I-Soliqua 100/33 (i-insulin glargine / lixisenatide)

-Delile

• Yini iSoliqua 100/33?
• Ukusebenza ngempumelelo
• I-Soliqua 100/33 ejwayelekile
• Isikali se-Soliqua 100/33
• Amafomu wezidakamizwa namandla
• Isikali seSoliqua 100/33
• Kuthiwani uma ngiphuthelwa umthamo?
• Ngabe kuzodingeka ngisebenzise lesi sidakamizwa isikhathi eside?
• Imiphumela emibi ye-Soliqua 100/33
• Imiphumela emibi ejwayelekile
• Imiphumela emibi kakhulu
• Izindleko zeSoliqua 100/33
• Usizo lwezezimali nolomshuwalense
• Ungayithatha kanjani iSoliqua 100/33
• Ungaphatha kanjani
• Isikhathi
• Ukuthatha iSoliqua 100/33 ngokudla
• Ezinye izindlela zeSoliqua 100/33
• I-Soliqua 100/33 vs. Xultophy
• Isebenzisa
• Amafomu wezidakamizwa nokuphathwa
• Imiphumela emibi kanye nezingozi
• Ukusebenza ngempumelelo
• Izindleko
• I-Soliqua 100/33 vs. ezinye izidakamizwa
• I-Soliqua 100/33 vs. Lantus
• I-Soliqua 100/33 vs. Victoza
• I-Soliqua 100/33 vs. Toujeo
• I-Soliqua 100/33 vs. Adlyxin
• Ukusetshenziswa kweSoliqua 100/33
• Ukusetshenziswa kweSoliqua 100/33 nezinye izidakamizwa
• ISoliqua 100/33 notshwala
• Ukusebenzisana kweSoliqua 100/33
• Soliqua 100/33 kanye neminye imithi
• I-Soliqua 100/33 namakhambi nezithako
• Isebenza kanjani iSoliqua 100/33
• I-insulin iwuthinta kanjani ushukela wegazi
• Okwenziwa uSoliqua 100/33
• Kuthatha isikhathi esingakanani ukusebenza?
• Soliqua 100/33 nokukhulelwa
• I-Soliqua 100/33 nokuncelisa ibele
• Imibuzo ejwayelekile ngeSoliqua 100/33
• Ingabe iSoliqua 100/33 ibangela ukuzuza kwesisindo?
• Ingabe i-Soliqua 100/33 i-insulin?
• Ngabe iSoliqua 100/33 isebenza isikhathi eside?
• Ngabe iSoliqua 100/33 ingasetshenziswa ukwelapha uhlobo lwesifo sikashukela sohlobo 1?
• Izexwayiso ze-Soliqua 100/33
• Ukudlula ngokweqile kweSoliqua 100/33
• Izimpawu zokudlula ngokweqile
• Okufanele ukwenze uma kwenzeka ukweqisa ngokweqile
• Ukuphelelwa yisikhathi nokugcinwa kweSoliqua 100/33
• Imininingwane yobuchwepheshe yeSoliqua 100/33
• Izinkomba
• Indlela yokusebenza
• I-Pharmacokinetics ne-metabolism
• Izimo
• Isitoreji

Yini iSoliqua 100/33?

I-Soliqua 100/33 iyimithi kadokotela enegama lomuthi. Isetshenziswa ngokudla nokuvivinya umzimba ukuthuthukisa amazinga kashukela egazini kubantu abadala abanesifo sikashukela sohlobo 2.

I-Soliqua 100/33 iqukethe izidakamizwa ezimbili:

• insulini glargine, eyi-insulin esebenza isikhathi eside
• i-lixisenatide, eyezigaba zemithi ebizwa nge-glucagon-like peptide 1 (GLP-1) receptor agonists

I-Soliqua 100/33 iza njengepeni elinomjovo elisetshenziselwa ukuzilimaza ngaphansi kwesikhumba (ngaphansi kwesikhumba). Ipeni ngalinye liqukethe i-3 mL yesixazululo sezidakamizwa, ngamayunithi ayi-100 e-insulin glargine kanye no-33 mcg we-lixisenatide nge-mL yesisombululo ngasinye. Izibaya zisetshenziswa ngezinaliti zokubhala, ezingafakwanga namapeni.

Ukusebenza ngempumelelo

ISoliqua 100/33 itholakale isebenza ngempumelelo ekwelapheni uhlobo lwesifo sikashukela sohlobo 2. Kwesinye isifundo somtholampilo, iSoliqua 100/33 ihlolwe kubantu abanesifo sikashukela sohlobo lwe-2 abelashwe ngama-insulins asebenza isikhathi eside okungenani izinyanga eziyisithupha. Ngemuva kwamasonto angama-30 elashwa nge-Soliqua 100/33, laba bantu behlise i-hemoglobin A1c (HbA1c) ngamaphesenti ayi-1.1. Futhi banciphise amazinga kashukela egazini azile ngo-5.7 mg / dL.

Kwesinye isifundo somtholampilo, iSoliqua 100/33 isetshenziswe ne-metformin amasonto angama-30. Ucwaningo belubandakanya abantu ababekade belashwa nge-metformin kuphela, noma nge-metformin nangesinye isidakamizwa sikashukela somlomo. Ukwelashwa nge-Soliqua 100/33 kanye ne-metformin kwehlise i-HbA1c ngamaphesenti ayi-1.6. Iphinde yehlisa amazinga kashukela egazini azile ngo-59.1 mg / dL.

I-Soliqua 100/33 ejwayelekile

I-Soliqua 100/33 itholakala kuphela njengomuthi wegama lomkhiqizo. Okwamanje ayitholakali ngendlela ejwayelekile.

I-Soliqua 100/33 iqukethe izidakamizwa ezimbili ezisebenzayo: i-insulin glargine ne-lixisenatide. Asikho isidakamizwa esitholakala ngendlela ejwayelekile.

I-insulin glargine iyi-insulin esebenza isikhathi eside etholakala yodwa njengezidakamizwa ezinamagama anjengeLantus, Toujeo, neBasaglar. ILixisenatide ingeyezigaba zemithi ebizwa nge-glucagon-like peptide 1 (GLP-1) receptor agonists. Itholakala njengegama lomuthi i-Adlyxin.

Isikali se-Soliqua 100/33

Imvamisa, udokotela wakho uzokuqala ngomthamo ophansi weSoliqua 100/33 bese ekulungisa ngokuhamba kwesikhathi ukuze ufinyelele kumthamo okukulungele. Le nqubo yokulungisa ibizwa ngokuthi i-titration. Udokotela wakho ekugcineni uzonikeza isilinganiso esincane kunazo zonke esihlinzeka ngomphumela oyifunayo.

Imininingwane elandelayo ichaza imithamo esetshenziswa kakhulu noma enconywayo. Kodwa-ke, qiniseka ukuthatha isilinganiso udokotela wakho akubekela sona. Udokotela wakho uzonquma isilinganiso esihle kakhulu ukuhlangabezana nezidingo zakho.

Amafomu wezidakamizwa namandla

Iphakeji ngalinye le-Soliqua 100/33 liqukethe izibaya ezinhlanu ezilahlwayo, ezifakiwe ze-Soliqua 100/33 ngebhokisi ngalinye. Izinaliti zepeni azifakwanga nezibaya. (Ezimweni eziningi, ungathenga izinaliti ezibayeni ekhemisi. Ungadinga incwadi kadokotela.)

Ipeni ngalinye elinomjovo liqukethe i-3 mL yesixazululo sezidakamizwa, enamayunithi angama-300 e-insulin glargine kanye ne-100 mcg ye-lixisenatide.

Izibaya zomjovo we-Soliqua 100/33 ngamunye wenzelwe ukuthi isetshenziswe kaningi. Inani lezikhathi lingaba kusuka ezikhathini ezi-5 kuye kwezingu-20, kuya ngomthamo wakho. Ipeni ngalinye lingasetshenziswa kuze kube yizinsuku ezingama-28 ngemuva kokusetshenziswa kokuqala. Ngemuva kwaleso sikhathi, kufanele ulahle ipeni, noma ngabe liqukethe okunye komuthi.

Izinaliti zepeni kufanele zisetshenziswe kanye kuphela.

Isikali seSoliqua 100/33

I-Soliqua 100/33 ijwayele ukunikezwa ngemijovo eyodwa yamayunithi ayi-15 kuye kwangama-60 lilinye. Igama elithi "amayunithi" liyindlela yokukala esetshenziselwa i-insulin glargine equkethwe ku-Soliqua 100/33. Umthamo omkhulu womjovo ngamunye ungamayunithi angama-60, okusho ukuthi amayunithi angama-60 e-insulin glargine kanye nama-20 mcg lixisenatide.

Isilinganiso sokuqala

Umthamo wokuqala onconyiwe weSoliqua 100/33 uncike ekwelashweni kwakho kwangaphambilini kwesifo sikashukela.

Qaphela: Ngaphambi kokuqala i-Soliqua 100/33, kufanele umise konke okunye ukwelashwa nge-lixisenatide noma i-insulin esebenza isikhathi eside.

Isilinganiso sesondlo

Ngemuva kokuqala iSoliqua 100/33, udokotela wakho uzoqapha amazinga kashukela egazini lakho futhi angahle alungise umthamo wakho ukuze ufinyelele inani elifanele wena. Umenzi walesi sidakamizwa uncoma ukufaka isilinganiso somthamo phezulu noma phansi ngamayunithi ama-2 kuye kwangama-4 njalo ngesonto njengoba kudingeka ukuhlangabezana nezinhloso zikashukela wegazi.

Ukulungiswa komthamo

Wena nodokotela wakho nizosebenza ndawonye ukwakha uhlelo lokuhlangabezana nezinhloso zakho zoshukela egazini.

Ngezansi kunesibonelo sokulungiswa kwedosi udokotela wakho angakusikisela. Udokotela wakho uzonquma uma udinga lezi zinguquko. Qinisekisa ukuthatha umthamo udokotela wakho awuncomayo. (Ungaguquli umthamo wakho ngaphandle kwemvume kadokotela wakho.)

Kuthiwani uma ngiphuthelwa umthamo?

Uma uphuthelwa umthamo we-Soliqua 100/33, weqa lowo umthamo bese uqhubeka nomthamo wakho olandelayo ohleliwe. Ungazami ukubamba ngokuthatha umthamo owengeziwe noma ukwandisa umthamo olandelayo. Lokhu kungadala imiphumela emibi eyingozi.

Ngabe kuzodingeka ngisebenzise lesi sidakamizwa isikhathi eside?

Uma i-Soliqua 100/33 isebenza ngempumelelo futhi iphephile kuwe, cishe uzosebenzisa lesi sidakamizwa isikhathi eside. I-Soliqua 100/33 ijwayele ukusetshenziswa isikhathi eside ukwelapha uhlobo lwesifo sikashukela sohlobo 2.

