Umlobi: Louise Ward
Usuku Lokudalwa: 4 Ufebhuwari 2021
Ukuvuselela Usuku: 1 Ujulayi 2024
Anonim
Inbrija® (levodopa inhalation powder) Demonstration Video
Ividiyo: Inbrija® (levodopa inhalation powder) Demonstration Video

-Delile

Yini u-Inbrija?

I-Inbrija umuthi kadokotela osetshenziswa ukwelapha isifo sika-Parkinson. Inqunyelwe abantu ababuya ngokungazelelwe izimpawu zikaParkinson ngenkathi bethatha inhlanganisela yezidakamizwa ebizwa nge-carbidopa / levodopa. Lokhu kubuya kwezimpawu kubizwa ngokuthi "yisikhathi esiphumile." Kwenzeka lapho imiphumela ye-carbidopa / levodopa iphela noma umuthi ungasebenzi njengoba kufanele.

Ngemuva kokuthatha i-Inbrija, ifinyelela ebuchosheni bakho bese iphenduka into ebizwa nge-dopamine. I-Dopamine isiza ukuqeda izimpawu zesifo sika-Parkinson.

I-Inbrija iza njenge-capsule enempuphu ngaphakathi kuyo. Ngaso sonke isikhathi uma uthenga i-Inbrija, uzophinda uthole idivayisi ye-inhaler. Ubeka amaphilisi kudivayisi bese uhogela i-Inbrija ngomlomo wakho. Umuthi utholakala kuphela ngamandla owodwa: ama-milligram angama-42 (mg) ngephilisi ngalinye.

Ukusebenza ngempumelelo

U-Inbrija utholakale esebenza kahle ekwelapheni izikhathi zesifo sika-Parkinson.

Esifundweni somtholampilo, imiphumela ye-Inbrija yaqhathaniswa ne-placebo (ukwelashwa ngaphandle kwesidakamizwa esisebenzayo) kubantu abangama-226 abanesifo sikaParkinson. Bonke abantu abebesocwaningweni bebethatha i-carbidopa / levodopa kodwa bebesenezimpawu ezingazelelwe zeParkinson’s.


U-Inbrija wanikezwa abantu isikhathi ngasinye lapho kubuya uphawu olungazelelwe. Ngemuva kokuthatha i-Inbrija, ama-58% wabantu abuyele "esikhathini" sesifo sikaParkinson. Isikhathi sangesikhathi lapho ungazizwa khona izimpawu. Kubantu abathathe i-placebo, ama-36% abuyele esikhathini seParkinson's.

Inbrija ejwayelekile

Inbrija (levodopa) itholakala kuphela njengomuthi wegama lomkhiqizo. Okwamanje ayitholakali ngendlela ejwayelekile.

Imiphumela emibi ye-Inbrija

I-Inbrija ingadala imiphumela emibi noma emibi. Uhlu olulandelayo luqukethe eminye yemiphumela emibi engase yenzeke ngenkathi uthatha i-Inbrija. Lezi zinhlu azibandakanyi yonke imiphumela emibi engaba khona.

Ukuthola eminye imininingwane ngemiphumela engemihle ye-Inbrija, khuluma nodokotela wakho noma usokhemisi. Bangakunika amathiphu okuthi ungabhekana kanjani nanoma yimiphi imiphumela emibi engase ikukhathaze.

Imiphumela emibi ejwayelekile

Imiphumela emibi ejwayelekile ye-Inbrija ingafaka:

  • ukukhwehlela
  • ukutheleleka okuphezulu kokuphefumula, njengomkhuhlane ovamile
  • isicanucanu esihlala isikhathi eside (bona “Imininingwane yomthelela oseceleni” ngezansi)
  • uketshezi lomzimba olunombala omnyama njengomchamo noma umjuluko (bheka “Imininingwane yomthelela ongezansi” ngezansi)

Iningi lalemiphumela emibi ingahle ihambe ezinsukwini ezimbalwa noma emasontweni ambalwa. Uma zinzima kakhulu noma zingahambi, khuluma nodokotela wakho noma usokhemisi.


Imiphumela emibi kakhulu

Imiphumela emibi ebucayi evela ku-Inbrija ayijwayelekile, kodwa ingenzeka. Shayela udokotela wakho ngokushesha uma unemiphumela emibi kakhulu. Shayela u-911 uma izimpawu zakho zizizwa zisongela impilo noma uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha.

Imiphumela emibi kanye nezimpawu zabo zingafaka:

  • ukuhoxiswa kwesifo
  • i-hypotension (umfutho wegazi ophansi)
  • i-psychosis kanye nemibono (ukubona noma ukuzwa okuthile okungekho lapho)
  • ukunxusa okungavamile
  • i-dyskinesia (ukunyakaza komzimba okungalawulwa nokungazelelwe)
  • ukulala ngesikhathi semisebenzi ejwayelekile
  • imiphumela engajwayelekile kusuka ekuhlolweni kwelabhoratri, kufaka phakathi ukuhlolwa kwesibindi (kungaba uphawu lokulimala kwesibindi)

Qaphela: Bona isigaba esithi “Imininingwane yomthelela oseceleni” ngezansi ukuze ufunde kabanzi ngalowo nalowo miphumela emibi.

Imininingwane yomphumela oseceleni

Ungazibuza ukuthi kaningi kangakanani imiphumela emibi ethile eba khona ngalo muthi, noma ukuthi imiphumela ethile engemihle ihlobene nawo yini. Nayi eminye imininingwane ngemiphumela emibi eminingi lo muthi ongahle uyibangele noma ongabanga yiyo.


Isifo sokuhoxa

Ungaba nesifo sokuhoxa ngemuva kokwehlisa ngokungazelelwe umthamo wakho we-Inbrija noma uyeke ukuwuthatha. Lokhu kungenxa yokuthi umzimba wakho ujwayele ukuba ne-Inbrija. Uma uyeka ngokungazelelwe ukuthatha, umzimba wakho awunaso isikhathi sokuzivumelanisa kahle nokungabi nawo.

Izimpawu zesifo sokuhoxa zingabandakanya:

  • umkhuhlane omkhulu noma imfiva ehlala isikhathi eside
  • ukudideka
  • ukuqina kwemisipha
  • isigqi senhliziyo esingajwayelekile (kushintsha ukushaya kwenhliziyo yakho)
  • izinguquko ekuphefumuleni

Tshela udokotela wakho uma uhlangabezana nezimpawu zokuhoxa. Ungaqali ukuthatha i-Inbrija futhi uma uzwa izimpawu zesifo sokuhoxa ngaphandle kokuthi udokotela wakho akweluleke. Bangakunikeza eminye imithi yokusiza ngezimpawu zakho.

I-Hypotension (umfutho wegazi ophansi)

Ungaba nomfutho wegazi ophansi lapho uthatha i-Inbrija. Esifundweni somtholampilo, u-2% wabantu abathatha i-Inbrija babenomfutho wegazi ophansi. Akekho noyedwa kubantu abathathe i-placebo (ukwelashwa ngaphandle kwesidakamizwa esisebenzayo) owayenomfutho wegazi ophansi.

Kwezinye izimo, umfutho wegazi ophansi ungakwenza ulahlekelwe ibhalansi yakho futhi uwe. Ukusiza ukugwema lokhu, sukuma kancane uma ngabe uhleli noma ulele phansi isikhathi esithile.

Izimpawu zomfutho wegazi ophansi zingafaka:

  • isiyezi
  • isicanucanu esihlala isikhathi eside
  • ukuquleka
  • isikhumba se-clammy

Tshela udokotela wakho uma uhlangabezana nezimpawu zomfutho wegazi ophansi ezingapheli. Bangabheka umfutho wegazi lakho ukubona ukuthi une-hypotension yini. Futhi, zingakusiza ukuthi wakhe uhlelo lokudla okunempilo noma unikeze imithi yokwengeza umfutho wegazi lakho.

Ingqondo

Ungahle uthole iziqephu ze-psychotic (kufaka phakathi ukusangana) ngenkathi uthatha i-Inbrija. Ngeziqephu ze-psychotic, umuzwa wakho weqiniso ungashintshwa. Ungahle ubone, uzwe, noma uzizwe izinto ezingezona ezangempela. Akwaziwa ukuthi uvame kangakanani lo mphumela oseceleni no-Inbrija.

