Izinzuzo ezi-9 eziphezulu ze-NAC (N-Acetyl Cysteine)

-Delile

• 1. Kubalulekile Ekwenzeni I-Antioxidant Glutathione Enamandla
• 2. Isiza Nge-Detoxification Ukuvimbela noma Ukunciphisa Ukulimala Kwezinso Nesibindi
• 3. Kwangathi Kungathuthukisa Ukuphazamiseka Kwengqondo Nokuziphatha Okuluthayo
• 4. Isiza Ukuqeda Izimpawu Zezimo Zokuphefumula
• 5. Kukhulisa Impilo YeBongo Ngokulawula i-Glutamate nokugcwalisa iGlutathione
• 6. Kwangathi Kungathuthukisa Ukuzala Kokubili Abesilisa Nabesifazane
• 7. Kwangathi Kungazinziswa Ushukela Wegazi Ngokunciphisa Ukuvuvukala Emaseleni Amafutha
• 8. Kwangathi Kunganciphisa Ubungozi Bezifo Zenhliziyo Ngokuvimbela Ukulimala Kwe-Oxidative
• 9. Amandla Okukhulisa Amazinga E-Glutathione Angathuthukisa Umsebenzi We-immune
• Isikali
• Okuqhamuka uma udla imishanguzo
• Okusemqoka

ICysteine ​​iyi-amino acid ebalulekile.

Kuthathwa njengokusemqoka ngoba umzimba wakho ungawukhiqiza kusuka kwamanye ama-amino acid, okuyi-methionine ne-serine. Kuba kubalulekile kuphela lapho ukudla okudliwayo kwe-methionine ne-serine kuphansi.

ICysteine ​​itholakala kokudla okunamaprotheni amaningi, njengenkukhu, ikalikuni, iyogathi, ushizi, amaqanda, imbewu ye-sunflower nemidumba.

I-N-acetyl cysteine ​​(NAC) iyindlela yokwengeza ye-cysteine.

Ukusebenzisa i-cysteine ​​eyanele ne-NAC kubalulekile ngezizathu ezahlukahlukene zezempilo - kufaka phakathi ukugcwalisa i-antioxidant enamandla kakhulu emzimbeni wakho, i-glutathione. La ma-amino acid futhi asiza ngezimo zokuphefumula ezingapheli, ukuzala kanye nempilo yobuchopho.

Nazi izinzuzo eziyisishiyagalolunye zezempilo ze-NAC.

1. Kubalulekile Ekwenzeni I-Antioxidant Glutathione Enamandla

I-NAC ihlonishwa ngokuyinhloko ngendima yayo ekukhiqizeni i-antioxidant.

Kanye namanye ama-amino acid amabili - i-glutamine ne-glycine - i-NAC iyadingeka ukwenza futhi igcwalise i-glutathione.

I-Glutathione ingenye ye-antioxidants ebaluleke kakhulu yomzimba, esiza ukunciphisa ama-radicals wamahhala angalimaza amaseli nezicubu emzimbeni wakho.

Kubalulekile empilweni yomzimba nokulwa nokulimala kwamaselula. Abanye abacwaningi bakholelwa ukuthi kungahle kube nomthelela empilweni ende ().

Izakhiwo zayo zokulwa ne-antioxidant zibalulekile ekulweni nezinye izifo eziningi ezibangelwa yingcindezi ye-oxidative, njengesifo senhliziyo, ukungabi nenzalo nezinye izimo zengqondo ().

Isifinyezo I-NAC isiza ukugcwalisa i-glutathione, ngokungangabazeki i-antioxidant yomzimba wakho enamandla kakhulu. Ngakho-ke, ingathuthukisa izimo ezahlukahlukene zezempilo.

2. Isiza Nge-Detoxification Ukuvimbela noma Ukunciphisa Ukulimala Kwezinso Nesibindi

I-NAC ibamba iqhaza elibalulekile kunqubo yokukhipha umzimba emzimbeni.

Kungasiza ukuvimbela imiphumela emibi yezidakamizwa nobuthi bezemvelo ().

Eqinisweni, odokotela bahlala benikeza ngemithambo yegazi (IV) NAC kubantu abane-acetaminophen overdose ukuvimbela noma ukunciphisa ukulimala kwezinso nesibindi ().

