I-Short-Chain Fatty Acids Iyithinta Kanjani Impilo Nesisindo

-Delile

• Yini i-Short-Chain Fatty Acids?
• Imithombo Yokudla Yama-Acid-Chain Fatty Acid
• I-Short-Chain Fatty Acids kanye nokuphazamiseka kokugaya ukudla
• Uhudo
• Izifo Zamathumbu Okuvuvukala
• Ama-Fatty-Chain Fatty Acids kanye Nomdlavuza Wamakholoni
• I-Short-Chain Fatty Acids neSifo Sikashukela
• I-Short-Chain Fatty Acids kanye Nokwehlisa Isisindo
• I-Short-Chain Fatty Acids Nempilo Yenhliziyo
• Ingabe Kufanele Uthathe Isengezo?
• Thatha Umlayezo Wekhaya

Ama-fatty chain-short chain akhiqizwa ngama-bacteria anobungane esiswini sakho.

Eqinisweni, zingumthombo oyinhloko wokudla okunomsoco kumaseli kukholoni yakho.

Ama-fatty chain-short chain nawo angadlala indima ebalulekile kwezempilo nasezifweni.

Banganciphisa ubungozi bezifo ezivuthayo, uhlobo lwesibili sikashukela, ukukhuluphala, isifo senhliziyo nezinye izimo ().

Lo mbhalo uhlola ukuthi ama-fatty-chain fatty acids ayithinta kanjani impilo.

Yini i-Short-Chain Fatty Acids?

Ama-fatty-chain fatty chain anamafutha acid anama-athomu angaphansi kuka-6 wekhabhoni (C) ().

Akhiqizwa lapho ama-gut gut anobungani evundisa ifayibha kukholoni yakho, futhi angumthombo oyinhloko wamandla kumaseli afaka ikholoni yakho.

Ngalesi sizathu, badlala indima ebalulekile kwezempilo yekoloni ().

Ama-fatty acids amaningi angaphezulu asetshenziselwa eminye imisebenzi emzimbeni. Isibonelo, bangahlinzeka cishe ngo-10% wezidingo zakho zansuku zonke zekhalori ().

Ama-fatty-chain fatty acids nawo abandakanyekile ekuguqulweni komzimba kwezakhi ezibalulekile ezinjenge-carbs namafutha ().

Cishe ama-95% wama-fatty-chain fatty emzimbeni wakho yi:

• I-Acetate (C2).
• I-Propionate (C3).
• I-Butyrate (C4).

I-Propionate ibandakanyeka kakhulu ekukhiqizeni i-glucose esibindini, kuyilapho i-acetate ne-butyrate ifakwa kwamanye ama-acid namafutha ().

Izici eziningi zithinta inani lama-acid fatty chain ku-colon yakho, kufaka phakathi ukuthi mangaki ama-microorganisms akhona, umthombo wokudla nesikhathi okuthatha ukudla ukuhamba ngohlelo lwakho lokugaya ukudla ().

Ama-acid fatty-chain akhiqizwa lapho i-fiber ivutshelwa kukholoni. Zisebenza njengomthombo wamandla amangqamuzana agqoke ikholoni.

Imithombo Yokudla Yama-Acid-Chain Fatty Acid

Ukudla ukudla okuningi okune-fiber, njengezithelo, imifino nemidumba, kuxhunyaniswe nokwanda kwama-fatty chain acid ().

Ucwaningo olulodwa lwabantu abayi-153 luthole ubudlelwane obuhle phakathi kokudla okuphezulu kokudla kwezitshalo kanye namazinga akhuphukayo wama-fatty chain fat at stools (7).

Kodwa-ke, inani nohlobo lwefayibha oyidlayo kuthinta ukwakheka kwamagciwane esiswini sakho, okuthinta ukuthi yimaphi ama-fatty chain fat akhiqizwa ().

Isibonelo, ucwaningo lukhombisile ukuthi ukudla ifayibha eyengeziwe kwandisa ukukhiqizwa kwe-butyrate, ngenkathi ukunciphisa ukungena kwakho kwe-fiber kunciphisa ukukhiqizwa ().

