Umlobi: Louise Ward
Usuku Lokudalwa: 6 Ufebhuwari 2021
Ukuvuselela Usuku: 11 Hamba 2025
Anonim
Neulasta (Pegfilgrastim) Injection
Ividiyo: Neulasta (Pegfilgrastim) Injection

-Delile

Yini i-Neulasta?

INeulasta umuthi kadokotela ogama lomuthi. Kuvunyelwe i-FDA yalokhu okulandelayo:

  • Ukunciphisa ubungozi bokutheleleka ngenxa yesimo esibizwa nge-febrile neutropenia kubantu abanomdlavuza ongewona we-myeloid. Ukuze usebenzise i-Neulasta, kufanele uthathe umuthi olwa nomdlavuza ongadala i-febrile neutropenia (izinga eliphansi lamaseli amhlophe egazi abizwa nge-neutrophils).
  • Ukwelapha ukugula ngemisebe. Uhlobo lokugula ngemisebe okusetshenziselwa i-Neulasta lubizwa nge-hematopoietic subsyndrome.

Isigaba sezidakamizwa se-Neulasta namafomu

INeulasta iqukethe isithako somuthi esisodwa esisebenzayo: i-pegfilgrastim. INeulasta ingeyesigaba sezidakamizwa esibizwa ngokuthi yizici zokukhula kwe-leukocyte. Isigaba sezidakamizwa siyiqoqo lemithi esebenza ngendlela efanayo.

INeulasta iza ngezindlela ezimbili. Esinye isirinji ekhethwe ngomthamo owodwa. Leli fomu linikezwa usuku ngemuva kokuthola i-chemotherapy njengomjovo ongaphansi (umjovo ngqo ngaphansi kwesikhumba sakho).

Umhlinzeki wezokunakekelwa kwempilo uzokunika umjovo we-Neulasta, noma ungakwazi ukuzinikeza umjovo ekhaya ngemuva kokuqeqeshwa. Isiponji siyatholakala ngamandla ayisithupha: 6 mg / 0.6 mL.


Ifomu lesibili libizwa ngeNeulasta Onpro, okuyi-injector esemzimbeni (OBI). Umhlinzeki wezokunakekelwa kwempilo uzokufaka esiswini sakho noma ngemuva kwengalo yakho ngalo lolo suku uthola i-chemotherapy.

INeulasta Onpro ihambisa umthamo womuthi cishe usuku ngemuva kokufakwa kwe-OBI. Lokhu kusho ukuthi akudingeki ubuyele ehhovisi likadokotela wakho ukujova. INeulasta Onpro itholakala ngamandla owodwa: 6 mg / 0.6 mL.

Qaphela: Ngenkathi isirinji ye-Neulasta ingasetshenziswa ukwelapha zombili lezi zimo ezibalwe ngenhla, i-Neulasta Onpro ayisetshenziselwa ukwelapha ukugula ngemisebe.

Ukusebenza ngempumelelo

Ukuze uthole ukwaziswa ngokusebenza kwe-Neulasta, bheka isigaba esithi “Neulasta uses” ngezansi.

I-Neulasta ejwayelekile noma i-biosimilar

INeulasta iyatholakala njengomuthi wegama lomkhiqizo. INeulasta inezinguqulo ezintathu ze-biosimilar: iFulphila, i-Udenyca, neZiextenzo.

I-biosimilar yisidakamizwa esifana nomuthi wegama lomkhiqizo. Umuthi ojwayelekile, ngakolunye uhlangothi, uyikhophi ngqo yesithako esisebenzayo kumuthi wegama lomkhiqizo.


Ama-biosimilars asuselwa kuzidakamizwa ze-biologic, ezidalwe kusuka ezingxenyeni zezinto eziphilayo. Ama-Generics asekelwe emithini ejwayelekile eyenziwe ngamakhemikhali. Ama-biosimilars nemithi ejwayelekile nayo ibiza izindleko ezingaphansi kwezidakamizwa ezibizwa ngegama.

INeulasta iqukethe isithako somuthi esisodwa esisebenzayo: i-pegfilgrastim. Lokhu kusho ukuthi i-pegfilgrastim iyisithako esenza i-Neulasta isebenze.

Imiphumela emibi ye-Neulasta

I-Neulasta ingadala imiphumela emibi noma emibi. Uhlu olulandelayo luqukethe eminye yemiphumela emibi engaba khona ngenkathi uthatha i-Neulasta. Lezi zinhlu azibandakanyi yonke imiphumela emibi engaba khona.

Ukuthola eminye imininingwane ngemiphumela emibi engaba khona yeNeulasta, khuluma nodokotela wakho noma usokhemisi. Bangakunika amathiphu okuthi ungabhekana kanjani nanoma yimiphi imiphumela emibi engase ikukhathaze.

Qaphela: Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kulandelela imiphumela emibi yezidakamizwa abazivumile. Uma ungathanda ukubika kwi-FDA imiphumela eseceleni obukade unayo nge-Neulasta, ungakwenza lokho nge-MedWatch.


Imiphumela emibi emincane

Imiphumela emibi ye-Neulasta ingafaka:

  • ubuhlungu bamathambo (eminye imininingwane ku- “Side effect imininingwane” ngezansi)
  • ubuhlungu ezingalweni noma emilenzeni

Iningi lalemiphumela emibi ingahle ihambe ezinsukwini ezimbalwa noma emasontweni ambalwa. Kepha uma ziba nzima kakhulu noma zingahambi, khuluma nodokotela wakho noma usokhemisi.

Imiphumela emibi kakhulu

Imiphumela emibi ebucayi evela kuNeulasta ayijwayelekile, kepha ingenzeka. Shayela udokotela wakho ngokushesha uma unemiphumela emibi kakhulu. Shayela ku-911 uma izimpawu zakho zizizwa zisongela impilo noma uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha.

Imiphumela emibi kanye nezimpawu zabo zingafaka:

  • I-aortitis (ukuvuvukala kwe-aorta, umthambo oyinhloko wenhliziyo). Izimpawu zingafaka:
    • ukuhlungu obusemhlane
    • i-malaise (imizwa yokungakhululeki noma yokungakhululeki)
    • imfiva
    • ubuhlungu besisu

Eminye imiphumela emibi emibi, echazwe ngokuningiliziwe ngezansi ku- "Side effect imininingwane," ifaka:

  • ukusabela okweqile
  • isifo sokuphefumula kakhulu (uhlobo lwesimo samaphaphu)
  • i-capillary leak syndrome (isimo lapho kuvuza khona imithambo yegazi emincane)
  • i-glomerulonephritis (iqembu lezimo zezinso)
  • i-leukocytosis (ukwanda kwezinga lamaseli amhlophe egazi abizwa ngama-leukocyte)
  • ubende oluqhekekile (ukuvulwa kwesitho esibizwa ubende)

Imininingwane yomphumela oseceleni

Ungase uzibuze ukuthi kaningi kangakanani imiphumela emibi ethile eba khona ngalo muthi. Nayi imininingwane ngeminye yemiphumela emibi engahle yenzeke noma nge-Neulasta shot noma nge-patch.

Ukusabela okweqile

Njengezidakamizwa eziningi, abanye abantu bangaba ne-allergen reaction ngemuva kokuthatha i-Neulasta. Akwaziwa ukuthi bangaki abantu ababene-allergen reaction ku-Neulasta ezivivinyweni zokwelashwa. Kodwa ukusabela okuningi kwenzeke kubantu abathole umthamo weNeulasta okokuqala ngqa.

Futhi kwabanye abantu, ukusabela kwenzeka futhi ezinsukwini ezimbalwa ngemuva kokumiswa kokwelashwa kokungazwani komzimba. Isinamathelisi se-acrylic sisetshenziswa ne-Neulasta on-body injector (OBI) futhi singadala ukusabela okweqile uma umuntu eguliswa yizinto ezinamathelayo.

Izimpawu zokuphendula okuncane komzimba zingabandakanya:

  • ukuqubuka kwesikhumba
  • ukulunywa
  • ukuqhuma (ukufudumala nokubomvu esikhunjeni sakho)

Ukusabela okweqile okwedlulele akuvamile kodwa kungenzeka. Izimpawu zokuphendula okweqile kakhulu zingabandakanya:

  • ukuvuvukala ngaphansi kwesikhumba sakho, imvamisa ezinkalweni zakho, izindebe, izandla, noma izinyawo
  • ukuvuvukala kolimi lwakho, umlomo, noma umphimbo
  • inkinga yokuphefumula

Shayela udokotela wakho ngokushesha uma une-negulasta. Shayela ku-911 uma izimpawu zakho zizizwa zisongela impilo noma uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha.

Ubuhlungu bamathambo

Ubuhlungu bethambo bungumphumela ojwayelekile we-Neulasta. Ezifundweni zokwelashwa, abantu abangu-31% abathathe i-Neulasta babike ubuhlungu bamathambo uma kuqhathaniswa nabantu abangama-26% abathathe i-placebo (ukwelashwa ngaphandle kwesidakamizwa esisebenzayo).

Akwaziwa kahle ukuthi kungani iNeulasta ibangela ubuhlungu bamathambo kwabanye abantu. Umbono owodwa uhilela i-histamine, iphrotheni elenziwa amasosha akho omzimba ukusiza ukulwa nezifo.

INeulasta ivuselela amasosha akho omzimba ekukhiqizeni amangqamuzana egazi amhlophe amaningi, nawo aholele ekwakhiweni kwe-histamine eyengeziwe. Futhi ukukhishwa kwe-histamine kuxhunyaniswe nokuvuvukala komnkantsha kanye nobuhlungu. Kodwa kudingeka olunye ucwaningo ngaphambi kokuba lwaziwe ngokuqinisekile ukuthi kungani i-Neulasta ibangela ubuhlungu bamathambo.

Uma unezinhlungu zethambo ngenkathi usebenzisa i-Neulasta, tshela udokotela wakho. Bangase banikeze umuthi wezinhlungu, njenge-ibuprofen noma i-naproxen. Noma bangakushintshela emithini engeyona iNeulasta.

