IStiff Person Syndrome

-Delile

• Yini i-stiff person syndrome?
• Ziyini izimpawu ze-stiff person syndrome?
• Yini ebangela i-stiff person syndrome?
• Sitholakala kanjani isifo somuntu onzima?
• Uphathwa kanjani umuntu onesifo esiqinile?
• Uyini umbono we-stiff person syndrome?

Yini i-stiff person syndrome?

I-Stiff person syndrome (i-SPS) yisifo se-autoimmune neurological disorder. Njengezinye izinhlobo zokuphazamiseka kwemizwa, i-SPS ithinta ubuchopho bakho nentambo yomgogodla (uhlelo oluphakathi lwezinzwa).

Isifo sokuzivikela komzimba senzeka lapho amasosha akho omzimba ekhomba ngokungalungile izicubu zomzimba ezijwayelekile njengezingozi futhi azihlasela.

I-SPS ayivamile. Kungathinta kakhulu impilo yakho ngaphandle kokwelashwa okufanele.

Ziyini izimpawu ze-stiff person syndrome?

Okuphawuleka kakhulu, i-SPS ibangela ukuqina kwemisipha. Izimpawu zokuqala zifaka:

• ukuqina kwesitho
• imisipha eqinile esiqwini
• izinkinga zokuma kusuka kwimisipha yangemuva eqinile (lokhu kungadala ukuthi uzingele ngaphezulu)
• ubuhlungu bemisipha obuhlungu
• ubunzima bokuhamba
• izingqinamba zezinzwa, njengokuzwela ukukhanya, umsindo, nomsindo
• ukujuluka okweqile (hyperhidrosis)

Ama-Spasms ngenxa ye-SPS angaba namandla kakhulu futhi angadala ukuthi uwe uma umile. Ama-Spasms kwesinye isikhathi angaba namandla ngokwanele ukuphula amathambo. Ama-Spasms abi kakhulu uma ukhathazekile noma ucasukile. Ama-Spasms nawo angadalwa ukunyakaza okungazelelwe, umsindo omkhulu, noma ukuthintwa.

Uma uhlala ne-SPS, ungahle ube nokudangala noma ukukhathazeka. Lokhu kungabangelwa ezinye izimpawu ongahle ubhekane nazo noma ukwehla kwama-neurotransmitters ebuchosheni.

Amandla wokucindezeleka ngokomzwelo angakhuphuka njengoba i-SPS iqhubeka. Ungaqaphela ukuthi ukugaxekile kuyadlondlobala uma uphumela emphakathini. Lokhu kungaholela ekukhuleni kokukhathazeka ngokuya emphakathini.

Ezigabeni zakamuva ze-SPS, ungahlangabezana nokuqina kwemisipha nokuqina.

Ukuqina kwemisipha kungasakazeka nakwezinye izingxenye zomzimba wakho, njengasebusweni bakho. Lokhu kungafaka imisipha esetshenziselwa ukudla nokukhuluma. Imisipha ebandakanyeka ekuphefumuleni nayo ingathinteka ibangele izinkinga ezisongela impilo zokuphefumula.

Ngenxa yokuba khona kwama-antibodies e-amphiphysin, i-SPS ingabeka abanye abantu engcupheni yokwanda komdlavuza othile, kufaka phakathi:

• isifuba
• ikholoni
• amaphaphu

Abanye abantu abane-SPS bangathuthukisa ezinye izifo ezizimele, kufaka phakathi:

• isifo sikashukela
• Izinkinga ze-thyroid
• i-anemia eyingozi
• i-vitiligo

Yini ebangela i-stiff person syndrome?

Imbangela ngqo ye-SPS ayaziwa. Kungenzeka ufuzo.

Ungaba futhi engozini eyengeziwe yokuthuthukisa lesi sifo uma wena noma omunye emndenini wakho unolunye uhlobo lwesifo esizimele. Lokhu kufaka phakathi:

• thayipha isifo sikashukela sohlobo 1 no-2
• i-anemia eyingozi
• isifo samathambo
• I-thyroiditis
• i-vitiligo

Ngezizathu ezingaziwa, izifo ezizimele zihlasela izicubu ezinempilo emzimbeni. Nge-SPS, izicubu ebuchosheni nasemgogodleni ziyathinteka. Lokhu kubangela izimpawu ezisuselwa kwizicubu ezihlaselwe.

I-SPS idala amasosha omzimba ahlasela amaprotheni kuma-neuron obuchopho alawula ukunyakaza kwemisipha. Lawa abizwa ngamagciwane e-glutamic acid decarboxylase (GAD).

I-SPS imane yenzeke kubantu abadala abaphakathi kweminyaka yobudala engama-30 nengama-60. Iphinde futhi iphindwe kabili kwabesifazane uma iqhathaniswa neyabesilisa.

Sitholakala kanjani isifo somuntu onzima?

Ukuxilonga i-SPS, udokotela wakho uzobheka umlando wakho wezokwelapha bese enza ukuhlolwa komzimba.