Izinhlobo ezilandelayo ze-fiber zingcono kakhulu ekukhiqizeni ama-fatty-chain fatty acids kukholoni (,):

• Inulin: Ungathola i-inulin kuma-artichokes, u-garlic, amalikhi, u-anyanisi, ukolweni, i-rye ne-asparagus.
• I-Fructooligosaccharides (i-FOS): Ama-FOS atholakala ezithelweni nasemifino ehlukahlukene, kufaka phakathi ubhanana, u-anyanisi, ugarlic kanye ne-asparagus.
• Isitashi Esimelana: Ungathola isitashi esimelana nokusanhlamvu, ibhali, ilayisi, ubhontshisi, ubhanana oluhlaza, imidumba namazambane okuphekiwe kwaphola.
• I-Pectin: Imithombo emihle ye-pectin ifaka ama-apula, amabhilikosi, izaqathe, amawolintshi nokunye.
• I-Arabinoxylan: I-Arabinoxylan itholakala ezinhlamvini zokusanhlamvu. Isibonelo, iyi-fiber ejwayelekile kakhudlwana kukolweni we-kakolweni, okwenza cishe i-70% yengqikithi yengqikithi yefayibha.
• Ushingamu Ushungamu ungakhishwa kubhontshisi we-guar, okuyimidumba.

Ezinye izinhlobo zoshizi, ibhotela nobisi lwenkomo nazo ziqukethe inani elincane le-butyrate.

Ukudla okune-fiber eningi, njengezithelo, imifino, okusanhlamvu kanye nezinhlamvu ezigcwele, kukhuthaza ukukhiqizwa kwama-acid fatty chain.

I-Short-Chain Fatty Acids kanye nokuphazamiseka kokugaya ukudla

Ama-fatty-chain fat-chain angasiza ekuphazamisweni kokugaya ukudla.

Isibonelo, i-butyrate inemiphumela yokulwa nokuvuvukala esiswini ().

Uhudo

Amabhaktheriya akho esiswini aguqula isitashi esimelana ne-pectin sibe ngama-fatty chain fat-chain, futhi ukuwadla kukhonjisiwe ukunciphisa isifo sohudo ezinganeni (,).

Izifo Zamathumbu Okuvuvukala

I-ulcerative colitis kanye nesifo sikaCrohn yizinhlobo ezimbili eziyinhloko zezifo zamathumbu ezivuthayo (IBD). Zombili zibonakala ngokuvuvukala kwamathumbu okungapheli.

Ngenxa yezindawo zayo ezilwa nokuvuvukala, i-butyrate isetshenziselwe ukwelapha zombili lezi zimo.

Ucwaningo kumagundane lukhombisile ukuthi izithasiselo ze-butyrate zinciphisa ukuvuvukala kwamathumbu, futhi izithasiselo ze-acetate zinezinzuzo ezifanayo. Ngokwengeziwe, amazinga aphansi e-fatty chain fatty acids axhumene ne-ulcerative colitis (,).

Izifundo zabantu ziphinde ziphakamise ukuthi ama-fatty-chain fatty acids, ikakhulukazi i-butyrate, angathuthukisa izimpawu zesifo sezilonda kanye nesifo sikaCrohn (,,,).

Ucwaningo olubandakanya iziguli ezingama-22 ezine-ulcerative colitis luthole ukuthi ukusebenzisa ama-gramu angama-60 e-oat bran nsuku zonke izinyanga ezintathu kuthuthukise izimpawu ().

Olunye ucwaningo oluncane luthole ukuthi izithasiselo ze-butyrate ziholele ekuthuthukisweni komtholampilo nasekuxolelweni kweziguli ezingama-53% zezifo zikaCrohn ().

Ezigulini ze-ulcerative colitis, i-enema yama-fatty chain chain fatty, kabili ngosuku amasonto ayisithupha, isize ukunciphisa izimpawu ngo-13% ().

Ama-fatty-chain fat-chain anganciphisa isifo sohudo futhi asize ekwelapheni izifo zamathumbu ezivuthayo.

Ama-Fatty-Chain Fatty Acids kanye Nomdlavuza Wamakholoni

Ama-fatty-chain fat-chain angadlala indima enkulu ekuvikeleni nasekwelapheni umdlavuza othile, ikakhulukazi umdlavuza wamakholoni (,,).

Ucwaningo lweLab lubonisa ukuthi i-butyrate isiza ukugcina amangqamuzana ekholoni enempilo, ivimbela ukukhula kwamangqamuzana e-tumor futhi ikhuthaze ukubhujiswa kwamangqamuzana omdlavuza kukholoni (,,,).

Kodwa-ke, indlela esebenza ngemuva kwalokhu ayiqondakali kahle (,,).