Isifo sokuphefumula esibucayi (i-ARDS)

I-acute yokuphefumula syndrome (i-ARDS) ingumphumela wecala we-Neulasta, kepha kuyaqabukela kwenzeka. I-ARDS ayibikwanga ngesikhathi sokuhlolwa komtholampilo komuthi, kodwa isimo sibikiwe kubantu abambalwa abathatha iNeulasta selokhu yafika emakethe.

Nge-ARDS, amaphaphu akho agcwala uketshezi futhi awakwazi ukuletha umoya-mpilo owenele kuwo wonke umzimba wakho. Lokhu kungaholela kwezinye izinkinga zamaphaphu njenge-pneumonia noma izifo.

Izimpawu ze-ARDS zingafaka:

  • ukudideka
  • ukukhwehlela okomile, nokugenca
  • ukuzizwa ngibuthakathaka
  • imfiva
  • umfutho wegazi ophansi

I-ARDS yisimo esisongela impilo esidinga ukunakekelwa kwezokwelapha ngokushesha. Uma uthatha i-Neulasta futhi unenkinga yokuphefumula, ukuphefumula okusheshayo, noma ukuphefumula okuncane, shayela ku-911 noma uye egumbini lezimo eziphuthumayo.

ICapillary leak syndrome

ICapillary leak syndrome ingumphumela ongathandeki kodwa ongathí sina ongaba khona we-Neulasta. Akwaziwa ngokuqinisekile ukuthi kwenzeka kangaki ezifundweni zokwelashwa.

Ama-capillaries yimithambo yegazi emincane. ICapillary leak syndrome yenzeka lapho uketshezi namaprotheni ekwazi ukuphuma kuma-capillaries nasezicutshini zomzimba ezizungezile. Lokhu kungadala umfutho wegazi ophansi kanye ne-hypoalbuminemia (amazinga aphansi eprotheni ebalulekile ebizwa nge-albumin).

Izimpawu ze-capillary leak syndrome zingafaka:

  • i-edema (ukuqunjelwa nokugcina uketshezi)
  • isifo sohudo
  • ukukhathala (ukungabi namandla)
  • uzizwe womile ngokweqile
  • isicanucanu
  • ubuhlungu besisu

Njengoba kushiwo ngenhla, i-capillary leak syndrome ayivamile, kepha ingabulala. Ngakho-ke uma ucabanga ukuthi unezimpawu ze-capillary leak syndrome ngenkathi uthatha i-Neulasta, shayela u-911 noma uye egumbini labezimo eziphuthumayo.

I-Glomerulonephritis

Yize i-glomerulonephritis ingazange ibikwe ezifundweni zokwelashwa ze-Neulasta, kuye kwabikwa kubantu abathathe lesi sidakamizwa selokhu safika emakethe.

IGlomerulonephritis isho ukuvuvukala (ukuvuvukala) kwama-glomeruli, okuyizigaxa zemithambo yegazi ezinso zakho. IGlomeruli isiza ukuhlunga imfucuza egazini lakho bese iyidlulisela emchameni.

Izimpawu ze-glomerulonephritis zingafaka:

  • ukuqunjelwa nokuvuvukala ngenxa yokugcina uketshezi, ikakhulukazi ebusweni, ezinyaweni, ezandleni noma esiswini
  • umfutho wegazi ophakeme
  • umchamo onombala opinki noma onsundu ngombala
  • umchamo obukeka ugwebu

Uma ucabanga ukuthi une-glomerulonephritis ngenkathi uthatha i-Neulasta, tshela udokotela wakho. Banganciphisa umthamo wakho, okuvame ukusula i-glomerulonephritis. Kepha uma lokho kungasebenzi, kungenzeka udokotela wakho ayeke ukuthatha i-Neulasta. Kungenzeka ukuthi uzame imithi ehlukile esikhundleni salokho.

Ileukocytosis

I-Leukocytosis ingumphumela ongavamile kodwa ongaba mibi kakhulu we-Neulasta.

Ezifundweni zokwelashwa, i-leukocytosis yenzeke kubantu abangaphansi kuka-1% abathathe lesi sidakamizwa. INeulasta yaqhathaniswa ne-placebo, kodwa akwaziwa ukuthi i-leukocytosis yenzeke noma kangaki kubantu abathathe i-placebo. Azikho izinkinga ezihlobene ne-leukocytosis ezibikiwe kulezi zifundo.

I-leukocytosis yisimo lapho izinga lamaseli amhlophe egazi abizwa ngokuthi ama-leukocyte liphakeme kunokujwayelekile. Lokhu ngokuvamile kuyisibonakaliso sokuthi umzimba wakho uzama ukulwa nokutheleleka. Kodwa-ke, i-leukocytosis futhi ingaba uphawu lwe-leukemia (umdlavuza othinta umnkantsha noma igazi).

Izimpawu ze-leukocytosis zingafaka:

  • ukopha noma ukulimaza
  • izinkinga zokuphefumula njengokuvuthwa
  • imfiva

Ngoba usengozini enkulu yokutheleleka ngenkathi uthatha i-Neulasta, tshela udokotela wakho ngokushesha uma uba nomkhuhlane noma ezinye izimpawu ze-leukocytosis. Bazosiza ekunqumeni imbangela nokuthi yikuphi ukwelashwa okulungele wena.

Ubende obuqhekekile

Ubende obukhulisiwe kanye nobende obuqhekekile akuzange kubikwe ezivivinyweni zokwelashwa zaseNeulasta. Kodwa-ke, lezi zimo zibikiwe kubantu abathathe iNeulasta selokhu kwafika lesi sidakamizwa emakethe.

Ubende isitho esisenhla kwesobunxele sesisu sakho, ngaphansi kwezimbambo zakho. Kuyasebenza ukuhlunga igazi nokulwa nokutheleleka.

Izimpawu zesipele esiphukile zingabandakanya:

  • ukudideka
  • ukuzizwa ukhathazekile noma ungenakho ukuphumula
  • ubumhlophe
  • isicanucanu
  • ubuhlungu endaweni engenhla kwesobunxele esiswini
  • isikhumba esiphaphathekile
  • ubuhlungu behlombe

I-spleen ruptured yisimo esisongela impilo esidinga ukunakekelwa kwezokwelapha ngokushesha. Uma uthatha i-Neulasta futhi unezinhlungu ehlombe lakho lesobunxele noma endaweni ephezulu yesisu yangakwesokunxele, tshela udokotela wakho khona manjalo.

Umkhuhlane (hhayi umphumela ohlangothini)

Imfiva akuyona imiphumela emibi elindelekile yokuthatha i-Neulasta.

Ukuthuthukisa umkhuhlane ngesikhathi sokwelashwa kwe-Neulasta kungasho ukuthi unesifo. Umkhuhlane futhi ungaba wuphawu lwemiphumela emibi engajwayelekile kodwa ebucayi yeNeulasta, efana ne-acute respiratory stress syndrome (ARDS), aortitis, noma leukocytosis. (Ukuthola okuningi nge-ARDS ne-leukocytosis, bona lezo zingxenye ezingezansi.)

Uma uba nomkhuhlane ngenkathi uthatha i-Neulasta, tshela udokotela wakho khona manjalo. Bangasiza ukuthola ukuthi yini ebangela umkhuhlane wakho kanye nendlela engcono yokuyelapha.

Isilinganiso se-Neulasta

Umthamo weNeulasta odokotela wakho onqunyiwe uzoncika ezicini ezithile. Lokhu kufaka phakathi:

  • uhlobo nobukhali besimo osisebenzisayo ukwelapha i-Neulasta
  • iminyaka yakho
  • ifomu le-Neulasta oyithathayo
  • ezinye izimo zezokwelapha ongahle ube nazo

Imvamisa, udokotela wakho uzokuqala ngomthamo ophansi. Ngemuva kwalokho bazoyilungisa ngokuhamba kwesikhathi ukufinyelela inani elifanele wena. Udokotela wakho ekugcineni uzonikeza isilinganiso esincane kunazo zonke esihlinzeka ngomphumela oyifunayo.

Imininingwane elandelayo ichaza imithamo esetshenziswa kakhulu noma enconywayo. Kodwa-ke, qiniseka ukuthatha isilinganiso udokotela wakho akubekela sona. Udokotela wakho uzonquma isilinganiso esihle kakhulu ukulingana nezidingo zakho.

Amafomu wezidakamizwa namandla

INeulasta iza ngezindlela ezimbili. Esinye isirinji ekhethwe ngomthamo owodwa. Leli fomu linikezwa usuku ngemuva kokuthola i-chemotherapy njengomjovo ongaphansi (umjovo ngqo ngaphansi kwesikhumba sakho).

Umhlinzeki wezokunakekelwa kwempilo uzokunika umjovo we-Neulasta, noma ungakwazi ukuzinikeza umjovo ekhaya ngemuva kokuqeqeshwa. Isiponji siyatholakala ngamandla ayisithupha: 6 mg / 0.6 mL.

Ifomu lesibili libizwa ngeNeulasta Onpro, okuyi-injector esemzimbeni (OBI). Umhlinzeki wezokunakekelwa kwempilo uzokufaka esiswini sakho noma ngemuva kwengalo yakho ngalo lolo suku uthola i-chemotherapy.

INeulasta Onpro ihambisa umthamo womuthi cishe usuku ngemuva kokufakwa kwe-OBI. Lokhu kusho ukuthi akudingeki ubuyele ehhovisi likadokotela wakho ukujova. INeulasta Onpro itholakala ngamandla owodwa: 6 mg / 0.6 mL.

Kubalulekile ukuqaphela ukuthi i-Neulasta Onpro ayisetshenziselwa ukwelapha ukugula kwemisebe.

Isilinganiso sokuvimbela izifo ngesikhathi se-chemotherapy

Ngokuvikela ukutheleleka ngesikhathi se-chemotherapy, i-Neulasta inikezwa njengomthamo owodwa kanye ngomjikelezo ngamunye we-chemotherapy. Umthamo owodwa kungaba umjovo owodwa ngesirinji noma ukusetshenziswa kwe-Neulasta Onpro eyodwa.

Akufanele usebenzise i-Neulasta noma izinsuku eziyi-14 ngaphambi noma amahora angama-24 ngemuva kokuthola i-chemotherapy.