Imiphumela emibi ye-Soliqua 100/33

I-Soliqua 100/33 ingadala imiphumela emibi noma emibi. Uhlu olulandelayo luqukethe eminye yemiphumela emibi engase ivele ngenkathi uthatha i-Soliqua 100/33. Lolu hlu alubandakanyi yonke imiphumela emibi engaba khona.

Ngeminye imininingwane ngemiphumela engemihle ye-Soliqua 100/33, noma amathiphu wokuthi ungabhekana kanjani nemiphumela emibi ekhathazayo, khuluma nodokotela wakho noma usokhemisi.

Imiphumela emibi ejwayelekile

Imiphumela emibi ejwayelekile yeSoliqua 100/33 ingafaka:

• isicanucanu
• izifo zokuphefumula ezifana nomkhuhlane ovamile noma umkhuhlane
• isifo sohudo
• ikhanda
• i-hypoglycemia (ushukela ophansi wegazi)

Iningi lalemiphumela emibi ingahle ihambe ezinsukwini ezimbalwa noma emasontweni ambalwa. Uma zinzima kakhulu noma zingahambi, khuluma nodokotela wakho noma usokhemisi.

Imiphumela emibi kakhulu

Imiphumela emibi ebucayi evela kuSoliqua 100/33 ayijwayelekile, kodwa ingenzeka. Shayela udokotela wakho ngokushesha uma unemiphumela emibi kakhulu. Shayela u-911 uma izimpawu zakho zizizwa zisongela impilo noma uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha.

Imiphumela emibi kanye nezimpawu zayo zingafaka okulandelayo:

• Ukusabela okweqile komzimba. Izimpawu zingafaka:
• ukuqubuka
• ukuqhuma
• ukuvuvukala
• isikhumba esilumayo
• inkinga yokuphefumula
• umfutho wegazi ophansi
• I-Pancreatitis (ukuvuvukala kwamanyikwe). Izimpawu zingafaka:
• ubuhlungu noma isisa esiswini sakho
• ukuhlungu obusemhlane
• isicanucanu
• ukuhlanza
• imfiva
• ukuncipha komzimba
• Ukulimala kwezinso. Izimpawu zingafaka:
• ukunciphisa ukuchama
• ukuvuvukala emilenzeni yakho, emaqakaleni, noma ezinyaweni
• ukudideka
• ukukhathala
• isicanucanu
• ubuhlungu besifuba noma ingcindezi
• ukushaya kwenhliziyo okungajwayelekile
• isithuthwane
• I-Hypokalemia (i-potassium ephansi). Izimpawu zingafaka:
• ubuthakathaka
• ukukhathala
• ukuqunjelwa
• ukuqunjelwa kwemisipha
• ukushaya kwenhliziyo okungajwayelekile

Ukuzuza kwesisindo noma ukunciphisa umzimba

Ekuvivinyweni kwemitholampilo, iSoliqua 100/33 ayitholakalanga ukuthi ibangele ukushintsha kwesisindo. Kodwa-ke, ocwaningweni olulodwa lomtholampilo, abantu abathathe i-Soliqua 100/33 amasonto angama-30 balahlekelwe cishe ngamakhilogremu ayi-1.5.

Ngaphezu kwalokho, izidakamizwa ngazinye eziqukethwe yiSoliqua 100/33 zixhunyaniswe nezinguquko zesisindo. I-Soliqua 100/33 iqukethe i-insulin glargine, i-insulin esebenza isikhathi eside. Izidakamizwa eziqukethe i-insulin zingadala ukuzuza kwesisindo.

I-Soliqua 100/33 futhi iqukethe i-lixisenatide, i-peptide 1 efana ne-glucagon-like 1 (GLP-1) receptor agonist. Ezifundweni ezahlukahlukene zemitholampilo, imishanguzo ekilasini lezidakamizwa le-GLP-1 ikhombise ukwehla kwesisindo njengomphumela oseceleni.

Uma ukhathazekile ngokushintshwa kwesisindo ngenkathi usebenzisa iSoliqua 100/33, khuluma nodokotela wakho.

I-Hypoglycemia

I-insulin, esinye sezidakamizwa eSoliqua 100/33, isetshenziselwa ukusiza ukwehlisa amazinga kashukela egazini. Kodwa-ke, amazinga kashukela egazi angancishiswa kakhulu, okuholela ku-hypoglycemia. I-Hypoglycemia ingumphumela ohlangothini ovame kakhulu obangelwa yimithi ye-insulin, kufaka phakathi iSoliqua 100/33.

Ezifundweni zokwelashwa, i-hypoglycemia yenzeke ngamaphesenti ayi-8.1 kuye kwayi-17.8 wabantu abathatha iSoliqua 100/33. Futhi i-hypoglycemia enamandla yenzeka cishe kumaphesenti ama-1 wabantu abathatha lesi sidakamizwa.

Izici eziningi zingakhuphula ubungozi bakho be-hypoglycemia. Lokhu kufaka phakathi ukuthatha imithamo ephezulu yomuthi wakho wesifo sikashukela nokuthatha izidakamizwa ezingaphezu kwesisodwa sikashukela. Ezinye izinto ezingathinta ubungozi bakho zibandakanya imikhuba yakho yokudla nokuvivinya umzimba, nokuthi ngabe uyayisebenzisa yini eminye imithi.

Izimpawu ze-hypoglycemia zingavela ngokuzumayo futhi zingafaka ukuzamazama, ukukhathala, ukozela nokudideka. I-hypoglycemia enamandla ingaholela emiphumeleni emibi efana nokuquleka noma ngisho nokufa. Khuluma nodokotela wakho mayelana nokuthi kufanele uhlole kaningi kangakanani amazinga kashukela egazini lakho ukuvimbela i-hypoglycemia ngenkathi uthatha iSoliqua 100/33.

Ukudana komoya noma isikhumba esijiyile

Uthatha iSoliqua 100/33 ngomjovo ongaphansi, okusho ukuthi uyifaka ngaphansi kwesikhumba sakho. Umjovo ongena ngaphansi ungadala i-lipodystrophy (ukucindezeleka noma ukuqina kwesikhumba) eduze kwesiza somjovo.

Ukunciphisa ubungozi be-lipodystrophy, shintsha amasayithi lapho ufaka khona umuthi. Isibonelo, ngolunye usuku ungajova umuthi esiswini sakho, kuthi olandelayo usebenzise ithanga lakho langaphandle.

Uma ukhathazekile ngemiphumela yesikhumba ebangelwa ukujova i-Soliqua 100/33, khuluma nodokotela wakho.

Ukulimala kwezinso

Ukulimala kwezinso akubonwanga ezifundweni zomtholampilo zeSoliqua 100/33. Kodwa-ke, kube khona imibiko yokulimala kwezinso kubantu abaphathwa ngemithi ye-peptide 1 (GLP-1) efana ne-glucagon. ILixisenatide, engesinye sezidakamizwa eSoliqua 100/33, isidakamizwa se-GLP-1.

Izimpawu zokulimala kwezinso zingafaka:

• ukuvuvukala kwemilenze, amaqakala, noma izinyawo
• ukukhathala
• isicanucanu
• ukuhlanza

Ukulimala kwezinso kwenzeka kakhulu kubantu ababephelelwe amanzi emzimbeni ngenxa yemiphumela ethile emibi ye-Soliqua 100/33, enjengokuhlanza, ukuhlanza nokuhuda.

Uma uthuthukisa lezi zimpawu ngenkathi uthatha i-Soliqua 100/33, noma ukhathazekile ngempilo yakho yezinso, khuluma nodokotela wakho.

Izindleko zeSoliqua 100/33

Njengayo yonke imithi, izindleko ze-Soliqua 100/33 zingahluka.

Izindleko zakho zangempela zizoxhomeka kumshuwalense wakho.

Usizo lwezezimali nolomshuwalense

Uma udinga uxhaso lwezezimali ukukhokhela i-Soliqua 100/33, usizo luyatholakala. ISanofi Aventis, umkhiqizi weSoliqua 100/33, unikela ngeSoliqua 100/33 Savings Card. Ngeminye imininingwane, vakashela iwebhusayithi yohlelo.

Ungayithatha kanjani iSoliqua 100/33

Ngezansi kunemiyalo eyisisekelo yokuthi ungazinikeza kanjani umjovo usebenzisa ipeni le-Soliqua 100/33. Qiniseka njalo ukuthi uthatha i-Soliqua 100/33 ngokwemiyalo kadokotela wakho noma yomhlinzeki wezokunakekelwa kwempilo.

Ungaphatha kanjani

Isinyathelo 1. Lungisa futhi uhlole ipeni lakho.

Uma lokhu kungukuqala kwakho ukusebenzisa, khipha ipeni esiqandisini bese uvumela ipeni ukuthi lifinyelele ekamelweni lokushisa.

• Hlanganisa ama-swabs otshwala, inaliti entsha, kanye nesitsha sakho sokulahla okubukhali.
• Geza izandla zakho.
• Susa ikepisi bese uqinisekisa ukuthi umuthi ucacile futhi awunambala. (Ungayisebenzisi uma isixazululo singacacile futhi singenambala. Amagwebu omoya alungile.)
• Hlanza uphawu lwenjoloba nge-swab yotshwala.

Isinyathelo 2. Namathisela inaliti entsha yepeni.

Ngomjovo ngamunye, sebenzisa njalo inaliti entsha yepeni. Qiniseka ukuthi inaliti yepeni ingasetshenziswa neSoliqua 100/33. Uma ungazi ukuthi iziphi izinaliti okufanele uzisebenzise, ​​buza udokotela wakho noma usokhemisi.

• Susa inaliti yepeni ephaketheni layo lokuzivikela.
• Ukugcina inaliti yepeni iqonde, uyijike esibayeni.
• Susa ikepisi lenaliti langaphandle bese ulibeka eceleni. (Yigcine ukuze uyisebenzise ngemuva komjovo.)
• Susa ikepisi lenaliti yangaphakathi bese uyilahla kudoti.

Isinyathelo 3. Yenza ukuhlolwa kokuphepha.

Hlala uhlola ukuphepha ngaphambi kwawo wonke umjovo ukuze uqiniseke ukuthi ipeni nenaliti kusebenza kahle.