Izimpawu zengqondo zingabandakanya:

  • ukusangana
  • ukudideka, ukudideka, noma ukucabanga okungahlelekile
  • ukuqwasha (kunzima ukulala)
  • ngiphupha kakhulu
  • i-paranoia (ecabanga ukuthi abantu bafuna ukukulimaza)
  • ukukhohlisa (ukukholelwa izinto ezingelona iqiniso)
  • isimilo esinolaka
  • ukudinwa noma ukuzizwa ungenakho ukuthula

Iziqephu ze-Psychotic kufanele zilashwe ukuze zingakulimazi. Yazisa udokotela wakho ngokushesha uma unezimpawu zengqondo. Bangabhala imishanguzo yokusiza ngezimpawu neziqephu zengqondo. Shayela u-911 uma izimpawu zakho zizizwa zisongela impilo noma uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha.

Ukunxusa Okungajwayelekile

I-Inbrija ingathinta izingxenye zobuchopho bakho ezilawula lokho ofuna ukukwenza. Ngakho-ke ukuthatha i-Inbrija kungashintsha lokho nokuthi ufuna ukwenza izinto nini futhi nini. Ikakhulu, ungazizwa unesifiso esedlulele sokwenza izinto ovame ukungazenzi.

Izimpawu zingafaka:

  • isifiso esingazelelwe sokugembula
  • ukuziphatha okuphoqelela (njengokudla noma ukuthenga)
  • isifiso eseqile sokwenza ucansi

Akwaziwa ukuthi uvame kangakanani lo mphumela wecala.

Kwezinye izimo, abantu abathatha i-Inbrija abakwazi ukubona izifiso zabo ezingavamile. Naka ngokukhethekile uma umngani noma ilungu lomndeni lithi awuzenzi njengawe. Kungenzeka ukuthi unezikhalazo ezingavamile ungazi.

Tshela udokotela wakho uma wena, umndeni wakho, noma abangane bakho nibona isimilo esingavamile kini. Udokotela wakho anganciphisa umthamo wakho we-Inbrija ukusiza ukunciphisa ingozi yokuba nalezi zikhalazo ezingavamile.

I-Dyskinesia

Ungaba ne-dyskinesia (ukunyakaza komzimba okungalawulwa nokungazelelwe) ngenkathi uthatha i-Inbrija. Esifundweni somtholampilo, u-4% wabantu abathatha i-Inbrija babene-dyskinesia. Ngokuqhathanisa, u-1% wabantu abathatha i-placebo babene-dyskinesia. Lokhu kunyakaza kwenzeke ebusweni babantu, ezilimini, nakwezinye izingxenye zemizimba yabo.

Izimpawu ze-dyskinesia zingafaka:

  • ehambisa ikhanda phezulu naphansi
  • ukugembula
  • ukungakwazi ukuphumula
  • ukunyakazisa umzimba
  • ukudikiza kwemisipha
  • kuphithizela

Yazisa udokotela wakho uma unezimpawu ze-dyskinesia ngenkathi uthatha i-Inbrija. Udokotela wakho uzobheka isimo sakho ukuze anqume ukuthi i-Inbrija iyimithi engcono kakhulu kuwe yini.

Ukulala ngesikhathi semisebenzi ejwayelekile

U-Inbrija angashintsha ukuthi ulala kanjani nokuthi nini. Ungazizwa uvuke ngokuphelele kepha ulale ngokuzumayo. Akwaziwa ukuthi uvame kangakanani lo mphumela wecala.

Ngenkathi uthatha i-Inbrija, ungahle ulale ngokuzumayo ngenkathi wenza imisebenzi ejwayelekile, efana nale:

  • ukushayela
  • ukusebenzisa noma ukuphatha izinto eziyingozi, njengemimese
  • ukudla
  • ukwenza imisebenzi ebonakalayo, njengokuphakamisa izinto ezisindayo
  • ngikhuluma nabantu

Ukuzuma ngokuzumayo kungaba yingozi, kuya ngokuthi wenzani. Isibonelo, ungazilimaza kakhulu wena nabanye uma ulala ngenkathi ushayela. Ngakho-ke, kufanele ugweme ukushayela noma ukuphatha izinto eziyingozi, ezifana nemimese noma ezinye izikhali, ngenkathi uthatha i-Inbrija.

Yazisa udokotela wakho uma ukulala kungazelelwe kuthinta imisebenzi yakho yansuku zonke. Bazokweluleka ngokuthi ungabhekana kanjani kahle nalomphumela oseceleni. Bazobuye baxoxe ngokuthi i-Inbrija iyimithi ekufanele yini.

Ngokungazelelwe ukulala kungaqhubeka ukwenzeka isikhathi esingaphezu konyaka ngemuva kokuqala ukuthatha i-Inbrija. Uma uyeka ukuthatha i-Inbrija, buza udokotela wakho mayelana nokushayela, ukusebenzisa imishini nokuphakamisa izinto ezisindayo. Bangakweluleka ngokuthi ngabe le misebenzi iphephile kuwe ngalesi sikhathi.

Imiphumela yokuhlola elebhu engajwayelekile

I-Inbrija ingadala imiphumela engeyona kokunye ukuhlolwa kwelabhorethri, kufaka phakathi ukuhlolwa kwesibindi. Le miphumela engajwayelekile ingaba uphawu lokulimala kwesibindi. Akwaziwa ukuthi uvame kangakanani lo mphumela wecala.

Uma ucabanga ukuthi imiphumela yokuhlolwa kwelabhorethri ayijwayelekile (ukuthi into iphakeme kakhulu), buza udokotela wakho. Bangabheka imiphumela yakho ukubheka ukuthi kukhona yini okungahambi kahle.

Isicanucanu

Esifundweni somtholampilo, u-5% wabantu abathathe i-Inbrija baba nesicanucanu. Uma kuqhathaniswa, abantu abangu-3% abathathe i-placebo baba nesicanucanu. Kuzona zozimbili lezi zigameko, isicanucanu besingenzima, futhi asibanga nezinkinga ezinkulu.

Khuluma nodokotela wakho uma unesicanucanu izinsuku ezingaphezu kwezintathu. Bangakusiza ukuthi wakhe uhlelo lokudla okunempilo ukusiza ukukhulula isicanucanu. Uma izinguquko ekudleni kwakho zingakusizi, udokotela wakho angakunikeza imithi yokuqeda isicanucanu.

Umchamo onombala omnyama

Ngenkathi uthatha i-Inbrija, ungahle ube nomchamo onombala omnyama. Olunye uketshezi lomzimba olufana nomjuluko, amathe noma i-phlegm kungenzeka lube nombala omnyama futhi. Ngokuvamile, lokhu akulimazi futhi akunayo imiphumela emibi emzimbeni wakho.

Uma uqhubeka nokuba nomchamo onombala omnyama noma olunye uketshezi lomzimba bese uqala ukukhathazeka, khuluma nodokotela wakho. Bangaphakamisa ukuhlolwa kwegazi ukuqinisekisa ukuthi i-Inbrija iphephile kuwe.

Ukucindezeleka (hhayi umphumela ohlangothini)

Ukudangala akuzange kubikwe njengomphumela wecala kunoma yisiphi isifundo somtholampilo se-Inbrija. Kodwa-ke, ukucindezeleka kungaba nomphumela oseceleni wesifo sikaParkinson.

Kulinganiselwa ukuthi cishe abantu abangama-35% abanesifo sikaParkinson bangaba nezimpawu zokucindezeleka. Le phesenti ingahluka ngokuya ngeminyaka yabantu. Imvamisa, abantu abasha abane-Parkinson's banengozi ephezulu yokudangala.