Isikali sokugula ngemisebe

Ekwelapheni i-hematopoietic subsyndrome ye-acute radiation syndrome (ukugula ngemisebe), i-Neulasta inikezwa ngemithamo emibili. Uzoba nazo iviki eli-1 zihlukanisiwe. Umthamo owodwa umjovo owodwa onesipontsho.

Umthamo wezingane

INeulasta ivunyelwe ukusiza ukuvikela ukutheleleka ezinganeni ezithola i-chemotherapy.Umuthi nawo uvunyelwe ukuthi usetshenziswe ezinganeni ezinezifo zemisebe. Ayikho imikhawulo esuselwa eminyakeni yokusebenzisa i-Neulasta.

Ngemithamo ye-Neulasta ezinganeni ezinesisindo esingaphezu kwamakhilogremu angama-99, bheka izigaba zomthamo ngenhla.

Imithamo yezingane ezinesisindo esingaphansi kwamakhilogremu angama-45 (45 kg) isuselwa kusisindo. Udokotela wengane yakho uzonquma ukuthi iyiphi isilinganiso se-Neulasta esifanele ingane yakho.

Kuthiwani uma ngiphuthelwa umthamo?

Uma uphuthelwa ukuzinika umjovo we-Neulasta ngesirinji, shayela udokotela wakho ngokushesha lapho ukubona lokhu. Bangakweluleka uma uthatha umthamo wakho.

Uma uphuthelwa i-aphoyintimenti yomjovo we-Neulasta, shayela ihhovisi likadokotela wakho. Abasebenzi bangakuhlehlela kabusha futhi balungise isikhathi sokuvakasha okuzayo, uma kunesidingo.

Kungenzeka futhi ukuphuthelwa umthamo ngenkathi usebenzisa i-Neulasta Onpro. Lokhu kungenxa yokuthi i-injector esemzimbeni kwesinye isikhathi ingahluleka ukusebenza noma ukuvuza. Uma lokhu kwenzeka, shayela ihhovisi likadokotela wakho ngokushesha. Abasebenzi bazohlela isikhathi sokuthi ungene umjovo weNeulasta ukuze uthole umthamo wakho ogcwele.

Ukusiza ukuqinisekisa ukuthi awuphuthelwa umthamo, zama ukusetha isikhumbuzi efonini yakho. Ungabhala futhi uhlelo lwakho lokwelashwa ekhalendeni.

Ngabe kuzodingeka ngisebenzise lesi sidakamizwa isikhathi eside?

I-Neulasta yenzelwe ukuthi isetshenziswe njengokwelashwa kwesikhathi eside, inqobo nje uma uthola i-chemotherapy. Uma wena nodokotela wakho nibona ukuthi i-Neulasta iphephile futhi isebenza kahle kini, kungenzeka niyithathe isikhathi eside.

Imibuzo ejwayelekile mayelana neNeulasta

Nazi izimpendulo zemibuzo ebuzwa njalo mayelana neNeulasta.

Ngabe uClaritin angangisiza ngilawule imiphumela emibi yeNeulasta?

Mhlawumbe. I-Neulasta isebenza ngokubangela amasosha akho omzimba ukuba enze amangqamuzana amhlophe egazi amaningi.

Amaprotheni athile abizwa ngama-histamines nawo akhishwa yile nqubo. Akwaziwa kahle ukuthi kungani ukukhishwa kwe-histamines kuholela emiphumeleni emibi efana nobuhlungu bethambo. Kepha ucwaningo lukhombisile ukuthi i-histamine iyabandakanyeka ekuvukeleni, okungadala ubuhlungu.

I-Claritin ngumuthi we-antihistamine. Isebenza ngokuvimba isenzo se-histamine. Ngokwenza njalo, uClaritin angasiza ekunciphiseni ubuhlungu bamathambo kubantu abathatha i-Neulasta, kepha kudingeka olunye ucwaningo.

Uma uthatha i-Neulasta futhi unezinhlungu zethambo, khuluma nodokotela wakho. Bangabuyekeza ukwelashwa okutholakalayo futhi basize ukunquma ukuthi yikuphi okulungele wena.

Imiphumela emibi yesibhamu seNeulasta ihlala isikhathi esingakanani?

Ayaziwa ngoba ayikho idatha eyanele yokuthi imiphumela emibi kangakanani yesibhamu seNeulasta yagcina kanjani.

Ezifundweni zokwelashwa, abanye abantu babike ubuhlungu bamathambo noma ubuhlungu ezingalweni noma emilenzeni yabo ngemuva kokuthola i-Neulasta. Kodwa abacwaningi abazange babhale ukuthi imiphumela emibi yahlala isikhathi eside kangakanani.

Ngemininingwane engaphezulu ngemiphumela emibi engaba khona ye-Neulasta, sicela ubheke esigabeni se- "Neulasta side effects" ngenhla. Ungafinyelela futhi kudokotela wakho.

Uhlala isikhathi esingakanani uNeulasta ohlelweni lwakho?

Isikhathi singahluka. Ucwaningo lomtholampilo lukhombisile ukuthi ukususa i-Neulasta emzimbeni kuthinteka isisindo somzimba wakho kanye nenani lama-neutrophils (uhlobo lweseli elimhlophe) elikhona egazini lakho.

Ngokuvamile, ngemuva komjovo owodwa, i-Neulasta isuswe ngokuphelele kusistimu yakho zingakapheli izinsuku eziyi-14.

Lapho ngindiza, ngidinga ukutshela ukuphepha kwesikhumulo sezindiza ukuthi ngineNeulasta Onpro?

Yebo. Umenzi weNeulasta unekhadi lezaziso leTransportation Security Administration (TSA) ongaliphrinta futhi ulethule kwabezokuphepha esikhumulweni sezindiza. Chofoza lapha ukufinyelela ikhadi.

Kodwa-ke, kunconywa ukuthi ugweme ukuhamba (kufaka phakathi ukushayela) phakathi kwewindi lamahora angama-26 kuya kwangu-29 ngemuva kokuthola i-Neulasta Onpro. Idivayisi ihambisa umuthi emzimbeni wakho ngalesi sikhathi. Futhi ukuhamba kungandisa ubungozi bokuthi uNeulasta Onpro akhishwe emzimbeni wakho.

Uma unemibuzo mayelana nokwelashwa kwakho kwe-Neulasta ngenkathi usohambweni, khuluma nodokotela wakho.

Kungani kufanele ngigcine iNeulasta Onpro ikude namaselula nezinye izinto zikagesi?

Izimpawu ezivela kulawa madivayisi kagesi zingaphazamisa iNeulasta Onpro futhi ziyigcine ekuhlinzekeni umthamo wakho.

Kunconywa ukuthi ugcine i-Neulasta Onpro okungenani amasentimitha angu-4 kude namadivayisi kagesi, kufaka phakathi omakhalekhukhwini nama-microwaves.

Uma unemibuzo mayelana nokusebenzisa i-Neulasta Onpro, buza udokotela wakho.

Kufanele ngiyilahle kanjani iNeulasta Onpro?

Ngemuva kokuthi uthole umthamo wakho ophelele we-Neulasta ngokusebenzisa i-Neulasta Onpro, kufanele ulahle le divayisi ngokuyifaka esitsheni se-Sharps.

Umenzi weNeulasta unohlelo lweSharps Disposal Container Program ukukusiza ulahle ngokuphepha iNeulasta Onpro. Lokhu kunikezwa ngaphandle kwezindleko ezengeziwe kuwe. Ungachofoza lapha ukuze ubhalisele lolu hlelo (bona isigaba esithi “Injector Disposal Program”), noma ushayele ku-1-844-696-3852.

I-Neulasta isebenzisa

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kugunyaza imishanguzo kadokotela efana neNeulasta ukwelapha izimo ezithile. INeulasta nayo ingasetshenziswa ngaphandle kwelebula kwezinye izimo. Ukusetshenziswa okungekho kwelebula kulapho umuthi ovunyelwe ukwelapha umbandela owodwa usetshenziselwa ukwelapha isimo esihlukile.

I-Neulasta yokuvimbela izifo ngesikhathi se-chemotherapy

I-Chemotherapy uhlobo lokwelashwa komdlavuza olusebenzisa imishanguzo ukubulala amaseli omdlavuza ahlukanisayo. Lokhu kusiza ukuvimbela umdlavuza ekukhuleni nasekusabalaleni.

Kodwa-ke, i-chemotherapy ayicaciseli amaseli womdlavuza. I-Chemotherapy ibuye ibulale amanye amaseli ahlukanisayo emzimbeni, kufaka phakathi amaseli awusizo njengamaseli amhlophe egazi.

I-Neutropenia yisimo segazi lapho amazinga we-neutrophil eba phansi. Ama-neutrophils awuhlobo lwamaseli amhlophe egazi avikela umzimba wakho ekuthelelekeni. Uma amazinga akho e-neutrophil ephansi, umzimba wakho ngeke ukwazi ukulwa kahle namagciwane. Ngakho-ke ukuba ne-neutropenia kwandisa ingozi yokutheleleka.

I-Febrile neutropenia yenzeka uma une-neutropenia futhi uba nomkhuhlane, okungaba wuphawu lokutheleleka. Futhi ukuba ne-neutropenia kusho ukuthi awukwazi ukulwa nezifo njengokujwayelekile. Ngakho-ke i-febrile neutropenia yisimo esibi kakhulu okufanele udokotela asihlole khona manjalo.

Okwenziwa uNeulasta

I-Neulasta isetshenziselwa ukusiza ukuvimbela ukutheleleka kubantu abanomdlavuza othile abathola i-chemotherapy. Imidlavuza ibizwa ngama-non-myeloid cancer, angahileli umnkantsha (izicubu ezingaphakathi kwamathambo ezakha amangqamuzana egazi). Isibonelo somdlavuza ongewona we-myeloid umdlavuza webele.

INeulasta ikusiza ekwakheni ama-neutrophil amaningi namanye amaseli amhlophe egazi. Lokhu kusiza umzimba wakho ukuthi ukulungele ukulwa nezifo, kusize ukuvimbela i-febrile neutropenia, futhi kunciphise ukuthi une-neutropenia isikhathi esingakanani.