I-NAC nayo inezicelo zezinye izifo zesibindi ngenxa yezinzuzo zayo zokulwa nokuvuvukala ().

Isifinyezo I-NAC isiza ukukhipha umzimba emzimbeni futhi ingaphatha ukweqisa ngokweqile kwe-acetaminophen.

3. Kwangathi Kungathuthukisa Ukuphazamiseka Kwengqondo Nokuziphatha Okuluthayo

I-NAC isiza ukulawula amazinga e-glutamate - i-neurotransmitter ebaluleke kakhulu ebuchosheni bakho ().

Ngenkathi i-glutamate idingeka esenzweni esijwayelekile sobuchopho, i-glutamate ngokweqile ebhangqwe nokuncipha kwe-glutathione kungadala ukulimala kobuchopho.

Lokhu kungaba nomthelela ezimeni zempilo yengqondo, njenge-bipolar disorder, schizophrenia, i-obsessive-compulsive disorder (OCD) nokuziphatha okuluthayo (7,).

Kubantu abanesifo se-bipolar kanye nokudangala, i-NAC ingasiza ukwehlisa izimpawu futhi ithuthukise ikhono lakho jikelele lokusebenza. Ngaphezu kwalokho, ucwaningo lukhombisa ukuthi lungadlala indima ekwelapheni i-OCD elinganiselayo nelinzima (,).

Ngokufanayo, isifundo sezilwane sisho ukuthi i-NAC ingahle inciphise imiphumela emibi ye-schizophrenia, njengokuhoxa komphakathi, ukunganaki nokunciphisa isikhathi sokunaka ().

Izengezo ze-NAC zingasiza futhi ekunciphiseni izimpawu zokuhoxa futhi zivimbele ukubuyela kumilutha ye-cocaine (,).

Ngokwengeziwe, izifundo zokuqala zikhombisa ukuthi i-NAC ingahle inciphise ukusetshenziswa kwensangu kanye ne-nicotine kanye nezifiso (, 15).

Eziningi zalezi zinkinga zinezinketho zokwelashwa ezinomkhawulo noma okwamanje ezingasebenzi. I-NAC ingaba usizo olusebenzayo kubantu abanale mibandela ().

Isifinyezo Ngokulawula amazinga e-glutamate ebuchosheni bakho, i-NAC inganciphisa izimpawu zezifo eziningi zengqondo futhi yehlise nokuziphatha okuluthayo.

4. Isiza Ukuqeda Izimpawu Zezimo Zokuphefumula

I-NAC inganciphisa izimpawu zezimo zokuphefumula ngokusebenza njenge-antioxidant ne-expectorant, ikhulule amafinyila ezindleleni zakho zomoya.

Njenge-antioxidant, i-NAC isiza ukugcwalisa amazinga e-glutathione emaphashini akho futhi inciphise ukuvuvukala kumashubhu akho we-bronchial kanye nezicubu zamaphaphu.

Abantu abanesifo esingamahlalakhona sokuphazamiseka kwamaphaphu (COPD) babhekana nomonakalo wesikhathi eside we-oxidative nokuvuvukala kwezicubu zamaphaphu, okwenza ukuthi imigwaqo yomoya icindezeleke - okuholela ekuphefumuleni nasekukhohleleni.

Izithasiselo ze-NAC zisetshenziselwe ukuthuthukisa izimpawu ze-COPD, ukukhuphuka kanye nokwehla kwamaphaphu (,, 19).

Esifundweni sonyaka owodwa, ama-600 mg we-NAC kabili ngosuku athuthukise kakhulu ukusebenza kwamaphaphu nezimpawu kulabo abane-COPD ezinzile ().

Labo abane-bronchitis engapheli nabo bangazuza kwi-NAC.

I-bronchitis yenzeka lapho ulwelwesi lwamafinyila emigwaqeni yamaphaphu yakho luvuvukala, luvuvukale luvale imigwaqo yomoya emaphashini akho (,).

Ngokuncipha amafinyila kumashubhu akho we-bronchial nokukhulisa amazinga e-glutathione, i-NAC ingasiza ekunciphiseni ubunzima nokuvama kokushaywa ngumoya, ukukhwehlela nokuhlaselwa ukuphefumula (23).