Izimpawu zokucindezeleka kubantu abanesifo sikaParkinson zihlukile kunezabantu abangenalesi simo. Izimpawu zokucindezeleka ezivame kakhulu kubantu abane-Parkinson zifaka:

  • ukudabuka
  • ukukhathazeka ngokweqile
  • ukucasuka
  • i-dysphoria (ukuzizwa ungajabule neze ngempilo)
  • ukungabi nethemba (ukuzizwa sengathi konke kubi noma ukulindela imiphumela emibi kakhulu)
  • imicabango yokuzibulala

Khuluma nodokotela wakho uma ucabanga ukuthi ungahle ucindezeleke. Bangakuxhuma ngezinsizakusebenza nokusekelwa ukukusiza uzizwe ungcono. Uma bekuxilonga ukuthi unokudangala, bangahle bakunikeze izidakamizwa ezizokwelapha.

Ukungasebenzi kahle kwe-Erectile (hhayi umphumela ohlangothini)

Ukungasebenzi kahle kwe-Erectile (ED) akuzange kubikwe njengomphumela wecala kunoma yisiphi isifundo somtholampilo se-Inbrija. Kodwa amadoda anesifo sikaParkinson angaba ne-ED.

Kulinganiselwa ukuthi i-79% yamadoda ane-Parkinson's ane-ED, izinkinga zokujula, noma anenkinga yokuba ne-orgasm. Uma isifo seParkinson sowesilisa sithuthuke kakhulu, singadala i-ED ebucayi kakhulu.

Amadoda anesifo sikaParkinson abuye abe nokukhathazeka, ukudangala, noma ingcindezi kungenzeka ukuthi andise i-ED uma kuqhathaniswa nabanye. Futhi, ukuphuza utshwala nokubhema ugwayi kungenza i-ED ibe nzima kakhulu. Kufanele ugweme ukuphuza noma ukubhema uma une-ED.

Yazisa udokotela wakho uma une-ED engapheli. Bangase bakunikeze izidakamizwa zokwelapha i-ED yakho.

Ukujuluka (hhayi umphumela ohlangothini)

Ukujuluka okweqile akubikwanga njengomphumela oseceleni kunoma yisiphi isifundo somtholampilo se-Inbrija. Kodwa ukujuluka kungaba uphawu lwe-hypotension (umfutho wegazi ophansi). Umfutho wegazi ophansi ungumphumela omubi we-Inbrija.

Umfutho wegazi ophansi othinta ibhalansi yakho nokuma komzimba ubizwa ngokuthi i-orthostatic hypotension. Ukujuluka kuyisifo esivamile salokhu. Ezinye izimpawu ezivamile ze-orthostatic hypotension zifaka:

  • isiyezi
  • isicanucanu
  • ukuquleka

Yazisa udokotela wakho uma uhlangabezana nokujuluka okweqile noma ezinye izimpawu ze-orthostatic hypotension. Bazolinganisa umfutho wegazi lakho ukuze babone ukuthi une-hypotension yini. Uma wenza kanjalo, zingakusiza ukuthi wakhe uhlelo lokudla okunempilo ukwandisa umfutho wegazi lakho. Uma ingakhuphuki ngezinguquko ekudleni kwakho, udokotela wakho angakunikeza imithi yokwandisa umfutho wegazi.

Inbrija isilinganiso

Umthamo we-Inbrija odonswa ngudokotela wakho uzoncika ebukhulwini besimo osisebenzisa ukwelapha i-Inbrija nokuthi umzimba wakho uphendula kanjani kulowo muthi.

Imvamisa, udokotela wakho uzokuqala ngomthamo ophansi. Ngemuva kwalokho bazoyilungisa ngokuhamba kwesikhathi ukufinyelela inani elifanele wena. Udokotela wakho ekugcineni uzonikeza isilinganiso esincane kunazo zonke esihlinzeka ngomphumela oyifunayo.

Imininingwane elandelayo ichaza imithamo esetshenziswa kakhulu noma enconywayo. Kodwa-ke, qiniseka ukuthatha isilinganiso udokotela wakho akubekela sona. Udokotela wakho uzonquma isilinganiso esihle kakhulu ukulingana nezidingo zakho.

Amafomu wezidakamizwa namandla

I-Inbrija iza njenge-capsule oyidonsa usebenzisa i-inhaler. Itholakala kuphela ngamandla owodwa: ama-42 mg nge-capsule ngayinye.

Isilinganiso sesifo sikaParkinson

Umthamo ojwayelekile we-Inbrija ngamaphilisi amabili "ngakunye" kwesikhathi se-Parkinson's disease. Isikhathi sokuphumula yilapho uba nezimpawu zeParkinson's naphezu kokwelashwa kwakho kwe-carbidopa / levodopa.

Akufanele uthathe umthamo ongaphezu kowodwa (amaphilisi amabili) we-Inbrija ngesikhathi ngasinye. Futhi, ungathathi imithamo engaphezu kwamahlanu (amaphilisi ayi-10) ka-Inbrija ngosuku.

Kuthiwani uma ngiphuthelwa umthamo?

I-Inbrija kufanele isetshenziswe kuphela uma unesikhathi sokuphumula. Uma ungenasikhathi sokuphumula, awudingi ukuthatha i-Inbrija. Uma unemibuzo mayelana nokuthi kufanele uyithathe nini i-Inbrija, khuluma nodokotela wakho.

Ngabe kuzodingeka ngisebenzise lesi sidakamizwa isikhathi eside?

I-Inbrija yenzelwe ukuthi isetshenziswe njengokwelashwa okuqhubekayo. Uma wena nodokotela wakho ninquma ukuthi i-Inbrija iphephile futhi iyasebenza kuwe, cishe uzothatha lesi sidakamizwa isikhathi eside.

Inbrija yesifo sikaParkinson

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuvumela imishanguzo kadokotela efana ne-Inbrija ukwelapha izimo ezithile.

I-Inbrija ivunyelwe yi-FDA ukwelapha "izikhathi ezingekho" zesifo sika-Parkinson kubantu abathatha inhlanganisela yezidakamizwa ebizwa nge-carbidopa / levodopa.

Izikhathi zokuphumula zikaParkinson zenzeka lapho imiphumela ye-carbidopa / levodopa iqala ukusebenza noma umuthi ungasebenzi ngendlela efanele. Uma lokhu kwenzeka, ungaba nezimpawu ezinzima zeParkinson's, kufaka phakathi ukunyakaza okungalawulwa. Ngemuva kokuphela kwesikhathi, i-carbidopa / levodopa ingaqala ukukusebenzela kahle futhi.

Ukusebenza ngempumelelo

Esifundweni somtholampilo, u-Inbrija waphumelela ekwelapheni izikhathi zesifo sikaParkinson kubantu abathatha i-carbidopa / levodopa. U-Inbrija wazikhulula izimpawu ezinzima zeParkinson ezazinabantu ngesikhathi ngasinye sokuphumula.Iningi labantu abathatha i-Inbrija linokuphela kwesikhathi sabo sokuphela ngemuva kokuthatha umthamo womuthi.

Kulolu cwaningo, ama-58% abantu abahlangabezana nezimpawu ezingazelelwe zesifo sikaParkinson futhi abathathe u-Inbrija bakwazi ukubuyela esigabeni sabo "esiteji" (bengenazo izimpawu zeParkinson's). Ngokuqhathanisa, ama-36% wabantu abathathe i-placebo (ukwelashwa ngaphandle kwesidakamizwa esisebenzayo) babuyela esikhathini sabo.

Futhi kulolu cwaningo, ukusebenza kwe-Inbrija kukalwe kusetshenziswa isikali semoto se-UPDRS Part III imizuzu engama-30 ngemuva kokuthatha umthamo. Lesi yisikali esikala ukuthi zinzima kangakanani izimpawu zomzimba zomuntu zesifo sikaParkinson. Ukwehla kwamaphuzu kusho ukuthi izimpawu zomuntu azinamandla kakhulu kunakuqala.

Ngemuva kwamasonto awu-12, abantu abathathe i-Inbrija behla nomthamo wemoto ye-UPDRS Part III engu-9.8. Lokhu kuqhathaniswa nokwehla kwamaphuzu ka-5.9 kubantu abathathe i-placebo.

Inbrija notshwala

Akukho ukuxhumana okwaziwayo phakathi kuka-Inbrija notshwala. Kodwa-ke, i-Inbrija notshwala kungadala isizungu nesokozela uma kusetshenziswa bodwa. Futhi, ungaba nenkinga yokugxila futhi usebenzise ukwahlulela okuhle ngakunye kwazo. Ukuphuza utshwala ngenkathi uthatha i-Inbrija kungenza le miphumela ibe mibi kakhulu.