• Lungisa i-counter counter ukuze ifunde amayunithi ama-2.
• Cindezela inkinobho yokujova ungene ngaphakathi bese uhlola isixazululo esithile semithi ukuze uphume kutiphu yenaliti. Uma lokhu kwenzeka, qhubeka isinyathelo 4.
• Uma kungekho muthi ophumayo, phinda isivivinyo sokuphepha kuze kube izikhathi ezi-3.
• Uma kungekho muthi ophumayo ngemuva kokuhlolwa kathathu, shintsha inaliti bese uphinda izivivinyo zokuphepha.
• Uma kungekho muthi ophumayo ngemuva kokufaka inaliti esikhundleni, ungasebenzisi ipeni ngoba kungenzeka ilimele. Sebenzisa ipeni elisha.

Isinyathelo 4. Khetha umthamo wakho.

• Guqula isibali sedosi uze ufinyelele umthamo wakho obekiwe.

Isinyathelo 5. Jova umthamo.

Kunezindawo ezintathu emzimbeni wakho ongazisebenzisela isiza somjovo: isisu sakho (ngaphandle kwamasentimitha ama-2 enkinobho yesisu sakho), emuva kwengalo yakho ephezulu (indawo enamafutha), nethanga lakho langaphandle.

• Khetha indawo yokujova bese usula isikhumba kusayithi nge-swab yotshwala.
• Endaweni yomjovo, faka inaliti esikhunjeni sakho nge-engela engu-90 degree.
• Cindezela inkinobho yokujova phansi ngokuphelele bese uyibamba uze ubone u- “0” ewindini lomthamo.
• Ngemuva kokuthi ikhawunda lomthamo liphendukele ku- “0,” ubale uye ku-10 ngaphambi kokukhipha inkinobho yomjovo futhi ususe inaliti. Lokhu kumiswa kancane kusiza ukuqinisekisa ukuthi uthola umthamo ophelele.
• Khipha inkinobho yomjovo bese ususa inaliti esikhunjeni sakho.

Isinyathelo 6. Lahla inaliti bese ugcina ipeni.

• Beka ikepisi lenaliti langaphandle emuva enalithini.
• Susa inaliti esibayeni esinomjovo bese ulahla ngokushesha inaliti esitsheni esibukhali. (Yilahle khona manjalo ukugwema ukuyidida ngenaliti entsha.)
• Beka ipeni likapeni emuva epeni.
• Gcina ipeni ekamelweni lokushisa ngemuva kokusetshenziswa kokuqala.

Isikhathi

Kufanele uthathe i-Soliqua 100/33 kungakapheli ihora ngaphambi kokudla kwakho kokuqala kosuku.

Ukuthatha iSoliqua 100/33 ngokudla

I-Soliqua 100/33 akufanele ithathwe nokudla. Kufanele ithathwe kungakapheli ihora ngaphambi kokudla kwakho kokuqala kosuku.

Ezinye izindlela zeSoliqua 100/33

Ezinye izidakamizwa ziyatholakala ezingelapha isifo sikashukela sohlobo 2. Ezinye zingakulungela kangcono kunabanye. Uma unentshisekelo yokuthola enye indlela ye-Soliqua 100/33, khuluma nodokotela wakho ukuze ufunde kabanzi ngeminye imithi engakusebenzela kahle.

I-Soliqua 100/33 iqukethe imishanguzo emibili: i-insulin esebenza isikhathi eside ebizwa nge-insulin glargine, kanye ne-glucagon-like peptide 1 (GLP-1) receptor agonist ebizwa nge-lixisenatide.

Izibonelo zemithi engasetshenziswa njengezinye izindlela ze-Soliqua 100/33 zifaka:

• ama-insulins asebenza isikhathi eside, njenge:
• i-insulin glargine (iLantus, Toujeo)
• insulini detemir (Levemir)
• Ama-agonists we-GLP-1 receptor, anjenge:
• i-exenatide (Bydureon, Byetta)
• i-liraglutide (eVictoza, eSaxenda)
• i-lixisenatide (i-Adlyxin)
• i-semaglutide (i-Ozempic)
• i-dipeptidyl peptidase-4 (DPP-4) inhibitors, efana:
• i-alogliptin (Nesina)
• linagliptin (i-Tradjenta)
• i-saxagliptin (i-Onglyza)
• sitagliptin (Januvia)
• ama-meglitinides, anjenge:
• i-repaglinide (Prandin)
• isigaba (Starlix)
• i-metformin (iGlucophage, iGlumetza, iRiomet)
• i-sodium-glucose cotransporter 2 (SGLT2) inhibitors, efana:
• i-canagliflozin (i-Invokana)
• dapagliflozin (Farxiga)
• empagliflozin (Jardiance)
• sulfonylureas, njenge:
• i-glimepiride (Amaryl)
• i-glipizide (iGlucotrol)
• i-glyburide (i-DiaBeta, i-Glynase)
• thiazolidinediones, njenge:
• pioglitazone (Actos)
• i-rosiglitazone (Avandia)

I-Soliqua 100/33 vs. Xultophy

Ungase uzibuze ukuthi i-Soliqua 100/33 iqhathanisa kanjani neminye imithi enikezwe ukusetshenziswa okufanayo.Lapha sibheka ukuthi iSoliqua 100/33 neXultophy ziyefana futhi zehlukile kanjani.

Isebenzisa

I-Soliqua 100/33 ne-Xultophy zombili zivunyelwe yi-FDA ukwenza ngcono amazinga kashukela egazini kubantu abadala abanesifo sikashukela sohlobo 2. Zombili zinqunyelwe ukusetshenziswa nezinguquko zokudla nokuvivinya umzimba.

I-Soliqua 100/33 ne-Xultophy yomibili iqukethe imishanguzo emibili, futhi le mithi ingeyezigaba ezifanayo zemithi. Lokhu kusho ukuthi basebenza ngendlela efanayo emzimbeni.

I-Soliqua 100/33 iqukethe:

• i-insulin glargine (i-insulin esebenza isikhathi eside)
• i-lixisenatide (i-peptide efana ne-glucagon efana ne-1 [GLP-1] receptor agonist)

I-Xultophy iqukethe:

• i-insulin degludec (i-insulin esebenza isikhathi eside)
• i-liraglutide (i-GLP-1 receptor agonist)

Amafomu wezidakamizwa nokuphathwa

I-Soliqua 100/33 ne-Xultophy zombili ziza njengezixazululo zoketshezi esibayeni esilahlwayo esilahlwayo. Bobabili bazijove ngaphansi kwesikhumba (ngaphansi kwesikhumba) kanye ngosuku.

Imiphumela emibi kanye nezingozi

I-Soliqua 100/33 ne-Xultophy inemiphumela efanayo emzimbeni ngakho-ke idala imiphumela emibi efanayo.

Imiphumela emibi ejwayelekile

Lolu hlu luqukethe izibonelo zemiphumela emibi ejwayelekile engenzeka ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

• Kungenzeka ngamabili i-Soliqua 100/33 ne-Xultophy:
• izifo zokuphefumula ezifana nomkhuhlane ovamile noma umkhuhlane
• isicanucanu
• isifo sohudo
• ikhanda
• i-hypoglycemia (ushukela ophansi wegazi)

Imiphumela emibi kakhulu

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi engaba khona ne-Soliqua 100/33, ne-Xultophy, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

• Kungenzeka nge-Soliqua 100/33:
• nemiphumela engemihle embalwa eyingqayizivele
• Kungenzeka nge-Xultophy:
• umdlavuza wegilo *
• isifo se-gallbladder
• Kungenzeka ngamabili i-Soliqua 100/33 ne-Xultophy:
• ukusabela okweqile komzimba
• i-hypoglycemia enamandla (ushukela wegazi ophansi kakhulu)
• i-pancreatitis (ukuvuvukala kwamanyikwe)
• ukulimala kwezinso
• i-hypokalemia (amazinga aphansi e-potassium)

I-Xultophy inesixwayiso esibhokisi esivela ku-FDA ngomdlavuza wegilo. Isexwayiso esibhakeleni yisixwayiso esiqine kakhulu esidingwa yi-FDA. Kwazisa odokotela neziguli ngemiphumela yezidakamizwa engaba yingozi.

Ukusebenza ngempumelelo

I-Soliqua 100/33 ne-Xultophy azizange ziqhathaniswe ngqo ezifundweni zokwelashwa, kodwa zombili zitholakale zisebenza kahle ekwelapheni uhlobo lwesifo sikashukela sohlobo lwe-2.

Ezifundweni ezihlukene, i-Soliqua 100/33 ne-Xultophy zombili beziphumelela ekwehliseni zombili i-HbA1c kanye nokuzila amazinga kashukela egazini.

• Esifundweni somtholampilo, uSoliqua 100/33 wehlise i-hemoglobin A1c (HbA1c) ngamaphesenti ayi-1.1 kanye namazinga okushukela egazini azila ngo-5.7 mg / dL ngemuva kwamasonto angama-30 elashwa.
• Ezifundweni zomtholampilo, i-Xultophy inciphise i-HbA1c ngo-1.31 yaya ku-1.94% kanye namazinga kashukela egazini azila ngama-49.9 mg / dL aya kuma-63.5 mg / dL ngemuva kwamasonto angama-26 okwelashwa. Abantu abasebenzisa i-Xultophy bathole namakhilogremu angama-4.4 ngaphezu kwamasonto angama-26 okwelashwa.

Qaphela: Kubalulekile ukukhumbula ukuthi noma iyiphi yalezi zidakamizwa inganciphisa kangakanani i-HbA1c yakho noma amazinga kashukela egazi ancike ezintweni eziningi, kufaka phakathi:

• amazinga kashukela egazini lakho lapho uqala umuthi
• izindlela zakho zokudla nokuvivinya umzimba
• eminye imithi yesifo sikashukela oyiphuzayo
• ulandela eduze kangakanani umuthi wakho wokwelashwa

Izindleko

I-Soliqua 100/33 ne-Xultophy yomibili imishanguzo enegama lomkhiqizo. Okwamanje awekho amafomu ejwayelekile atholakala kunoma imuphi umuthi. Imithi enegama lomkhiqizo ivame ukubiza ngaphezu kwama-generic.

Ngokuya ngesilinganiso esivela kuGoodRx.com, iXultophy ingabiza ngaphezu kukaSoliqua 100/33. Intengo yangempela ongayikhokhela noma yimuphi umuthi izoncika kumthamo wakho, uhlelo lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

I-Soliqua 100/33 vs. ezinye izidakamizwa

Kuneminye imithi ngaphandle kweSoliqua 100/33 neXultophy (ngenhla) engasetshenziswa ukwelapha uhlobo lwesifo sikashukela sohlobo 2. Ngezansi kukhona ukuqhathanisa phakathi kweSoliqua 100/33 neminye imithi eminingi.