Ukusebenza ngempumelelo

Ezifundweni zomtholampilo, i-Neulasta ikhonjisiwe ukuthi inciphisa bobabili ubungozi be-febrile neutropenia nokuthi isimo sihlala isikhathi esingakanani kubantu abasihlakulayo.

Ucwaningo olulodwa lwaqhathanisa i-Neulasta ne-filgrastim (Neupogen), okungenye yezidakamizwa ezifakazelwe ukusiza ukuvimbela nokwelapha i-neutropenia efebile. Abaphenyi babefuna ukubona ukuthi i-Neulasta yayisebenza njenge-filgrastim ekunciphiseni ukuthi i-febrile neutropenia ihlala isikhathi esingakanani.

Kulolu cwaningo, abantu bathole uhlobo lwemithi yokwelashwa ngamakhemikhali (uhlelo lokwelashwa) oluqukethe i-doxorubicin ne-docetaxel njalo ezinsukwini ezingama-21. Izinhlobo ezifanayo zixhunyaniswe ne-neutropenia enzima eyenzeke kuzo zonke izimo.

Isimo sithathe cishe izinsuku ezinhlanu kuya kweziyi-7 ngokwesilinganiso, futhi abantu ababalelwa ku-30% kuya ku-40% baba ne-febrile neutropenia.

Abantu babelwa ngezikhathi ezithile ukuthola i-Neulasta noma i-filgrastim. Abaphenyi bathola ukuthi iNeulasta yayisebenza ngokufana ne-filgrastim.

Abantu abathole i-Neulasta futhi bahlakulela i-neutropenia enamandla babenesimo esilinganisweni sezinsuku eziyi-1.8. Abantu abathole i-filgrastim futhi bakhulisa i-neutropenia enzima babenesimo sesilinganiso sezinsuku eziyi-1.7.

Ucwaningo lwesibili olunokusetha okufanayo nalo lathola imiphumela efanayo. Abantu abathole i-Neulasta futhi bahlakulela i-neutropenia enamandla babenesimo esilinganisweni sezinsuku eziyi-1.7. Lokhu kwaqhathaniswa nesilinganiso sezinsuku eziyi-1.6 kubantu abathola i-filgrastim.

I-Neulasta yokugula ngemisebe

INeulasta nayo ivunyelwe yi-FDA ukwelapha ukugula ngemisebe. Isimo singabizwa nangokuthi yi-acute radiation syndrome noma i-radiation toxicity.

Uhlobo lokugula ngemisebe okusetshenziselwa i-Neulasta lubizwa nge-hematopoietic subsyndrome. Inani lokuvezwa kwemisebe okubangela le syndrome lichazwa njenge-myelosuppressive, okusho ukuthi bahola umnkantsha wakho wokwenza amangqamuzana egazi ambalwa.

Ukugula kwemisebe kwenzeka lapho umuntu echayeka emithanjeni ephezulu yemisebe isikhathi esifushane kakhulu (imvamisa imizuzu embalwa nje). Ukweqiwa okuphezulu kwemisebe kungabulala amaseli emzimbeni wakho. Ukugula ngemisebe kungabulala uma ukuvezwa yimisebe kunzima ngokwanele.

Ngenxa yezizathu zokuziphatha, abacwaningi abakwazanga ukuhlola ikhono likaNeulasta lokwelapha ukugula ngemisebe kubantu. Esikhundleni salokho, lo muthi uvunyelwe ukwelapha ukugula ngemisebe okususelwa ezifundweni zezilwane, ngaphezu kwedatha eshiwo ku- "Neulasta yokuvimbela izifo ngesikhathi sekhemotherapy" isigaba esingenhla.

Qaphela: I-Neulasta Onpro (i-Neulasta on-body injector) akufanele isetshenziselwe ukwelapha ukugula kwemisebe.

Ukusetshenziswa okungekho kwelebula kweNeulasta

Ngaphezu kokusetshenziswa okubalwe ngenhla, i-Neulasta ingasetshenziswa ngaphandle kwelebula ezimweni ezithile. Ukusetshenziswa kwezidakamizwa ezingekho ilebula kulapho umuthi ovunyelwe ukusetshenziswa kokunye usetshenziselwa okwehlukile okungavunyelwe.

Ukufakwa kweseli ngemuva kwe-hematopoietic

I-Neulasta ayivunyelwe i-FDA ukuthi isetshenziswe ngemuva kokufakwa kwe-hematopoietic cell transplant (HCT). Noma kunjalo, lesi sidakamizwa singasetshenziswa ngaphandle kwelebula ngale njongo.

I-HCT inqubo eyenziwa ngemuva kokuthi uthole ukwelashwa ngamakhemikhali. Uma i-chemotherapy isetshenziselwe ukubulala amangqamuzana omdlavuza, amaseli ama-stem afakwa kuwe ngesikhathi se-HCT. Lokhu kwenziwa ngoba i-chemotherapy ayihlaseli nje amangqamuzana omdlavuza. Ingabulala nama-stem cells enziwe ngomnkantsha wakho.

Ama-stem cell ngokuvamile aba ama-platelets (amangqamuzana egazi asiza igazi lakho), amangqamuzana abomvu egazi, namaseli amhlophe egazi, konke okubalulekile ekugcineni impilo.

Lapho i-HCT inikezwa abantu abanomdlavuza wegazi, ukutheleleka kungenzeka. Lokhu kungenxa yokuthi amangqamuzana amasha awasebenzi ngokugcwele ngemuva kokufakelwa.

Ukusebenzisa i-Neulasta ngemuva kwe-HCT kusiza umzimba wakho ukwenza amangqamuzana amhlophe egazi amasha, kufaka phakathi i-neutrophils. Izinga elinempilo lama-neutrophils lisiza umzimba wakho ukulwa nokutheleleka kangcono.

Ukusebenza ngempumelelo

Yize i-Neulasta ingavunyelwe i-FDA ukuthi isetshenziswe ngemuva kwe-HCT, izifundo zomtholampilo zikhombisile ukuthi umuthi uyasebenza kulokhu kusetshenziswa.

Ucwaningo olulodwa lwaqhathanisa i-Neulasta nomuthi ofanayo, i-filgrastim (Neupogen), evunyelwe yi-FDA ukuthi isetshenziswe ngemuva kwe-HCT. I-Neulasta inikezwa njengomjovo owodwa nje, kuyilapho i-filgrastim inikezwa njengemijovo eminingi ezinsukwini ezimbalwa.

Ocwaningweni, abantu abangu-14 abane-non-Hodgkin lymphoma, multiple myeloma, noma i-amyloidosis bathole i-Neulasta ngemuva kokuba ne-HCT.

Abaphenyi baqhathanisa imiphumela yalaba bantu nemiphumela yabantu abathola i-filgrastim esikhathini esedlule. Lokhu kusho ukuthi bekungekho iqembu le-placebo (ukwelashwa ngaphandle kwesidakamizwa esisebenzayo).

Abaphenyi bathole ukuthi kuthatha cishe izinsuku eziyi-11 ukuthi ama-neutrophil abuyele emazingeni aphephile kubantu abathola i-Neulasta. Ngokuqhathanisa, kuthathe isilinganiso sezinsuku eziyi-14 kubantu abathathe i-filgrastim esikhathini esedlule.

Uma unemibuzo mayelana nokuthatha i-Neulasta ngemuva kwe-HCT, khuluma nodokotela wakho.

UNeulasta nezingane

INeulasta ivunyelwe ukusiza ukuvikela ukutheleleka ezinganeni ezithola i-chemotherapy. Umuthi nawo uvunyelwe ukuthi usetshenziswe ezinganeni ezinezifo zemisebe. Ayikho imikhawulo esuselwa eminyakeni yokusebenzisa i-Neulasta.

Ukusetshenziswa kwe-Neulasta nezinye izidakamizwa

I-Neulasta ijwayele ukusetshenziswa nezinye izidakamizwa. Lokhu kungenxa yokuthi iNeulasta yingxenye eyodwa kuphela yohlelo lokwelashwa komdlavuza (uhlelo).

I-Neulasta isetshenziswa kakhulu nge-chemotherapy ngoba i-Neulasta isiza ukuvimbela noma ukwelapha imiphumela emibi ye-chemotherapy.

Izidakamizwa ezijwayele ukusetshenziswa ngamakhemikhali zifaka:

  • i-bleomycin
  • I-carboplatin
  • cyclophosphamide
  • i-docetaxel (Taxotere)
  • i-doxorubicin (Doxil)
  • i-gemcitabine (iGemzar)
  • hbokuhle

Khumbula ukuthi lolu akulona uhlu olugcwele lwemithi yokwelashwa ngamakhemikhali. Khuluma nodokotela wakho uma unemibuzo mayelana nanoma imiphi imithi yokwelashwa ngamakhemikhali nokuthi ngabe iNeulasta ingakusiza yini.

Ezinye izindlela zeNeulasta

Ezinye izidakamizwa ziyatholakala ezingelapha isimo sakho. Abanye bangakulungela kangcono kuwe kunabanye. Uma unentshisekelo yokuthola enye indlela ye-Neulasta, khuluma nodokotela wakho. Bangakutshela ngeminye imithi engakusebenzela kahle.

Qaphela: Eminye yemithi ebalwe ngezansi isetshenziswa ngaphandle kwelebula ukwelapha lezi zimo ezithile. Ukusetshenziswa okungekho kwelebula kulapho umuthi ovunyelwe ukwelapha umbandela owodwa usetshenziselwa ukwelapha isimo esihlukile.