Uma uphuza utshwala, khuluma nodokotela wakho mayelana nokuthi kuphephile yini ukuphuza ngenkathi uthatha i-Inbrija.

Ukusebenzisana kwe-Inbrija

U-Inbrija angaxhumana neminye imithi eminingana. Ingasebenzisana nezithasiselo ezithile.

Ukuxhumana okuhlukile kungadala imiphumela ehlukile. Isibonelo, ukuxhumana okuthile kungaphazamisa ukuthi u-Inbrija usebenza kahle kangakanani. Okunye ukuxhumana kungakhuphula imiphumela yaso emibi noma kubenze babe nzima kakhulu.

Inbrija neminye imithi

Ngezansi kunohlu lwemithi engasebenzisana no-Inbrija. Lolu hlu aluqukethe yonke imishanguzo engasebenzisana no-Inbrija.

Ngaphambi kokuthatha i-Inbrija, khuluma nodokotela wakho nosokhemisi. Batshele ngayo yonke imishanguzo oyinikezwa ngudokotela, i-counter-counter, nezinye izidakamizwa oziphuzayo. Batshele futhi nganoma yimaphi amavithamini, amakhambi, nezithako ozisebenzisayo. Ukwabelana ngalolu lwazi kungakusiza ugweme ukuhlangana okungenzeka.

Uma unemibuzo mayelana nokuhlangana kwezidakamizwa okungakuthinta, buza udokotela wakho noma usokhemisi.

Inbrija nezidakamizwa ezithile zokudangala

I-Monoamine oxidase inhibitors (MAOIs) yizidakamizwa ezisetshenziselwa ukwelapha ukudangala. Abantu abathatha uhlobo oluthile lwale mithi, olubizwa nge-nonselective MAOIs, akufanele bathathe i-Inbrija.Ukuyithatha nge-Inbrija kungadala umfutho wegazi ophezulu, okungaholela ezinkingeni ezinkulu ezifana nesifo senhliziyo.

Uma uthatha i-MAOI engakhethi, udinga ukulinda okungenani amasonto amabili ngemuva komthamo wakho wokugcina ngaphambi kokuqala i-Inbrija.

Ama-MAOI we-Nonselective asetshenziswa kakhulu ekucindezelekeni afaka:

  • isocarboxazid (Marplan)
  • i-phenelzine (Nardil)
  • i-tranylcypromine (iParnate)

Khuluma nodokotela wakho uma uthatha i-MAOI engakhethi. Bangakubeka enye indlela ye-Inbrija noma i-antidepressant engaphepha kuwe.

Uma uthatha olunye uhlobo lwe-MAOI, olubizwa nge-MAO-B-inhibitor, ungathatha i-Inbrija. Kodwa-ke, ukuthatha le mithi ndawonye kungaphakamisa ingozi yokuba ne-hypotension (umfutho wegazi ophansi). Ikakhulu, kungakhuphula amathuba okuba nomfutho wegazi ophansi othinta ukuma kwakho nokulinganisela kwakho. Lokhu kungakwenza ulahlekelwe ibhalansi yakho bese uwa.

Ama-MAO-B-inhibitors asetshenziswa kakhulu ekucindezelekeni afaka:

  • i-rasagiline (Azilect)
  • i-selegiline (Emsam, Zelapar)

Khuluma nodokotela wakho uma uthatha i-MAO-B-inhibitor. Bangakwazi ukuqapha ukucindezelwa kwegazi lakho ukuze babone ukuthi une-hypotension yini. Uma kudingeka, zingakusiza futhi ukuthi wakhe uhlelo lokudla okunempilo noma ukunikeze umuthi wokulawula umfutho wegazi.

Qaphela: Ngemininingwane engaphezulu mayelana nomfutho wegazi ophansi, bona isigaba se- "Inbrija side effects" ngenhla.

Abamelene ne-Inbrija kanye ne-dopamine D2 receptor

Ukuthatha abaphikisi be-dopamine D2 receptor ne-Inbrija kungenza i-Inbrija ingasebenzi kahle. Lokhu kungenxa yokuthi abaphikisi be-D2 receptor ne-Inbrija banemiphumela ehlukile ebuchosheni bakho. Abaphikisi be-D2 receptor banciphisa amazinga e-dopamine ebuchosheni bakho, kuyilapho i-Inbrija ibakhulisa.

Abaphikisi be-D2 receptor basetshenziselwa ukwelapha i-psychosis. Abaphikisi abajwayelekile be-dopamine D2 receptor bafaka:

  • prozlorperazine
  • i-chlorpromazine
  • i-haloperidol (Haldol)
  • i-risperidone (Risperdal)

Omunye umphikisi we-D2, i-metoclopramide (Reglan), isetshenziselwa ukwelapha isifo se-reflux se-gastroesophageal, okuyindlela engapheli ye-acid reflux.

Yazisa udokotela wakho uma uthatha umphikisi we-dopamine D2 receptor. Bangakhuluma nawe ngokuthi ungayithatha yini i-Inbrija noma ngabe omunye umuthi ungaba ngcono kuwe.

Inbrija ne-isoniazid

I-Isoniazid iyi-antibiotic esetshenziselwa ukwelapha isifo sofuba (TB). Ukusebenzisa i-Inbrija kanye ne-isoniazid kungenza i-Inbrija ingasebenzi kahle. Lokhu kungenxa yokuthi lezi zidakamizwa ezimbili zingadala imiphumela ehlukile ebuchosheni bakho. I-Isoniazid inciphisa amazinga e-dopamine ebuchosheni bakho, kuyilapho i-Inbrija iwandisa.

Tshela udokotela wakho ngokushesha uma unikezwe i-isoniazid yokwelapha i-TB ngenkathi uthatha i-Inbrija. Ungakhuluma ngokuthi ngabe elinye i-antibiotic lingakulungela yini. Uma i-isoniazid iyindlela engcono kakhulu, udokotela wakho angakushintsha usuke ku-Inbrija uye emithini ehlukile yokwelapha isifo sika-Parkinson.

Inbrija kanye nosawoti wensimbi noma amavithamini

Ukuthatha i-Inbrija kanye nemithi equkethe usawoti wensimbi noma amavithamini kungenza i-Inbrija ingasebenzi kahle. Lokhu kungenxa yokuthi usawoti wensimbi namavithamini kunganciphisa inani le-Inbrija elifinyelela ebuchosheni bakho.

Yazisa udokotela wakho ngayo yonke imishanguzo oyiphuzayo, kufaka phakathi leyo etafuleni. Ungakhuluma ngokuthi kufanele uyeke yini ukusebenzisa izidakamizwa ezinosawoti bensimbi noma amavithamini ngenkathi uthatha i-Inbrija.

Inbrija namakhambi nezithako

Abanye abantu bathatha isitshalo semithi esibizwa ngokuthi IMucuna pruriens (Mucuna) ukusiza ukukhulula izimpawu zesifo sikaParkinson. IMucuna iza njengephilisi noma impuphu. Kokubili i-Inbrija neMucuna ziqukethe i-levodopa, futhi zombili zandisa inani le-dopamine ebuchosheni bakho.

Ukuba ne-dopamine eningi ebuchosheni bakho kungaba yingozi. Kungadala imiphumela emibi kakhulu, kufaka phakathi umfutho wegazi ophansi, i-psychosis, ne-dyskinesia (bona isigaba se- "Inbrija side effects" ngenhla).

Khuluma nodokotela wakho uma uthatha noma ufuna ukuthatha iMucuna ngenkathi usebenzisa i-Inbrija. Ungaxoxa ukuthi ngabe lokhu kuphephile yini, futhi uma kunjalo, yiluphi isilinganiso seMucuna esinconywayo.

U-Inbrija usebenza kanjani

Isifo sikaParkinson yisifo se-neurodegenerative. Lokhu kusho ukuthi kubangela ukuthi amaseli (abizwa ngokuthi ama-neurons) ebuchosheni bakho nasentanjeni yomgogodla afe. Akukaziwa ukuthi kungani amaseli efa nokuthi kungani amangqamuzana amasha engakhuli endaweni yawo.