Ngaphezu kokudambisa i-COPD ne-bronchitis, i-NAC ingathuthukisa ezinye izimo zamaphaphu nezokuphefumula njenge-cystic fibrosis, isifuba somoya kanye ne-pulmonary fibrosis, kanye nezimpawu zokucinana kwamakhala kanye ne-sinus ngenxa yokungezwani komzimba noma izifo ().

Isifinyezo Amandla we-NAC's antioxidant ne-expectorant angathuthukisa ukusebenza kwamaphaphu ngokunciphisa ukuvuvukala kanye nokuqhekeza amafinyila.

5. Kukhulisa Impilo YeBongo Ngokulawula i-Glutamate nokugcwalisa iGlutathione

Ikhono le-NAC lokugcwalisa i-glutathione nokulawula amazinga e-glutamate yobuchopho kungakhulisa impilo yobuchopho.

I-neurotransmitter glutamate yobuchopho ibandakanyeka ebangeni elibanzi lokufunda, ukusebenza kanye nezenzo zememori, ngenkathi i-antioxidant glutathione isiza ukunciphisa ukulimala kwe-oxidative kumaseli obuchopho ahlobene nokuguga ().

Ngoba i-NAC isiza ukulawula amazinga e-glutamate futhi igcwalise i-glutathione, ingazuzisa labo abanezifo zobuchopho nezinkumbulo ().

Isifo semizwa Isifo se-Alzheimer sibambezela amandla omuntu okufunda nokukhumbula. Izifundo zezilwane ziphakamisa ukuthi i-NAC inganciphisa ukulahleka kwekhono lokuqonda kubantu abane-Alzheimer's (,).

Esinye isimo sobuchopho, isifo sikaParkinson, sibonakala ngokuwohloka kwamaseli akhiqiza i-neurotransmitter dopamine. Kokubili ukulimala okwenziwe nge-oxidative kumaseli nokuncipha kwekhono le-antioxidant kunomthelela kulesi sifo.

Izengezo ze-NAC zibonakala zithuthukisa ukusebenza kwe-dopamine nezimpawu zezifo ezinjengokuthuthumela ().

Ngenkathi i-NAC ingathuthukisa impilo yobuchopho, ucwaningo olwengeziwe lwabantu luyadingeka ukwenza iziphetho eziqinile.

Isifinyezo Ngokusiza ukugcwalisa i-antioxidant glutathione nokulawula i-glutamate, i-NAC inamandla okwelapha izifo ezinjenge-Alzheimer's kanye neParkinson's.

6. Kwangathi Kungathuthukisa Ukuzala Kokubili Abesilisa Nabesifazane

Cishe i-15% yabo bonke abashadikazi abazama ukukhulelwa bayathinteka ngokungazali. Cishe uhhafu wamacala la, ukungabi nenzalo kwabesilisa yiyona nto ebangela kakhulu ().

Izinkinga eziningi zokungazali zingakhula lapho amazinga e-antioxidant enganele ukulwa nokwakheka okukhululekile kohlelo lwakho lokuzala. Ukucindezeleka okwenziwe nge-oxidative kungadala ukufa kweseli nokuncipha kokuzala ().

Kwezinye izimo, i-NAC ikhonjisiwe ukuthi ithuthukise ukuzala kwabesilisa.

Isimo esisodwa esifaka isandla ekungazali kwabesilisa yi-varicocele - lapho imithambo ngaphakathi kwesikhotha ikhula ngenxa yomonakalo omkhulu wamahhala. Ukuhlinzwa ukwelashwa okuyinhloko.

Kwesinye isifundo, amadoda angama-35 ane-varicocele anikezwa ama-600 mg we-NAC ngosuku izinyanga ezintathu ngemuva kokuhlinzwa. Ukuhlanganiswa kokuhlinzwa kanye nokwengezwa kwe-NAC kuthuthukise ubuqotho besidoda kanye nezinga lokukhulelwa kozakwethu ngo-22% ngokuqhathaniswa neqembu elilawulayo ().

Olunye ucwaningo emadodeni angama-468 angenakuthola luthole ukuthi ukwengeza nge-600 mg ye-NAC kanye ne-200 mcg ye-selenium amasonto angama-26 ithuthukise ikhwalithi yesidoda ().