Ezinye izindlela zokuvimbela izifo ngesikhathi se-chemotherapy

Izibonelo zezinye izidakamizwa ezingasetshenziswa ukuvimbela izifo ngesikhathi se-chemotherapy zifaka:

  • i-tbo-filgrastim (Granix)
  • i-pegfilgrastim (iFulphila)
  • sargramostim (Leukine)
  • i-filgrastim (Neupogen)
  • i-filgrastim-aafi (i-Nivestym)
  • i-pegfilgrastim-cbqv (Udenyca)
  • i-filgrastim-sndz (i-Zarxio)
  • i-pegfilgrastim-bmez (iZiextenzo)

Ezinye izindlela zokugula ngemisebe

Izibonelo zezinye izidakamizwa ezingasetshenziswa ukwelapha ukugula ngemisebe zifaka:

  • i-tbo-filgrastim (Granix)
  • iodide ye-potassium
  • I-Prussia eluhlaza okwesibhakabhaka
  • i-pegfilgrastim (iFulphila)
  • i-filgrastim (Neupogen)
  • i-filgrastim-aafi (i-Nivestym)
  • i-pegfilgrastim-cbqv (Udenyca)
  • i-filgrastim-sndz (i-Zarxio)
  • i-pegfilgrastim-bmez (iZiextenzo)

I-Neulasta vs. Granix

Ungase uzibuze ukuthi i-Neulasta iqhathanisa kanjani neminye imithi enikezwe ukusetshenziswa okufanayo. Lapha sibheka ukuthi uNeulasta noGranix bafana futhi bahlukile kanjani.

Izithako

I-Neulasta iqukethe i-pegfilgrastim yezidakamizwa esebenzayo. I-Granix iqukethe isidakamizwa esisebenzayo i-tbo-filgrastim.

Kokubili i-pegfilgrastim ne-tbo-filgrastim kungokwesigaba semithi esaziwa njenge-granulocyte-colony factor stimulating (G-CSFs). Isigaba semithi siyiqembu lezidakamizwa ezisebenza ngendlela efanayo.

I-G-CSF ngumuthi obangela ukuthi i-neutrophils (uhlobo lweseli elimhlophe) lukhule emnkantsheni wakho wethambo. Umnkantsha wethambo izicubu ezingaphakathi kwamathambo ezakha amangqamuzana egazi. Ama-G-CSFs ngamakhophi enziwe ngabantu we-G-CSF hormone eyenziwa ngumzimba wakho ngokwemvelo.

Isebenzisa

Kokubili i-Neulasta ne-Granix kuvunyelwe yi-Food and Drug Administration (FDA) ukwehlisa ubungozi bokutheleleka ngenxa yesimo esibizwa nge-febrile neutropenia kubantu abanomdlavuza ongelona i-myeloid. isidakamizwa somdlavuza esingadala i-febrile neutropenia.

INeulasta nayo ivunyelwe yi-FDA ukwelapha ukugula ngemisebe. * Uhlobo lokugula ngemisebe okusetshenziselwa i-Neulasta lubizwa nge-hematopoietic subsyndrome.

Amafomu wezidakamizwa nokuphathwa

Nalu olunye ulwazi mayelana namafomu kaNeulasta noGranix nokuthi anikezwa kanjani.

Amafomu we-Neulasta

INeulasta iza ngezindlela ezimbili. Esinye isirinji ekhethwe ngomthamo owodwa. Leli fomu linikezwa usuku ngemuva kokuthola i-chemotherapy njengomjovo ongaphansi (umjovo ngqo ngaphansi kwesikhumba sakho).

Umhlinzeki wezokunakekelwa kwempilo uzokunika umjovo we-Neulasta, noma ungakwazi ukuzinikeza umjovo ekhaya ngemuva kokuqeqeshwa.

Ifomu lesibili libizwa ngeNeulasta Onpro, okuyi-injector esemzimbeni (OBI). Umhlinzeki wezokunakekelwa kwempilo uzokufaka esiswini sakho noma ngemuva kwengalo yakho ngalo lolo suku uthola i-chemotherapy.

INeulasta Onpro ihambisa umthamo womuthi cishe usuku ngemuva kokufakwa kwe-OBI. Lokhu kusho ukuthi akudingeki ubuyele ehhovisi likadokotela wakho ukujova.

Qaphela: INeulasta Onpro ayisetshenziselwa ukwelapha ukugula ngemisebe.

Amafomu we-Granix

I-Granix ibuye ibe yizinhlobo ezimbili: isiponji esigcwaliswe ngomthamo owodwa kanye nesitsha sethamo elilodwa lesisombululo samanzi. Womabili la mafomu anganikezwa ngumhlinzeki wezokunakekelwa kwezempilo njengomjovo ngaphansi kwesikhumba sakho, ngqo ngaphansi kwesikhumba sakho. Kepha ngokuqeqeshwa okuthile, ungakwazi ukuzinikeza imijovo ekhaya.

Isilinganiso imvamisa

Umehluko owodwa obalulekile phakathi kwe-Neulasta ne-Granix ukuthi imithi inikezwa kangaki ukunciphisa ingozi yokutheleleka ngesikhathi samakhemikhali.

I-Neulasta inikezwa kanye kuphela phakathi nomjikelezo ngamunye we-chemotherapy. Ngakolunye uhlangothi, i-Granix inikezwa nsuku zonke kuze kube yilapho amazinga ama-neutrophils egazini lakho ebuyela kokujwayelekile.

Imiphumela emibi kanye nezingozi

I-Neulasta ne-Granix zombili zisetshenziselwa ukusiza ukuvikela izifo ngesikhathi se-chemotherapy. Ngakho-ke, le mithi ingadala imiphumela emibi efanayo, kepha eminye ihlukile. Ngezansi kunezibonelo zale miphumela emibi.

Imiphumela emibi emincane

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi engaba khona ne-Neulasta, ne-Granix, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

  • Kungenzeka nge-Neulasta:
    • imiphumela embalwa engemihle eyingqayizivele
  • Kungenzeka ngeGranix:
    • ikhanda
    • ubuhlungu bemisipha
    • ukuhlanza
  • Kungenzeka ngamabili uNeulasta noGranix:
    • ubuhlungu bamathambo
    • ubuhlungu ezingalweni noma emilenzeni

Imiphumela emibi kakhulu

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi engaba khona ne-Neulasta, ne-Granix, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

  • Kungenzeka nge-Neulasta:
    • imiphumela embalwa engemihle eyingqayizivele
  • Kungenzeka ngeGranix:
    • i-vasculitis enqamulelayo (ukuvuvukala kwemithambo yegazi yesikhumba)
    • i-thrombocytopenia (amazinga aphansi eplatelet)
    • iziyaluyalu zeseli (iqembu lezinkinga ezithinta amangqamuzana abomvu egazi, ikakhulukazi i-hemoglobin)
  • Kungenzeka ngamabili uNeulasta noGranix:
    • ukusabela okweqile
    • i-leukocytosis (ukwanda kwezinga lamaseli amhlophe egazi)
    • ubende oluqhekekile (ukuvulwa kwesitho esibizwa ubende)
    • isifo sokuphefumula kakhulu (uhlobo lwesimo samaphaphu)
    • i-glomerulonephritis (iqembu lezimo zezinso)
    • i-capillary leak syndrome (isimo lapho kuvuza khona imithambo yegazi emincane)
    • i-aortitis (ukuvuvukala kwe-aorta, umthambo oyinhloko wenhliziyo)

Ukusebenza ngempumelelo

Ukuphela kokusetshenziswa okuvunyelwe i-Neulasta ne-Granix kunciphisa ubungozi bokutheleleka ngenxa yesimo esibizwa nge-febrile neutropenia kubantu abanomdlavuza ongelona owami.

Izifundo ezihlukile zemithi emibili zaqhathaniswa nokubuyekezwa okukhudlwana kwezifundo ezibizwa ngokuthi ukubuyekeza okuhlelekile. Abaphenyi babheka imininingwane evela ezifundweni eziyi-18.

Abantu bathole i-pegfilgrastim (umuthi osebenzayo eNeulasta), i-filgrastim, noma umuthi ofanayo, kufaka phakathi i-Granix. Iqembu le-pegfilgrastim belingenamathuba amancane okuba ne-febrile neutropenia futhi kungenzeka ukuthi lingadingi ukuhlala esibhedlela ngenxa ye-febrile neutropenia. Lokhu kwaqhathaniswa namanye amaqembu ezidakamizwa.

Izindleko

INeulasta neGranix yizidakamizwa ezibizwa ngamagama.

INeulasta inezinguqulo ezintathu ze-biosimilar: iFulphila, i-Udenyca, neZiextenzo.

I-Granix ayithathwa ngobuchwepheshe njenge-biosimilar, ngokwe-FDA.

I-biosimilar yisidakamizwa esifana nomuthi wegama lomkhiqizo. Umuthi ojwayelekile, ngakolunye uhlangothi, uyikhophi ngqo yesithako esisebenzayo kumuthi wegama lomkhiqizo.

Ama-biosimilars asuselwa kuzidakamizwa ze-biologic, ezidalwe kusuka ezingxenyeni zezinto eziphilayo. Ama-Generics asekelwe emithini ejwayelekile eyenziwe ngamakhemikhali. Ama-biosimilars nemithi ejwayelekile nayo ibiza izindleko ezingaphansi kwezidakamizwa ezibizwa ngegama.

Ngokuya ngokulinganiselwa ku-GoodRx.com, amanani eNeulasta naseGranix azohluka ngokuya ngomthamo wakho onqunyiwe. Intengo yangempela ozoyikhokhela noma yimuphi umuthi izoncika ohlelweni lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

INeulasta vs.Fulphila

NjengoGranix (okuxoxwe ngenhla), umuthi uFulphila awusebenzisayo ufana noweNeulasta. Nakhu ukuqhathanisa ukuthi uNeulasta noFulphila bafana futhi bahlukile kanjani.

Izithako

INeulasta neFulphila ziqukethe umuthi ofanayo osebenzayo, i-pegfilgrastim.

Ngokobuchwepheshe, iFulphila iqukethe isithako esisebenzayo i-pegfilgrastim-jmdb. Lokhu kungenxa yokuthi uFulphila uhlobo lomuthi owaziwa ngokuthi yi-biosimilar. I-biosimilar yisidakamizwa esifana nomuthi wegama lomkhiqizo. Ama-biosimilars asuselwa kuzidakamizwa ze-biologic, ezidalwe kusuka ezingxenyeni zezinto eziphilayo.

Kulokhu, i-Neulasta iyisidakamizwa se-biologic, kanti iFulphila iyona efana nayo. I-Pegfilgrastim ne-pegfilgrastim-jmdb zombili zisebenza ngendlela efanayo.