Isifo sikaParkinson senza ulahlekelwe amaseli amaningi ezingxenyeni zomzimba wakho ezikhiqiza i-dopamine (into edingekayo ukulawula ukunyakaza). Ngakho-ke kwenziwa i-dopamine encane, enikela ekuthuthukiseni izimpawu zikaParkinson.

Ngokuhamba kwesikhathi, ukulahleka kwamaseli kuthinta ukulawula kwakho ukunyakaza komzimba wakho. Lapho lokhu kulahlekelwa ukulawula kwenzeka, izimpawu ezivame kakhulu zesifo sikaParkinson ngokuvamile ziqala ukuvela (kufaka phakathi ukunyakaza okungalawulwa).

Wenzani u-Inbrija?

I-Inbrija isebenza ikakhulu ngokwandisa inani le-dopamine ebuchosheni bakho.

Inani eliphezulu le-dopamine lisiza amangqamuzana akho asele ukuthi athuthukise ukusebenza kwawo. Lokhu kusiza ukukhulula izimpawu zesifo sikaParkinson futhi kukuvumela ukuthi ulawule kangcono ukunyakaza kwakho.

Kuthatha isikhathi esingakanani ukusebenza?

U-Inbrija uqala ukusebenza kungakapheli nemizuzu emingaki uyithathile. Kubantu abaningi, izimpawu ezinzima zesifo sikaParkinson ziyancipha kungakapheli imizuzu engama-30 kokuthatha i-Inbrija.

I-Inbrija isetshenziselwa kuphela ukwelapha izimpawu ezinzima ngesikhathi "sokuphela kwesikhathi" sesifo sikaParkinson. Izimpawu zakho zingabuya ngemuva kwemiphumela ye-Inbrija. Kulokhu, thatha i-Inbrija futhi njengoba kunconywe udokotela wakho (bheka isigaba “Inbrija dosage” esigabeni ngenhla).

Khuluma nodokotela wakho uma unezikhathi ezingaphezu kwezihlanu zesifo sikaParkinson ngosuku. Ngokubambisana, ninganquma ukuthi umuthi wakho wamanje weParkinson usebenza kahle yini kuwe noma uma kufanele uzame umuthi ohlukile.

Izindleko ze-Inbrija

Njengayo yonke imithi, izindleko ze-Inbrija zingahluka. Ukuthola izintengo zamanje ze-Inbrija endaweni yangakini, hlola i-WellRx.com. Izindleko ozithola ku-WellRx.com yilokho ongakukhokha ngaphandle komshwalense. Intengo yangempela ozoyikhokha incike ohlelweni lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

Kubalulekile ukuqaphela ukuthi i-Inbrija ingatholakala kuphela emakhemisi akhethekile. Lawa ngamakhemisi agunyazwe ukuphatha imishanguzo ekhethekile (izidakamizwa eziyinkimbinkimbi, ezinamanani aphezulu, noma okunzima ukuziphuza).

Usizo lwezezimali nolomshuwalense

Uma udinga ukwesekwa kwezezimali ukukhokhela i-Inbrija, noma uma udinga usizo lokuqonda umshuwalense wakho, usizo luyatholakala.

Abakwa-Acorda Therapeutics Inc., abakhiqizi be-Inbrija, banikela ngohlelo olubizwa ngePrescription Support Services. Lolu hlelo lungakwazi ukusiza ukwehlisa izindleko zemithi yakho. Ukuthola eminye imininingwane nokuthola ukuthi ukulungele yini ukwesekwa, shayela u-888-887-3447 noma uvakashele iwebhusayithi yohlelo.

Inbrija ukweqisa izidakamizwa

Ukusebenzisa okungaphezu kwesilinganiso esinconyiwe se-Inbrija kungaholela emiphumeleni emibi kakhulu.

Izimpawu zokudlula ngokweqile

Izimpawu zokudlula ngokweqile zingabandakanya:

  • izinkinga zenhliziyo, kufaka phakathi i-arrhythmia (isilinganiso esisheshayo noma esingajwayelekile senhliziyo) kanye ne-hypotension (umfutho wegazi ophansi)
  • i-rhabdomyolysis (ukwehla kwemisipha)
  • Izinkinga zezinso
  • i-psychosis (bona isigaba se- "Inbrija side effects" ngenhla)

Okufanele ukwenze uma kwenzeka ukweqisa ngokweqile

Uma ucabanga ukuthi uthathe kakhulu i-Inbrija, shayela udokotela wakho. Ungashayela futhi i-American Association of Poison Control Centers ku-800-222-1222 noma usebenzise ithuluzi labo eliku-inthanethi. Kepha uma izimpawu zakho zinzima, shayela ku-911 noma uye egumbini lezimo eziphuthumayo eliseduze ngokushesha.

Ezinye izindlela ze-Inbrija

Eminye imithi iyatholakala ukwelapha isifo sikaParkinson. Abanye bangakulungela kangcono kuwe kunabanye.

Ezinye izindlela ezijwayelekile ze-Inbrija ezelapha "iziqephu ezingekho" zifaka:

  • i-apomorphine (Apokyn)
  • i-safinamide (Xadago)

Ezinye izindlela ezijwayelekile ze-Inbrija zokwelapha isifo sikaParkinson zifaka:

  • i-carbidopa / levodopa (iSinemet, iDuopa, iRytary)
  • i-pramipexole (i-Mirapex, i-Mirapex ER)
  • i-ropinirole (i-Requip, i-Requip XL)
  • i-rotigotine (Neupro)
  • i-selegiline (iZelapar)
  • i-rasagiline (Azilect)
  • i-entacapone (Comtan)
  • i-benztropine (Cogentin)
  • sdubhabha

Uma unentshisekelo yokuthola enye indlela ye-Inbrija, khuluma nodokotela wakho. Bangakutshela ngeminye imithi engakusebenzela kahle.

Inbrija vs. Apokyn

Ungase uzibuze ukuthi i-Inbrija iqhathanisa kanjani neminye imithi enikezwe ukusetshenziswa okufanayo. Lapha sibheka ukuthi u-Inbrija no-Apokyn bafana futhi bahlukile kanjani.

Isebenzisa

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kugunyaze bobabili i-Inbrija ne-Apokyn ukuthi belaphe abantu "ngezikhathi ezingekho" zesifo sikaParkinson. Izikhathi zokuvala zenzeka lapho abantu abathatha imithi yeParkinson ngokuzumayo baba nezimpawu ezinzima zikaParkinson's.

Abantu kuphela abathatha i-carbidopa / levodopa ukwelapha iParkinson’s okufanele bathathe i-Inbrija. Isetshenziselwa ukwelapha noma yiluphi uphawu lweParkinson's.

I-Apokyn ingasetshenziswa kubantu abathatha noma yikuphi ukwelashwa kwe-Parkinson. Isetshenziselwa ukwelapha ukunyakaza komzimba okunciphile ngezikhathi zeParkinson's.

Inbrija iqukethe i-levodopa yezidakamizwa. I-Apokyn iqukethe i-apomorphine yezidakamizwa.

U-Inbrija no-Apokyn bobabili bakhulisa umsebenzi we-dopamine ebuchosheni bakho. Lokhu kusho ukuthi banemiphumela efanayo emzimbeni wakho.

Amafomu wezidakamizwa nokuphathwa

I-Inbrija iza njengephilisi eline-powder oyidonsa. Itholakala ngamandla owodwa: 42 mg. Umthamo ojwayelekile we-Inbrija ungama-84 mg (amaphilisi amabili) esikhathini ngasinye sesifo sikaParkinson.

Uthatha i-Apokyn ngokuyijova ngaphansi kwesikhumba sakho (umjovo ongena ngaphansi kwesikhumba). I-Apokyn itholakala ngamandla owodwa: 30 mg. Umthamo onconyiwe ngu-2 mg kuya ku-6 mg ngesikhathi ngasinye se-Parkinson.

Imiphumela emibi kanye nezingozi

U-Inbrija no-Apokyn banemiphumela efanayo efanayo kanti eminye yehlukile. Ngezansi kunezibonelo zale miphumela emibi.