I-Soliqua 100/33 vs. Lantus

I-Soliqua 100/33 iqukethe izidakamizwa ezimbili:

• insulini glargine, eyi-insulin esebenza isikhathi eside
• i-lixisenatide, eyezigaba zemithi ebizwa nge-glucagon-like peptide 1 (GLP-1) receptor agonists

I-insulin glargine yisidakamizwa esiqukethwe eLantus. Ngoba iSoliqua 100/33 neLantus babelana ngesithako esisebenzayo, basebenza ngezindlela ezifanayo emzimbeni.

Isebenzisa

I-Soliqua 100/33 ivunyelwe i-FDA ukuthi isetshenziswe nezinguquko zokudla nokuvivinya umzimba ukuze ithuthukise amazinga kashukela egazini kubantu abadala abanesifo sikashukela sohlobo 2.

ILantus ivunyelwe yi-FDA ukwenza ngcono amazinga kashukela egazini kubantu abadala nasezinganeni ezinesifo sikashukela sohlobo 1, nabantu abadala abanesifo sikashukela sohlobo 2.

Amafomu wezidakamizwa nokuphathwa

ISoliqua 100/33 iza njengesixazululo soketshezi esibayeni esilahlwayo. ILantus iza njengesixazululo soketshezi esitsheni esinemithamo eminingi noma ngepeni elilahlwayo elilahlwayo. Yomibili le mithi izifakela yona ngaphansi kwesikhumba (ngaphansi kwesikhumba) kanye ngosuku.

Imiphumela emibi kanye nezingozi

I-Soliqua 100/33 neLantus zombili ziqukethe i-insulin esebenza isikhathi eside efanayo, i-insulin glargine. Ngakho-ke, yomibili le mithi ingadala imiphumela emibi efanayo. Ngezansi kunezibonelo zale miphumela emibi.

Imiphumela emibi ejwayelekile

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi ejwayelekile engenzeka ngeSoliqua 100/33, neLantus, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

• Kungenzeka nge-Soliqua 100/33:
  • isicanucanu
  • izifo zokuphefumula ezifana nomkhuhlane ovamile noma umkhuhlane
  • ikhanda
  • isifo sohudo
• Kungenzeka ngeLantus:
  • ukuzuza kwesisindo
  • i-lipodystrophy (ukuqaqanjelwa noma ukuqina kwesikhumba endaweni yomjovo)
  • ukuphendula kwesiza somjovo
• Kungenzeka ngeSoliqua 100/33 neLantus:
  • i-hypoglycemia (ushukela ophansi wegazi)

Imiphumela emibi kakhulu

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi engaba khona ne-Soliqua 100/33, ne-Lantus, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

• Kungenzeka nge-Soliqua 100/33:
  • i-pancreatitis (ukuvuvukala kwamanyikwe)
  • ukulimala kwezinso
• Kungenzeka ngeLantus:
  • nemiphumela engemihle embalwa eyingqayizivele
• Kungenzeka ngeSoliqua 100/33 neLantus:
  • ukusabela okweqile komzimba
  • i-hypoglycemia enamandla (ushukela wegazi ophansi kakhulu)
  • amazinga aphansi e-potassium (hypokalemia)

Ukusebenza ngempumelelo

Ukusebenza kweSoliqua 100/33 neLantus kuqhathaniswe ngqo ezifundweni ezimbili. Esifundweni sokuqala, lezi zidakamizwa ezimbili zazisetshenziswa zodwa. Elesibili, zazisetshenziswa ngayinye zihlangene ne-metformin (umuthi wesifo sikashukela ngomlomo).

Sebenzisa wedwa

Ucwaningo lokuqala belugxile kubantu abadala abane-type 2 yesifo sikashukela abake balashwa ngaphambilini ngama-insulins asebenza isikhathi eside. Kukhombisile ukuthi iSoliqua 100/33 ingasebenza kangcono kancane kuneLantus yokwehlisa i-hemoglobin A1c (HbA1c), kepha hhayi ekunciphiseni amazinga kashukela egazini.

Ngemuva kokulashwa amasonto angama-30, uSoliqua 100/33 wehlise i-HbA1c ngamaphesenti ayi-1.1, futhi amazinga okushukela egazini azile ngo-5.7 mg / dL. Ngesikhathi esifanayo, uLantus wehlise i-HbA1c ngamaphesenti angu-0.6, kanye namazinga okushukela egazini azila ngo-7.0 mg / dL.

Sebenzisa nge-metformin

Ucwaningo lwesibili luhlole iSoliqua 100/33 nge-metformin elwa neLantus ene-metformin kubantu abadala abanesifo sikashukela sohlobo lwe-2. Laba bantu bake baphathwa nge-metformin kuphela, noma nge-metformin nangesinye isidakamizwa sikashukela somlomo.

Ngaphezulu kwamasonto angama-30, iSoliqua 100/33 ene-metformin yayisebenza kancane kuneLantus ene-metformin. I-Soliqua 100/33 ene-metformin inciphise i-HbA1c ngamaphesenti ayi-1.6 futhi izila amazinga kashukela ngo-59.1 mg / dL. I-Lantus ne-metformin, ngakolunye uhlangothi, yehlise i-HbA1c ngamaphesenti ayi-1.3 nezinga lokuzila ushukela egazini lehle ngo-55.8 mg / dL.

Qaphela: Kubalulekile ukukhumbula ukuthi noma iyiphi yale mithi izokwehlisa kanjani i-HbA1c yakho noma amazinga kashukela egazi ancike ezintweni eziningi, kufaka phakathi:

• amazinga kashukela egazini lakho lapho uqala umuthi
• izindlela zakho zokudla nokuvivinya umzimba
• eminye imithi yesifo sikashukela oyiphuzayo
• ulandela eduze kangakanani umuthi wakho wokwelashwa

Izindleko

I-Soliqua 100/33 neLantus zombili izidakamizwa ezidla igama. Okwamanje awekho amafomu ejwayelekile atholakala kunoma imuphi umuthi. Imithi enegama lomkhiqizo ivame ukubiza ngaphezu kwama-generic.

Ngokwezibalo ezivela kuGoodRx.com, iLantus ngokuvamile ibiza ngaphansi kukaSoliqua 100/33. Intengo yangempela ongayikhokhela noma yimuphi umuthi izoncika kumthamo wakho, uhlelo lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

I-Soliqua 100/33 vs. Victoza

I-Soliqua 100/33 iqukethe izidakamizwa ezimbili:

• insulini glargine, eyi-insulin esebenza isikhathi eside
• i-lixisenatide, eyezigaba zemithi ebizwa nge-glucagon-like peptide 1 (GLP-1) receptor agonists

IVictoza iqukethe i-liraglutide yezidakamizwa, nayo eyi-GLP-1 receptor agonist. Ngoba iSoliqua 100/33 kanye neVictoza babelana ngesithako esisebenzayo esigabeni esifanayo semithi, basebenza ngezindlela ezifanayo emzimbeni.

Isebenzisa

I-Soliqua 100/33 ivunyelwe yi-FDA ukuthuthukisa amazinga kashukela egazini kubantu abadala abanesifo sikashukela sohlobo 2. Kunqunyelwe ukuthi kusetshenziswe nezinguquko zokudla nokuvivinya umzimba.

IVictoza nayo ivunyelwe ukuthuthukisa amazinga kashukela egazini kubantu abadala abanesifo sikashukela sohlobo 2 ngokuhambisana nokudla okuthuthukisiwe nokuzivocavoca umzimba. Ngaphezu kwalokho, kuvunyelwe ukunciphisa ubungozi bezinkinga ezinkulu zenhliziyo njengokuhlaselwa yinhliziyo nokushaywa unhlangothi kubantu abanesifo sikashukela sohlobo 2 nesifo senhliziyo.

Amafomu wezidakamizwa nokuphathwa

Kokubili iSoliqua 100/33 neVictoza ziza njengesixazululo soketshezi esibayeni esilahlwayo. Yomibili le mithi izifakela yona ngaphansi kwesikhumba (ngaphansi kwesikhumba) kanye ngosuku.

Imiphumela emibi kanye nezingozi

Ngoba iSoliqua 100/33 neVictoza zombili ziqukethe umuthi ongowesigaba semithi se-GLP-1, yomibili le mithi ingadala imiphumela emibi efanayo. Ngezansi kunezibonelo zale miphumela emibi.

Imiphumela emibi ejwayelekile

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi ejwayelekile engenzeka ngeSoliqua 100/33, neVictoza, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

• Kungenzeka nge-Soliqua 100/33:
  • i-hypoglycemia (ushukela ophansi wegazi)
  • izifo zokuphefumula ezifana nomkhuhlane ovamile noma umkhuhlane
  • ikhanda
• Kungenzeka nge-Victoza:
  • ukuncipha kokudla
  • ukuhlanza
  • ukuqunjelwa
  • ukucasuka kwesisu
• Kungenzeka ngamabili Soliqua 100/33 kanye neVictoza:
  • isicanucanu
  • isifo sohudo

Imiphumela emibi kakhulu

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi engaba khona ne-Soliqua 100/33, ne-Victoza, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

• Kungenzeka nge-Soliqua 100/33:
  • i-hypokalemia (amazinga aphansi e-potassium)
• Kungenzeka nge-Victoza:
  • umdlavuza wegilo *
  • isifo se-gallbladder
• Kungenzeka ngamabili Soliqua 100/33 kanye neVictoza:
  • ukusabela okweqile komzimba
  • i-hypoglycemia enamandla (ushukela wegazi ophansi kakhulu)
  • i-pancreatitis (ukuvuvukala kwamanyikwe)
  • ukulimala kwezinso

UVictoza unesixwayiso esibhokisi esivela ku-FDA ngomdlavuza wegilo. Isexwayiso esibhakeleni yisixwayiso esiqine kakhulu esidingwa yi-FDA. Kwazisa odokotela neziguli ngemiphumela yezidakamizwa engaba yingozi.

Ukusebenza ngempumelelo

I-Soliqua 100/33 ne-Victoza azizange ziqhathaniswe ngqo ezifundweni zomtholampilo, kodwa womabili atholakale ephumelela ekwelapheni uhlobo lwesifo sikashukela sohlobo lwe-2.

Ezifundweni ezihlukene, bobabili uSoliqua 100/33 noVictoza behlise i-HbA1c futhi bazila amazinga kashukela egazini kubantu abanesifo sikashukela sohlobo 2.

• Esifundweni somtholampilo, ngemuva kokwelashwa amasonto angama-30, uSoliqua 100/33 wehlise i-hemoglobin A1c (HbA1c) ngamaphesenti ayi-1.1 kanye namazinga kashukela egazini azila ngo-5.7 mg / dL.
• Kwezinye izifundo zomtholampilo, ukwelashwa okungaphezu kwamasonto angama-52, uVictoza wehlise i-HbA1c cishe ngamaphesenti ayi-0.8 kuya ku-1.1 kanye namazinga okushukela egazini ngo-15 kuye ku-26 mg / dL.

