I-MS-Progressive MS (PPMS): Izimpawu nokuxilongwa

-Delile

• Ngabe i-PPMS ihluke kanjani kwezinye izinhlobo ze-MS?
• Yini ebangela i-PPMS?
• Ziyini izimpawu ze-PPMS?
• Ukuqina kwemisipha
• Ukukhathala
• Ubundikindiki / ukuncinza
• Izinkinga ngombono
• Izinkinga ezinokuqonda
• Isiyezi
• Izinkinga zesinye namathumbu
• Ukucindezeleka
• I-PPMS itholakala kanjani?
• Izinketho zokwelashwa
• Umbono

Yini i-PPMS?

I-Multiple sclerosis (MS) yisifo esivame kakhulu sohlelo lwezinzwa oluphakathi. Kubangelwa ukuphendula komzimba okucekela phansi i-myelin sheath, noma ukumboza izinzwa.

I-multiple sclerosis eqhubekayo eyisisekelo (PPMS) ingenye yezinhlobo ezine ze-MS. Ezinye izinhlobo ezintathu ze-MS yilezi:

• isifo esihlukaniswe ngokwasemtholampilo (i-CIS)
• ukuxolelwa okuphindayo (RRMS)
• okuqhubekayo kwesibili (SPMS)

I-PPMS ingenye yezinhlobo ezivame kakhulu, ezithinta cishe amaphesenti ayishumi abo bonke abantu abatholakala bene-MS.

Ngabe i-PPMS ihluke kanjani kwezinye izinhlobo ze-MS?

Iningi labantu abathintekayo yi-MS banokuhlaselwa okunamandla ngezimpawu, okubizwa ngokuthi ukubuyela emuva, nezikhathi zezinyanga noma zeminyaka ezingenazimpawu, ezibizwa ngokuthi yi-remissions.

I-PPMS yehlukile. Lesi sifo siqhubeka lapho izimpawu seziqala ukuvela, yingakho igama liqhubeka ngokuqhubekayo. Kungaba nezikhathi zokuqhubeka okusebenzayo bese kuba nezikhathi zokuqhubeka kokungasebenzi kwezimpawu nokukhubazeka.

Umehluko owodwa phakathi kwe-PPMS namafomu abuyayo ukuthi ngenkathi ukuqhubeka okusebenzayo kungama okwesikhashana, izimpawu azixazululi. Kumafomu abuyela emuva, izimpawu zingathuthuka empeleni noma zibuyele eduze nalapho bezikhona ngaphambi kokubuyela emuva kwakamuva kakhulu.

Omunye umehluko ukuthi akukho ukuvuvukala okungako ku-PPMS uma kuqhathaniswa namafomu abuyela emuva. Ngenxa yalokhu, izidakamizwa eziningi ezisebenzela amafomu abuyela emuva azisebenzi ku-PPMS noma i-SPMS. Ukuqhubeka kwezimpawu kungadlulela ezinyangeni ezimbalwa noma eminyakeni eminingana.

I-PPMS ivame ukutholakala kubantu abaneminyaka engama-40 nengama-50. I-RRMS, ngakolunye uhlangothi, imvamisa iletha kubantu abaneminyaka engama-20 nengama-30. I-PPMS nayo ithinta bobabili abesilisa ngokulingana, kuyilapho i-RRMS ithinta abesifazane kabili noma kathathu kunabesilisa.

Yini ebangela i-PPMS?

I-PPMS ibangelwa ukulimala kwezinzwa okuhamba kancane okuvimba izinzwa ekuthumeleni amasiginali komunye nomunye. Zonke izinhlobo ezine ze-MS zibandakanya ukulimala kwengubo yokuvikela (i-myelin) yesistimu yezinzwa emaphakathi, ebizwa nge-demyelination, kanye nokonakala kwenzwa.

Ziyini izimpawu ze-PPMS?

Izimpawu ze-PPMS ziyefana nezimpawu ze-SPMS. Vele, lokho umuntu abhekana nakho kuzohluka komunye.

Izimpawu ze-PPMS zingafaka okulandelayo:

Ukuqina kwemisipha

Ukuncipha okuqhubekayo kwemisipha ethile kungadala ukuqina nokuqina, okungathinta ukunyakaza. Lokhu kungenza kube nzima ukuhamba, ukusebenzisa izitebhisi, nokuthonya izinga lakho lomsebenzi jikelele.

Ukukhathala

Cishe amaphesenti angama-80 alabo abane-PPMS abahlangabezana nokukhathala. Lokhu kungathinta kakhulu impilo yansuku zonke futhi kwenze kube nzima ukusebenza nokuqedela imisebenzi ejwayelekile. Labo abatholakala ukuthi bane-PPMS bangazithola bekhathele kakhulu yimisebenzi elula. Isibonelo, umsebenzi wokupheka isidlo sakusihlwa ubungaguga futhi ubadinge ukuthi balale kancane.