Abaphenyi basikisela ukuthi lesi sengezo esihlanganisiwe kufanele sithathwe njengenketho yokwelashwa kokuzala kwabesilisa.

Ngaphezu kwalokho, i-NAC ingathuthukisa ukuzala kwabesifazane abane-polycystic ovary syndrome (i-PCOS) ngokunciphisa noma ngokwengeza umjikelezo we-ovulation ().

Isifinyezo I-NAC ingasiza ukuthuthukisa ukuzala emadodeni ngokunciphisa ukucindezeleka kwe-oxidative okulimaza noma okubulala amaseli okuzala. Kungasiza futhi ukuzala kwabesifazane abane-PCOS.

7. Kwangathi Kungazinziswa Ushukela Wegazi Ngokunciphisa Ukuvuvukala Emaseleni Amafutha

Ushukela ophakeme wegazi nokukhuluphala kunomthelela ekuvukeleni kwezicubu ezinamafutha.

Lokhu kungaholela ekulimaleni noma ekubhujisweni kwama-insulin receptors futhi kukubeka engcupheni enkulu yohlobo lwesifo sikashukela sohlobo 2 ().

Ucwaningo lwezilwane lukhombisa ukuthi i-NAC ingaqinisa ushukela wegazi ngokunciphisa ukuvuvukala kumaseli anamafutha ngaleyo ndlela ithuthukise ukumelana ne-insulin (,).

Lapho ama-insulin receptors engashintshi futhi enempilo, asusa kahle ushukela egazini lakho, agcina amazinga abe semikhawulweni ejwayelekile.

Kodwa-ke, khumbula ukuthi ucwaningo lomuntu nge-NAC luyadingeka ukuqinisekisa le miphumela ekulawuleni ushukela wegazi.

Isifinyezo Ngokunciphisa ukuvuvukala kwezicubu ezinamafutha, i-NAC inganciphisa ukumelana ne-insulin futhi ithuthukise ukulawulwa kukashukela egazini, kepha ucwaningo olwenziwe ngabantu luyashoda.

8. Kwangathi Kunganciphisa Ubungozi Bezifo Zenhliziyo Ngokuvimbela Ukulimala Kwe-Oxidative

Ukulimala okwenziwe nge-oxidative ezicutshini zenhliziyo kuvame ukuholela esifo senhliziyo, kubangele ukushaywa unhlangothi, isifo senhliziyo nezinye izimo ezinzima.

I-NAC inganciphisa ingozi yesifo senhliziyo ngokunciphisa ukulimala kwe-oxidative ezicutshini ezisenhliziyweni yakho ().

Kuboniswe futhi ukuthi kukhulisa ukukhiqizwa kwe-nitric oxide, okusiza imithambo ivuleke futhi ithuthukise ukugeleza kwegazi. Lokhu kusheshisa ukuhamba kwegazi kubuyele enhliziyweni yakho futhi kunganciphisa ubungozi bokuhlaselwa yinhliziyo ().

Kuyathakazelisa ukuthi ucwaningo lwe-test-tube lubonise ukuthi - uma ihlanganiswe netiye eluhlaza - i-NAC ibonakala inciphisa ukulimala okuvela kwi-cholesterol "embi" ye-LDL ene-oxidized, omunye umnikeli wesifo senhliziyo ().

Isifinyezo I-NAC inganciphisa ukulimala kwe-oxidative enhliziyweni yakho, nakho okunganciphisa ingozi yesifo senhliziyo.

9. Amandla Okukhulisa Amazinga E-Glutathione Angathuthukisa Umsebenzi We-immune

I-NAC ne-glutathione nazo zithuthukisa impilo yomzimba.

Ukucwaninga ngezifo ezithile ezihlotshaniswa nokushoda kwe-NAC kanye ne-glutathione kusikisela ukuthi ukusebenza komzimba kungathuthukiswa - futhi kungabuyiselwa - ngokwengeza nge-NAC ().

Lesi sici sifundwe kakhulu kubantu abanegciwane lesandulela ngculazi (i-HIV).

Ezifundweni ezimbili, ukwengeza nge-NAC kuholele ekwandeni okukhulu kokuzivikela komzimba - ngokubuyiselwa okuphelele kwamangqamuzana ababulali emvelo (,,).

