebenza

IHarvoni iqukethe izidakamizwa ezimbili: i-ledipasvir ne-sofosbuvir.

I-Ledipasvir ivimbela amaprotheni e-HCV NS5A, adingekayo ekusebenzeni kahle kwe-phosphorylation ye-RNA yegciwane. Ukuvinjelwa kwe-NS5A kuvimba ukuphindaphindeka kwe-RNA nokuhlangana.

ISofosbuvir iyi-HCV NS5B polymerase inhibitor ene-metabolite esebenzayo (i-nucleoside analog triphosphate) efakwe kwi-HCV RNA. I-metabolite esebenzayo isebenza njenge-terminator chain, imisa ukuphindaphindeka kwe-HCV.

IHarvoni inomsebenzi olwa ne-HCV genotypes 1, 4, 5, no-6.

I-Pharmacokinetics ne-metabolism

IHarvoni iqukethe izithako ezimbili ezisebenzayo: i-ledipasvir ne-sofosbuvir.

I-Ledipasvir ifinyelela ekugxileni okuphezulu cishe emahoreni amane futhi icishe ibopheke ngokuphelele kumaphrotheni e-plasma. I-Metabolism yenzeka nge-oxidation ngokusebenzisa indlela engaziwa. Isikhathi sempilo cishe ngamahora angama-47. Isidakamizwa esingashintshiwe kanye nama-metabolite aso oketshezi aqedwa ikakhulukazi endleni.

Ukuhlushwa okuphezulu kweSofosbuvir kwenzeka ngemizuzu engama-45 kuya ehoreni elilodwa. Ama-akhawunti abopha amaprotheni e-Plasma cishe ngamaphesenti angama-65 omuthi ojikelezayo. ISofosbuvir isidakamizwa esiguqulwa sibe yi-metabolite esebenzayo (GS-461203) nge-hydrolysis ne-phosphorylation esibindini. I-GS-461203 iphinde yenziwe i-dephosphorylated to an metabolite engasebenzi.

Kufika kumaphesenti angama-80 omthamo asuswe emchameni. Isigamu sempilo yomzali yimizuzu engama-30, kanti isigamu sempilo yemetabolite engasebenzi cishe amahora angama-27.

Izimo

Akukho ukuphikisana nokusetshenziswa kweHarvoni. Bheka i-ribavirin echaza imininingwane yokuphikisana kwabantu abathola iHarvoni nge-ribavirin.

Isitoreji

IHarvoni kufanele igcinwe esitsheni sayo sokuqala emazingeni okushisa angaphansi kuka-86⁰F (30⁰C).

UkuzikhululaI-MedicalNewsToday yenze yonke imizamo yokuqinisekisa ukuthi lonke ulwazi luyiqiniso, luphelele futhi lusesikhathini. Kodwa-ke, le ndatshana akufanele isetshenziswe njengokungena esikhundleni solwazi nobungoti bochwepheshe bezokunakekelwa kwezempilo onelayisense. Kufanele uhlale uthintana nodokotela wakho noma omunye uchwepheshe wezokunakekelwa kwempilo ngaphambi kokuthatha noma imuphi umuthi. Imininingwane yezidakamizwa equkethwe lapha ingashintsha futhi ayihloselwe ukumboza konke ukusetshenziswa okungaba khona, izinkomba, izixwayiso, izexwayiso, ukuxhumana kwezidakamizwa, ukungezwani komzimba, noma imiphumela emibi. Ukungabikho kwezixwayiso noma olunye ulwazi lomuthi othile awukhombisi ukuthi inhlanganisela yezidakamizwa noma yezidakamizwa iphephile, iyasebenza, noma ilungele zonke iziguli noma konke ukusetshenziswa okuthile.