Imiphumela emibi ejwayelekile

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi ejwayelekile engenzeka nge-Inbrija, ne-Apokyn, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

  • Kungenzeka nge-Inbrija:
    • ukukhwehlela
    • ukutheleleka okuphezulu kokuphefumula, njengomkhuhlane ovamile
    • uketshezi lomzimba olunombala omnyama njengomchamo noma umjuluko
  • Kungenzeka nge-Apokyn:
    • ukuzamula ngokweqile
    • ukozela
    • isiyezi
    • ikhala eligijimayo
    • ukuhlanza okuhlala isikhathi eside
    • ukusangana (ukubona noma ukuzwa okuthile okungekho lapho)
    • ukudideka
    • ukuvuvukala emilenzeni yakho, emaqakaleni, ezinyaweni, ezandleni, noma kwezinye izitho zomzimba wakho
    • ukuphendula kwesiza somjovo, njengokulimala, ukuvuvukala, noma ukulunywa
  • Kungenzeka ngamabili i-Inbrija ne-Apokyn:
    • isicanucanu esihlala isikhathi eside

Imiphumela emibi kakhulu

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi engaba khona ne-Inbrija, ne-Apokyn, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

  • Kungenzeka nge-Inbrija:
    • imiphumela engajwayelekile kusuka ekuhlolweni kwelabhoratri, kufaka phakathi ukuhlolwa kwesibindi (kungaba uphawu lokulimala kwesibindi)
  • Kungenzeka nge-Apokyn:
    • ukusabela okweqile
    • amahlule egazi
    • ukuwa
    • izinkinga zenhliziyo, kufaka phakathi isifo senhliziyo
    • isigqi senhliziyo esingajwayelekile
    • izinkinga ze-fibrotic (izinguquko ezicutshini zakho)
    • i-priapism (ukuvinjelwa okude, okubuhlungu)
  • Kungenzeka ngamabili i-Inbrija ne-Apokyn:
    • i-psychosis
    • ukunxusa okungavamile
    • i-dyskinesia (ukunyakaza komzimba okungalawulwa nokungazelelwe)
    • ukulala ngesikhathi semisebenzi ejwayelekile
    • ukuhoxiswa kwesifo, okunezimpawu ezifana nomkhuhlane noma isigqi senhliziyo esingajwayelekile
    • i-hypotension (umfutho wegazi ophansi)

Ukusebenza ngempumelelo

Le mithi ayikaze iqhathaniswe ngqo ezifundweni zokwelashwa. Kodwa-ke, ucwaningo luthole ukuthi i-Inbrija ne-Apokyn ziyasebenza ekwelapheni izikhathi zesifo sika-Parkinson.

Izindleko

U-Inbrija no-Apokyn bobabili yizidakamizwa ezinamagama. Okwamanje azikho izinhlobo ezijwayelekile zomuthi. Imithi enegama lomkhiqizo ivame ukubiza ngaphezu kwama-generic.

Ngokusho kwe-WellRx, i-Inbrija ne-Apokyn ngokuvamile kubiza ngokufana. Inani ozolikhokhela i-Inbrija noma i-Apokyn lizoya ngohlelo lwakho lomshuwalense, indawo okuyo, kanye nekhemisi oyisebenzisayo.

Kubalulekile ukuqaphela ukuthi i-Inbrija ne-Apokyn zingatholakala kuphela emakhemisi akhethekile. Lawa ngamakhemisi agunyazwe ukuphatha imishanguzo ekhethekile (izidakamizwa eziyinkimbinkimbi, ezinamanani aphezulu, noma okunzima ukuziphuza).

Ungamthatha kanjani u-Inbrija

I-Inbrija iza njengephilisi eline-powder oyidonsa. Thatha i-Inbrija ngokwemiyalelo kadokotela wakho noma wemithi. Iwebhusayithi ka-Inbrija inevidiyo yokubonisa kanye nemiyalo yesinyathelo ngesinyathelo ukukusiza uthathe i-Inbrija kahle.

Kufanele uthathe i-Inbrija kuphela ngokuyihogela. Kubalulekile ukuthi ungavuli noma ugwinye noma iyiphi i-Inbrija capsule. Ama-capsules kufanele afakwe kuphela kudivayisi ye-Inbrija inhaler. Idivayisi izosebenzisa i-powder ngaphakathi kwamaphilisi ukukuvumela ukuthi uhogele umuthi.

Ungasebenzisi amaphilisi we-Inbrija kunoma iyiphi idivayisi ye-inhaler ngaphandle kwe-Inbrija inhaler.Futhi, musa ukuhogela noma imuphi omunye umuthi ngokusebenzisa i-Inbrija inhaler yakho.

Buza udokotela noma usokhemisi wakho uma unezinkinga ngokuthatha i-Inbrija. Bazokuhamba kuzo zonke izinyathelo ukuze baqiniseke ukuthi uhamba ngendlela efanele.

Ukuthatha nini

Kufanele uthathe i-Inbrija ekuqaleni kwesikhathi esingaphandle kwesifo sikaParkinson. Kodwa-ke, ungathathi imithamo engaphezu kwamahlanu (amaphilisi ayi-10) ka-Inbrija ngosuku olulodwa. Uma usenesikhathi sokuphumula ngemuva kokuthatha imithamo emihlanu ye-Inbrija ngosuku, shayela udokotela wakho. Ungaxoxa ngokuthi ngabe udinga imithi ehlukile yansuku zonke yokwelapha isifo sikaParkinson ngakho-ke akudingeki usebenzise i-Inbrija kaningi.

Ungayeki ukuthatha eminye imithi yakho yansuku zonke ukwelapha iParkinson's ngesikhathi noma ngemuva kokuthatha i-Inbrija.

Inbrija nokukhulelwa

Azikho izifundo zokwelashwa ze-Inbrija kwabesifazane abakhulelwe. Ezifundweni zezilwane, u-Inbrija ube nemiphumela emibi ezinganeni zezilwane. Izingane zazalwa zinokukhubazeka kokuzalwa, kufaka phakathi izinkinga ezithweni nasemathanjeni azo. Kodwa-ke, izifundo zezilwane azikhombisi njalo ukuthi kwenzekani kubantu.

Khuluma nodokotela wakho uma ukhulelwe noma uhlela ukukhulelwa ngenkathi uthatha i-Inbrija. Ungaxoxa ngobungozi nezinzuzo zokuthatha i-Inbrija.

Inbrija nokulawulwa kokuzalwa

Akwaziwa ukuthi i-Inbrija iphephile ukusetshenziswa ngesikhathi sokukhulelwa. Uma wenza ucansi futhi wena noma umlingani wakho ningakhulelwa, khuluma nodokotela wakho ngezidingo zakho zokulawula ukubeletha ngenkathi usebenzisa i-Inbrija.

Inbrija nokuncelisa

Azikho izifundo zokwelashwa ezibheka imiphumela ye-Inbrija ngesikhathi sokuncelisa. Kepha ukuhlolwa kwelabhoratri kukhombisa ukuthi u-Inbrija udlulela obisini lwebele lomuntu. Futhi, ucwaningo lukhombisa ukuthi i-Inbrija ingadala ukuthi umzimba wakho ukhiqize ubisi oluncane. Akwaziwa ukuthi ngabe lezi zinkinga zingaba yingozi kuwe noma enganeni yakho.

Tshela udokotela wakho uma uncelisa noma uhlela ukuncelisa ngenkathi uthatha i-Inbrija. Ungakhuluma ngokuthi ngabe kuphephile yini ukuthatha i-Inbrija ngenkathi uncelisa.

Imibuzo ejwayelekile mayelana no-Inbrija

Nazi izimpendulo zemibuzo ebuzwa njalo mayelana no-Inbrija.

Kusho ukuthini ukuba nesikhathi sokuphela kwesifo sikaParkinson?

Izikhathi ezingasebenzi zesifo sikaParkinson yizikhathi lapho imithi yakho yansuku zonke yokwelapha isifo sikaParkinson igqoke noma ingasebenzi ngendlela efanele. Uma lokhu kwenzeka, izimpawu zakho zeParkinson zibuyela ngokuzumayo.