Ucwaningo olwehlukile lomtholampilo lubonise ukuthi uVictoza wehlise ubungozi bezinkinga ezinkulu zenhliziyo njengokuhlaselwa yisifo senhliziyo nokushaywa unhlangothi ngamaphesenti ayi-13. Lo mphumela awuzange ucwaningwe ocwaningweni lweSoliqua 100/33.

Qaphela: Kubalulekile ukukhumbula ukuthi noma iyiphi yalezi zidakamizwa inganciphisa kangakanani i-HbA1c yakho noma amazinga kashukela egazi ancike ezintweni eziningi, kufaka phakathi:

• amazinga kashukela egazini lakho lapho uqala umuthi
• izindlela zakho zokudla nokuvivinya umzimba
• eminye imithi yesifo sikashukela oyiphuzayo
• ulandela eduze kangakanani umuthi wakho wokwelashwa

Izindleko

I-Soliqua 100/33 ne-Victoza yizidakamizwa ezibizwa ngegama. Okwamanje awekho amafomu ejwayelekile atholakala kunoma imuphi umuthi. Imithi enegama lomkhiqizo ivame ukubiza ngaphezu kwama-generic.

Ngokuya ngokulinganisela okuvela ku-GoodRx.com, iVictoza ngokuvamile ibiza ngaphezu kukaSoliqua 100/33. Izindleko ozozikhokhela noma imuphi umuthi zizoncika kumthamo wakho, uhlelo lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

I-Soliqua 100/33 vs. Toujeo

I-Soliqua 100/33 iqukethe izidakamizwa ezimbili:

• insulini glargine, eyi-insulin esebenza isikhathi eside
• i-lixisenatide, eyezigaba zemithi ebizwa nge-glucagon-like peptide 1 (GLP-1) receptor agonists

I-insulin glargine yisidakamizwa esiqukethwe eToujeo. Ngoba iSoliqua 100/33 neToujeo babelana ngesithako esisebenzayo, basebenza ngezindlela ezifanayo emzimbeni.

Isebenzisa

I-Soliqua 100/33 ivunyelwe yi-FDA ukuthuthukisa amazinga kashukela egazini kubantu abadala abanesifo sikashukela sohlobo 2. Kuvunyelwe ukusetshenziswa ngezinguquko zokudla nokuvivinya umzimba.

I-Toujeo igunyazwe yi-FDA ukuthi ithuthukise amazinga kashukela egazini kubantu abadala abanesifo sikashukela sohlobo 2, kanye nabantu abadala nezingane ezinesifo sikashukela sohlobo 1.

Amafomu wezidakamizwa nokuphathwa

I-Soliqua 100/33 neToujeo zombili ziza njengezixazululo zoketshezi esibayeni esilahlwayo esilahlwayo. Yomibili le mithi izifakela yona ngaphansi kwesikhumba (ngaphansi kwesikhumba) kanye ngosuku.

ISoliqua 100/33 iza ngenani elilodwa. Ipeni ngalinye liqukethe i-3 mL yesisombululo sezidakamizwa, ngamayunithi angama-300 e-insulin glargine kanye ne-100 mcg ye-lixisenatide. Umthamo omkhulu womjovo ngamunye ungamayunithi angama-60, okusho ukuthi amayunithi angama-60 e-insulin glargine kanye nama-20 mcg lixisenatide.

IToujeo iza ngamanani amabili ahlukene:

• I-Toujeo SoloStar iqukethe amayunithi angama-450 e-insulin glargine ku-1.5 mL wesisombululo, ngomthamo omkhulu wamayunithi angama-80 ngomjovo ngamunye.
• I-Toujeo Max SoloStar iqukethe amayunithi we-900 we-insulin glargine ku-3 mL yesisombululo, ngomthamo omkhulu wamayunithi ayi-160 ngomjovo ngamunye.

Imiphumela emibi kanye nezingozi

USoliqua 100/33 noToujeo bobabili babelana nge-insulin esebenza isikhathi eside efanayo, i-insulin glargine. Ngakho-ke, yomibili le mithi ingadala imiphumela emibi efanayo. Ngezansi kunezibonelo zale miphumela emibi.

Imiphumela emibi ejwayelekile

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi ejwayelekile engenzeka ngeSoliqua 100/33, neToujeo, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

• Kungenzeka nge-Soliqua 100/33:
  • isicanucanu
  • isifo sohudo
  • ikhanda
• Kungenzeka ngeToujeo:
  • ukuzuza kwesisindo
  • ukuphendula kwesiza somjovo
  • i-lipodystrophy (induction noma ukudangala endaweni yomjovo)
  • ukulunywa
  • ukuqubuka
  • ukuvuvukala emilenzeni yakho, emaqakaleni, noma ezinyaweni
• Kungenzeka ngeSoliqua 100/33 neToujeo:
  • izifo zokuphefumula ezifana nomkhuhlane ovamile noma umkhuhlane
  • i-hypoglycemia (ushukela ophansi wegazi)

Imiphumela emibi kakhulu

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi engaba khona ne-Soliqua 100/33, ne-Toujeo, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

• Kungenzeka nge-Soliqua 100/33:
  • i-pancreatitis (ukuvuvukala kwamanyikwe)
  • ukulimala kwezinso
• Kungenzeka ngeToujeo:
  • nemiphumela engemihle embalwa eyingqayizivele
• Kungenzeka ngeSoliqua 100/33 neToujeo:
  • ukusabela okweqile komzimba
  • i-hypoglycemia enamandla (ushukela wegazi ophansi kakhulu)
  • i-hypokalemia (amazinga aphansi e-potassium)

Ukusebenza ngempumelelo

I-Soliqua 100/33 neToujeo azizange ziqhathaniswe ngqo ezifundweni zokwelashwa. Kodwa-ke, ucwaningo lomuntu ngamunye lukhombisile ukuthi iToujeo neSoliqua 100/33 zingasebenza ekwehliseni kokubili i-HbA1c nokuzila amazinga kashukela egazini.

• Esifundweni somtholampilo, uSoliqua 100/33 wehlise i-hemoglobin A1c (HbA1c) ngamaphesenti ayi-1.1 kanye namazinga okushukela egazini azila ngo-5.7 mg / dL ngemuva kwamasonto angama-30 elashwa.
• Kwezinye izifundo zomtholampilo, uToujeo wehlise i-HbA1c cishe ngo-0.73 waya ku-1.42 wamaphesenti kanye nokuzila ukudla amazinga kashukela nge-18 kuye ku-61 mg / dL ngaphezulu kwamasonto angama-26 okwelashwa.

Qaphela: Kubalulekile ukukhumbula ukuthi noma iyiphi yalezi zidakamizwa izokwehlisa kanjani i-HbA1c yakho noma amazinga kashukela egazini ancike ezintweni eziningi, kufaka phakathi:

• amazinga kashukela egazini lakho lapho uqala umuthi
• izindlela zakho zokudla nokuvivinya umzimba
• eminye imithi yesifo sikashukela oyiphuzayo
• ulandela eduze kangakanani umuthi wakho wokwelashwa

Izindleko

ISoliqua 100/33 neToujeo yizidakamizwa ezibizwa ngegama. Okwamanje awekho amafomu ejwayelekile atholakala kunoma imuphi umuthi. Imithi enegama lomkhiqizo ivame ukubiza ngaphezu kwama-generic.

Ngokwezibalo ezivela ku-GoodRx.com, iToujeo ngokuvamile ibiza ngaphezu kukaSoliqua 100/33. Intengo yangempela ongayikhokhela noma yimuphi umuthi izoncika kumthamo wakho, uhlelo lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

I-Soliqua 100/33 vs. Adlyxin

I-Soliqua 100/33 iqukethe izidakamizwa ezimbili:

• insulini glargine, eyi-insulin esebenza isikhathi eside
• i-lixisenatide, eyezigaba zemithi ebizwa nge-glucagon-like peptide 1 (GLP-1) receptor agonists

ILixisenatide nayo iyisidakamizwa esiku-Adlyxin. Ngoba iSoliqua 100/33 kanye ne-Adlyxin babelana ngesithako esisebenzayo, basebenza ngezindlela ezifanayo emzimbeni.

Isebenzisa

I-Soliqua 100/33 ivunyelwe i-FDA ukuthi isetshenziswe nezinguquko zokudla nokuvivinya umzimba ukuze ithuthukise amazinga kashukela egazini kubantu abadala abanesifo sikashukela sohlobo 2.

I-Adlyxin ivunyiwe yi-FDA ukuthi isetshenziswe ngokudla nokuvivinya umzimba ukuze ithuthukise amazinga kashukela egazini kubantu abadala abanesifo sikashukela sohlobo 2.

Amafomu wezidakamizwa nokuphathwa

I-Soliqua 100/33 ne-Adlyxin zombili ziza njengezixazululo zoketshezi ngepeni elilahlwayo elilahlwayo. Yomibili le mithi izifakela yona ngaphansi kwesikhumba (ngaphansi kwesikhumba) kanye ngosuku.

Ipeni likaSoliqua 100/33 liza ngenani elilodwa. Ipeni ngalinye liqukethe i-3 mL yesixazululo sezidakamizwa, ngamayunithi ayi-100 e-insulin glargine kanye nama-33 mcg we-lixisenatide nge-mL ngayinye. Umthamo omkhulu womjovo ngamunye ungamayunithi angama-60, okusho ukuthi amayunithi angama-60 e-insulin glargine kanye nama-20 mcg lixisenatide.

Ipeni le-Adlyxin liza ngamanani amabili ahlukene:

• Ipeni eliluhlaza i-Adlyxin liqukethe ama-50 mcg / mL ku-3 mL wesisombululo, nomthamo ka-10 mcg ngomjovo ngamunye.
• Ipeni le-burgundy Adlyxin liqukethe i-100 mcg / mL ku-3 mL yesisombululo, ngomthamo we-20 mcg ngomjovo ngamunye.

Imiphumela emibi kanye nezingozi

I-Soliqua 100/33 ne-Adlyxin zombili ziqukethe i-lixisenatide yezidakamizwa. Ngakho-ke, yomibili le mithi ingadala imiphumela emibi efanayo. Ngezansi kunezibonelo zale miphumela emibi.