I-Pegfilgrastim ingeyesigaba semithi esaziwa njenge-granulocyte-colony stimulating factors (G-CSFs). Isigaba semithi siyiqembu lezidakamizwa ezisebenza ngendlela efanayo.

I-G-CSF ngumuthi obangela ukuthi i-neutrophils (uhlobo lweseli elimhlophe) lukhule emnkantsheni wakho wethambo. Umnkantsha wethambo izicubu ezingaphakathi kwamathambo ezakha amangqamuzana egazi. Futhi ama-G-CSFs angamakhophi enziwe ngabantu we-G-CSF hormone eyenziwa ngumzimba wakho ngokwemvelo.

Isebenzisa

Kokubili i-Neulasta neFulphila kuvunyelwe yi-Food and Drug Administration (FDA) ukwehlisa ubungozi bokutheleleka ngenxa yesimo esibizwa nge-febrile neutropenia kubantu abanomdlavuza ongelona i-myeloid. * Ukuze usebenzise le mithi, kufanele ukuthi uthatha i-anti- isidakamizwa somdlavuza esingadala i-febrile neutropenia.

INeulasta nayo ivunyelwe yi-FDA ukwelapha ukugula ngemisebe. * Uhlobo lokugula ngemisebe okusetshenziselwa i-Neulasta lubizwa nge-hematopoietic subsyndrome.

UFulphila akavunyelwe ukusiza ukuhambisa amangqamuzana egazi emnkantsheni wethambo aye egazini ngokufakelwa kweseli le-hematopoietic (HCT).

Amafomu wezidakamizwa nokuphathwa

Kokubili iNeulasta neFulphila kuza njengesirinji ekhethwe ngomthamo owodwa. Leli fomu linikezwa usuku ngemuva kokuthola i-chemotherapy njengomjovo ongaphansi (umjovo ngqo ngaphansi kwesikhumba sakho).

Umhlinzeki wezokunakekelwa kwempilo uzokunika umjovo we-Neulasta, noma ungakwazi ukuzinikeza umjovo ekhaya ngemuva kokuqeqeshwa.

INeulasta ibuye ifike nangenye indlela ebizwa nge-Neulasta Onpro, eyi-injector esemzimbeni (OBI). Umhlinzeki wezokunakekelwa kwempilo uzokufaka esiswini sakho noma ngemuva kwengalo yakho ngalo lolo suku uthola i-chemotherapy.

INeulasta Onpro ihambisa umthamo womuthi cishe usuku ngemuva kokufakwa kwe-OBI. Lokhu kusho ukuthi akudingeki ubuyele ehhovisi likadokotela wakho ukujova.

Qaphela: INeulasta Onpro ayisetshenziselwa ukwelapha ukugula ngemisebe.

Imiphumela emibi kanye nezingozi

INeulasta neFulphila zombili ziqukethe i-pegfilgrastim. Ngakho-ke, le mithi ingadala imiphumela emibi efanayo. Ngezansi kunezibonelo zale miphumela emibi.

Imiphumela emibi emincane

Lolu hlu luqukethe izibonelo zemiphumela emibi engaba khona neNeulasta neFulphila (uma ithathwa ngawodwana):

  • ubuhlungu bamathambo
  • ubuhlungu ezingalweni noma emilenzeni

Imiphumela emibi kakhulu

Lolu hlu luqukethe izibonelo zemiphumela emibi engaba khona neNeulasta neFulphila (uma ithathwa ngawodwana):

  • ukusabela okweqile
  • isifo sokuphefumula kakhulu (uhlobo lwesimo samaphaphu)
  • i-aortitis (ukuvuvukala kwe-aorta, umthambo oyinhloko wenhliziyo)
  • i-capillary leak syndrome (isimo lapho kuvuza khona imithambo yegazi emincane)
  • i-glomerulonephritis (iqembu lezimo zezinso)
  • i-leukocytosis (ukwanda kwezinga lamaseli amhlophe egazi)
  • ubende oluqhekekile (ukuvulwa kwesitho esibizwa ubende)

Ukusebenza ngempumelelo

Ukuphela kokusetshenziswa okuvunyelwe yiNeulasta neFulphila kunciphisa ubungozi bokutheleleka ngenxa yesimo esibizwa nge- febrile neutropenia kubantu abanomdlavuza ongelona i-myeloid.

Le mithi ayiqhathaniswanga ngqo ezifundweni zomtholampilo, kepha ucwaningo luthole ukuthi zombili i-Neulasta neFulphila ziyasebenza ekunciphiseni ubungozi bokutheleleka ngenxa yesimo esibizwa nge-febrile neutropenia kubantu abanomdlavuza ongelona i-myeloid.

Izindleko

Ngokuya ngokulinganiselwa ku-GoodRx.com, iNeulasta ibiza kakhulu kunoFulphila. Intengo yangempela ozoyikhokhela noma yimuphi umuthi izoncika ohlelweni lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

Ama-Generics noma ama-biosimilars

Izidakamizwa eziningi ezijwayelekile ezenziwe ngamakhemikhali zinezinhlobo ezejwayelekile. Isidakamizwa esijwayelekile ikhophi eliqondile lesithako esisebenzayo kumuthi wegama lomkhiqizo. Imvamisa kubiza okungaphansi kwenguqulo enegama lomkhiqizo.

Kodwa-ke, iNeulasta neFulphila yomibili imishanguzo enegama lomkhiqizo, eyakhiwe ngezingxenye zezinto eziphilayo. Esikhundleni semithi ejwayelekile, izidakamizwa ze-biologic zinama-biosimilars. I-biosimilar yisidakamizwa esifana nesidakamizwa se-biologic.

Njengama-generic, ama-biosimilars ngokuvamile abiza ngaphansi kunegama lomkhiqizo i-biologic asuselwa kuwo.

INeulasta inezinguqulo ezintathu ze-biosimilar: iFulphila, i-Udenyca, neZiextenzo. Ngakho-ke uFulphila uyi-biosimilar yeNeulasta. Uma ungathanda ukufunda okwengeziwe ngezinguqulo ze-biosimilar ze-Neulasta, kufaka phakathi i-Fulphila, khuluma nodokotela wakho noma usokhemisi.

Isebenza kanjani iNeulasta

Nalu ulwazi mayelana nokuthi i-Neulasta ikuphatha nokuthi umuthi usebenza kanjani.

I-neutropenia ye-Febrile

I-Neulasta isiza ukunciphisa ubungozi bokutheleleka ngenxa yesimo esibizwa nge-febrile neutropenia kubantu abanomdlavuza ongewona we-myeloid.

I-Neutropenia yisimo segazi lapho amazinga we-neutrophil eba phansi. Ama-neutrophils awuhlobo lwamaseli amhlophe egazi avikela umzimba wakho ekuthelelekeni. Uma amazinga akho e-neutrophil ephansi, umzimba wakho ngeke ukwazi ukulwa kahle namagciwane. Ngakho-ke ukuba ne-neutropenia kwandisa ingozi yokutheleleka.

I-Febrile neutropenia yenzeka uma une-neutropenia futhi uba nomkhuhlane, okungaba wuphawu lokutheleleka. Futhi ukuba ne-neutropenia kusho ukuthi awukwazi ukulwa nezifo njengokujwayelekile. Ngakho-ke i-febrile neutropenia yisimo esibi kakhulu okufanele udokotela asihlole khona manjalo.

Umdlavuza ongewona we-myeloid yimidlavuza engabandakanyi umnkantsha, okuyizicubu ezingaphakathi kwamathambo ezenza amangqamuzana egazi. Isibonelo somdlavuza ongewona we-myeloid umdlavuza webele.

Ukugula kwemisebe

I-Neulasta ibuye isetshenziselwe ukwelapha ukugula ngemisebe, isimo esenzeka lapho uvezwa amazinga aphezulu emisebe. Kungabizwa nangokuthi i-acute radiation syndrome.

Uhlobo lokugula ngemisebe okusetshenziselwa i-Neulasta lubizwa nge-hematopoietic subsyndrome. Inani lokuvezwa kwemisebe okubangela le syndrome lichazwa njenge-myelosuppressive, okusho ukuthi bahola umnkantsha wakho wokwenza amangqamuzana egazi ambalwa.

Isebenza kanjani iNeulasta

IGranulocyte-colony stimulating factor (G-CSF) iyi-hormone ebangela ukuthi i-neutrophils ikhule emnkantsheni wakho.

Isidakamizwa esisebenzayo eNeulasta, pegfilgrastim, yikhophi elenziwe ngabantu lehomoni ye-G-CSF eyenziwa ngumzimba wakho ngokwemvelo. I-Pegfilgrastim isebenza ngendlela efanayo ne-G-CSF yemvelo.

INeulasta ikusiza ekwakheni ama-neutrophil amaningi namanye amaseli amhlophe egazi. Lokhu kusiza umzimba wakho ukulungele ukulwa nezifo, uvimbele i-febrile neutropenia, futhi unciphise ukuthi une-neutropenia isikhathi esingakanani.

Nge-hematopoietic subsyndrome ngenxa yokugula kwemisebe, i-Neulasta isiza umzimba wakho ukuthi ungene esikhundleni samaseli amhlophe egazi abhujiswa emnkantsheni ngokuvezwa yimisebe.

Kuthatha isikhathi esingakanani ukusebenza?

INeulasta iqala ukusebenza ngemuva nje kokufakwa emzimbeni wakho. Kodwa-ke, izifundo zomtholampilo zikhombisa ukuthi kungathatha amaviki awu-1 kuya kwamabili ukuze amazinga e-neutrophil abuyele kokujwayelekile ngemuva kokuthola umthamo weNeulasta kulandela ukwelashwa ngamakhemikhali.

I-Neulasta notshwala

Njengamanje, akukho ukuxhumana okwaziwayo phakathi kweNeulasta notshwala.

Kodwa-ke, utshwala bungaphazamisa ezinye izidakamizwa ze-chemotherapy noma bube nemiphumela emibi kakhulu.

Khuluma nodokotela wakho mayelana nokuthi utshwala kuphephile yini ukuthi ungabuphuza ngenkathi welashwa ngamakhemikhali. (INeulasta inikezwa ngemuva komthamo we-chemotherapy.)