Ukuhlola nakho kubalulekile. Okokuqala, ukuhlolwa kwegazi kungasetshenziswa ukuthola amasosha omzimba we-GAD. Wonke umuntu one-SPS akanawo la magciwane. Kodwa-ke, kuze kufike kumaphesenti angama-80 abantu abaphila ne-SPS abakwenzayo.

Udokotela wakho angalawula ukuhlolwa kokuhlolwa okubizwa nge-electromyography (EMG) ukukala umsebenzi kagesi wemisipha. Udokotela wakho angaphinde alayishe i-MRI noma i-lumbar puncture.

I-SPS ingatholwa kanye nesifo sokuwa. Kwesinye isikhathi kuyiphutha kwezinye izifo zemizwa, njenge-multiple sclerosis (MS) nesifo sikaParkinson.

Uphathwa kanjani umuntu onesifo esiqinile?

Alikho ikhambi le-SPS. Kodwa-ke, ukwelashwa kuyatholakala ukukusiza ukuphatha izimpawu zakho. Ukwelashwa nakho kungamisa isimo ukuthi singabi sibi kakhulu. Ukuphazamiseka kwemisipha nokuqina kungaphathwa ngomuthi owodwa noma ngaphezulu walokhu okulandelayo:

• I-Baclofen, isidambisi semisipha.
• I-Benzodiazepines, njenge-diazepam (Valium) noma i-clonazepam (iKlonopin). Le mithi yehlisa imisipha yakho futhi isize ngokukhathazeka. Imithamo ephezulu yale mithi ivame ukusetshenziselwa ukwelapha ukuphazamiseka kwemisipha.
• UGabapentin uhlobo lomuthi osetshenziselwa ubuhlungu bezinzwa nokudlikizela.
• Iziphumuli zemisipha.
• Imithi yezinhlungu.
• I-Tiagabine ngumuthi olwa nokuquleka.

Abanye abantu abane-SPS nabo baye bathola ukukhululeka kwezimpawu nge:

• Ukufakelwa kwe-stem cell kwe-Autologous inqubo lapho amaseli akho omnkantsha wegazi namathambo eqoqwa futhi andiswa ngaphambi kokubuyela emzimbeni wakho. Lokhu ukwelashwa kokuhlola okucatshangelwa kuphela ngemuva kokuthi ezinye izindlela zokwelapha zehlulekile.
• I-immunoglobin efakwa ngaphakathi lingehlisa inani lama-antibodies ahlasela izicubu ezinempilo.
• I-Plasmapheresis inqubo lapho i-plasma yakho yegazi ithengiswa khona nge-plasma entsha ukunciphisa inani lama-antibody emzimbeni.
• Amanye ama-immunotherapies njenge-rituximab.

Ama-anti-depressants, anjenge-serotonin reuptake inhibitors (SSRIs) akhethiwe angasiza ngokudangala nokukhathazeka. I-Zoloft, i-Prozac, ne-Paxil ziphakathi kwemikhiqizo udokotela ongayiphakamisa. Ukuthola umkhiqizo ofanele kuvame ukuthatha inqubo yokulinga nephutha.

Ngaphezu kwemithi, udokotela wakho angakudlulisela kuchwepheshe wezempilo. Ukwelashwa komzimba kukodwa akukwazi ukwelapha i-SPS. Kodwa-ke, izivivinyo zingasiza kakhulu nge:

• inhlalakahle engokomzwelo
• ukuhamba
• ukuzimela
• ubuhlungu
• ukuma
• umsebenzi wosuku nosuku
• ububanzi bokunyakaza

Ngokuya ngokuthi zinzima kangakanani izimpawu zakho, umelaphi wakho womzimba uzokuqondisa ekuzivocavoca ukuhamba nokuzilibazisa. Ngosizo lomelaphi wakho, ungakwazi ngisho nokwenza iminyakazo ethile ekhaya.

Uyini umbono we-stiff person syndrome?

Uma uphila nalesi simo, uthambekele kakhulu ekuweni ngenxa yokuntuleka kokuzinza nokucabanga. Lokhu kungandisa ubungozi bokulimala kanzima ngisho nokukhubazeka unomphela.

Kwezinye izimo, i-SPS ingathuthuka futhi isakaze kwezinye izindawo zomzimba wakho.

Alikho ikhambi le-SPS. Kodwa-ke, ukwelashwa kuyatholakala ukukusiza ukuphatha izimpawu zakho. Umbono wakho jikelele uncike ekutheni uhlelo lwakho lwezokwelapha lusebenza kanjani.

Wonke umuntu usabela ekwelashweni ngendlela ehlukile. Abanye abantu baphendula kahle emithini nasekwelashweni ngokomzimba, kanti abanye bangase bangaphenduli kahle nasekwelashweni.

Xoxa nodokotela wakho ngezimpawu zakho. Kubaluleke kakhulu ukuxoxa nganoma yiziphi izimpawu ezintsha ohlangabezana nazo noma uma ungaboni nhlobo ukuthuthuka. Lolu lwazi lungabasiza banqume ngohlelo lokwelashwa olukusebenzela kangcono.