Izinga eliphakeme le-NAC emzimbeni wakho lingahle likunqande ukukhiqizwa kabusha kwe-HIV-1 ().

Ucwaningo lwe-test-tube lukhombise ukuthi kwezinye izimo ezithikameza amasosha omzimba, njengomkhuhlane, i-NAC ingaphazamisa ikhono legciwane lokuziphindaphinda. Lokhu kunganciphisa izimpawu nobude bempilo yokugula ().

Ngokufanayo, ezinye izifundo ze-test-tube zixhumanise i-NAC nomdlavuza wokufa kwamangqamuzana womdlavuza futhi kwavimbela ukuphindaphindeka kweseli lomdlavuza (,).

Kukonke, kudingeka izifundo eziningi zabantu. Ngakho-ke, qiniseka ukuthi ukhuluma nodokotela wakho ngaphambi kokuthatha i-NAC ngesikhathi sokwelapha umdlavuza ().

Isifinyezo Ikhono le-NAC lokukhuphula amazinga e-glutathione lingahle lithuthukise ukusebenza kwamasosha omzimba ezifweni ezahlukahlukene.

Isikali

Akunasincomo esithile sokudla se-cysteine ​​ngoba umzimba wakho ungakhiqiza amanani amancane.

Ukuze umzimba wakho wenze i-amino acid cysteine, udinga inani elanele le-folate, uvithamini B6 novithamini B12. Lezi zinongo zingatholakala kubhontshisi, udali, isipinashi, ubhanana, isalmon ne-tuna.

Ngenkathi ukudla okuningi okunothe ngamaprotheni, njengenkukhu, i-turkey, i-yogurt, ushizi, amaqanda, imbewu ye-sunflower kanye nemidumba, kune-cysteine, abanye abantu bakhetha ukunezela nge-NAC ukukhuphula i-cysteine.

I-NAC inokutholakala kokutholakala okuphansi kokuphansi njengesengezo somlomo, okusho ukuthi ayishutheki kahle. Incomo yokwamukelwa yansuku zonke eyamukelwe ingama-600-1,800 mg we-NAC (,).

I-NAC ingalawulwa njenge-IV noma ithathwe ngomlomo, njenge-spray ye-aerosol noma ifomu eliketshezi noma le-powder.

Isifinyezo Ukudla ukudla okunamaprotheni amaningi kunganikeza umzimba wakho i-amino acid cysteine, kepha i-NAC nayo ingathathwa njengesengezo esisiza ukwelapha izimo ezithile.

Okuqhamuka uma udla imishanguzo

I-NAC kungenzeka iphephile kubantu abadala uma inikezwa njengomuthi kadokotela.

Kodwa-ke, amanani aphezulu angadala isicanucanu, ukuhlanza, isifo sohudo nokuqunjelwa ().

Lapho uhogela, kungadala ukuvuvukala emlonyeni, ikhala eligobayo, ukozela nokuqina kwesifuba.

Abantu abanezinkinga zokopha noma abathatha imishanguzo yokuncipha kwegazi akufanele bathathe i-NAC, ngoba inganciphisa ukujiya kwegazi ().

I-NAC inephunga elingathandeki elenza kube nzima ukuyidla. Uma ukhetha ukuyithatha, thintana nodokotela wakho kuqala.

Isifinyezo Ngenkathi i-NAC ithathwa njengephephile njengomuthi kadokotela, ingadala isicanucanu, ukuhlanza, ukuphazamiseka kwamathumbu, kanye nezinkinga zomlomo uma uhogela.

Okusemqoka

I-NAC idlala izindima eziningi ezibalulekile empilweni yomuntu.

Idume ngekhono layo lokugcwalisa amazinga e-antioxidant glutathione, futhi ilawula ubuchopho obubalulekile be-neurotransmitter glutamate. Ngokwengeziwe, i-NAC isiza uhlelo lokukhipha umzimba emzimbeni.

Le misebenzi yenza ukuthi i-NAC yengeze inketho yokwelashwa esebenzayo yezinkinga eziningi zezempilo.

Xhumana nodokotela wakho ukuze ubone ukuthi ngabe i-NAC ingayithuthukisa yini impilo yakho.