Ukusebenzisana kwe-Neulasta

Akukho ukuxhumana okwaziwayo phakathi kwe-Neulasta neminye imithi, amakhambi nezithako, nokudla.

I-Neulasta neminye imithi

Akwaziwa noma ngabe kukhona yini ukuxhumana kwezidakamizwa phakathi kweNeulasta neminye imithi. Lokhu kungenxa yokuthi azikho izifundo ezihlelekile ezenziwe ukuthola ukuxhumana kwezidakamizwa. Ngokuya ngokuthi umuthi usebenza kanjani, ukuxhumana neminye imithi akunakwenzeka.

Uma unemibuzo mayelana nokuhlangana kwezidakamizwa okungakuthinta, buza udokotela wakho noma usokhemisi.

I-Neulasta namakhambi nezithako

Awekho amakhambi noma izengezo ezibikwe ngokukhethekile ukuthi zisebenzisana neNeulasta. Kodwa-ke, kusamele uhlole udokotela wakho noma usokhemisi ngaphambi kokusebenzisa noma iyiphi yale mikhiqizo ngenkathi uthatha i-Neulasta.

I-Neulasta nokudla

Akukho ukudla okuye kwabikwa ngokukhethekile ukuthi kusebenzisana neNeulasta. Uma unemibuzo mayelana nokudla ukudla okuthile ngenkathi uthatha i-Neulasta, khuluma nodokotela wakho.

Izindleko ze-Neulasta

Njengayo yonke imithi, izindleko ze-Neulasta zingahluka.

Inani langempela ozolikhokha lizoya ngohlelo lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

Kubalulekile ukuthi wazi ukuthi kuzodingeka uthole iNeulasta ekhemisi ekhethekile. Lolu hlobo lwekhemisi lugunyaziwe ukuphatha imithi ekhethekile. Lezi yizidakamizwa ezingabiza kakhulu noma ezingadinga usizo kochwepheshe bezokunakekelwa kwezempilo ukuze zisetshenziswe ngokuphepha nangempumelelo.

Uhlelo lwakho lomshuwalense lungadinga ukuthi uthole ukugunyazwa kwangaphambili ngaphambi kokuvumela ukufakwa kwe-Neulasta. Lokhu kusho ukuthi udokotela wakho nenkampani yomshuwalense bazodinga ukuxhumana ngomuthi wakho ngaphambi kokuba inkampani yomshuwalense izokwemboza umuthi. Inkampani yomshwalense izosibuyekeza isicelo bese ikwazisa wena nodokotela wakho ukuthi uhlelo lwakho luzohlanganisa i-Neulasta.

Uma ungaqiniseki ukuthi uzodinga ukuthola ukugunyazwa kwangaphambili kwe-Neulasta, xhumana nohlelo lwakho lomshuwalense.

Usizo lwezezimali nolomshuwalense

Uma udinga ukwesekwa kwezezimali ukukhokhela i-Neulasta, noma uma udinga usizo lokuqonda ukutholakala komshuwalense wakho, usizo luyatholakala.

I-Amgen Inc., umkhiqizi weNeulasta, unikela ngezinhlelo ezibizwa nge-Amgen FIRST STEP ne-Amgen Assist 360. Ukuthola eminye imininingwane nokuthola ukuthi ukulungele yini ukwesekwa, shayela ku-888-657-8371 noma uvakashele iwebhusayithi yohlelo.

Uhlobo lwe-Biosimilar

INeulasta itholakala ngezinhlobo ezintathu ze-biosimilar: iFulphila, i-Udenyca, neZiextenzo.

I-biosimilar yisidakamizwa esifana nomuthi wegama lomkhiqizo. Umuthi ojwayelekile, ngakolunye uhlangothi, uyikhophi ngqo yesithako esisebenzayo kumuthi wegama lomkhiqizo.

Ama-biosimilars asuselwa kuzidakamizwa ze-biologic, ezidalwe kusuka ezingxenyeni zezinto eziphilayo. Izakhi zokwenziwa zisuselwa emithini ejwayelekile eyenziwe ngamakhemikhali. Ama-biosimilars nemithi ejwayelekile nayo ibiza izindleko ezingaphansi kwezidakamizwa ezibizwa ngegama.

Ukuthola ukuthi izindleko zeFulphila, Udenyca, neZiextenzo ziqhathaniswa kanjani nezindleko zeNeulasta, vakashela iGoodRx.com. Futhi, izindleko ozithola ku-GoodRx.com yilokho ongakukhokha ngaphandle komshwalense.Inani langempela ozolikhokha lizoya ngohlelo lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

Uma udokotela wakho enikeze uNeulasta futhi unentshisekelo yokusebenzisa iFulphila, Udenyca, neZiextenzo esikhundleni salokho, khuluma nodokotela wakho. Bangaba nokuthanda kwenguqulo eyodwa noma enye. Kuzodingeka futhi uhlole uhlelo lwakho lomshuwalense, ngoba lungahlanganisa eyodwa noma enye kuphela.

Ungayithatha kanjani iNeulasta

Kufanele uthathe i-Neulasta ngokuya ngemiyalo kadokotela wakho noma yomhlinzeki wezokunakekelwa kwempilo.

Ukuthatha nini

INeulasta iza ngezindlela ezimbili. Esinye isirinji ekhethwe ngomthamo owodwa. Leli fomu linikezwa usuku ngemuva kokuthola i-chemotherapy njengomjovo ongaphansi (umjovo ngqo ngaphansi kwesikhumba sakho). Umhlinzeki wezokunakekelwa kwempilo uzokunika umjovo we-Neulasta, noma ungakwazi ukuzinikeza umjovo ekhaya ngemuva kokuqeqeshwa.

Ifomu lesibili libizwa ngeNeulasta Onpro. Kuyinto yokujova umzimba (OBI) umhlinzeki wezokunakekelwa kwempilo azoyisebenzisa esiswini sakho noma emuva kwengalo yakho. Bazokwenza lokhu ngosuku olufanayo lapho uthola khona i-chemotherapy.

Ngemuva kwalokho i-OBI izoletha ngokuzenzakalela umthamo wakho we-Neulasta cishe amahora angama-27 ngemuva kokunamathiselwa. Lokhu kusho ukuthi awudingi ukubuyela ehhovisi likadokotela wakho ukujova.

Kubalulekile ukuqaphela ukuthi i-Neulasta Onpro ayisetshenziselwa ukwelapha ukugula kwemisebe.

I-Neulasta nokukhulelwa

Akwaziwa ukuthi i-Neulasta iphephile yini ukuyithatha ngesikhathi sokukhulelwa.

Izifundo zenziwe ezilwaneni ezikhulelwe ezinikezwe i-filgrastim (umuthi ofana neNeulasta). Abaphenyi abatholanga bungozi obengeziwe bokukhubazeka kokuzalwa, ukuphuphuma kwesisu, noma izinkinga zempilo ezinganeni noma kumama.

Kodwa-ke, izifundo zezilwane azikhombisi njalo ukuthi kwenzekani kubantu. Ucwaningo oluningi nge-Neulasta nokukhulelwa luyadingeka.

Uma ukhulelwe noma uhlela ukukhulelwa, khuluma nodokotela wakho ngaphambi kokusebenzisa i-Neulasta. Bangachaza ubungozi nezinzuzo zomuthi kanye nezinye izindlela zokwelashwa.

I-Neulasta nokulawulwa kokuzalwa

Akwaziwa ukuthi i-Neulasta iphephile yini ukuyithatha ngesikhathi sokukhulelwa. (Bheka isigaba se- "Neulasta nokukhulelwa" ngenhla ukuze ufunde kabanzi.) Uma uhlanganyela ocansini futhi wena noma umlingani wakho ningakhulelwa, khuluma nodokotela wakho ngezidingo zakho zokulawulwa kokubeletha ngenkathi usebenzisa i-Neulasta.

I-Neulasta nokuncelisa

Akwaziwa noma kuphephile yini ukuthatha i-Neulasta ngenkathi uncelisa.

Asazi ukuthi umuthi osebenzayo eNeulasta, pegfilgrastim, ukhona ebisini lwebele lomuntu.

Uma uthatha i-Neulasta futhi ucabangela ukuncelisa, khuluma nodokotela wakho.

Ukuqapha kwe-Neulasta

Lesi sidakamizwa siza nokuqapha okuningi. Ngaphambi kokuthatha i-Neulasta, khuluma nodokotela wakho ngomlando wakho wezempilo. INeulasta ingahle ingakulungeli uma unezimo ezithile zezokwelapha noma ezinye izinto ezithinta impilo yakho. Lokhu kufaka phakathi:

  • Umdlavuza othile wegazi. Uma unomdlavuza we-myeloid (umdlavuza obandakanya umnkantsha wethambo), akufanele usebenzise i-Neulasta. Isidakamizwa singadala ukukhula kwesimila kubantu abanomdlavuza othile wegazi, ikakhulukazi umdlavuza we-myeloid. Izimila ziyizinqwaba zezicubu ezinomdlavuza. Buza udokotela wakho ukuthi yiziphi ezinye izindlela zokwelashwa ezingaba ukukhetha okungcono kuwe.
  • Ukuphazamiseka kwamaseli okugula. Ukuthatha i-Neulasta uma unesifo se-sickle cell kungadala inkinga ye-sickle cell, engabulala. (Lesi sifo sithinta i-hemoglobin, etholakala kumaseli abomvu egazi.) Uma unesifo se-sickle cell disorder, khuluma nodokotela wakho ngaphambi kokusebenzisa i-Neulasta. Bangakuncoma izindlela ezingcono kakhulu zokwelashwa.
  • Ukungezwani komzimba nama-acrylics. Uma uxabana nezinto zokunamathisela ze-acrylic, akufanele usebenzise i-Neulasta Onpro, i-Neulasta injector on-body. Idivayisi isebenzisa i-acrylic adhesive. Buza udokotela wakho ukuthi isirinji ekhethiwe ye-Neulasta ingukukhetha okuhle kuwe.
  • Ukungezwani komzimba ne-latex. Uma une-latex yokungezwani nezinto ezithile, akufanele usebenzise imijovo ekhethiwe ye-Neulasta. Ikepisi lenaliti emasirinji linerabha yemvelo ethathwe ku-latex. Buza udokotela wakho ukuthi ngabe i-Neulasta Onpro on-body injector iyisinqumo esihle kuwe.
  • Ukungezwani komzimba ne-Neulasta. Uma uxabana neNeulasta noma ezinye izithako zayo, akufanele usebenzise lesi sidakamizwa. Buza udokotela wakho ngezinye izindlela zokwelashwa.
  • Ukukhulelwa. Akwaziwa ukuthi i-Neulasta iphephile yini ukusebenzisa ngesikhathi sokukhulelwa. Ngeminye imininingwane, sicela ubheke isigaba se- "Neulasta nokukhulelwa" ngenhla.
  • Ukuncelisa ibele. Akwaziwa noma kuphephile yini ukuthatha i-Neulasta ngenkathi uncelisa. Ngeminye imininingwane, sicela ubheke isigaba se- "Neulasta nokuncelisa ibele" ngenhla.

