Yini i-Vogt-Koyanagi-Harada syndrome

-Delile

• Yini ebangela
• Izimpawu ezingenzeka
• Yelashwa kanjani

IVogt-Koyanagi-Harada Syndrome yisifo esingajwayelekile esithinta izicubu ezinama-melanocyte, njengamehlo, isistimu yezinzwa emaphakathi, indlebe nesikhumba, okwenza ukuvuvukala ku-retina yeso, okuvame ukuhlotshaniswa nezinkinga zesikhumba nezokuzwa.

Lesi sifo sivela ikakhulu kubantu abadala abaphakathi kweminyaka engama-20 nengama-40, kanti abesifazane yibo abathinteka kakhulu. Ukwelashwa kuqukethe ukuphathwa kwama-corticosteroids nama-immunomodulators.

Yini ebangela

Imbangela yalesi sifo ayikaziwa, kodwa kukholelwa ukuthi yisifo esizimele, lapho kukhona khona ubudlova ebusweni bama-melanocyte, okukhuthaza ukusabela kokuvuvukala okunama-T lymphocyte amaningi.

Izimpawu ezingenzeka

Izimpawu zalesi sifo zincike esigabeni okuso:

Isigaba se-Prodromal

Kulesi sigaba, kuvela izimpawu zesistimu ezifana nezimpawu zomkhuhlane, ezihambisana nezimpawu zemizwa ezihlala izinsuku ezimbalwa kuphela. Izimpawu ezivame kakhulu umkhuhlane, ikhanda elibuhlungu, meningism, isicanucanu, isiyezi, ubuhlungu obuzungeze amehlo, i-tinnitus, ubuthakathaka bemisipha obujwayelekile, ukukhubazeka okuyingxenye kolunye uhlangothi lomzimba, ubunzima bokuchaza amagama kahle noma ukubona ulimi, i-photophobia, ukudwengula, isikhumba kanye nekhanda ukuzwela ngokweqile.

Isigaba se-Uveitis

Kulesi sigaba, ukubonakaliswa kwe-ocular kudlangile, njengokuvuvukala kwe-retina, ukwehla kombono futhi ekugcineni kutholwe i-retina. Abanye abantu bangase babe nezimpawu zokuzwa ezinjenge-tinnitus, ubuhlungu nokungahambi kahle ezindlebeni.

Isigaba esingapheli

Kulesi sigaba, izimpawu ze-ocular ne-dermatological ziyabonakala, njenge-vitiligo, ukumiswa kwe-eyelashes, amashiya, angahlala ezinyangeni kuye eminyakeni. IVitiligo ivame ukusatshalaliswa ngokulingana phezu kwekhanda, ebusweni nasesiqwini, futhi ingahlala unomphela.

Isigaba sokuphindaphinda

Kulesi sigaba abantu bangakhula ukuvuvukala okungapheli kwe-retina, i-cataract, i-glaucoma, i-choroidal neovascularization kanye ne-subretinal fibrosis.

Yelashwa kanjani

Ukwelashwa kuqukethe ukuphathwa kwamanani aphezulu ama-corticosteroids afana ne-prednisone noma i-prednisolone, ikakhulukazi esigabeni esibucayi sesifo, okungenani izinyanga eziyisithupha. Lokhu kwelashwa kungadala ukumelana nokungasebenzi kwesibindi futhi kulezi zimo kungenzeka ukhethe ukusetshenziswa kwe-betamethasone noma i-dexamethasone.

Kubantu imiphumela emibi ye-corticosteroids eyenza ukuthi basebenzise imithamo ephumelelayo engagcineki, ama-immunomodulators afana ne-cyclosporine A, methotrexate, azathioprine, tacrolimus noma i-adalimumab angasetshenziswa ngemiphumela emihle.

Ezimweni zokumelana nama-corticosteroids nakubantu abangaphenduli ekwelashweni kwe-immunomodulatory, i-immunoglobulin efakwa ngaphakathi ingasetshenziswa.