Ucwaningo oluningi lokuhlola lubonisa ukuxhumana phakathi kokudla okuphezulu kwe-fiber kanye nengozi encishisiwe yomdlavuza wekoloni. Ochwepheshe abaningi basikisela ukuthi ukukhiqizwa kwama-fatty chain fat-chain kungaba yingxenye yalokhu (,).

Ezinye izifundo zezilwane futhi zibika ukuxhumana okuhle phakathi kokudla okuphezulu kwe-fiber kanye nengozi encishisiwe yomdlavuza wekoloni (,).

Kokunye ukuhlola, amagundane ekudleni okunefayibha ephezulu, amathumbu awo aqukethe amabhaktheriya akhiqiza i-butyrate, athola izicubu ezimbalwa ezingama-75% kunamagundane angenawo amabhaktheriya ().

Kuyathakazelisa ukuthi ukudla okuphezulu kwe-fiber kukodwa - ngaphandle kwamagciwane okwenza i-butyrate - akubanga nemiphumela yokuvikela umdlavuza wekoloni. Ukudla okune-fiber encane - noma ngabe kunamagciwane akhiqiza i-butyrate - nakho bekungasebenzi ().

Lokhu kuphakamisa ukuthi izinzuzo ezilwa nomdlavuza zitholakala kuphela lapho ukudla okunomthamo omkhulu kuhlanganiswa namagciwane afanelekile esiswini.

Kodwa-ke, izifundo zabantu zihlinzeka ngemiphumela exubile. Abanye bakhombisa ukuxhumana phakathi kokudla okuphezulu kwe-fiber kanye nokwehla kwengozi yomdlavuza, kanti abanye abatholi sixhumanisi (,,,).

Kodwa-ke lezi zifundo azizange zibheke emathunjini amabhaktheriya, futhi umehluko ngamanye emathunjini wegciwane angadlala indima.

Ama-fatty-chain fatty acids akhonjisiwe ukuvikela umdlavuza wekoloni ezifundweni zezilwane nezelebhu. Noma kunjalo, kudingeka olunye ucwaningo.

I-Short-Chain Fatty Acids neSifo Sikashukela

Ukubuyekezwa kobufakazi kubike ukuthi i-butyrate ingaba nemiphumela emihle kuzo zombili izilwane nabantu abane-type 2 diabetes ().

Ukubuyekezwa okufanayo kuphinde kwagcizelela ukuthi kubonakala sengathi kukhona ukungalingani kumathumbu ama-microorganisms kubantu abanesifo sikashukela (,).

Ama-fatty-chain fatty acids akhonjisiwe ukuthi akhulisa umsebenzi we-enzyme esibindini nasemisipheni yezicubu, okuholela ekulawuleni ushukela wegazi kangcono (,,).

Ezifundweni zezilwane, ama-acetate kanye ne-propionate supplements athuthukise amazinga kashukela egazini kumagundane esifo sikashukela namagundane ajwayelekile (,,).

Kodwa-ke kunezifundo ezimbalwa ezibandakanya abantu, futhi imiphumela ixubekile.

Olunye ucwaningo luthole ukuthi ama-propionate supplements anciphise amazinga kashukela egazini, kepha olunye ucwaningo luthole ukuthi izithasiselo ezinama-acid ezinama-short-chain azikuthinti kakhulu ukulawulwa kukashukela egazini kubantu abaphilile (,).

Izifundo eziningi zabantu zibike nokuhlangana phakathi kwefayibha evutshelwayo nokulawulwa ushukela osegazini kanye nokuzwela kwe-insulin (,).

Kodwa-ke lo mphumela uvame ukubonakala kubantu abakhuluphele ngokweqile noma abangazweli ku-insulin, hhayi kubantu abaphilile (,,).

Ama-fatty-chain fatty acids abonakala esiza ukulawula amazinga kashukela egazini, ikakhulukazi kubantu abanesifo sikashukela noma i-insulin.

I-Short-Chain Fatty Acids kanye Nokwehlisa Isisindo

Ukwakheka kwamagciwane amancane esiswini kungathinta ukumuncwa komsoco nokulawulwa kwamandla, ngaleyo ndlela kube nomthelela ekukhuleni kokukhuluphala (,).

Ucwaningo lukhombisile ukuthi ama-fatty-chain fatty acids futhi alawula imetabolism yamafutha ngokwandisa ukushiswa kwamafutha nokunciphisa ukugcinwa kwamafutha ().

Lapho lokhu kwenzeka, inani lamafutha acid amahhala egazini liyancipha, futhi lingasiza futhi ekuvikeleni ekuzuzeni isisindo (,,,).