Imiphumela emibi ejwayelekile

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi ejwayelekile engenzeka ngeSoliqua 100/33, ne-Adlyxin, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

• Kungenzeka nge-Soliqua 100/33:
  • izifo zokuphefumula ezifana nomkhuhlane ovamile noma umkhuhlane
• Kungenzeka nge-Adlyxin:
  • ukuhlanza
  • isiyezi
• Kungenzeka ngamabili Soliqua 100/33 kanye ne-Adlyxin:
  • isicanucanu
  • isifo sohudo
  • ikhanda
  • i-hypoglycemia (ushukela ophansi wegazi)

Imiphumela emibi kakhulu

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi engaba khona ne-Soliqua 100/33, ne-Adlyxin, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

• Kungenzeka nge-Soliqua 100/33:
  • i-hypokalemia (amazinga aphansi e-potassium)
• Kungenzeka nge-Adlyxin:
  • nemiphumela engemihle embalwa eyingqayizivele
• Kungenzeka ngamabili Soliqua 100/33 kanye ne-Adlyxin:
  • ukusabela okweqile komzimba
  • i-hypoglycemia enamandla (ushukela wegazi ophansi kakhulu)
  • i-pancreatitis (ukuvuvukala kwamanyikwe)
  • ukulimala kwezinso

Ukusebenza ngempumelelo

Ukusetshenziswa kwe-Soliqua 100/33 noma i-Adlyxin njengokwelashwa kwesidakamizwa esisodwa sohlobo lwe-2 sikashukela akuqhathaniswanga ngqo ocwaningweni lomtholampilo.Kodwa-ke, ukusetshenziswa komuthi ngamunye kuhlanganiswe ne-metformin (isidakamizwa sikashukela somlomo) kuqhathaniswe ngqo.

Izifundo ezihlukile lapho zisetshenziswa zodwa

Ezifundweni ezihlukene zomtholampilo, i-Soliqua 100/33 ne-Adlyxin zombili bezisebenza zodwa ekwehliseni ukuzila ushukela egazini kulabo abane-type 2 yesifo sikashukela.

• Esifundweni somtholampilo, uSoliqua 100/33 wehlise i-hemoglobin A1c (HbA1c) ngamaphesenti ayi-1.1 kanye namazinga okushukela egazini azila ngo-5.7 mg / dL ngemuva kwamasonto angama-30 elashwa.
• Esifundweni esihlukile somtholampilo, i-Adlyxin yehlise i-HbA1c ngo-0.57 yaya ku-0.71 wamaphesenti kanye namazinga okushukela egazini azila ngo-4.48 kuya ku-24.56 mg / dL ngaphezulu kwamasonto angama-24 okwelashwa.

Ukuqhathanisa okuqondile lapho kusetshenziswa ne-metformin

Olunye ucwaningo luhlolisise ukusetshenziswa kweSoliqua 100/33 nge-metformin ngqo ngokusetshenziswa kwe-Adlyxin ene-metformin kubantu abadala abanesifo sikashukela sohlobo 2. Abantu abakucwaningo babekade belashwa nge-metformin kuphela, noma nge-metformin nangesinye isidakamizwa sikashukela somlomo.

Ngemuva kwamasonto angama-30, i-Soliqua 100/33 ene-metformin yayisebenza kangcono kune-Adlyxin ene-metformin. I-Soliqua 100/33 ene-metformin inciphise i-HbA1c ngamaphesenti ayi-1.6 futhi izila amazinga kashukela ngo-59.1 mg / dL. I-Adlyxin ne-metformin, ngakolunye uhlangothi, yehlise i-HbA1c ngamaphesenti angu-0.9 kanye namazinga okushukela egazini azila ngama-27.2 mg / dL.

Qaphela: Kubalulekile ukukhumbula ukuthi noma iyiphi yale mithi izokwehlisa kanjani i-HbA1c yakho noma amazinga kashukela egazi ancike ezintweni eziningi, kufaka phakathi:

• amazinga kashukela egazini lakho lapho uqala umuthi
• izindlela zakho zokudla nokuvivinya umzimba
• eminye imithi yesifo sikashukela oyiphuzayo
• ulandela eduze kangakanani umuthi wakho wokwelashwa

Izindleko

I-Soliqua 100/33 ne-Adlyxin yizidakamizwa ezibizwa ngegama. Okwamanje awekho amafomu ejwayelekile atholakala kunoma imuphi umuthi. Imithi enegama lomkhiqizo ivame ukubiza ngaphezu kwama-generic.

Ngokwezibalo ezivela kuGoodRx.com, i-Adlyxin ngokuvamile ibiza ngaphezu kweSoliqua 100/33. Intengo yangempela ongayikhokhela noma yimuphi umuthi izoncika kumthamo wakho, uhlelo lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

NgoMeyi 2020, i-Food and Drug Administration (i-FDA) yancoma ukuthi abanye abenzi be-metformin enwetshiwe bakhiphe amanye amaphilisi abo emakethe yase-U.S. Lokhu kungenxa yokuthi izinga elingamukeleki le-carcinogen (i-agent ebangela umdlavuza) itholakale kwamanye amaphilisi e-metformin akhululwa isikhathi eside. Uma okwamanje uthatha lo muthi, shayela umhlinzeki wakho wezokunakekelwa kwempilo. Bazokweluleka ngokuthi ngabe kufanele uqhubeke nokudla imishanguzo yakho noma uma udinga incwadi kadokotela entsha.

Ukusetshenziswa kweSoliqua 100/33

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kugunyaza imishanguzo kadokotela efana neSoliqua 100/33 ukwelapha izimo ezithile. I-Soliqua 100/33 ivunyelwe i-FDA ukuthi isetshenziswe nezinguquko zokudla nokuvivinya umzimba ukuze ithuthukise amazinga kashukela egazini kubantu abadala abanesifo sikashukela sohlobo 2.

Esifundweni semitholampilo samasonto angama-30 sabantu ababelashwe ngohlobo lwe-basal insulin (njenge-insulin glargine), iSoliqua 100/33 kwatholakala ukuthi iyasebenza. Inciphise i-hemoglobin A1c (HbA1c) ngamaphesenti ayi-1.1 kanye namazinga kashukela egazini azile ngo-5.7 mg / dL.

Ucwaningo lomtholampilo lwamaviki angama-30 lwalugxile kubantu ababelashwe nge-metformin bodwa, noma nge-metformin kanye nomunye umuthi wesifo sikashukela ngomlomo. Kubantu abakucwaningo, uSoliqua 100/33 kanye ne-metformin banciphise i-HbA1c yabo ngamaphesenti angu-1.6 futhi bazila amazinga kashukela egazini ngo-59.1 mg / dL.

Ukusetshenziswa kweSoliqua 100/33 nezinye izidakamizwa

I-Soliqua 100/33 ingasetshenziswa yodwa noma ihlanganiswe neminye imithi yokuthuthukisa amazinga kashukela egazini kubantu abanesifo sikashukela sohlobo 2. Ekwelapheni isifo sikashukela, kuyinto ejwayelekile ukuthi imishanguzo engaphezu kweyodwa isetshenziselwe ukulawula amazinga kashukela egazini uma umuthi owodwa uwodwa ungazange uthuthukise amazinga kashukela ngokwanele.

Izibonelo zemithi engasetshenziswa neSoliqua 100/33 zifaka:

• i-canagliflozin (i-Invokana)
• dapagliflozin (Farxiga)
• i-glimepiride (Amaryl)
• i-glipizide (iGlucotrol)
• i-glyburide (i-DiaBeta, i-Glynase)
• i-metformin (iGlucophage, iGlumetza, iRiomet)
• pioglitazone (Actos)

ISoliqua 100/33 notshwala

Gwema ukuphuza kakhulu utshwala ngenkathi uthatha iSoliqua 100/33. Utshwala bungashintsha amazinga kashukela egazini lakho futhi benyuse ubungozi bakho be-hypoglycemia (ushukela ophansi wegazi) kanye ne-pancreatitis (amanyikwe avuthayo).

Uma uphuza utshwala, khuluma nodokotela wakho ngokuthi ungakanani utshwala obuphephile kuwe.

Ukusebenzisana kweSoliqua 100/33

I-Soliqua 100/33 ingaxhumana neminye imithi eminingi. Ingasebenzisana nezithasiselo ezithile kanye nokudla okuthile.

Ukuxhumana okuhlukile kungadala imiphumela ehlukile. Isibonelo, ezinye zingaphazamisa ukuthi usebenza kanjani umuthi, kanti ezinye zingadala imiphumela emibi eyengeziwe.

Soliqua 100/33 kanye neminye imithi

Ngezansi kunohlu lwemithi engasebenzisana neSoliqua 100/33. Lolu hlu aluqukethe yonke imishanguzo engasebenzisana neSoliqua 100/33.

Ngaphambi kokuthatha i-Soliqua 100/33, qiniseka ukuthi utshela udokotela kanye nosokhemisi ngayo yonke imishanguzo kadokotela, i-counter-counter, nezinye izidakamizwa oziphuzayo. Batshele futhi nganoma yimaphi amavithamini, amakhambi, nezithako ozisebenzisayo. Ukwabelana ngalolu lwazi kungakusiza ugweme ukuhlangana okungenzeka.

Uma unemibuzo mayelana nokuhlangana kwezidakamizwa okungakuthinta, buza udokotela wakho noma usokhemisi.

Eminye imithi yesifo sikashukela

Ukuthatha i-Soliqua 100/33 ngeminye imithi yesifo sikashukela kungaholela emazingeni eshukela aphansi egazi futhi kwandise ubungozi bakho be-hypoglycemia (ushukela ophansi wegazi). Uma uthatha noma iyiphi yale mithi, kungadingeka ukuthi uhlole amazinga kashukela egazini lakho kaningi. Futhi, udokotela wakho angadinga ukushintsha isilinganiso sakho seSoliqua 100/33.

Izibonelo zemithi yesifo sikashukela zifaka:

• i-canagliflozin (i-Invokana)
• dapagliflozin (Farxiga)
• empagliflozin (Jardiance)
• i-glyburide (i-DiaBeta, i-Glynase, i-Micronase)
• i-glimepiride (Amaryl)
• i-glipizide (iGlucotrol)
• ama-insulins wesikhathi sokudla (Humalog, Novolog)
• i-metformin (iGlucophage)
• isigaba (Starlix)
• i-repaglinide (Prandin)

Ngaphezu kwalokho, ukusebenzisa i-Soliqua 100/33 enezidakamizwa zesifo sikashukela ezibizwa nge-thiazolidinediones (TZDs) kungadala ukugcinwa koketshezi. Kungakhuphula nengozi yakho yokwehluleka kwenhliziyo noma kube zimbi izimpawu zokuhluleka kwenhliziyo (bona isexwayiso ngezansi). Izibonelo zale mithi zifaka:

• pioglitazone (Actos)
• i-rosiglitazone (Avandia)

Uma uthatha i-TZD, khuluma nodokotela wakho ngaphambi kokuqala i-Soliqua 100/33. Uma udokotela wakho evuma ukusebenzisa kwakho i-TZD ngenkathi usebenzisa i-Soliqua 100/33, qiniseka ukuthi ubheka izimpawu zokwehluleka kwenhliziyo. Uma uhlakulela ukwehluleka kwenhliziyo, udokotela wakho anganciphisa umthamo we-TZD yakho noma uyeke ukuyithatha.