Ubundikindiki / ukuncinza

Esinye isibonakaliso sokuqala se-PPMS ukundikindiki noma ukuncinza ezingxenyeni ezahlukahlukene zomzimba, njengobuso bakho, izandla nezinyawo. Lokhu kungagcinwa endaweni eyodwa yomzimba wakho, noma uye kwezinye izingxenye.

Izinkinga ngombono

Lokhu kungafaka ukubona kabili, ukungaboni kahle, ukungakwazi ukubona imibala nokuqhathanisa, nobuhlungu lapho uhambisa amehlo akho.

Izinkinga ezinokuqonda

Ngenkathi i-PPMS ivame ukuthinta ukuhamba, abanye abantu bangathola ukwehla kwengqondo. Lokhu kungaphazamisa kakhulu ukukhumbula nokucubungula imininingwane, ukuxazulula izinkinga, ukugxila, nokufunda noma yini entsha.

Isiyezi

Labo abane-PPMS bangaba neziqephu zesiyezi nobunzima. Abanye bangathola i-vertigo, umuzwa wokuthi bayazula futhi balahlekelwa ibhalansi yabo.

Izinkinga zesinye namathumbu

Izinkinga zesinye namathumbu zingahle zihlukane nokungabambeki, kuye njalo ekudingeni ukuya ekuqunjelweni. Lokhu kungaholela ezinkingeni zocansi, njengokuncipha kokushayela ngocansi, ubunzima bokugcina ukwakhiwa, nokuzwa okuncane esithweni sangasese.

Ukucindezeleka

Cishe uhhafu wabo bonke abantu abane-MS bazobhekana okungenani nesiqephu esisodwa sokucindezeleka. Yize kujwayelekile ukucasuka noma ukuthukuthela ngokwanda kokukhubazeka, lezi zinguquko zemizwa zivame ukuhamba nesikhathi. Ukudangala komtholampilo, ngakolunye uhlangothi, akupheli futhi kudinga ukwelashwa.

I-PPMS itholakala kanjani?

I-PPMS inezimpawu ezifanayo nakwezinye izinhlobo ze-MS, kanye nokunye ukuphazamiseka kwesistimu yezinzwa. Ngenxa yalokhu, kungathatha isikhathi esingangeminyaka emithathu ukuthola ukuxilongwa okuqinisekisiwe kwe-PPMS kunokuxilongwa kwe-RRMS.

Ukuthola ukuxilongwa kwe-PPMS okuqinisekisiwe, kufanele:

• ube nonyaka wokuqhubeka nokusebenza kabi kwe-neurologic
• uhlangabezane nemibandela emibili elandelayo:
  • isilonda sobuchopho esivamile ku-MS
  • izilonda ezimbili noma ngaphezulu ezifanayo emgogodleni wakho
  • ukutholakala kwamaprotheni abizwa ngama-immunoglobulin

Udokotela wakho kungenzeka enze ukuhlolwa komlando wezokwelapha futhi akubuze nganoma yimiphi imicimbi yangaphambilini ye-neurologic. Bangacela amalungu omndeni ukuthi abekhona, njengoba benganikela ngokuhlangenwe nakho kwabo ngezimpawu ezedlule. Udokotela wakho lapho-ke kungenzeka enze ukuhlolwa okuphelele komzimba, ikakhulukazi ahlole izinzwa nemisipha yakho.

Udokotela wakho uzo-oda ukuskena kwe-MRI ukuhlola izilonda ebuchosheni nasentanyeni yomgogodla. Bangaphinde ba-oda ukuhlolwa kokukhishwa kwamandla (EP) ukuhlola ukusebenza kukagesi ebuchosheni. Ekugcineni, udokotela wakho uzokwenza umpompi womgogodla ukuze afune izimpawu ze-MS kuketshezi lomgogodla.

Izinketho zokwelashwa

Alikho ikhambi le-PPMS. Umuthi owodwa, i-ocrelizumab (i-Ocrevus), uvunyelwe i-PPMS kanye namafomu abuyayo e-MS. Ama-immunosuppressants ajwayele ukusetshenziselwa amafomu abuyela emuva, noma kunjalo, ngoba anciphisa ukuvuvukala. I-PPMS ayinakho ukuvuvukala okuningi, ngakho-ke ama-immunosuppressants kungenzeka anganconywa ukuthi awusizo. Ucwaningo lwezokwelapha olusebenzayo luyaqhubeka.

Umbono

Yize lungekho ikhambi le-PPMS, labo abatholakala ukuthi bane-PPMS akufanele balahle ithemba. Ngosizo lodokotela, ochwepheshe bezokwelapha ngokomzimba, odokotela bokukhuluma, kanye nochwepheshe bezempilo yengqondo, kunezindlela zokuphatha lesi sifo. Lokhu kungafaka imithi esiza ukukhulula izimpawu, njengokuphumula kwemisipha yemisipha, kanye nokudla okunempilo, ukuzivocavoca umzimba, kanye nendlela efanele yokulala.