Izifundo eziningana zezilwane zihlolisise lo mphumela. Ngemuva kokwelashwa kwamaviki ama-5 nge-butyrate, amagundane akhuluphele alahlekelwa yi-10.2% yesisindo somzimba wawo wokuqala, namafutha omzimba ancishiswa ngo-10%. Kumagundane, izengezo ze-acetate zinciphise ukugcinwa kwamafutha (,).

Kodwa-ke, ubufakazi obuxhumanisa ama-fatty-chain fatty acids ekunciphiseni isisindo bususelwa ikakhulu ezifundweni zezilwane kanye ne-test-tube.

Ucwaningo lwezilwane nolwe-test-tube lukhombisa ukuthi ama-fatty-chain fatty acids angasiza ekuvimbeleni nasekwelapheni ukukhuluphala. Noma kunjalo, izifundo zabantu ziyadingeka.

I-Short-Chain Fatty Acids Nempilo Yenhliziyo

Izifundo eziningi zokubheka zixhume ukudla okuphezulu kwefayibha engcupheni encishisiwe yesifo senhliziyo.

Kodwa-ke, amandla alo nhlangano ngokuvamile ancike kohlobo lwefayibha nomthombo ().

Kubantu, ukudla i-fiber nakho kuye kwaxhunyaniswa nokuncipha kokuvuvukala ().

Esinye sezizathu zokuthi i-fiber inciphise ubungozi besifo senhliziyo kungahle kube ngenxa yokukhiqizwa kwama-fatty-chain fatty colon (,,).

Ucwaningo kuzo zombili izilwane nabantu lubike ukuthi ama-fatty-chain fatty acids anciphisa amazinga e-cholesterol (,,,,).

I-Butyrate kucatshangwa ukuthi ihlangana nezakhi zofuzo ezisemqoka ezenza i-cholesterol, mhlawumbe inciphise ukukhiqizwa kwe-cholesterol ().

Isibonelo, ukukhiqizwa kwe-cholesterol kwehle kwizibindi zamagundane anikezwe izithako ze-propionate. I-Acetic acid iphinde yehlise amazinga e-cholesterol kumagundane (,,).

Lo mphumela ofanayo ubonwe kubantu abakhuluphele, njengoba i-acetate kuviniga yehlisa inani le-cholesterol eyeqile egazini ().

Ama-fatty-chain fat-chain anganciphisa ingozi yesifo senhliziyo ngokunciphisa ukuvuvukala nokuvimba ukukhiqizwa kwe-cholesterol.

Ingabe Kufanele Uthathe Isengezo?

Izithasiselo zama-acid ezinama-chain amafushane zivame ukutholakala njengosawoti be-butyric acid.

Lezi zivame ukubizwa nge-sodium, potassium, calcium noma i-magnesium butyrate. Zitholakala kalula ku-intanethi noma ngaphezulu kwe-counter.

Kodwa-ke, ama-supplements kungenzeka angabi yindlela engcono kakhulu yokwandisa amazinga akho ama-fatty chain fatty. Izithasiselo ze-Butyrate zimuncwa ngaphambi kokuba zifinyelele kukholoni, imvamisa emathunjini amancane, okusho ukuthi zonke izinzuzo zamaseli ekholoni zizolahleka.

Ngokwengeziwe, kunobufakazi obuncane kakhulu besayensi mayelana nokusebenza kwama-supplements e-short-chain fatty supplements.

I-Butyrate ifinyelela ikholoni kahle kakhulu lapho ibilisiwe kusuka ku-fiber. Ngakho-ke, ukwandisa inani lokudla okuphezulu kwe-fiber ekudleni kwakho mhlawumbe kuyindlela engcono kakhulu yokwenza ngcono amazinga akho e-fatty chain.

Ukudla ukudla okune-fiber ephezulu kuyindlela engcono kakhulu yokwandisa amazinga we-fatty chain, njengoba izithako zitholwa ngaphambi kokufinyelela kukholoni.

Thatha Umlayezo Wekhaya

Ngenxa yezindawo zabo ezilwa nokuvuvukala kanye nomdlavuza, kungenzeka ukuthi ama-fatty-chain fatty acids anemiphumela ehlukahlukene enenzuzo emzimbeni wakho.

Yinye into eqinisekile: ukunakekela ama-gut gut wakho onobungane kungaholela enhlanganweni yonke yezinzuzo zezempilo.

Indlela engcono kakhulu yokondla amabhaktheriya amahle esiswini sakho ukudla ukudla okuningi okune-fiber eningi.