Izimpawu zokwehluleka kwenhliziyo zingafaka:

• inkinga yokuphefumula
• ukuvuvukala kwemilenze, amaqakala nezinyawo
• ukushaya kwenhliziyo okusheshayo noma okungajwayelekile
• izinhlungu zesifuba

Imithi yomfutho wegazi ophakeme

Ukuthatha i-Soliqua 100/33 ngemithi ethile yomfutho wegazi ophakeme kungaholela emazingeni eshukela aphansi kakhulu futhi kwandise ingozi yakho ye-hypoglycemia (ushukela ophansi wegazi). Uma uthatha noma iyiphi yale mithi, kungadingeka ukuthi uhlole amazinga kashukela egazini lakho kaningi. Futhi, udokotela wakho angadinga ukushintsha isilinganiso sakho seSoliqua 100/33.

Izibonelo zemithi yomfutho wegazi ophezulu engakhuphula ubungozi be-hypoglycemia lapho ithathwa nge-Soliqua 100/33 ifaka phakathi:

• ama-angiotensin-converting enzyme (ACE) inhibitors, njenge:
• i-benazepril (Lotensin)
• bongiwe
• i-enalapril (Vasotec)
• i-lisinopril (iZestril)
• ama-angiotensin II receptor blockers (ama-ARB), anjenge:
• i-valsartan (Diovan)
• i-candesartan (Atacand)
• I-irbesartan (Avapro)
• i-losartan (Cozaar)
• i-olmesartan (i-Benicar)

Eminye imishanguzo yegazi ingazifihla izimpawu zamazinga kashukela aphansi kakhulu egazi. Le mithi ingakhuphula futhi inciphise ukuthi iSoliqua 100/33 isebenza ngempumelelo kangakanani ekwehliseni amazinga kashukela egazini. Uma uthatha le mithi nge-Soliqua 100/33, kungadingeka ukuthi uhlole amazinga kashukela egazini lakho kaningi. Futhi, udokotela wakho angadinga ukushintsha isilinganiso sakho seSoliqua 100/33.

Izibonelo zemithi yomfutho wegazi engazifihla izimpawu zomfutho wegazi ophansi noma ithinte ukuthi iSoliqua 100/33 isebenza kahle kanjani ifaka:

• i-clonidine (Catapres)
• i-metoprolol (iLopressor, iTrolrol-XL)
• i-atenolol (Tenormin)

Ezinye izidakamizwa ezingafihla izimpawu ze-hypoglycemia

Eminye imithi ingazifihla izimpawu nezimpawu zamazinga kashukela aphansi egazini. Uma uthatha le mithi, kungadingeka ukuthi uhlole amazinga kashukela egazini lakho kaningi. Futhi, udokotela wakho angadinga ukushintsha isilinganiso sakho seSoliqua 100/33.

Izibonelo zale mithi zifaka:

• i-albuterol (ProAir, Proventil, Ventolin)
• guanethidine
• qalela kabusha

Eminye imithi enganciphisa amazinga kashukela egazini

Ukuthatha i-Soliqua 100/33 ngeminye imishanguzo kungaholela emazingeni aphansi kashukela egazini futhi kwandise ubungozi bakho be-hypoglycemia (ushukela ophansi wegazi). Uma uthatha noma iyiphi yale mithi, kungadingeka ukuthi uhlole amazinga kashukela egazini lakho kaningi. Futhi, udokotela wakho angadinga ukushintsha isilinganiso sakho seSoliqua 100/33.

Izibonelo zale mithi zifaka:

• i-disopyramide (i-Norpace)
• imithi ethile ye-cholesterol, njenge-fenofibrate (Tricor, Triglide) ne-gemfibrozil (Lopid)
• ama-anti-depressants athile, njenge-fluoxetine (i-Prozac, i-Sarafem) ne-selegiline (i-Emsam, i-Zelapar)
• i-octreotide (iSandostatin)
• i-sulfamethoxazole-trimethoprim (iBactrim, Septra)

Eminye imithi ekhulisa amazinga kashukela egazini lakho

Eminye imithi ingakhuphula amazinga kashukela emzimbeni wakho. Uma uthatha le mithi, kungadingeka ukuthi uhlole amazinga kashukela egazini lakho kaningi ukuvimbela i-hyperglycemia (ushukela ophakeme wegazi). Futhi, udokotela wakho angadinga ukushintsha isilinganiso sakho seSoliqua 100/33.

Izibonelo zale mithi zifaka:

• i-albuterol (ProAir, Proventil, Ventolin)
• imishanguzo ethile, efana ne-atazanavir (Reyataz) ne-lopinavir / ritonavir (Kaletra)
• ama-steroids athile, njenge-budesonide (i-Entocort EC, i-Pulmicort, i-Uceris), i-prednisone, ne-fluticasone (i-Flonase, i-Flovent)
• izidakamizwa ezithile, njenge-chlorothiazide (Diuril) ne-hydrochlorothiazide (Microzide)
• ama-antipsychotic, afana ne-clozapine (Clozaril, Fazaclo) ne-olanzapine (Zyprexa)
• ama-hormone athile, njenge-danazol (iDanazol), i-levothyroxine (i-Levoxyl, i-Synthroid) ne-somatropin (i-Genotropin)
• i-glucagon (GlucaGen)
• i-niacin (i-Niaspan, iSlo-Niacin, abanye)
• izinto zokuvimbela inzalo ngomlomo (amaphilisi okulawula ukubeletha)

Izidakamizwa ezandisa noma ezinciphisa imiphumela yeSoliqua 100/33

Eminye imithi ingathinta indlela iSoliqua 100/33 esebenza ngayo emzimbeni wakho. Uma uthatha le mithi, kungadingeka ukuthi uhlole amazinga kashukela egazini lakho kaningi. Futhi, udokotela wakho angadinga ukushintsha isilinganiso sakho seSoliqua 100/33.

Izibonelo zale mithi zifaka:

• i-albuterol (ProAir, Proventil, Ventolin)
• lithium

I-Soliqua 100/33 namakhambi nezithako

Ukuthatha i-Soliqua 100/33 ngamakhambi noma izithasiselo ezithile kungandisa ubungozi be-hypoglycemia (amazinga kashukela aphansi). Izibonelo zalokhu zifaka:

• i-alpha-lipoic acid
• banaba
• ikhabe elibabayo
• chromium
• i-gymnema
• i-cactus eliphakathi kwe-prickly
• kamalibhele omhlophe

Isebenza kanjani iSoliqua 100/33

I-Soliqua 100/33 isiza ukuthuthukisa amazinga kashukela egazini kubantu abanesifo sikashukela sohlobo 2.

I-insulin iwuthinta kanjani ushukela wegazi

Imvamisa, lapho udla ukudla, umzimba wakho ukhipha ihomoni ebizwa nge-insulin. Iglucose (ushukela) ovela ekudleni uya egazini lakho, kanti i-insulin iyasiza ukukuhambisa kumaseli omzimba wakho. Amaseli abe eseguqula i-glucose ibe ngamandla.

Abantu abanesifo sikashukela sohlobo 2 bavame ukumelana ne-insulin. Lokhu kusho ukuthi umzimba wabo awuphenduli ku-insulin ngendlela okufanele. Ngokuhamba kwesikhathi, abantu abanesifo sikashukela sohlobo 2 bangayeka nokukhiqiza i-insulin eyanele.

Lapho umzimba wakho ungaphenduli ku-insulin ngendlela okufanele, noma uma ungakhiqizi i-insulin eyanele, lokhu kudala izinkinga. Amaseli omzimba wakho kungenzeka angayitholi i-glucose ayidingayo ukuze isebenze kahle.

Futhi, ungathola i-glucose eningi egazini lakho. Lokhu kubizwa ngokuthi yi-hyperglycemia (ushukela ophakeme wegazi). Ukuba ne-glucose eningi egazini lakho kungalimaza umzimba wakho nezitho zomzimba, kufaka phakathi amehlo akho, inhliziyo, izinzwa nezinso.

Okwenziwa uSoliqua 100/33

I-Soliqua 100/33 iqukethe imishanguzo emibili. Lezi yi-insulin glargine, eyi-insulin esebenza isikhathi eside, ne-lixisenatide, eyi-glucagon efana ne-peptide 1 (GLP-1) receptor agonist.

I-insulini glargine isebenza ngendlela eyodwa: yehlisa amazinga kashukela egazini ngokuhambisa ushukela kusuka egazini lakho uye kumaseli akho.

ILixisenatide isebenza ngezindlela ezintathu. Okokuqala, kwandisa inani le-insulin elenziwa ngumzimba wakho. Le insulin eyandisiwe isiza ukuhambisa i-glucose eyengeziwe egazini lakho iye kumaseli akho. Okwesibili, kubangela isisu sakho ukuba siphume kancane ngemuva kokudla, kukwenze uzizwe ugcwele isikhathi eside. Okwesithathu, itshela isibindi sakho ukuthi sikhiphe ushukela omncane egazini lakho.

Kuthatha isikhathi esingakanani ukusebenza?

ISoliqua 100/33 iqala ukusebenza ngemuva nje kokuyijova. Kodwa-ke, ifinyelela umphumela wayo ophakeme kakhulu cishe ngamahora ama-2,5 kuya kwayi-3 ngemuva komjovo ngamunye.

Soliqua 100/33 nokukhulelwa

Idatha yokufunda ikhawulelwe ukusetshenziswa kweSoliqua 100/33 ngesikhathi sokukhulelwa kubantu. Kodwa-ke, ucwaningo lwezilwane lukhombisa ukuthi kungaba nobungozi bokukhubazeka kokuzalwa kusetshenziswa i-lixisenatide ngesikhathi sokukhulelwa. ILixisenatide ngomunye wemithi etholakala eSoliqua 100/33. Ngakho-ke, iSoliqua 100/33 kufanele isetshenziswe kuphela ngesikhathi sokukhulelwa uma inzuzo engaba khona idlula ubungozi obungaba khona.

Uma ukhulelwe noma uhlela ukukhulelwa, khuluma nodokotela wakho ngezingozi nezinzuzo zokusebenzisa iSoliqua 100/33 ngesikhathi sokukhulelwa.

I-Soliqua 100/33 nokuncelisa ibele

Akwaziwa ukuthi iSoliqua 100/33 idlula ibisi lwebele. Ngaphambi kokuncelisa, kufanele uxoxe nodokotela wakho ngobungozi kanye nezinzuzo zokuthatha lo muthi ngenkathi uncelisa.

