Yini i-Kallmann Syndrome

-Delile

• Ziyini izimpawu
• Izimbangela ezingaba khona
• Ukuxilongwa kwenziwa kanjani
• Yini ukwelashwa

I-Kallman's syndrome yisifo esingajwayelekile sofuzo esibonakala ngokulibaziseka kokuthomba nokuncipha noma ukungabi khona kwephunga, ngenxa yokuntuleka kokukhiqizwa kwehomoni ekhipha i-gonadotropin.

Ukwelashwa kuqukethe ukuphathwa kwama-gonadotropin namahomoni ezocansi futhi kufanele kwenziwe ngokushesha okukhulu ukugwema imiphumela engokomzimba nengokwengqondo.

Ziyini izimpawu

Izimpawu zincike kwizakhi zofuzo ezenzeka ekuguqulweni kwezakhi, okuvame kakhulu ukungabi khona noma ukunciphisa iphunga ekubambezelekeni kokuthomba.

Kodwa-ke, ezinye izimpawu zingavela, njengokungaboni kombala, izinguquko ezibukwayo, ubumpumputhe, ulwanga oluqaqekile, ukungahambi kahle kwezinso nokugula kwemizwa nokungabikho kokwehla kwamasende esikhunjeni.

Izimbangela ezingaba khona

I-Kallmann's syndrome isebenza ngenxa yokushintsha kwezakhi zofuzo okufaka amaprotheni abhekele ukukhula kwe-neuronal, kudale ushintsho ekukhuleni kwe-bulb olfactory kanye noshintsho olulandelayo emazingeni e-gonadotropin-release hormone (GnRH).

Ukushoda kweCongenital GnRH kusho ukuthi ama-hormone LH ne-FSH akhiqizwa ngobuningi obanele ukukhuthaza izitho zocansi ukuthi zikhiqize i-testosterone ne-estradiol, ngokwesibonelo, ukubambezela ukuthomba. Bona ukuthi yiziphi izinguquko zomzimba ezenzeka lapho uthomba.

Ukuxilongwa kwenziwa kanjani

Izingane ezingaqali ukukhula kwezocansi cishe eminyakeni engu-13 ubudala emantombazaneni neminyaka engu-14 kubafana, noma izingane ezingathuthuki ngokujwayelekile ngesikhathi sobusha, kufanele zihlolwe ngudokotela.

Udokotela kufanele ahlaziye umlando wezokwelapha womuntu, enze ukuhlolwa komzimba futhi acele ukukalwa kwamazinga we-plasma gonadotropin.

Ukuxilongwa kufanele kwenziwe ngesikhathi sokuqala ukwelashwa ngokufaka ama-hormone futhi kuvimbele imiphumela engokomzimba nengokwengqondo yokubambezeleka kokuthomba

Yini ukwelashwa

Ukwelashwa emadodeni kufanele kwenziwe esikhathini eside, ngokuphathwa kwe-chorionic gonadotropin noma i-testosterone nakwabesifazane abane-cyclic estrogen ne-progesterone.

Inzalo nayo ingabuyiselwa ngokuphatha ama-gonadotropin noma ngokusebenzisa ipompo lokumnika eliphathekayo ukuletha i-pulned subcutaneous GnRH.