Abantu abanesifo sikaParkinson bathatha imishanguzo yokwandisa inani le-dopamine ebuchosheni babo. I-Dopamine yinto edingekayo ukulawula ukunyakaza komzimba wakho. Ngaphandle kwe-dopamine, umzimba wakho awukwazi ukuhamba kahle. Lokhu kudala ukuthi izimpawu zeParkinson’s zivele.

Imithi yokwengeza inani le-dopamine ebuchosheni bakho ivame ukusebenza kahle ngesikhathi eside. Kepha kwesinye isikhathi bayayeka ukusebenza isikhashana. Ngalesi sikhathi ezingasebenzi, ungaba nezimpawu zikaParkinson. Lezi zikhathi lapho umuthi wakho ungasebenzi zibizwa ngokuthi yizikhathi zeParkinson's.

Ngabe ngizokwazi yini ukuthola u-Inbrija ekhemisi lasekhaya?

Cishe cha. Ungakwazi kuphela ukuthola i-Inbrija ezikhemisi ezikhethekile, ezigunyaziwe ukuphatha imishanguzo ekhethekile. Le yimithi eyinkimbinkimbi, enamanani aphezulu, noma okunzima ukuyiphuza.

Buza udokotela wakho uma ungaqiniseki ukuthi ungayithathaphi i-Inbrija. Bangancoma ikhemisi elikhethekile elisendaweni yakho eliyithwalayo.

Ngabe u-Inbrija uzothatha indawo yomthamo wami ojwayelekile we-carbidopa / levodopa?

Cha, ngeke. I-Inbrija isetshenziselwa kuphela ukwelapha izikhathi zesifo sika-Parkinson. Akufanele ithathwe nsuku zonke ukufaka esikhundleni sokusebenzisa kwakho i-carbidopa / levodopa.

Khuluma nodokotela wakho uma unenkinga ngokuthatha kokubili i-carbidopa / levodopa ne-Inbrija. Udokotela wakho angachaza ukubaluleka kwakho kokubili ukwelashwa ukulawula ngokuphelele izimpawu zakho zesifo sikaParkinson.

Ngabe kufanele ngilandele indlela ethile yokudla ngenkathi ngisebenzisa i-Inbrija?

Kungenzeka ukuthi udokotela wakho angakutusa ukuthi ulandele ukudla okuthile ngenkathi uthatha i-Inbrija.

Ukudla okunothe ngamaprotheni noma amavithamini kungenza i-Inbrija ingasebenzi kahle uma idliwa ngasikhathi sinye nomuthi. Lokhu kungenxa yokuthi amaprotheni namavithamini anganciphisa inani le-Inbrija elifinyelela ebuchosheni bakho. U-Inbrija udinga ukufinyelela ebuchosheni bakho ukuze asebenze emzimbeni wakho.

Udokotela wakho angase asikisele izinguquko lapho uthatha umthamo wakho we-Inbrija ukugwema ukuwuthatha ngasikhathi sinye lapho udla ukudla okunothe ngamavithamini noma amaprotheni.

Khuluma nodokotela wakho uma unemibuzo mayelana nokuthi yini okufanele uyidle. Unganikezwa uhlelo lokudla okufanele ululandele ngenkathi uthatha i-Inbrija.

Ngingakwazi ukugwinya i-Inbrija capsule?

Cha, awukwazi. Ukugwinya i-Inbrija capsule kungenza kungasebenzi kahle. Lokhu kungenxa yokuthi u-Inbrija omncane uzokwazi ukufinyelela ebuchosheni bakho.

Ama-Inbrija capsules kufanele afakwe ku-Inbrija inhaler device eza namaphilisi. Kule divayisi, ama-capsule akhipha i-powder oyidonsela ngaphakathi.

Buza udokotela wakho noma usokhemisi uma unemibuzo ngokuthatha i-Inbrija. Bangachaza ukuthi ungayisebenzisa kanjani i-inhaler device ukuze uqiniseke ukuthi uthatha i-Inbrija kahle. Ungavakashela iwebhusayithi ka-Inbrija ukubona ividiyo yokubonisa futhi uthole imiyalelo yesinyathelo ngesinyathelo yokuthatha i-Inbrija kahle.

Ngizoba nezimpawu zokuhoxa uma ngiyeka ngokungazelelwe ukuthatha i-Inbrija?

Mhlawumbe. Ungaba nezimpawu zokuhoxa uma wehlisa ngokungazelelwe umthamo wakho we-Inbrija noma uyeke ukuwuthatha. Lokhu kungenxa yokuthi umzimba wakho ujwayela i-Inbrija. Uma uyeka ngokungazelelwe ukuthatha, umzimba wakho awunaso isikhathi sokuzivumelanisa kahle nokungabi nawo.

Izimpawu zokuhoxa ongazithola nge-Inbrija zifaka:

  • umkhuhlane ophakeme kakhulu noma ohlala isikhathi eside
  • ukudideka
  • imisipha eqinile
  • izigqi zenhliziyo ezingavamile (izinguquko ekushayeni kwenhliziyo)
  • izinguquko ekuphefumuleni

Tshela udokotela wakho uma uzwa izimpawu zokuhoxa ngemuva kokwehlisa umthamo wakho we-Inbrija noma uyeke ukuwuthatha. Bangakunikeza imithi yokusiza ngezimpawu zakho.

Ngingayithatha yini i-Inbrija uma ngine-chronic obstructive pulmonary disease (COPD) noma i-asthma?

Cishe cha. I-Inbrija ingadala izinkinga ngokuphefumula kwakho futhi ingenza izimpawu zezifo zamaphaphu ezingapheli (zesikhathi eside) zibe nzima kakhulu. Ngakho-ke, i-Inbrija ayinconywa kubantu abane-asthma, i-COPD, noma ezinye izifo zamaphaphu ezingapheli.

Khuluma nodokotela wakho uma unesifo esingalapheki samaphaphu. Bangakusiza ukuthi uthole umuthi ongakulungela kangcono.

Inbrija izinyathelo zokuqapha

Ngaphambi kokuthatha u-Inbrija, khuluma nodokotela wakho ngomlando wakho wezempilo. I-Inbrija kungenzeka ingakulungeli uma unezimo ezithile zezokwelapha. Lokhu kufaka phakathi:

  • Ingqondo. I-Inbrija ingadala izimpawu zengqondo, ezenzeka lapho kushintsha umqondo wakho weqiniso. Ungahle ubone, uzwe, noma uzizwe izinto ezingezona ezangempela. Ngaphambi kokuthatha i-Inbrija, tshela udokotela wakho uma uke waba nezimpawu zengqondo ngaphambili. Uma kunjalo, ukuthatha i-Inbrija kungenzeka kungakulungeli.
  • Ukuphazamiseka kokulawula umfutho. I-Inbrija ingathinta izingxenye zobuchopho bakho ezilawula lokho ofuna ukukwenza. Kungakwenza uzimisele ngokwengeziwe ukwenza izinto ngokuvamile ongazenzi, njengokugembula nokuthenga. Ukuphazamiseka kokulawula umfutho kuthinta futhi lokho abantu abafuna ukukwenza nokuthi bafuna ukukwenza nini. Ngakho-ke ukuthatha i-Inbrija kungakhuphula lezi zinkanuko ezingavamile uma unomlando wokuphazamiseka kokulawula umfutho.
  • I-Dyskinesia. Uma uke waba ne-dyskinesia (ukunyakaza okungalawuleki noma okungazelelwe komzimba) esikhathini esedlule, i-Inbrija ingahle ingaphephile kuwe. Ukuthatha i-Inbrija kungakhuphula ubungozi bokuthola i-dyskinesia uma uke waba nalesi simo phambilini.
  • I-Glaucoma. Uma une-glaucoma (isifo samehlo esithinta ukubona kwakho), i-Inbrija kungenzeka ingaphephi kuwe. Lokhu kungenxa yokuthi i-Inbrija ingadala ingcindezi ye-intraocular (ukwanda kwengcindezi emehlweni), okungayenza ibe mbi i-glaucoma yakho. Uma une-glaucoma, udokotela wakho uzoqapha ukucindezela kwamehlo akho ngenkathi uthatha i-Inbrija ukubona ukuthi ingcindezi iyanda yini. Uma ukucindezela kwamehlo akho kuphakeme, udokotela wakho angakuyekisa ukuthatha i-Inbrija bese uzama umuthi ohlukile.
  • Izifo ezingalapheki (zesikhathi eside) zamaphaphu. I-Inbrija ayinconywa kubantu abane-asthma, isifo esingapheliyo se-pulmonary disease (COPD), noma ezinye izifo ezingapheli zamaphaphu. I-Inbrija ingadala izinkinga ngokuphefumula kwakho futhi ingenza izimpawu zalezi zifo zamaphaphu zibe zimbi kakhulu.