Imibuzo ejwayelekile ngeSoliqua 100/33

Nazi izimpendulo zemibuzo ebuzwa njalo ngeSoliqua 100/33.

Ingabe iSoliqua 100/33 ibangela ukuzuza kwesisindo?

Ezivivinyweni zomtholampilo, iSoliqua 100/33 ayitholakalanga ukuthi ibangele ukuzuza kwesisindo. Eqinisweni, ocwaningweni olulodwa lomtholampilo, abantu abathathe i-Soliqua 100/33 amasonto angama-30 balahle cishe amakhilogremu ayi-1.5.

Kuyathakazelisa ukuphawula ukuthi izidakamizwa ngazinye eziqukethwe yiSoliqua 100/33 zibukeka zinemiphumela ehlukene esisindweni. Esinye sezidakamizwa i-insulin glargine, okuyi-insulin esebenza isikhathi eside. Imvamisa, izidakamizwa eziqukethe i-insulin zixhunywe nokuzuza kwesisindo.

Kodwa-ke, esinye isidakamizwa eSoliqua 100/33 sibizwa nge-lixisenatide, eyi-peptide 1 efana ne-glucagon-like peptide 1 (GLP-1) receptor agonist. Imithi esigabeni semithi ye-GLP-1 ikhombise ukwehla kwesisindo njengomphumela wecala ezifundweni ezahlukahlukene zomtholampilo.

Uma ukhathazekile ngemiphumela uSoliqua 100/33 angaba nayo esisindweni sakho, khuluma nodokotela wakho.

Ingabe i-Soliqua 100/33 i-insulin?

Yebo, iSoliqua 100/33 iqukethe i-insulin. I-Soliqua 100/33 yenziwe ngemithi emibili, enye yazo i-insulin glargine, i-insulin esebenza isikhathi eside.

Umuthi wesibili yi-lixisenatide, eyi-peptide 1 efana ne-glucagon-like 1 (GLP-1) receptor agonist.

Ngabe iSoliqua 100/33 isebenza isikhathi eside?

Yebo. I-Soliqua 100/33 iqukethe izidakamizwa ezimbili ezisebenzayo. Enye yazo i-insulin glargine, eyi-insulin esebenza isikhathi eside.

Ngabe iSoliqua 100/33 ingasetshenziswa ukwelapha uhlobo lwesifo sikashukela sohlobo 1?

Cha, iSoliqua 100/33 akufanele isetshenziselwe ukwelapha uhlobo lwesifo sikashukela sohlobo 1. ISoliqua 100/33 ayikaze ifundwe noma ivunywe yi-Food and Drug Administration ukwelapha leso simo. Kuvunyelwe kuphela ukwelapha uhlobo lwesifo sikashukela sohlobo 2.

Izexwayiso ze-Soliqua 100/33

Ngaphambi kokuthatha i-Soliqua 100/33, khuluma nodokotela wakho ngomlando wakho wezempilo. ISoliqua 100/33 kungenzeka ingakulungeli uma unezimo ezithile zezempilo. Lokhu kufaka phakathi:

• Isifo sezinso. Uma unesifo sezinso, ukuthatha i-Soliqua 100/33 kungasenza sibe sibi isimo sakho. Uma isimo sakho siba sibi, kungadingeka ukuthi uyeke ukuthatha iSoliqua 100/33. Ungathathi lo muthi uma unesifo esibi sezinso.
• Ukukhipha isisu kancane. ILixisenatide, esinye sezidakamizwa eSoliqua 100/33, sinciphisa ukusebenza kwezicubu zakho zesisu. Uma une-gastroparesis, okusho ukuthi umzimba wakho ugaya ukudla kancane, ukuthatha iSoliqua 100/33 kungasenza sibe sibi isimo sakho. Abantu abane-gastroparesis enamandla akufanele bathathe le mithi.
• Izinkinga zepancreas noma i-gallbladder, noma inkinga yokusebenzisa utshwala. I-Soliqua 100/33 ingakhuphula ingozi yokuba ne-pancreatitis. Ungaba sengozini enkulu yokuthola i-pancreatitis uma unomlando we-pancreatitis, amatshe e-gallbladder, noma i-alcoholism. Uma unomlando walezi zinkinga, khuluma nodokotela wakho mayelana nokuthi iSoliqua 100/33 ikulungele yini.

Ukudlula ngokweqile kweSoliqua 100/33

Ukuthatha kakhulu lo muthi kungandisa ubungozi bemiphumela emibi kakhulu.

Izimpawu zokudlula ngokweqile

Izimpawu zokudlula ngokweqile zingabandakanya:

• i-hypoglycemia enamandla (ushukela wegazi ophansi kakhulu), ongadala ukuxegiselwa, ukukhathazeka nokudideka
• i-hypokalemia (amazinga aphansi e-potassium), angadala ubuthakathaka, ukuqunjelwa, kanye namajaqamba emisipha
• izinkinga zamathumbu, ezingadala uhudo, isicanucanu nokuhlanza

Okufanele ukwenze uma kwenzeka ukweqisa ngokweqile

Uma ucabanga ukuthi uthathe kakhulu lo muthi, shayela udokotela wakho noma funa ukuholwa yi-American Association of Poison Control Centers ku-800-222-1222 noma ngethuluzi labo eliku-inthanethi. Kepha uma izimpawu zakho zinzima, shayela ku-911 noma uye egumbini lezimo eziphuthumayo eliseduze ngokushesha.

Ukuphelelwa yisikhathi nokugcinwa kweSoliqua 100/33

Lapho iSoliqua 100/33 ikhishwa ekhemisi, usokhemisi uzokwengeza usuku lokuphelelwa yisikhathi kwilebula esesitsheni. Lolu suku luvame unyaka owodwa kusukela ngosuku okwakhishwa ngalo umuthi.

Inhloso yezinsuku zokuphelelwa isikhathi ezinjalo ukuqinisekisa ukusebenza komuthi ngalesi sikhathi. Isimo samanje se-Food and Drug Administration (i-FDA) ukugwema ukusebenzisa imishanguzo ephelelwe yisikhathi.

Ukuthi umuthi uhlala ulungile isikhathi eside kangakanani kungancika ezintweni eziningi, kufaka phakathi ukuthi umuthi ugcinwa kanjani futhi kuphi. Gcina izibaya zakho ze-Soliqua 100/33 esiqandisini sakho, ezingeni lokushisa eliphakathi kuka-36 ° F no-46 ° F (2 ° C no-8 ° C). Ungalokothi ubambe amapeni akho.

Ngemuva kokusetshenziswa kokuqala kwepeni ngalinye, ungaligcina ekamelweni lokushisa (77 ° F / 25 ° C), kepha qiniseka ukulivikela ekukhanyeni. Lahla ipeni ngalinye ngemuva kwezinsuku ezingama-28 kusukela ekusetshenzisweni kwalo kokuqala.

Uma usebenzise umuthi ongasetshenziswanga osudlulile esikhathini sokuphelelwa yisikhathi, khuluma nosokhemisi wakho mayelana nokuthi usengakwazi yini ukuwusebenzisa.

Imininingwane yobuchwepheshe yeSoliqua 100/33

Imininingwane elandelayo inikezwa odokotela nabanye ochwepheshe bezempilo.

Izinkomba

I-Soliqua 100/33 ivunyelwe i-FDA ukuthi isetshenziswe ngokudla nokuvivinya umzimba ukuthuthukisa ukulawulwa kwe-glycemic kubantu abadala abane-type 2 diabetes mellitus.

Indlela yokusebenza

I-Soliqua 100/33 iyinhlanganisela ye-insulin glargine (i-basal insulin analog) ne-lixisenatide (i-peptide efana ne-glucagon efana ne-1 [GLP-1] receptor agonist).

I-insulin glargine yehlisa ushukela wegazi ngokwandisa ukuthathwa kweglucose okuphathelene nomzimba nokunciphisa ukukhiqizwa kweglucose esibindini. I-Lixisenatide inciphisa i-glucose yegazi ngokwandisa uketshezi lwe-insulin, ukunciphisa uketshezi lwe-glucagon, nokunciphisa ukukhipha isisu.

I-Pharmacokinetics ne-metabolism

Isilinganiso se-insulin glargine-to-lixisenatide asinamthelela kuma-pharmacokinetics yanoma iyiphi into.

I-insulini glargine ayinayo isiqongo futhi i-metabolized ngokwengxenye ku-carboxyl terminus yochungechunge lwe-B edepho engaphansi kwesikhumba.

Isikhathi sokuhlushwa okukhulu kwe-lixisenatide ngamahora ama-2,5 kuya ku-3. ILixisenatide inesilinganiso sokubopha amaprotheni esingamaphesenti angama-55 futhi isuswa ngomchamo nokucekelwa phansi kwe-proteolytic. Kusho isigamu sempilo cishe ngamahora ama-3.

Izimo

I-Soliqua 100/33 iyaphikiswa ezigulini:

• ngesikhathi seziqephu ze-hypoglycemic
• ngomlando wokuzwela ngokweqile kwe-insulin glargine noma i-lixisenatide

Isitoreji

Izibaya ze-Soliqua 100/33 kufanele zigcinwe esiqandisini, ezingeni lokushisa eliphakathi kuka-36 ° F no-46 ° F (2 ° C no-8 ° C), kodwa ungalokothi ube yiqhwa. Ngemuva kokusetshenziswa kokuqala, izibaya zingagcinwa ekamelweni lokushisa lama-77 ° F (25 ° C). Kufanele zivikelwe ekukhanyeni. Lahla ipeni ngemuva kwezinsuku ezingama-28 kusukela ekusetshenzisweni kokuqala.

UkuzikhululaI-MedicalNewsToday yenze yonke imizamo yokuqinisekisa ukuthi lonke ulwazi luyiqiniso, luphelele futhi lusesikhathini. Kodwa-ke, le ndatshana akufanele isetshenziswe njengokungena esikhundleni solwazi nobungoti bochwepheshe bezokunakekelwa kwezempilo onelayisense. Kufanele uhlale uthintana nodokotela wakho noma omunye uchwepheshe wezokunakekelwa kwempilo ngaphambi kokuthatha noma imuphi umuthi. Imininingwane yezidakamizwa equkethwe lapha ingashintsha futhi ayihloselwe ukumboza konke ukusetshenziswa okungaba khona, izinkomba, izixwayiso, izexwayiso, ukuxhumana kwezidakamizwa, ukungezwani komzimba, noma imiphumela emibi. Ukungabikho kwezixwayiso noma olunye ulwazi lomuthi othile awukhombisi ukuthi inhlanganisela yezidakamizwa noma yezidakamizwa iphephile, iyasebenza, noma ilungele zonke iziguli noma konke ukusetshenziswa okuthile.