I-hepatopulmonary syndrome: kuyini, izimpawu nokwelashwa

-Delile

• Ziyini izimpawu
• Yini ebangela i-hepatopulmonary syndrome
• Ukuxilongwa kwenziwa kanjani
• Yini ukwelashwa

I-Hepatopulmonary syndrome ibonakala ngokuvuleka kwemithambo nemithambo yamaphaphu eyenzeka kubantu abanomfutho wegazi ophakeme emgudwini wesibindi. Ngenxa yokwandiswa kwemithambo yamaphaphu, izinga lokushaya kwenhliziyo liyakhuphuka okwenza ukuthi igazi elidonswa emzimbeni lingabi nomoya-mpilo owenele.

Ukwelashwa kwalesi sifo kuqukethe ukwelashwa komoya-mpilo, ukunciphisa ingcindezi ye-portal vein futhi, ezimweni ezinzima kakhulu, ukufakelwa kwesibindi.

Ziyini izimpawu

Izimpawu ezingenzeka kubantu abanalesi sifo ukuphefumula okuncane lapho umile noma uhleli. Ngaphezu kwalokho, iningi labantu abane-hepatopulmonary syndrome futhi banezimpawu zesifo esingalapheki sesibindi, esingahluka, kuye ngenkinga eyibangelayo.

Yini ebangela i-hepatopulmonary syndrome

Ngaphansi kwezimo ezijwayelekile, i-endothelin 1 ekhiqizwa isibindi inomsebenzi wokulawula ithoni yemithambo yamaphaphu futhi uma ibopha kuma-receptors atholakala ezicutshini zemisipha ebushelelezi yemisipha, i-endothelin 1 ikhiqiza i-vasoconstriction. Kodwa-ke, lapho ibophezela kuma-receptors atholakala ku-pulmonary vascular endothelium, ikhiqiza i-vasodilation ngenxa yokuhlanganiswa kwe-nitric oxide. Ngakho-ke, i-endothelin 1 ilinganisa umphumela wayo we-vasoconstrictor ne-vasodilator futhi isiza ukugcina umoya omncane wamaphaphu ngaphakathi kwemingcele ejwayelekile.

Kodwa-ke, lapho kwenzeka ukulimala kwesibindi, i-endothelin ifinyelela ekusakazeni kwamaphaphu futhi ihlangana ngokukhetha ne-pulmonary vascular endothelium, ikhuthaza i-vasodilation yamaphaphu. Ngaphezu kwalokho, ku-cirrhosis kukhona ukwanda kwamazinga we-tumor necrosis factor alpha, okufaka isandla ekuqoqeni kwama-macrophages ku-lumen yemikhumbi ye-pulmonary evuselela ukukhiqizwa kwe-nitric oxide, futhi okwenza i-vasodilation yamaphaphu, okuvimbela i-oxygenation yabo bonke igazi elimpontshwe.kuya emaphashini.

Ukuxilongwa kwenziwa kanjani

Ukuxilongwa kuqukethe ukuhlolwa kwezokwelapha kanye nokuhlolwa okufana ne-echocardiography ehlukile, i-nuclear lung scintigraphy, izivivinyo zomsebenzi wamaphaphu.

Ngaphezu kwalokho, udokotela futhi angalinganisa inani le-oxygen egazini ngokusebenzisa i-oximetry. Bona ukuthi yini i-oximetry nokuthi ilinganiswa kanjani.

Yini ukwelashwa

Ukwelashwa okuyinhloko kwe-hepatopulmonary syndrome ukuphathwa kwe-oxygen eyengeziwe yokuqeda ukuphefumula, kepha ngokuhamba kwesikhathi isidingo sokwengeza oksijini singakhuphuka.

Njengamanje, akukho ukungenelela kwemithi okukhonjisiwe ukuthi kuguqula kakhulu futhi kuthuthukise i-arterial oxygenation. Ngakho-ke, ukufakelwa kwesibindi ukuphela kwendlela esebenzayo yokwelapha yokuxazulula le nkinga.