Qaphela: Ukuthola eminye imininingwane ngemiphumela engemihle engaba khona ye-Inbrija, bheka isigaba "Inbrija side effects" ngenhla.

Ukuphelelwa yisikhathi kwe-Inbrija, ukugcina nokulahla

Uma uthola i-Inbrija ekhemisi, usokhemisi uzokwengeza usuku lokuphelelwa yisikhathi kwilebuli esephakeji. Lolu suku luvame unyaka owodwa kusukela ngosuku abakhipha ngalo umuthi.

Usuku lokuphelelwa isikhathi lusiza ukuqinisekisa ukuthi i-Inbrija izosebenza ngalesi sikhathi. Isimo samanje se-Food and Drug Administration (i-FDA) ukugwema ukusebenzisa imishanguzo ephelelwe yisikhathi. Uma usebenzise umuthi ongasetshenziswanga osedlule usuku lokuphelelwa yisikhathi, khuluma nosokhemisi wakho mayelana nokuthi usengakwazi yini ukuwusebenzisa.

Isitoreji

Ukuthi umuthi uhlala ulungile ukusebenzisa isikhathi esingakanani kungancika ezintweni eziningi, kufaka phakathi ukuthi uwugcina kanjani futhi kuphi umuthi.

Ama-Inbrija capsules kufanele agcinwe ekamelweni lokushisa (68 kuya ku-77 ° F noma okungu-20 kuye ku-25 ° C) esitsheni esivalwe ngokuqinile futhi esingamelana nokukhanya. Ungakhuphula ibanga lokushisa libe ngu-59 liye ku-86 ° F (15 kuye ku-30 ​​° C) uma usohambweni.

Ama-capsules we-Inbrija akufanele agcinwe ku-Inbrija inhaler. Lokhu kunganciphisa isikhathi lapho ama-capsules ahlala kahle. Amaphilisi angalungile angaba yingozi kuwe.

Phonsa idivayisi ye-inhaler ngemuva kokusebenzisa wonke amaphilisi ngaphakathi kwebhokisi. Uzothola i-inhaler entsha njalo uma uthola ukugcwaliswa komuthi we-Inbrija wakho.

Ukulahlwa

Uma ungasadingi ukuthatha i-Inbrija futhi unemithi esele, kubalulekile ukuyilahla ngokuphepha. Lokhu kusiza ukuvimbela abanye, kufaka phakathi izingane nezilwane ezifuywayo, ekuthatheni lesi sidakamizwa ngengozi. Kuyasiza futhi ukugcina umuthi ungalimazi imvelo.

Iwebhusayithi ye-FDA inikeza amathiphu amaningi awusizo ngokulahlwa kwemithi. Ungabuza futhi usokhemisi wakho imininingwane yokuthi ungayilahla kanjani imithi yakho.

Imininingwane yezobuchwepheshe ye-Inbrija

Imininingwane elandelayo inikezwa odokotela nabanye ochwepheshe bezempilo.

Izinkomba

U-Inbrija ukhonjiswa ukwelapha "izikhathi ezingekho" zesifo sikaParkinson. Inkomba yayo ikhawulelwe ezigulini ezelashwa nge-carbidopa / levodopa.

Indlela yokusebenza

Indlela yokusebenza u-Inbrija anciphisa ngayo izimpawu zezikhathi zesifo sikaParkinson ayaziwa.

I-Inbrija iqukethe i-levodopa, okuyisandulela se-dopamine. ILevodopa yeqa isithiyo segazi nobuchopho. Ebuchosheni, i-levodopa iguqulwa ibe yi-dopamine. I-Dopamine efinyelela ku-basal ganglia kucatshangwa ukuthi inciphisa izimpawu zeziqephu zesifo sika-Parkinson.

I-Pharmacokinetics ne-metabolism

Lapho kukhona i-carbidopa, ukuphathwa okukodwa kwe-Inbrija 84 mg kufinyelela ekugxileni okuphezulu kungakapheli imizuzu engama-30 ngemuva kokuphathwa. Ukuhlungwa kwayo okujwayelekile okwenziwe ngomthamo cishe kungama-50% wamathebulethi womlomo akhishwa ngokushesha we-levodopa.

Ukutholakala kwe-Inbrija cishe kungama-70% wamathebulethi womlomo akhishwa ngokushesha we-levodopa. Kanye ohlelweni, i-Inbrija 84 mg ifinyelela ivolumu yokusatshalaliswa kwe-168 L.

Iningi le-Inbrija libhekana ne-enzymatic metabolism. Imizila emikhulu ye-metabolic ifaka phakathi i-decarboxylation nge-dopa decarboxylase ne-O-methylation nge-catechol-O-methyltransferase. Lapho kukhona i-carbidopa, ukuphathwa okukodwa kwe-Inbrija 84 mg kune-half-life terminal yamahora we-2.3.

Akukho ukwehluka okubikiwe ekugxileni okuphezulu (i-Cmax) nendawo engaphansi kwejika (AUC) phakathi kwabesilisa nabesifazane abathatha i-Inbrija. Akukho mehluko obonwe phakathi kwabantu ababhemayo nalabo abangabhemi.

Izimo

Ukusetshenziswa kwe-Inbrija kuyaphikiswa ezigulini ezithatha i-nonselective monoamine oxidase inhibitors (MAOIs). Kuphikisiwe futhi ezigulini ezithathe ama-MAOI angakhethi phakathi kwamasonto amabili.

Inhlanganisela yama-Inbrija nama-MAOIs angakhethi angadala umfutho wegazi ophezulu. Uma isiguli siqala ukuthatha i-MAOI engakhethi, ukwelashwa nge-Inbrija kufanele kuyekwe.

Isitoreji

Ama-Inbrija capsules kufanele aqhubeke ephaketheni lawo langempela. Iphakethe nesiqukathi kufanele kugcinwe ku-68 kuye ku-77 ° F (20 kuye ku-25 ° C). Lokhu kushisa kungakhuphukela ku-59 kuye ku-86 ° F (15 kuye ku-30 ​​° C) lapho usohambweni.

Ukugcina amaphilisi we-Inbrija ku-Inbrija inhaler device kungashintsha ukuzinza kwesidakamizwa. Iziguli kufanele zixwayiswe ngokugcina amaphilisi ezitsheni zawo zangempela.

Ukuzikhulula: IMedical News Namuhla yenze yonke imizamo yokuqinisekisa ukuthi yonke imininingwane iyiqiniso, iphelele futhi ihambisana nesikhathi. Kodwa-ke, le ndatshana akufanele isetshenziswe njengokungena esikhundleni solwazi nobungoti bochwepheshe bezokunakekelwa kwezempilo onelayisense. Kufanele uhlale uthintana nodokotela wakho noma omunye uchwepheshe wezokunakekelwa kwempilo ngaphambi kokuthatha noma imuphi umuthi. Imininingwane yezidakamizwa equkethwe lapha ingashintsha futhi ayihloselwe ukumboza konke ukusetshenziswa okungaba khona, izinkomba, izixwayiso, izexwayiso, ukuxhumana kwezidakamizwa, ukungezwani komzimba, noma imiphumela emibi. Ukungabikho kwezixwayiso noma olunye ulwazi lomuthi othile awukhombisi ukuthi inhlanganisela yezidakamizwa noma yezidakamizwa iphephile, iyasebenza, noma ilungele zonke iziguli noma konke ukusetshenziswa okuthile.

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