Qaphela: Ukuthola eminye imininingwane ngemiphumela emibi engaba khona ye-Neulasta, bheka isigaba se- "Neulasta side effects" ngenhla.

Ukudlula ngokweqile kwe-Neulasta

Ukusebenzisa okungaphezu kwesilinganiso esinconyiwe se-Neulasta kungaholela emiphumeleni emibi kakhulu.

Izimpawu zokudlula ngokweqile

Izimpawu zokudlula ngokweqile zingabandakanya:

  • ukuqunjelwa nokugcina uketshezi
  • ubuhlungu bamathambo
  • ukuphelelwa umoya
  • i-pleural effusion (amanzi akha amanzi emaphashini)

Okufanele ukwenze uma kwenzeka ukweqisa ngokweqile

Uma ucabanga ukuthi uthathe kakhulu lo muthi, shayela udokotela wakho. Ungashayela futhi i-American Association of Poison Control Centers ku-800-222-1222 noma usebenzise ithuluzi labo eliku-inthanethi. Kepha uma izimpawu zakho zinzima, shayela ku-911 noma uye egumbini lezimo eziphuthumayo eliseduze ngokushesha.

Ukuphelelwa yisikhathi kwe-Neulasta, ukugcina nokulahla

Uma uthola i-Neulasta ekhemisi, usokhemisi uzokwengeza usuku lokuphelelwa yisikhathi kwilebula ebhokisini noma kwikhathoni. Lolu suku luvame unyaka owodwa kusukela ngosuku abakhipha ngalo umuthi.

Usuku lokuphelelwa isikhathi lusiza ukuqinisekisa ukuthi umuthi uyasebenza ngalesi sikhathi. Isimo samanje se-Food and Drug Administration (i-FDA) ukugwema ukusebenzisa imishanguzo ephelelwe yisikhathi.

Uma usebenzise umuthi ongasetshenziswanga osudlulile esikhathini sokuphelelwa yisikhathi, khuluma nosokhemisi wakho mayelana nokuthi usengakwazi yini ukuwusebenzisa.

Isitoreji

Ukuthi umuthi uhlala ulungile isikhathi eside kangakanani kungancika ezintweni eziningi, kufaka phakathi ukuthi uwugcina kanjani futhi kuphi umuthi.

Kufanele ugcine imijovo ekhethiwe ye-Neulasta esiqandisini (36 ° F kuye ku-46 ° F / 2 ° C kuye ku-8 ° C). Ungaziqandisi. Kepha uma ziba yiqhwa, vumela imijovo iphonseke esiqandisini ngaphambi kokuyisebenzisa. Uma isirinji ifriziwe isikhathi esingaphezu kwesisodwa, yilahle.

Kufanele futhi ulahle noma yimaphi amasirinji owagcine ekamelweni lokushisa isikhathi esingaphezu kwamahora angama-48. Ekugcineni, ungalokothi unyakazise imijovo ye-Neulasta.

Ukulahlwa

Nalu olunye ulwazi lokuthi ungayilahla kanjani imijovo ekhethiwe yeNeulasta kanye neNeulasta Onpro.

Neulasta imijovo ekhethiwe

Ngemuva nje kokusebenzisa isiponji esigcwalisiwe se-Neulasta, silahle esitsheni sokulahla esivunyelwe i-FDA. Lokhu kusiza ukuvimbela abanye, kufaka phakathi izingane nezilwane ezifuywayo, ekuthatheni lesi sidakamizwa ngengozi noma ukuzilimaza ngenaliti.

Ungathenga isitsha esibukhali online, noma ubuze udokotela wakho, usokhemisi, noma inkampani yomshuwalense wezempilo ukuthi ungayithola kuphi.

Lo mbhalo unikeza ngamathiphu amaningi awusizo ngokulahlwa kwemithi. Ungabuza futhi usokhemisi wakho ukuthola imininingwane yokuthi ungawalahla kanjani amasirinji akho.

I-Neulasta Onpro

Uma usebenzisa i-Neulasta Onpro, kunemiyalo ekhethekile yokulahla. Ngemuva kokuthola umthamo wakho ogcwele, kufanele ufake iNeulasta Onpro esitsheni esibukhali.

Umenzi weNeulasta Onpro unohlelo lweSharps Disposal Container Program ukukusiza ulahle ngokuphepha iNeulasta Onpro. Lokhu kunikezwa ngaphandle kwezindleko ezengeziwe kuwe. Ungachofoza lapha ukuze ubhalisele uhlelo, noma ushayele ku-844-696-3852.

Imininingwane yobuchwepheshe yeNeulasta

Imininingwane elandelayo inikezwa odokotela nabanye ochwepheshe bezempilo.

Izinkomba

I-Neulasta ikhonjisiwe yokwehlisa ingozi yokutheleleka ezigulini ezinokulimala okungelona i-myeloid elashwa ngomuthi wokwelapha umdlavuza we-myelosuppressive odala i-febrile neutropenia.

INeulasta ibuye ivunyelwe ngokwanda kokusinda kubantu abane-hematopoietic subsyndrome ye-acute radiation syndrome (ukugula ngemisebe).

Indlela yokusebenza

Isithako esisebenzayo eNeulasta, i-pegfilgrastim, siyinto yokwakha ikholoni yokwakha. Ibophezela kuma-receptors ebusweni beseli lamaseli we-hematopoietic, okubangela ukwanda kwawo, umehluko, nokwenza kusebenze. Lokhu kubangela ukwanda kwenani eliphelele le-neutrophil (ANC).

I-Pharmacokinetics ne-metabolism

Isikhathi sempilo se-serum se-Neulasta ngemuva kokuphathwa kwesikhumba kusuka kumahora ayi-15 kuye kwangama-80.

Iziguli ezinesisindo somzimba esiphezulu zithole ukuvezwa okuphezulu kohlelo ku-Neulasta ezivivinyweni zokwelashwa, okuqokomisa ukubaluleka kokulandela izincomo zokulinganisa ezenzelwe isisindo ezinikezwe ngumenzi.

Yize umenzi enganikeli ngemininingwane ethile ye-pharmacokinetic maqondana nobude besikhathi sokusebenza kwayo, izifundo zokwelashwa zikhombisile ukuthi i-ANC ithatha cishe izinsuku eziyi-10 kuye kwezingu-14 kusukela ngosuku lokuphathwa kwamakhemikhali ukubuyela emazingeni ajwayelekile lapho i-Neulasta inikezwa ngosuku olulandelayo olulandela i-chemotherapy.

Ukuhlushwa okuphezulu kwe-Neulasta

Ngemuva kokuphathwa okungaphansi, ukugxila okuphezulu kwe-Neulasta kwenzeka cishe emahoreni ayi-16 kuye kwayi-120 emuva kokuthakwa komthamo.

Izimo

I-Neulasta iyaphikiswa ezigulini ezinomlando wokusabela okubi kakhulu kwe-pegfilgrastim noma i-filgrastim.

Isitoreji

Imijovo ekhethiwe ye-Neulasta kufanele ifakwe esiqandisini phakathi kuka-36 ° F no-46 ° F (2 ° C no-8 ° C). Imijovo kufanele igcinwe ebhokisini lokuqala ukuvikela ekukhanyeni. Imijovo eshiywe ekamelweni lokushisa isikhathi esingaphezu kwamahora angama-48 kufanele ilahlwe.

Ungafrizi imijovo. Kepha uma imijovo iba yiqhwa, yiphonse esiqandisini ngaphambi kokuyisebenzisa. Lahla noma imiphi imijovo efriziwe isikhathi esingaphezu kwesisodwa.

Amakhithi we-Neulasta Onpro kufanele afakwe esiqandisini phakathi kuka-36 ° F no-46 ° F (2 ° C no-8 ° C) kuze kube yimizuzu engama-30 ngaphambi kokuwasebenzisa. Ungagcini amakhithi ekamelweni lokushisa amahora angaphezu kwangu-12 ngaphambi kokuwasebenzisa. Uma amakhithi agcinwa ekamelweni lokushisa isikhathi esingaphezu kwamahora ayi-12, lahla.

Ukuzikhulula: IMedical News Namuhla yenze yonke imizamo yokuqinisekisa ukuthi yonke imininingwane iyiqiniso, iphelele futhi ihambisana nesikhathi. Kodwa-ke, le ndatshana akufanele isetshenziswe njengokungena esikhundleni solwazi nobungoti bochwepheshe bezokunakekelwa kwezempilo onelayisense. Kufanele uhlale uthintana nodokotela wakho noma omunye uchwepheshe wezokunakekelwa kwempilo ngaphambi kokuthatha noma imuphi umuthi. Imininingwane yezidakamizwa equkethwe lapha ingashintsha futhi ayihloselwe ukumboza konke ukusetshenziswa okungaba khona, izinkomba, izixwayiso, izexwayiso, ukuxhumana kwezidakamizwa, ukungezwani komzimba, noma imiphumela emibi. Ukungabikho kwezixwayiso noma olunye ulwazi lomuthi othile awukhombisi ukuthi inhlanganisela yezidakamizwa noma yezidakamizwa iphephile, iyasebenza, noma ilungele zonke iziguli noma konke ukusetshenziswa okuthile.

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